돼지고기육종의 방사선 유래 휘발성 물질 분석

차용준,박지영,김훈,김소정,정연정,소양순,유영재 창원대학교 생활과학연구소 2000 생활과학연구 Vol.4 No.-

Bacillus cereus KCTC 3674 produced at least two kinds of extracellular proteases. Two major bands of the protease activity with molecular weights of approximately 100 and 38 kDa were obtained after gelatin-SDS-PAGE. The production of extracellular proteases occurred during the logarithmic growth phase and was greatest when cultures reached the stationary growth phase. On the other hand, the growth of B. cereus KCTC 3674 and the production of its extracellular proteases were severely inhibited by the addition of protonophore carbonylcyanide m-chlorophenylhydrazone (CCCP). Thus, it was concluded that the growth of B. cereus KCTC 3674 and the production of its extracellular pretenses were strongly affected by a H+ electrochemical potential.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

도로교통환경에 따른 지역주민들의 도로평가에 관한 연구

정준영,정헌영,김승룡 釜山大學校 都市問題硏究所 1998 都市硏究報 Vol.6 No.-

AbstractAs the purpose of this study is to figure out how residents (who are living near each road) estimate the road, we have focussed on the amenity, beauty, safety and convenience of roads from main arterial roads to local roads.Therefore, 14road-lines were selected out of 104 named in pusan to understand thier characteristics, current land-use and traffic characteristics. and we also have surveyed residents' oppinions on traffic environment.Based on these results, we have built local people's estimate-model over the amenity, beauty, safety and convenience of those roads to get thier characteristics.Additionally, we have estimated how much each characteristic effected on the aggregate estimation of the road. As the purpose of this study is to figure out how residents (who are living near each road) estimate the road, we have focussed on the amenity, beauty, safety and convenience of roads ranged from main arterial roads to local roads. Therefore, 14road-lines were selected out of 104 named roads in pusan to understand thier characteristics, current land-use and traffic characteristics, and we also have surveyed residents' oppinions on traffic environment. Based on these results, we have built local people's estimate-model over the amenity, beauty, safety and convenience of those roads to get thier characteristics. Additionally, we have estimated how much each characteristic effected on the aggregate estimation of the road.

부산시 교통사고 다발지점의 유형화와 그 대책에 관한 연구

정헌영,이광희 釜山大學校 1995 生産技術硏究所論文集 Vol.48 No.-

The traffic is very important function in the metropolitan. But, the trafic accidents has become terrible social problem. According to the road environment factors in which 386 high accident locations of Pusan, this study classified 7 classifications and suggested the model of countermeasurement in each classification. 교통은 대도시의 매우 중요한 기능이다. 그러나 교통사고는 심각한 사회문제가 되고 있다. 본 연구는 부산시 386개 사고다발지점을 도로 환경적 요인에 따라, 7개 유형으로 유형화하고 각 유형별로 대책 모델을 제시하였다.

대학 내 커피전문점에 대한 소비자의 요구도와 만족도

윤영훈, 김인호, 유현정 충북대학교 생활과학연구소 2012 생활과학연구논총 Vol.16 No.1

This study examined how much consumers were satisfied and what their needs were for a coffee shop located on a university campus. Also, it was examined what factors were influencing the satisfaction of a coffee shop located on a university campus. The questionnaire survey method was conducted and 194 university students who had experiences visiting a coffee shop located on university campus in Cheongju, were selected. For the statistical analysis, descriptive analysis, factor analysis, t-test and ANOVA were used by the SPSS 14.0 program. The findings were as following: First, consumers' overall satisfaction with a coffee shop located on a university campus was near mid-point. Second, the most important factor for consumers’ satisfaction of a coffee shop on university campus were location. And, price, taste, and various product options followed. Third, consumers' needs for a coffee shop on a university campus were composed of three factors: interior circumstance, service, and attendant circumstances. The most important out of these three factors was the service factor (m=3.89). Fourth, consumers' satisfaction for the coffee shop on a university campus was composed of four factors: interior circumstance, service, ease of access, and brand loyalty. Furthermore, ease of access was found to be the most important factor (m=3.98).

실측응력 및 시뮬레이션에 의한 트러스 철도교의 피로피해도 분석

정영화,김익겸,김지훈,김은성 강원대학교 산업기술연구소 2000 産業技術硏究 Vol.20 No.A

After measuring actual stress by two measurements(Dynamic Strain Meter, Histogram Recorder)on truss rail road bridge, we could perform time history analysis by 3-D beam element method on modelling bridge. And then,after analyzing bridge structure in static by 3-D modelling, we estimated degree of fatigue damage in main member, secondary member of tie zone,cutting area of base metal cross section for confirming the result. In case that the simulate stress is carried out on medeling bridge, most of those simulation mainly is performed by main members.But in real bridge fatigue damage problems generally caused by junctions, connections, joints in which especially local stress is activated. Therefore, in this paper actual stress on critical area was estimated through the analysis result by simulation. With this study, we can estimate the degree of fatigue damage from a safety point of view and comparative accuracy.

사상공업지역의 환경과 재개발에 관한 기업주의 의식분석

정헌영,김태규 釜山大學校 都市問題硏究所 1996 都市硏究報 Vol.4 No.-

Sasang Industrial Complex and hinter-residential areas caused some problems related to the infrastructures and environmental pollution in lack of some considerations from the land subdivision project. According to the Pusan Urban Masterplan(1992) and the Pusan-Kyungnam Metropolitan Development Plan(1995), then, the surveyed area will be redeveloped to the western core of the Pusan Metropolitan City and attracted to the mixed land-use complex with the commercial and distribution function, including the electricity, shoes, leports, and clothes wholesales. This results of the survey found that most subjects considered the environmental pollution as serious and the unsatisfactory factors were as follows: traffic jam and air pollution. According to whether you know the Complex Transferred Plan, 34.9% of them was responded to "yes" and the rest to "no". This finding means that the area is environmentally bad condition in terms of the transportation and infrastructures, however, most subjects were satisfied with the location because of easy access to the CBD. The results also suggested that the redevelopment of the area is needed and the way is mainly based on the individual improved construction.

울산-부산간 경전철 건설 타당성 분석

정헌영 울산대학교 2003 사회과학논집 Vol.13 No.1

출생전 흰쥐 콩팥에서 콩팥소체 벽상피 분화에 대한 아포프토시스의 역할

이승헌,김영희,김완영,차정호,김진,정진웅 대한해부학회 1997 Anatomy & Cell Biology Vol.30 No.6

다중 가설 추적 알고리듬의 성능 평가

정영헌,한찬호,최덕규 경운대학교 산업기술연구소 2001 産業技術硏究論文誌 Vol.3 No.2(C)

The Multiple Hypotheses Tracking (MHT) algorithm has been shown to be one of the most cost- effective estimation schemes for hybrid systems. Its performance, however, could only evaluated via expensive Monte-Carlo simulations. An effective hybrid approach to the performance evaluation without recourse to simulations is presented here. This approach is based on a scenario-conditional performance measure of hybrid nature in the sense that it is a continuous-valued function of a discrete-valued random sequence. The performance measure is calculated efficiently in an off-line recursion.