의약품의 효능별 안전성·유효성 평가에 관한 조사연구(Ⅰ) : 항균제 Antiboiotics

박윤주,최기환,김동섭,박인숙,정면우,임화경,오우용,강주희,박찬웅,김주일 식품의약품안전청 2001 식품의약품안전청 연보 Vol.5 No.-

새로운 물질이 개발되어 신약으로 탄생하기까지 많은 시간과 노력, 예산이 필요하다. 최근, 우리 나라에서도, 신약캐발이 어릴고 힘든 분야이지만 새로운 신약개발을 총해 얻어지는 분가가치가 막대함을 인식, 연구에 박차를 가하 있는 실정이다. 본 연구는, 의약품 개발 선진국인 미국 FDA에서 발행하는 참고자료 중 항균제 임상편가에 대한 가이드라인 및 주요 임상적응증별 항균제 기발(지역사획회득성 폐렴, 원내감염성 계렴, 급성기관지염의 2차세균감염, 만성기지염의 급성세균성 악화, 연쇄구균에 의한 인두영 및 편도염 , 단순성 요로감염증, 복합성 요로감염증 및 신우신영, 급성 세균성 부비동옆, 항 바이러스제 개발시 전임상단계에서 고려사항, 항 바이러스제 허가와 된련 잉상적 고려사항, 카레타 괸련 혈류감염)에 있어서의 파이드라인 등의 자료를 소개함으로져, 향후 제약사의 항균제 신약개발 및 허가 신청된 의악품의 전임상차료 및 잉상시험자료의 검토 평가업무에 참고자료로 활용될 수 있을 것이다. Changing or unclear interpretations of clinical trial data needed to demonstrate the effectiveness and safety of antimicrobial drug products have a times led to confusion and frustration on the part of both applicants and division of these drug products reviewers. The FDA published guidance on desing clinical protocols, implementing, and analyzing data from clinical trials for antimicrobial drug products has been presented and additional companion guidances introduced specific issues to individual infections. This document provides applicants and reviewers with minimal information appropriate for the clinical development of routine antimicrobial drug products and identifies issues common to many antimicrobial drug applications. The agency can use the kind of information to determine whether the antimicrobial drug product under study is safe and effective in the treatment of the specific infection studied.

발생원별에 따른 PAHs 배출특성

박찬구,윤중섭,김민영,손종열,모세영 한국대기환경학회 2004 한국대기환경학회지 Vol.20 No.3

The results of individual PAH source profiles that can be applied to receptor model are as follows. The sum of 16 PAH concentrations was 391.41 ng/S㎥ in a tunnel. Phenanthrene was the most abundant compound among 16 PAH, and then pyrene, fIuoranthene, anthracene, and naphthalene can be seen in elevated contents. 11,056.61 ng/S㎥ of 16 PAH concentrations in BC oil boiler was two times higher than 6,582.57 ng/S㎥ of those in LNG boiler. Naphthalene was the most abundant compound in both facilities. Phenanthrene, anthracene. and acenaphthylene were the second dominant compound group in order from both facilities. BC oil boiler had relatively high concentration of pyrene compared to LNG boiler that had high concentration of fluorene and did not detect pyrene. The sum of 16 PAH concentrations emitted from MSW incinerators after APCD (air pollution control device) was three times higher than those from MSW incinerators bcfore APCD. However, the concentrations of more than 4-ring PAH compounds (e.g., benzo (a)anthracene) before APCD were higher than those after APCD. This fact implies that PAHs generated by combustion process are eliminated in APCD and they are continuously produced in stack or atmosphere by PAHs precursors.

전기응집에 의한 도금폐수 처리의 최적화

이찬원,양기섭,윤재일,박영배 경남대학교 환경문제연구소 1998 환경연구 Vol.21 No.-

The zinc containing wastewater from the metal finishing industry was treated by electro-coagulation system. The zine was effectively removed with removal efficiency ranging from 95 to 99%. The operation of the system was conducted to find out the optimum conditions to reduce bleaching out effect from plate, changing important parameters such as reactor plate select, flow rate, pass, amperage and settling time, along with a consideration of O&M costs for the electro-coagulation system. The most effective and economical conditions was concluded to be a combination of Fe plate 1.0 L/min of flow rate, 5 pass, 15 amperage and 30 min settling. The copper plating wastewater was also effectively treated with 94% removal effectively under this optimum condition.

저주파수 및 저입력전압용 박막형 다중접합 열전변환기

황찬순,이형주,김진섭,이정희,박세일,권성원 한국센서학회 2002 센서학회지 Vol.11 No.3

저주파수의 저전압용 크로멜-알루멜 다중접합 열전변환기를 개발하고자 NiCr 히터의 두께를400 nm, 600 nm 및 800 nm로 변화시켰다. 40 Hz∼10 kHz의 직류 역방향 주파수 범위로 0.5 V의 교류 실효전압을 열전변환기에 인가시켰을 때 히터의 두께가 400 nm인 열전변환기가 ±0.51∼±1.69 ppm 범위의 열전효과에 의한 교류-직류 전압 변환오차를 나타내었고, 열전효과 및 주파수에 의한 교류-직류 변환오차는 40 Hz∼l MHz의 주파수 범위에서 ±40∼±115 ppm 범위를 나타내어, 저주파수의 저전압용으로 사용할 수 있었다. NiCr-heaters with three different thicknesses ranging from 400 nm to 800 nm were fabricated and their characteristics were compared for the purpose of developing a chromel-alumel multijunction thermal converter for low input voltage with low frequency. The thermoelectric effect-induced AC-DC voltage transfer difference of the thermal converter with a built-in NiCr-heater of 400 nm-thickness was ±0.51∼±1.69 ppm in the DC reversing frequency of 40 Hz∼10 kHz with appling 0.5 V_rms and the difference was increased to ±40∼±115 ppm in the frequency of 40 Hz~l MHz, when both thermoelectric effects and frequency effects were considered, showing the thermal converter would be suitable for the low input voltage application with low frequency.

RSA 암호화 알고리즘의 구현에 관한 연구

신인철,이민섭,박창섭,김범식,우찬일,최춘수 단국대학교 1998 論文集 Vol.33 No.-

Recently, the information exchange through a communication network has been increased rapidly. When the sensitive information being sent or stored, the cryptographic technique can be employed in order to prevent it from being exposed or modified by the illegal third party. To implement public key encryption systems based on the integer factorization and the discrete logaritm problem, an efficient exponential arithmetic is mandatory due to large numbers involved. In this paper, the general analysis about the high­speed implementation of primality testing and exponentiations are investigated as well as implementing RSA public­key system. The public­key cryptosystem can be applied to any applications which need both the privacy and the authentication. Finally, suing the software package named MIRACL which provides the basic number theoretic routines for cryptographic software developers. we have implemented the RSA encryption and decryption with Blum­Goldwasser probabilistic algorithm under various key and message size.

僞造旅券에 관한 硏究

양후열,진명수,최섭,이영수,박찬문,김동욱 內務部 國立科學搜査硏究所 2001 國立 科學 搜査 硏究所 年報 Vol.33 No.-

T 림프구 아형 측정에서 총 T 림프구 측정의 재현성 및 CD3⁺ CD4^- CD8^- 세포군의 특성

성흥섭,권수진,박찬정,지현숙 대한임상병리학회 2002 대한임상병리학회지 Vol.22 No.2

액와접근법을 이용한 무기하 내시경 갑상선 절제술 후 국소 부위 통증 조절 장치(On-Q^Ⓡ PainBuster^Ⓡ)와 자가 통증 조절 장치의 무작위 대조 연구에 대한 예비 자료

이경원,박찬흔,박용래,현기훈,윤지섭,Kyung-Won Lee,Chan-Heun Park,Yong-Lai Park,Ki-Hun Hyun,Ji-Sup Yoon 대한갑상선-내분비외과학회 2013 The Koreran journal of Endocrine Surgery Vol.13 No.4

Purpose: Gasless transaxillary approach to endoscopic thyroidectomy is a widely performed procedure for benign or malignant thyroid neoplasms. However, it requires wide dissection for approaching the target area. The intravenous patient-controlled analgesia (IV PCA) is an effective method for postoperative pain control and patients can use it according to their requirement. However, patients suffer from nausea, vomiting, sleep disturbance, etc. due to opioids. Pain pump ON-Q^Ⓡ PainBuster^Ⓡ (pain buster) has been used widely in various surgeries for control of postoperative localizing and wide area pain without side effects of opioid analgesia because it consists of Ropivacaine. Methods: From Aug. 2008 to Jan. 2013, Gasless transaxillary endoscopic thyroidectomy was performed in 90 patients in a single institution, who were divided into three groups, including the IV PCA, pain buster, and null groups. We compared postoperative outcomes, pain severity between groups. We recorded scores immediately, 6, 12, 24, and 48 hours after surgery following visual analog pain score (VAS), and investigated hospital stay and occurrence of events of nausea, vomiting, and complications. Results: In the IV PCA group, it was discontinued due to nausea in 36.7% of patients. No significant difference in pain severity following VAS score was observed among the three groups. However, smaller numbers of analgesia injections were required in the Pain buster group than in the other groups, and fewer patients suffered from constipation, compared with the PCA group. Conclusion: Pain buster showed even effects compared to IV PCA, with few side effects and less discomfort of patients, compared with the other groups. Therefore, pain buster was thought to be the proper method for pain control after dissection of the anterior chest wall, cervical area in order to secure an operative view for transaxillary endoscopic thyroi-dectomy.

외과 의사에 의해 시행된 갑상선 결절의 악성 종양을 시사하는 초음파 소견의 분석

고건,고진철<SUP>1<,SUP>,최상용,박신희,이광찬<SUP>1<,SUP>,김진승<SUP>1<,SUP>,Gun Go,M,D,Jin Chul Koh,M,D,<SUP>1<,SUP>,Sang Yong Choi,M,D,Shin Hee Park,M,D,Kwang Chan Lee,M,D,<SUP>1<,SUP> and Chin Seung Kim,M,D,<SUP>1< 대한갑상선-내분비외과학회 2010 The Koreran journal of Endocrine Surgery Vol.10 No.4

Purpose: Ultrasound is most effective study for evaluating thyroid nodules. In this review, we discuss that sonographic findings to differentiate benign from malignant nodules and suggest recommendations for indications of fine needle aspiration biopsy and thyroid nodule management. Methods: Sonographic scans of 206 thyroid nodules in 164 patients were candidated for this study. We evaluated sonographic findings by shape, calcification, margin, and echogenicity, retrospectively. Sonographic findings that suggested malignancy included microcalcifications, a speculated margin, marked hypoechogenicity and a shape that was taller than wide. The final diagnosis of lesion as benign (n=180) or malignant (n=26) was confirmed by fine needle aspiration biopsy and follow-up (>6 months). We demonstrated the difference of the sensitivity, specificity, positive predictive value, negative predictive value and accuracy. Results: Of 206 thyroid nodules, 26 were malignant. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy based on our sonographic classification method were 84.6%, 73.9%, 31.9%, 97.0% and 75.2%. Conclusion: Sonography can be helpful for making the differentiation between and malignant nodules. So, when well trained surgeon find thyroid nodules on sonography, we can make correct diagnosis of malignant nodules. (Korean J Endocrine Surg 2010;10:224-228)

A New Amorphous Semiconducting Polythiophene for High-Performance Organic Thin-Film Transistors

Kong, Hoyoul,Lee, Dong Hoon,Seo, Jung-In,Oh, Ji-Young,Chung, Dae Sung,Park, Jong-Won,Kwon, Soon-Ki,Lee, Yoon Sup,Park, Chan Eon,Shim, Hong-Ku American Chemical Society 2010 ACS APPLIED MATERIALS & INTERFACES Vol.2 No.4

<P>A new amorphous semiconducting polymer containing dodecylthiophene rings and a rigid thieno[3,2-<I>b</I>]thiophene ring, poly(2,5-bis(3′-dodecyl-2,2′-bithiophen-5-yl)thieno[3,2-<I>b</I>]thiophene) (<B>NAP</B>), was synthesized via a microwave-assisted Stille coupling reaction. The presence of the flexible unsubstituted thiophene ring units next to the rigid fused thiophene ring caused <B>NAP</B> to have an amorphous structure. This structure was confirmed by XRD, AFM, and computational calculations. In particular, the out-of-plane XRD patterns of <B>NAP</B> thin films exhibited no reflection peaks before or after the annealing process, indicating that the films had amorphous microstructures. In addition, AFM images of the <B>NAP</B> thin films showed amorphous surface morphologies with very small root-mean-square (rms) surface roughnesses of 0.3−0.5 nm, independent of surface treatment or heat treatment. Computational calculations performed to investigate the preferred conformation of the polymer confirmed the amorphous characteristics of the <B>NAP</B> structure. On the basis of these findings, we propose how an amorphous <B>NAP</B> semiconductor can maintain high carrier mobility. A <B>NAP</B>-based TFT device exhibited a very high carrier mobility of 0.02 cm<SUP>2</SUP> V<SUP>−1</SUP> s<SUP>−1</SUP> with an on/off ratio of 1 × 10<SUP>5</SUP> and a very small threshold voltage of −2.0 V. This carrier mobility is the highest yet reported for TFTs based on amorphous semiconductors. Thus, the present findings suggest that an amorphous semiconductor layer comprised of <B>NAP</B> would be suitable for use in high-performance organic TFTs fabricated via simple processes in which neither surface treatment nor heat treatment is necessary.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2010/aamick.2010.2.issue-4/am9008852/production/images/medium/am-2009-008852_0011.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/am9008852'>ACS Electronic Supporting Info</A></P>