http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
흰쥐에 재조합 인간 상피세포 성장인자(DWP401)를 연용피하투여했을 때 약물체내동태
남권호(Kweon Ho Nam),조재열(Jae Youl Cho),정주영(Joo Young Chung),장우익(Woo Ik Chang),강진석(Jin Seok Kang),유은숙(Eun Sook Yoo),박승국(Seung Kook Park),유영효(Young Hyo Yu),박명환(Myung Hwan Park),심창구(Chang Koo Shim) 대한약학회 1996 약학회지 Vol.40 No.5
The organ distribution and pharmacokinetics of DWP401, a recombinant human epidermal growth factor (rhEGF), were compared after single and repeated subcutaneous administration (50mcg/kg, 10mcCi/kg of 125I-DWP401, twice a day for 7 consecutive days) to rats. The pharmacokinetic parameters such as AUC and terminal half-life were similar between two different administration. During repeated administration, the plasma concentration of DWP401 seemed to be constant when the plasma was collected at 15 min after each dosing. The TCA-precipitated radioactivities in thyroid, liver, kidney, and stomach were higher than those of other organs studied after both single and repeated administration. The TCA-precipitated radioactivities after repeated administration in several organs, such as thyroid, stomach, prostate, adrenal, eye ball, and testis were higher than those after single administration. But, according to the observations using gel filtration chromatography and antibody binding assay, the radioactivities in thyroid and stomach were not primarily due to the intact DWP401 or its metabolites but due to the 125I-thyroxine binding protein. In conclusion, it can be suggested that DWP401 is metabolized to each amino acid or small polypeptides, and there was no significant changes in pharmacokinetics or any indications for accumulation of DWP401 in rat plasma and organs after repeated treatment.
Adverse Events With Sustained-Release Donepezil in Alzheimer Disease: Relation to Body Mass Index
Lee, Chunsoo,Lee, Kyungsang,Yu, Hyewon,Ryu, Seung-Ho,Moon, Seok Woo,Han, Changsu,Lee, Jun-Young,Lee, Young Min,Kim, Shin-Gyeom,Kim, Ki Woong,Lee, Dong Woo,Kim, Seong Yoon,Lee, Sang-Yeol,Bae, Jae Nam,J Wolters Kluwer Health, Inc. All rights reserved. 2017 JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY Vol.37 No.4
<P>Implications/Conclusions In Korean patients with moderate to severe AD receiving high-dose donepezil over 24 weeks, TEAEs were significantly more common in those with lower BMI (not clinically overweight), especially nausea. This finding may inform clinical practice for Asian patients.</P>
삼출성 나이관련황반변성에서 빛간섭단층계와 선택적 초시력 시야계와의 연관성
이승찬,남우호,유승영,곽형우,Seung Chan Lee,Woo Ho Nam,Seung Young Yu Hyung Woo Kwak 대한안과학회 2006 대한안과학회지 Vol.47 No.3
Purpose: Preferential hyperacuity perimeter (PHP) is a device that measures metamorphopsia in the central 14° of the macular visual field which is presented by hyperacuity defect. We elucidated a hyperacuity defect lesion of PHP in exudative age-related macular degeneration (AMD) by Optical coherence tomography (OCT). Methods: Nineteen eyes of 18 patients with exudative AMD diagnosed by fundus examination and fluorescein angiography (FA) underwent PHP. We then elucidated any hyperacuity defect lesion of PHP by fundus photography, FA and OCT. For a control, 20 eyes of 10 age-matched persons who had no ophthalmological abnormality underwent PHP and OCT to determine if hyperacuity defect would appear. Results: Hyperacuity defect lesion appeared in 18 eyes (95%) of AMD patients. There was good locational correlation between the hyperacuity defect lesions and lesions in the fudoscopic examination in 16 eyes of 18, but there was a counterpart relation at the superior-inferior and left-right in 2 eyes. Hyperacuity defect lesion in PHP was of smooth or irregular elevation of the retinal pigment epithelium (RPE) in OCT. In the control, hyperacuity defect lesion appeared in 1 eye (5%) and it was normal in OCT. Conclusions: PHP showed a highly positive rate in detecting AMD-related lesion. The hyperacuity defects that are noted by the PHP are produced from elevation of the RPE.
황반부이상을 나타내는 여러 망막질환에서 선택적초시력시야계 결과분석
김응석,남우호,유승영,곽형우,Eung Suk Kim,Woo Ho Nam Seung Young Yu,Hyung Woo Kwak 대한안과학회 2006 대한안과학회지 Vol.47 No.3
Purpose: The Preferential Hyperacuity Perimeter (PHP) is a device designed to monitor the development of choroidal neovascularization in age-related macular degeneration (AMD) patients. Recent studies have reported the efficacy of the PHP in early detection of AMD. To evaluate hyperacuity, a dot deviation signal is flashed to the central 14 degrees of the macular visual field and the patient`s perceived hyperacuity defect is recorded. The purpose of our study was to identify the role of the PHP in analyzing visual functions of patients with maculopathy caused by retinal diseases other than AMD. Methods: Seventy-four eyes of 55 patients with macular abnormalities caused by various retinal diseases (44 eyes of diabetic retinopathy, 6 eyes of central serous chorioretinopathy, 24 eyes of other retinal diseases) underwent PHP, Optical Coherence Tomography (OCT) and fluorescein angiography (FAG). Results: Of the 74 eyes with maculopathy, 60 eyes (81%) were positive on the PHP. By disease, 40 eyes (40/44, 91%) with diabetic retinopathy, 3 eyes (3/6, 50%) with central serous chorioretinopathy and 17 eyes (17/24, 71%) with other retinal diseases were positive. Among them, the location of hyperacuity defect lesions determined by PHP correlated well with the location shown on OCT and FAG in 6 eyes (6/40, 15%) with diabetic retinopathy, 1 eye (1/3, 33%) with central serous chorioretinopathy and 5 eyes (5/17, 29%) with other retinal diseases. Conclusions: Many retinal diseases that lead to maculopathy revealed a hyperacuity defect on PHP when the lesion was located not only in the retinal pigment epithelium but also in the outer retinal layer. Special attention to the patient`s visual acuity and visual field defects is required when analyzing PHP results since these factors can influence the PHP evaluation.
중심성장액맥락망막병증에서 레이저검안경검사상 과형광부위에 대한 광간섭단층촬영 검사결과 분석
이대영,김동희,남우호,유승영,곽형우,Dae-Young Lee,Dong-Hee Kim,Woo-Ho Nam,Seung-Young Yu,Hyung-Woo Kwak 대한안과학회 2005 대한안과학회지 Vol.46 No.6
Purpose: To analyze the optical coherence tomography (OCT) result at the area of hyperfluorescence by scanning laser ophthalmoscopy (SLO) in central serous chorioretinopathy. Methods: We investigated sensory detachment, pigment epithelial detachment (PED), choroidal neovascularization (CNV), and retinal pigment epithelial atrophy using OCT in the area of hyperfluorescein by scanning laser ophthalmoscopy (SLO) in 29 eyes of 29 patients with CSC. Results: Of 29 eyes, no specific finding was noted in 19 eyes. Small PED corresponding to the leaking point was noted in 3 eyes, large serous PED with leaking point in 2 eyes, hemorrhagic PED in 1 eye, subretinal precipitate and PED in 1 eye, and retinal pigment epithelial atrophy in 2 eyes. Conclusions: OCT provided intuitive and objective information on the pathophysiologic state of the retinal pigment epithelial layer at the area of hyperfluorescence by SLO in CSC.
활동성 궤양성 대장염 환자에서 발생한 뇌정맥 혈전증 1예
김종성,홍원선,남승우,민영일,정훈용,양석균,유창식,주연호,서대철 대한소화기학회 1998 대한소화기학회지 Vol.32 No.3
The cerebral thromboembolic disease is a rare extraintestinal manifestation of the ulcerative colitis. but it is one of the major causes of death in patients with ulcerative colitis. The outcome in cerebral venous thrombosis is poor, leading to death or major neurological sequelae in about 60% of patients. A 27-year old female with a 6-year history of ulcerative colitis episodically developed seizure for one month. Brain MRI showed cerebral infarction with old hemorrhage in the left frontotemporal hemisphere. Cerebral angiography showed no evidence of vasculitis or atheromatous cbange. Cardiac echocardiogram and radionuclide venography of the lower extremities revealed no evidence of thrombi. Tests for coagulation abnormality were also normal. She was managed with antiplatelet agent and antiepileptics. In addition, total proctocolectomy was performed for the patient.
조백기,박종갑,김형옥,김성욱,백승철,김진우,김시용,안규중,전재복,오지원,김낙인,이규석,오칠환,김수남,김상태,손숙자,신용우,김동석,이원우,권경술,서대헌,황규왕,이종석,고재경,강원형,정기양,최응호,김기홍,박석돈,강승주,함정희,명기범,김방순,구상완,김병수,원영호,김한욱,송은섭,정병수,노병인,홍창권,박장규,한지윤,김광중,구대원,김종민,김재홍,유희준,양경미 대한의진균학회 1998 대한의진균학회지 Vol.3 No.2
Background: Onychomycosis, especially toenail onychomycosis has become one of the common fungal infection and has historically been regarded as a cosmetic rather than medical problem by many patients, even by physicians. Recently, however, there are several reports that is a refractory disease which may cause a deleterious effect on patiets quality of life (QOL). Objective: The purpose of this study was to investigate the impact of toenail onychomycosis on QOL in Korea and to assess the chandes of QOL after treatment. Methods: Total 1004 patients with toenail onychomycosis which was confirmed by clinical findings and KOH preparation were were enrolled at 47 dermatologic centers in Korea, and interviewed with standardized QOL questionnaire before and after sytemic antifungal treatment. Responses to the questionnaire were scored by 5-point scale (1∼4) and averaged, and were analyzed for 5 dimensions of emotional impact, social impact, symptorn and functional impact, patients views concerning treatment, and relationship with doctor. Results: 1. Before and after treatment, the most serious impact was emotional dimension showing 1.90 and 1.30 in average score (AS), and social (AS: 1.14 and 0.83) and symptom and functional impact (AS: 1.05 and 0.92) was also affected. 2. In female rather than male, statistically more significant impact on patients QOL was observed in all dimensions. 3. After treatment, 3 of 5 dimensions were improved significantly - emotional dimension (AS : from 1.90 to 1.30), social dimension (AS: from 1.14 to 0.83), patients view concerning treatment (AS: from 1.34 to 1.02). 4. The drgree of patients satisfaction at the therapeutic effect was very high- 62.4% (immediately after treatment) and 65.8% (9 months affer initiation of treatment) of patients answered excellent or good. Conclusion: This study confirms that toenail onychomycosis has significant impact on the overall QOL of patients. Also the effect of antifungal therapy on patients QOL were watisfactory. Therefore, both doctor and patient should pay more attention to the treatment of onychomycosis. [Kor J Med Mycol 3(1): 115∼124]