한국 고인골에 남은 질병의 흔적

김명주(Kim, Myeung-Ju),김이석(Kim, Yi-Suk),이성준(Lee, Sung-Joon) 한국고대사학회 2021 韓國古代史硏究 Vol.- No.104

현재까지 많은 발굴조사가 실시되었으나, 시대별 또는 지역별로 유의미하게 활용할 수 있는 과거의 인체 정보는 미미하다. 이것은 연구 가능한 상태의 인골이 잔존하기 어려운 한국의 매장환경에 기인한 결과이겠지만, 고인골에 대한 의학적 연구가 폭넓게 진행되지 못했다는 점도 방증한다. 그럼에도 불구하고, 고고학과 의학의 융합연구는 다양한 가능성을 보여주었고, 대중적으로도 큰 주목을 받았다. 6세기 전후 사망한 창녕 송현동 15호분 출토 순장 인골, 7세기 전반에 사망한 익산 쌍릉 출토 인골, 16세기 후반 사망한 안동 가곡리 회곽묘 출토 미라, 17세기 중반 사망한 문경 진성이낭 묘 출토 미라 등이 좋은 사례이다. 그리고 다공성뼈과다증, 치아의 사기질저하증, 광범위특발성뼈과다증, 죽상동맥경화증, 복달렉탈장 등의 질병이 보고되었다. 과거의 사람과 삶을 복원하는 연구가 더욱 진전되기 위해서는 고고학과 의학 분야가 긴밀히 협업할 수 있는 체계가 마련되어야 한다. 앞으로 이와 같은 노력은 식생활, 질병(팬데믹), 이주 등 고대사회가 변동했던 역동적인 요인들을 규명하는 데 토대가 될 것이다. Although many excavations have been carried out, there is very little information about the human body in the past that can be used meaningfully. This is due to the burial environment in Korea, where it is difficult for human bones to remain in a researchable state, and it also proves that medical research on excavated human bones is insufficient. Nevertheless, the convergence researches of archeology and medicine showed various possibilities and received great attention from the public. Good examples are the human bones excavated from tomb no.5 of Songhyeon-dong in Changnyeong, who died around the 6th century, the human bones from Twin Tombs in Iksan, who died in the first half of the 7th century, the mummy from gagok-ri in Andong, who died in the late 16th century, and the mummy from Jinseong Yi’s tomb in Mungyeong, who died in the mid-17th century. And diseases such as porotic hyperostosis, enamel hypoplasia of tooth, diffuse idiopathic skeletal hyperostosis, and atherosclerosis were reported. In order to further advance the study of restoring people and lives in the past, a system in which archaeology and medicine can closely collaborate should be established. Such efforts will serve as a basis for identifying the factors that change ancient societies such as diet, disease (pandemic), and migration.

한국인 제2형 당뇨병 환자의 골격근에서 인슐린 신호전달체계의 결함

최준혁,이관우,김효정,이동훈,이종우,김정은,엄현채,김경미,최성이,정윤석,김현만 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.5

연구배경: 제2형 당뇨병에서 나타나는 인슐린 저항성은 간, 지방, 근육 같은 말초조직에서 인슐린의 작용이 떨어지는 것을 말한다. 제2형 당뇨병의 발생기전에 인슐린 저항성과 인슐린 분비능 저하가 같이 관여함은 잘 알려진 사실이다. 인슐린의 세포내에서의 저항성을 규명하기 위한 인슐린의 세포내 신호전달체계에 대한 연구가 활발히 진행되고 있으며 몇몇 연구에서 인슐린 저항성을 가진 골격근육에서 IRS와 관련된 PI3-kinase의 활성감소와 Akt kinase의 활성감소를 보고하고 있으나 아직까지 명확하게 그 기작이 설명되어지지 않고 있다. 본 연구에서는 정상성인, 제2형 당뇨병 환자를 대상으로 경구당부하검사 및 인슐린 클램프검사를 시행하고 인슐린 클램프 검사시 대상인의 근육을 채취하여 인슐린 신호전달 체계(IR-β, IRS, Akt(PKB, Rac) kinase, GSK-3)를 연구하였다. 방법: 연구대상자는 한국인으로서 경구당부하검사상 정상인 및 당뇨병 환자 각각 11명, 9명을 대상으로 하였으며, 정상인은 건강인으로 과거력상 당대사에 영향을 줄 질환이 없고, 현재 당대사에 영향을 줄 약물 복용 및 다른 소견이 없는 경구당부하검사상 정성 내당능을 보이는 대상자로 하였다. 당뇨병환자는 모두 제2형 당뇨병 환자로 이환기간이 만 5년 이내인 경우로 하고, 인슐린으로 치료하는 대상자는 제외하도록 하였다. 대상자의 연령, 체질량지수, 체지방량, 공복시 총콜레스테롤, 중성지방, 고밀도지단백 콜레스테롤 및 HbA1c, 인슐린, C-peptide를 측정하였고, "HOMA model"을 이용하여 베타세포의 기능와 인슐린저항성 정도를 평가하였다. 정상혈당클램프 검사(euhlycemic hyperinsulinemic clamp test)를 시행하고 인슐린 투입 전과 인슐린 투입 30분후, 두차례에 걸쳐 대퇴부 근육생검을 실시한후 western 법으로 IR-β, IRS, Akt kinase, GSK-3의 인산화량을 측정하였다. 결과: 정상인 11명과 당뇨병 환자 9명을 대상으로 하였으며 대상자의 평균 연령, 평균 체질량지수, 체지방량, 허리/엉덩이 둘레의 비(waist hip ratio; WHR)는 두 군간에 차이가 없었다. 평균 공복혈당은 정상군 98.0±0.3㎎/dL, 당뇨병군 208.1±16.5㎎/dL(p<0.05), HbA1c는 정상군 5.4±0.5%, 당뇨병군 9.2±0.6%(p<0.05)였다. "HOMA model"을 이용한 베타세포의 기능과 인슐린저항성은 정상군 56.4±8.5%, 1.4±0.2, 당뇨병군 72.2±52.3%(p<0.01), 10.2±6.3(p<0.01)였으며 정상혈당클램프 검사상 포도당 이용률은 정상군 8.2±0.6㎎/㎏/min, 당뇨병군 3.7±1.1㎎/㎏/min(p<0.01)로 정상군과 당뇨병군간에 유의한 차이를 나타내었다. Western blot법으로 IR-β, IRS, Akt kinase, GSK-3의 인산화량을 인슐린 투입전과 인슐린 투입 30분후 측정하였을 때 IR-β에서는 정상군이 103.9±2.3에서 241.3±18.6, 당뇨군이 108.9±2.2에서 198.7±6.3으로 증가하였다(p=NS). 이는 인슐린 투입후 당뇨병군이 정상군과 비교하여 인산화량의 증가정도가 통계적인 차이가 없었다. IRS에서는 정상군이 111.6±7.3에서 295.6±17.2, 당뇨군이 114.5±6.1에서 222.0±23.2로 증가하였으며(p<0.05), 인슐린 투입후 당뇨병군이 정상군과 비교하여 인산화량의 증가정도가 약 24% 감소하였다. Akt kinase에서는 103.4±6.0에서 416.8±29.5로 증가하였으며(p<0.01), 인슐린 투입후 당뇨병군이 정상군과 비교하여 인산화량의 증가정도가 약 43% 감소하였다. GSK-3에서는 정상군이 107.7±6.7에서 595.7±28.1, 당뇨군이 104.3±4.8에서 443.3±12.9로 증가하였으며(p<0.01), 인슐린 투입후 당뇨병군이 정상군과 비교하여 인산화량의 증가정도가 약 25% 감소하였다. 결론: 제2형 당뇨병 환자에서 정상인과 비교하여 인슐린 자극후 IR-β는 인산화량의 증가정도가 큰 차이가 없었으나, IRS, Akt kinase, GSK-3에서는 인산화량의 증가 정도가 감소되는 것으로 보아 상위 인슐린 신호전단체계부터 결함이 있는 것으로 생각된다. Background: The glucose uptake rate is the limiting step in glucose utilization and storage. The failure of insulin to stimulate glucose uptake in muscle appears to be a primary defect of insulin resistance. This study was undertaken to examine the effect of physiological hyperinsulinemia on the phosphorylation of the insulin receptor (IR-β), insulin receptor substrate (IRS), Akt kinase and GSK-3 in isolated skeletal muscle, in people with type 2 diabetes(n=9) and control subjects(n=11). Methods: 75g OGTT and euglycemic hyperinsulinemic clamp test were done. And vastus lateralis muscle was obtained before and 30 min into the euglycemic clamp. Western blots were performed for tyrosine phosphroylation of insulin receptor substrate (IRS) and phosphorylation of the insulin receptor(IR-β), Akt and GSK-3. Result: There were no statistical differences in the mean age, BMI and body fat between the control subjects and diabetic patients. The fasting blood sugar and HbA_1c in controls and diabetic patients were 98.0±0.3 and 208.1±16.5ng/dl, and 5.4±0.5 and 9.2±0.6%, and 1.4±0.2 in the control subjects, and 72.2±52.3%(p<0.01) and 10.2±6.3(p<0.01) in the diabetic patients, respectively. The insulin resistance from the euglycemic hyperinsulinemic clamp test were 8.2±0.6㎎/㎏/min and 3.7±1.1ng/㎏/min in the control subjects and in the diabetic patients, respectively(p<0.01). Compared with the normal controls, insulin-stimulated IR phosphorylation was no different to that in the diabetic patients. However, insulin-stimulated IRS phosphorylation, insulin-stimulated Akt phosphorylation and insulin-stimulated GSK-3 phosphorylation were reduced in the diabetic patients compared with the normal controls by 24, 43 and 25%, respectively(p<0.05). Conclusion: In Korean type 2 diabetic patients, the insulin resistance may be due to the impairment of the upstream insulin signal molecular network. Further studies will focus on determining whether these signaling defects are the cause of the development of insulin resistance, or secondary to the altered metabolic state, associated with type 2 diabetes mellitus (J Kor Soc Endocrinol 17:685∼697, 2002).

인체에서 방사되는 생물광자(生物光子)에 대한 소고

이승호,김진수,박하준,양준모,소광섭,임사비나 경희대학교 동서의학연구소 2006 東西醫學硏究所 論文集 Vol.2006 No.-

Objectives : The purpose of this study is to review research papers published by Korean research groups on biophoton of human beings based on experiment subject and methodology. Methods : In order to review human biophoton research executed in Korea, all the papers published in Korean and international journals by Korean research groups were selected. Several key foreign papers were also reviewed for clarification of this study. Based on experiment subjects, experiment methodology, and interpretation of experiment results were analyzed. On each experiment, its original interpretation was directly quoted. Issues on the experiment methodology and interpretation were expressed at the end of each subject. Results and Conclusions : We found that experiments on human biophoton were compelling. However it seemed that mom experiments, especially on their sample sizes, ate needed to demonstrate its clinical application. Interpretations based on Korean traditional medicine also need to be elaborated more. In order to do accomplish clinical application of biophoton, interdisciplinary works are required. Some suggestions on biophoton experiments were made.

난치성 측두엽 간질환자의 발작간 뇌파소견

김지언,손은익,김준식,이상도,박영춘 대한신경과학회 1998 대한신경과학회지 Vol.16 No.4

McNamara분석법에 의한 한국성인 정상교합자의 두부방사선 계측학적 연구

최이준,김종철 전남대학교 치과대학 1990 전남치대논문집 Vol.2 No.1

This study was performed to establish the Cephalometric standards of Korean adults by McNamara analysis. A cephalometric analysis was made from 103 subjects over 20 years of age, that consisted of 51 males and 52 females with normal occlusion and acceptable profile. The results of this study were obtained as follows : 1. Distribution from measured values were obtatined. 2. Greater measurements were shown in male than in female in Effective Mandibular Length(EML), Effective Midfacial Length(EMiL), Maxillo-mandibular differential(Mx-Mn diff) and Lower anterior facial height (LAFH) in linear measurement of each group. 3. Mandibular plane angle of female was larger than that of male. It represents female has more dolichocephalic pattern. 4. Facial axis angle of korean adult was greater than that of Ann Arbor sample. It means Gnathion of Korean adult is located more posteriorly than that of Ann Arbor sample.

가와사끼 병 환아에서 이상뇌파와 신경학적 합병증 발현과의 연관성에 대한 고찰

박준수,공도연,박경배,민용식,김영창,정순이,이혜경 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.2

목적 : 가와사끼 병의 뇌파 소견 및 다른 임상인자들과의 연관성을 알아보고자 하였다. 방법 : 1994년 1월부터 1995년 12월 사이에 순천향대학 천안병원 소아과에 입원한 23명의 신경학적으로 정상인 가와사끼 병 환아에게 뇌파검사를 실시하여 이를 검사시기, 성별, 연령, 혈소판, 간기능 검사치, 그리고 동맥류 유무등의 임상인자들과 비교하였다. 결과 : 이상뇌파가 23명중 52.2%인 12명에게서 관찰되었으며, 이상뇌파로는 예파 및 극파, 극·서파 복합 양상과 전반적인 배경파의 서파양상이 나타났다. 뇌파의 검사시기가 진단부터 1주 이내인 경우에 이상뇌파의 빈도가 그 후보다 의미있게 높았으나, 그 밖의 다른 임상인자와의 연관성은 별 의미가 없었다. 결론 : 가와사끼 병 초기에 이상뇌파가 나타나는 것은 비록 신경적 증상은 없지만 중추 신경계가 영향을 받는다는 간접적인 증거로 생각할 수 있어 향후 신경적 합병증 발생 여부에 대한 면밀한 관찰이 필요하다고 생각된다. Purpose : This study is to find out if there is any association between EEG abnormalities in Kawasaki disease with other clinical factors. Methods : We performed EEG in 23 Kawasaki disease patients without any neurologic sign who admitted in Soonchunhyang Chunan Hospital from 1994. 1. to 1995. 12. and compared it with sex, age, platelet count, liver function test and presence of coronary artery aneurysm. Results : Abnormal EEG findings were observed in 12 of 23 patients(52.2%) and as for abnormal EEG findings, sharp, spike, spike & slow wave complex, and generalized slow background activity were noted. When EEG was performed within a week after the diagnosis, the incidence of abnormalities of EEG increased significantly but there was no correlation with other clinical factors. Conclusion : EEG abnormalities in the early stage of Kawasaki disease indicate that although there is no abnormal neurologic signs clinically, central nervous system might be affected and there should be a close observation for the developement of neurologic complication.

치과기공사의 직업만족도 측정을 위한 설문도구의 개발

오세윤,김웅철,김지환,이병기,유진호,김태석,이준석,이주호 高麗大學校 倂設 保健大學 保健科學硏究所 2002 保健科學論集 Vol.28 No.2

Conflicts between individuals are quite natural and they can act as an positive contributing factor not only to the development of an individual but also to the organization to which one belongs. But too much conflicts will always induce dissatisfaction and stresses, which will be destructive and harmful to all of them, and that is why we are always tying to seek(find) out the causes for the origination of conflicts and remedies to cope with them effectively. The present study, as the first one in a series of studies which our researchers contemplate executing, was designed to develop a measure of job satisfaction for dental laboratory technicians. One job satisfaction measure and two job satisfaction related measures, one for faithfulness for the job and the other for environmental characteristics of dental laboratory were newly developed. The newly developed measures were comprised of a total of 38 items, which were each 12 items for job satisfaction and faithfulness for the job and 14 items for environmental characteristics of dental laboratory With the aid of factor analysis for principal components and categorization of items by panel of professionals, items of each measure were grouped into 2-4 subscales. Contribution to internal consistency was the fina) criterion for an item's inclusion in a subscale. Internal consistency reliability of each item was attested through the statistical analysis on the data obtained from 55 structured questionnaires. Reliability of internal consistency of subscales in each measure of job satisfaction and faithfulness for the job ranged from 0.74 to 0.79 and 0.90-0.91 respectively. The result from this research came to draw the following conclusions. 1. Validity and internal consistency reliability of all the items of each measure was attested. 2. The newly developed measure of job satisfaction was found to be appropriate for (measuring the degree of job satisfaction of) dental technicians, as well as for (other) dental office personnels.

일부 출판업 VDT 작업자들의 근골격계질환 자각 증상 호소율과 관련요인에 관한 연구

채창호,김영욱,이철호,김정일,김준연,이세훈 가톨릭대학산업의학센타 산업의학연구소 2003 韓國의 産業醫學 Vol.42 No.2

Objectives: This study was conducted to investigate the relationship between the self-reported musculoskeletal symptom prevalence and related factors among some VDT workers in publishing industries. Methods: The 201 study subjects consist of 130 VDT workers comprised of 59 edition workers and 71 data entry workers, and 71 Non-VDT workers. The study subjects were surveyed with structured self-reported questionnaire. Results: The prevalence of self-reported musculoskeletal symptom were 39.2% at neck, 36.2% at back and waist, 30.8% at shoulder, 25.4% at hand and wrist and 9.2% at arm on VDT workers. In logistic regression analysis. Type of VDT(data entry worker) work was related factor of musculoskeletal symptom prevalence at neck, shoulder, arm, back and waist, hand and wrist. VDT working time and working condition were related factors at back and waist. At neck, shoulder, hand and wrist, sex was one of the related factors. Conclusion: Our finding revealed that sex and type of VDT work were main related factors of musculoskeletal symptom prevalence in study subjects.

부산·울산·경남지역 직업병 감시체계

김정일,김병권,김정원,채창호,이철호,강동묵,김지홍,김진하,김영욱,이영하,이지호,김정호,윤형렬,유철인,정백근,장태원,김운규,윤동영,강진욱,김종은,안진홍,이동준,장준호,이광영,송혜란,최영희,이용환,조병만,최홍렬,고상백,김은아,이유진,홍영습,정갑열,김정만,김준연 大韓産業醫學會 2004 대한직업환경의학회지 Vol.16 No.1

Objective: Occupational medicine specialists in the Busan, Ulsan and Kyung-Nam areas established an area-based occupational disease surveillance system and used this system to collected case information for the purpose of preventing occupational diseases Methods: l l hospital participated in this system. The authors selected five main diseases, which were hand-arm vibration syndrome (HAVS), work-related musculoskeletal disorder (WRMSD), occupational asthma, occupational skin disease and occupational and occupational lung cancer and established their case definitions. All cases were reported on the web, and real time analysis was conducted. Results: Between April 2001 and April 2003, 192 cases of HAVS, 118 cases of WRMSD, 33 cases of occupational asthma, 17 cases of occupational skin disease and 17 cases of occupational lung cancer (for a total of 377 cases of these five main diseases) were reported. most of the HAVS cases came from shipbuilding, and 172 of them (92.7%) were associated with grinding. Of the four main types of WRMSD, carpal tunnel syndrome (CTS) was the most prevalent with 46 cases and shipbuilding was also the main industry involved (83.9%). The ergonomic risk factors involved mainly associated with the hand. In 19 (57.6%) and 4 (12.1%) cases of occupational asthma, the agents involved. The causative agents of occupational lung cancer included Cr, welding fume, PAH, Ni, etc. 10(58.8%) of the cases were diagnosed as squamous cell carcinoma and 5(29.4%) as adenoma. Conclusion: This result showed that an area-based occupational disease surveillance system might provide an effective method of evaluating the prevalence of such diseases, however the Busan, Ulsan and Kyung-Nam provinces are too large to be treated as individual areas. Therefore, the authors suggest that each province should establish its own surveillance system.

Acupuncture suppresses kainic acid-induced neuronal death and inflammatory events in mouse hippocampus

Kim, Seung-Tae,Doo, Ah-Reum,Kim, Seung-Nam,Kim, Song-Yi,Kim, Yoon Young,Kim, Jang-Hyun,Lee, Hyejung,Yin, Chang Shik,Park, Hi-Joon Springer-Verlag 2012 JOURNAL OF PHYSIOLOGICAL SCIENCES Vol.62 No.5

<P>The administration of kainic acid (KA) causes seizures and produces neurodegeneration in hippocampal CA3 pyramidal cells. The present study investigated a possible role of acupuncture in reducing hippocampal cell death and inflammatory events, using a mouse model of kainic acid-induced epilepsy. Male C57BL/6 mice received acupuncture treatments at acupoint HT8 or in the tail area bilaterally once a day for 2?days and again immediately after an intraperitoneal injection of KA (30?mg/kg). HT8 is located on the palmar surface of the forelimbs, between the fourth and fifth metacarpal bones. Twenty-four hours after the KA injection, neuronal cell survival, the activations of microglia and astrocytes, and mRNA expression of two proinflammatory cytokines, interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α), were measured in the hippocampus. Acupuncture stimulation at HT8, but not in the tail area, significantly reduced the KA-induced seizure, neuron death, microglial and astrocyte activations, and IL-1β mRNA expression in the hippocampus. The acupuncture stimulation also decreased the mRNA expression of TNF-α, but it was not significant. These results indicate that acupuncture at HT8 can inhibit hippocampal cell death and suppress KA-induced inflammatory events, suggesting a possible role for acupuncture in the treatment of epilepsy.</P>