職業病의 현황과 추세

李世薰 藥業新聞社 1987 (月刊) 醫藥情報 Vol.1987 No.12

고형암 환자에서 항암화학요법 후 발생한 호중구감소증에 대한 류코그린Ⓡ(G-CSF)의 제3상 다기관 공동 임상시험

이세훈 대한임상약리학회 2003 Translational and Clinical Pharmacology Vol.11 No.1

Background : Neutropenia is the main cause of therapy-related mortality in the patients who receive cytotoxic chemotherapy. Granulocyte colony-stimulating factor (G-CSF) can reduce the neutropenic severity and duration after cytotoxic chemotherapy. We performed a randomized, controlled, cross-over study of two G-CSF (LeucogreenⓇ and control drug) in the solid tumor patients who would receive cytotoxic chemotherapy. Methods : Patients received LeucogreenⓇ in the first cycle and control drug in the second cycle, or vice versa. They should have received at least two cycles of same chemotherapy for their solid tumor. They were administered G-CSF 50μg/m2 daily for 10 days since 24 hours after the last dose of chemotherapy. Results : Eighty-three patients received at least one dose of G-CSF, and 61 patients completed two cycles of G-CSF without major protocol violation. The prophylactic rate of neutropenia (<1,000/mm3) of test drug is 70.5%, and 95% confidence interval (CI) of the rate is 59.3-81.7%, which is included within the identical borderline (rate of control drug ± 20%, 48.9-88.9%). Two drugs did not show any significant difference in respect of incidence of abnormal neutrophil count (<2,000/mm3), nadir neutrophil count, duration of neutropenia and duration of abnormal neutrophil count. Mild to moderate cause-related adverse events were observed during trial period and no significant difference in incidence and severity between two drugs. Conclusion : LeucogreenⓇ showed similar efficacies for chemotherapy-induced neutropenia to control G-CSF and could safely be given.

일부 자동차정비업체 도장공정 근로자의 납 노출

이세훈,조상현 한국산업보건학회 2002 한국산업보건학회지 Vol.12 No.3

Q&A-허용기준

이세훈,Lee, Se-Hun 대한산업보건협회 1995 산업보건 Vol.82 No.-

망치를 놓은 12일, 그때부터 우리는 하나다

이세훈 노동사회과학연구소 2007 정세와노동 Vol.- No.26

연폭로시 혈구용적치 및 혈색소치의 변화

이세훈,Lee, Se-Hoon 대한예방의학회 1980 Journal of Preventive Medicine and Public Health Vol.13 No.1

In order to study the effect of lead exposure on the hematocrit and hemoglobin values in accordance with the level of lead exposure, twenty-four Sprague-Dawley rats were equally divided into four groups of six rats each. Lead acetate disolved in glucose was injected intraperitoneally six times a week, for four weeks with dose of 0.05 mg/kg/day for group I, 0.5 mg/kg/day for group II, and 5 mg/kg/day for group III. Control group was injected glucose only. Blood samples for the checking of the hematocrit and hemoglobin values, were taking from tail vein of rats before lead injection and on the third, seventh, fourteenth, twenty-first, and twenty-eighth days after lead injection. And also, the concentration of lead and ALA in urine were checked for evaluating the lead absorption. The results were as follows: 1. The alteration of the hematocrit and hemoglobin values of the group I was not significant as that of the control group. 2. In group II, the hematocrit values were significantly decreased from the fourteenth day after lead injection, and the hemoglobin values were decreased from the twenty-first day after lead injection when the concentration of lead in urine was elevated more than $260{\mu}g/liter$. 3. In group III, the hematocrit values were decreased from the seventh day after lead injection, and the hemoglobin values were decreased even from the third day after lead injection. And the hemoglobin values were more rapidly decreased than the hematocrit values. 4. In all groups, the correlation coefficient between hematocrit and hemoglobin was highly significant. And the difference between the correlation coefficient of the group III and that of the others was highly significant.

SCORM 기반의 교육용 컨텐츠 개발 시스템

이세훈,서대우,왕창종 한국스쿨넷학회 2003 학술발표 논문집 Vol.2003 No.1

Q&A-소음성 난청

이세훈,Lee, Se-Hun 대한산업보건협회 1995 산업보건 Vol.83 No.-

직업성 신경계 질환의 집단검진방법

이세훈 가톨릭대학산업의학센타 산업의학연구소 2002 韓國의 産業醫學 Vol.41 No.1

Contents for the clinical evaluation on the occupational neurotoxic disorders among workers occupationally exposed industrial harmful agents in the mass screening test was suggested in this text through literature review reported in the national and international journals. Particularly, though the World Health Organization's reports on chronic toxic encephalopathy and on periperal polyneuropathy. Reportedly, cases of severe chronic toxic encephalopathy was found only among so called solvent sniffers, and oreganic affective syndrome and mild chronic toxic encephalopathy are the cases found among workers occupationally exposed to industrial neurotoxic agents. Great emphasis should be put on detailed clinical interview and on history for the diagnosis of chronic toxic encephalopathy for the elimination of the confounding factors including age and education, and for ruling out other possible causes of nervous system disorders.

척 호버만의 트랜스포메이션 시스템의 시공간적 의미 연구

이세훈,안성모 한국기초조형학회 2019 기초조형학연구 Vol.20 No.6

Nowadays, we focus on the concept of the images rather than real things and pursuits new values. Among them, the area of `transformation design' has important value by enabling us to experience a new perspective of seeing through stimulating our senses as well as providing visual satisfaction. The purpose of the study is to analyze Chuck Hoberman's transformation system, an inventor and professor at the Harvard Graduate School of Design, and to study the meaning of his works in time and space. Analysis of essential design principles in Chuck Hoberman's theory and concept of the transformation system are as follows. Chuck Hoberman's transformation design achieves perfect three-dimensional deformation through a smooth continuous deformation process due to the stimulus occurring inside the object. These deformations should be able to be reverted to their original state before deformation and could be repeated throughout the whole process. Chuck Hoberman's transformation objects organize the whole from the combination of many parts, defined as 'kinetic building blocks', and show movement based on basic geometry in the combination of structure and mechanism. Chuck Hoberman's design can be divided into 'Scissor System' and 'Assembly System'. By deriving the spatio-temporal meaning from the cognitive point of view, these systems induce the observer's real-time experience and generate different accelerations from the actual time. As a result, the system blurs the boundaries by enabling the spaces of different positions can be perceived at a glance. Also, the transformation object, which performs repetitive movements, leaves the afterimages in memory as it moves, giving the experience of real and virtual overlapping. 현시대에는 실제하는 사물보다 이미지적인 개념에 집중하며 새로운 가치를 갈구한다. 그중에서 트랜스포메이션디자인(Transformation Design)이라는 영역은 인간의 시각적인 만족과 동시에 감각을 자극함으로써 사물을바라보는 새로운 관점을 경험하게 한다는 점에서 중요한 의미가 있다. 본 연구의 목적은 발명가이자 하버드 건축대학 교수인 척 호버만(Chuck Hoberman)의 트랜스포메이션(Transformation)시스템을 분석하고 그의 작품이 시공간적으로 어떠한 의미를 갖고 있는지에 대한 연구이다. 척 호버만의 트랜스포메이션 시스템 이론과 개념등, 디자인 시 필수적 디자인 요소와 디자인원리를 분석하고 시스템 별로 분리된 다양한 디자인 사례들을 연구한 결과는 다음과 같다. 척 호버만의 트랜스포메이션 디자인은 오브젝트 내부에서 일어나는 자극으로 인하여 부드러운 연속적 변형과정을 거쳐 완벽한 3차원의 형태변형을 이룬다. 이러한 변형은 변형 이전의 원상태로 되돌릴 수 있어야 하며 모든 과정을 반복 할 수 있어야 한다. 척 호버만의 트랜스포메이션 오브젝트들은 ‘키네틱 빌딩 블록’으로 정의된 많은 부품들의 조합으로 전체를 구성하고 있으며 구조와 매커니즘의 조화로 기본 지오메트리에 기초한 움직임을 보여준다. 척 호버만의 사례들은 크게 시져 시스템(Scissor System)과 어셈블리 시스템(Assembly System)으로 나눌 수 있으며 인지적 관점에서 시공간적 의미를 도출 한 결과, 관찰자로 하여금 실시간에 어긋나는 경험을 하도록 유도하여 축약된 시간성을 경험하게 하였으며, 모호한 경계들의 변화로 서로 다른 위치에 대한 동시적인 시지각의 경험과 반복적인 운동을 통해 남겨지는 기억적 잔상을 통해 서로 다른 층위를 경험함으로써 시공간의 개념을 넘나들게 하였다.