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      • KCI등재

        Nicotinamide의 투여가 일시적인 국소허혈로 유발된 흰쥐의 뇌경색에 미치는 영향

        이민섭,안영준,최기용,강구,강성식,정일영,이건재,김근우 대한병리학회 2006 Journal of Pathology and Translational Medicine Vol.40 No.2

        Background : Cerebral ischemia depletes ATP and causes irreversible tissue injury. Nicotinamide is a precursor of NAD+ and it is also a poly (ADP-ribose) polymerase (PARP) inhibitor that increases the neuronal ATP concentration and so protects against stroke. Therefore we examined whether nicotinamide could protect against cerebral ischemia by using a model of transient middle cerebral artery occlusion (MCAO) (reperfusion 2 h post ischemia) in Sprague- Dawley rats. Methods : Nicotinamide (500 mg/kg) or normal saline was administered intraperitoneally 24 and 0 h before and after MCAO, respectively. The infarction volumes were determined with triphenyltetrazolium chloride staining 24 h after reperfusion. The nitrotyrosine, PAR polymer and PARP-1 expressions were examined by immunohistochemistry with using brain slices obtained from the rats that were sacrificed at 0, 15, 30, 60 and 120 min after reperfusion. Results : The infarction volumes were significantly attenuated (21.8%, p<0.05). The nitrotyrosine expressions were increased at 0, 15 and 30 min, and those expressions for PARP polymer and PARP-1 were increased at 60 and 120 min, respectively. Nicotinamide partly reduced the expressions for nitrotyrosine and PAR polymer except for PARP-1. Conclusions : These results suggest that nicotinamide may attenuate ischemic brain injury through its antioxidant activity and the inhibition of PARP-1.

      • 투시도의 재인식을 위한 일고찰 ( A Study on the New Approach to Perspective )

        이민섭 대한건축학회 1978 建築 Vol.22 No.1

        인간이 3차원의 공간 및 입체를 2차원의 평면위에 표현하고자 할 때 간단하지 않은 문제가 생긴다. 투시도는 이문제를 해결하는 한 방법으로서 훌륭한 가치가 있는 것이나 어떤 사람은 이를 너무나 기계적 작도법으로만 생각하는 경향이 있고, 어떤사람은 투시도 위력을 과신하여 무리한 그림을 그리는 수도 있으며 또 어떤 사람은 이를 전문가의 전매특허처럼 오해하여 어렵고 까다로운 것으로만 생각하여 외면하는 수도 있다. 투시도란 원래 어떤 전문가가 만들어낸 발명품이 아니라 건축문화의 고전인 그리스와 로마때부터 오랜 역사를 통하여 발견되고 다듬어진 자연원리인 것이다. 필자는 여기서 투시도의 역사적 배경을 되돌아보고,투시도의 원리를 재음미하여 투시도법에 대한 용이한 접근 방법을 제시하며 정상적 투시도의 범위에 대하여 우리의 육안과 카메라의 화각, 필름 및 영화화면의 거형비등 몇가지 예를 들어 살펴볼가 한다.

      • KCI등재

        On a secure binary sequence generated by a quadratic polynomial on Z_(2^n)

        이민섭 한국전산응용수학회 2011 Journal of applied mathematics & informatics Vol.29 No.1

        Invertible functions with a single cycle property have many cryptographic applications. The main context in which we study them in this paper is pseudo random generation and stream ciphers. In some cryptographic applications we need a generator which generates binary sequences of period long enough. A common way to increase the size of the state and extend the period of a generator is to run in parallel and combine the outputs of several generators with different period. In this paper we will characterize a secure quadratic polynomial on Z_(2^n), which generates a binary sequence of period long enough and without consecutive elements.

      • KCI등재

        태지유사지질복합체의 제조와 특성

        이민섭,유영경,이건국 한국피부과학연구원 2014 대한피부미용학회지 Vol.12 No.4

        Vernix caseosa is the creamy white skin surface biofilm which covers the skin of the fetus and the newborn. A recent human clinical study demonstrated that vernix caseosa has skin moisturizing and skin barrierenhancing properties. The aim of this study was to develop vernix caseosa analogues mimicking the uniquestructure and properties of natural vernix caseosa. The vernix caseosa mimetic formulations were preparedusing high internal phase water-in-oil emulsion with skin barrier lipids, skin surface (sebaceous) lipids, cosurfactantsand emulsion stabilizers. Stability studies of these vernix caseosa mimetics were carried outat different storage conditions for 28days. Subsequently, we have investigated whether topical applicationof vernix caseosa mimetic (VCM Ⅷ) improve the water content of the skin surface and accelerate therecovery of the skin barrier. Our results showed that VCM Ⅷ improved the skin moisturization comparedwith W/O cream and O/W DMS cream. Moreover, Observation at five minutes after application of the testmaterials (vaseline, DMS cream and VCM Ⅷ) showed that the baseline water content of all samples werebetter than with control normal skin. After applying drops of water on the testing areas and wiping them off,DMS cream obtained the highest hygroscopicity (69.77), followed by VCM Ⅷ (68.17). But VCM Ⅷ showedhigh stability according to the water-holding capacity patterns observed after 10 minutes. Finally, VCM Ⅷshowed a significant improvement of barrier recovery (58.3%) after 3 days compared with vaseline (50.4%)and physiological lipid mixture (37.2%). The rate of barrier recovery was also greater for the VCM Ⅷ (101.8%)than skin barrier lipid mixture (76.3%) and vaseline (90.6%) on day 7. These studies show that vernixcaseosa analogue can both accelerate skin barrier recovery and enhance stratum corneum moisturization.

      • KCI등재

        ON SINGLE CYCLE T-FUNCTIONS GENERATED BY SOME ELEMENTS

        이민섭 충청수학회 2015 충청수학회지 Vol.28 No.2

        Invertible transformations over n-bit words are essen- tial ingredients in many cryptographic constructions. When n is large such invertible transformations are usually represented as a composition of simpler operations such as linear functions, S-P net- works, Feistel structures and T-functions. Among them we study T-functions which are probably invertible transformations and are very useful in stream ciphers. In this paper we study the number of single cycle T-functions satisfying some conditions and characterize single cycle T-functions on (Z2)n generated by some elements in (Z2)n 1.

      • KCI등재

        On a T-function f(x)=x+h(x) with a single cycle on Z_(2^n)

        이민섭 충청수학회 2011 충청수학회지 Vol.24 No.4

        Invertible transformations over n-bit words are essential ingredients in many cryptographic constructions. When n is large (e.g., n=64) such invertible transformations are usually represented as a composition of simpler operations such as linear functions, S-P networks, Feistel structures and T-functions. Among them we study T-functions which are probably invertible transformation and are very useful in stream ciphers. In this paper we study some conditions on a T-function h(x) such that f(x)=x+h(x) has a single cycle on Z_(2^n).

      • KCI등재

        ON A CHARACTERIZATION OF T_FUNCTIONS WITH ONE CYCLE PROPERTY

        이민섭 충청수학회 2008 충청수학회지 Vol.21 No.2

        To the design of secret key, there are two types of basic approaches called the tame approach and the wild approach. In the tame approach we try to use only simple primitives such as linear feedback shift registers and to prove mathematical theorems about their cryptographic properties. In the wild approach we try to use crazy compositions of operations which mix a variety of domains in a nonlinear and nonalgebraic way. There are several papers which try to bridge this gap by considering semi-wild constructions. A T_function on n-bit words plays an important role in semi-wild constructions. In this paper we study the invertibility and the period of some T_functions. Especially we characterize some polynomials which has a single cycle property.

      • KCI등재

        ON SECURE BINARY SEQUENCES GENERATED BY A FUNCTION f(x) = x + (g(x)² v C) mod 2ⁿ

        이민섭 충청수학회 2009 충청수학회지 Vol.22 No.4

        Invertible transformations over n-bit words are essential ingredients in many cryptographic constructions. When n is large (e.g., n = 64) such invertible transformations are usually represented as a composition of simpler operations such as linear functions, S-P networks, Feistel structures and T-functions. Among them we will study T-functions which are probably invertible transformation and are very useful in stream ciphers. In this paper we will show that f(x) = x + (g(x)² v C) mod 2ⁿ is a permutation with a single cycle of length 2n if both the least significant bit and the third significant bit in the constant C are 1, where g(x) is a T-function.

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