정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Thiol의 친핵성 첨가물의 합성(제Ⅸ보) (Diacylivinylaryloxy)acetic acid 유도체와 그 Thioglycolic Acid 참가생성물의 합성

한인섭,김태린,허태성,최재희 聖心女子大學校 1989 論文集 Vol.21 No.-

이뇨작용 및 항종양효과가 있으리라고 예상되는 (acetylbenzoylvinyloxy)acetic acid 유도체(3a-3d)와 (dibenzoylvinylaryloxy)acetic acid 유도체 (3e-3h) 및 이들의 thioglycolic acid 첨가생성물(4a-4h)을 합성하였다. (dibenzoylvinylaryloxy)acetic acid 유도체는 hydroxybenzaldehyde 유도체로부터 monochloroacetic acid를 이용하여 2단계 반응으로 합성하였다. (Acetylbenzoylvinyloxy)acetic acid derivatives(3a-3d), (dibenzoylvinylaryloxy) acetic acid dervatives(3e-3h) and their thioglycolic acid adducts(4a-4h) which are expected to have diurectic activities and antitumour effect were synthesized. (Diacylvinylaryloxy)acetic acid derivatives wer prepared from hydoxybenzaldehyde derivatives via two step reaction employing monochloraccetic acid.

비전시스템을 이용한 인간형 축구로봇에 관한 연구

노수희;김한정;김용태 한경대학교 2007 論文集 Vol.39 No.-

In this paper a humanoid soccer robot using vision system is presented. Soccer robot has 23 degrees of freedom and consists of various sensors such as IR and CCD camera, a remote controller and bluetooth module for the wireless telecommunication. We propose a soccer algorithm of humanoid robot in the various environments. The soccer algorithm is designed based on image processing and path planning. We verify our approach on a developed small humanoid robot in an experimental environment. The experimental result shows that the humanoid soccer robot plays soccer with a stable walking.

PLD 박막의 물리적 성질

한용진,조봉균,정재훈,이수빈,박해윤,이태기,채희백,홍진수 순천향대학교 기초과학연구소 1998 순천향자연과학연구 논문집 Vol.4 No.2

Thin amorphous carbon films were deposited by a Q-switched Nd;YAG 532nm with beam power density of ?? on the high purity graphite (99.7%). The pressure of vacuum chamber was ?? Torr. In order to estimate the quality of the Pulsed Laser Deposition films one of the most important optical properties, bandgap energy, was characterized by transmission and reflection in the range of the visible, and an optical direct bandgap energy of 2.45eV and indirect bandgap energy 0.36eV were obtained. Surface morphology of amorphous film was investigated by AFM (Atomic Force Microscopy). Its surface roughness is 70nm. Comparing our results with the published values in the literature we have confidence that our films show the good quality for optical properties.

상전위 촉매에 의한 Chalone에 대한 Thioglycolic acid의 Michael 첨가반응

한인섭,허태성,유희종 聖心女子大學校 1983 論文集 Vol.14 No.2

Michael additions of thioglycolic acid to chalcone and its derivatives can be efficiently catalysed, giving high yields, by potassium fluoride and tetra-n-butyl-ammonium bromide in aprotic solvents.

DCJTB를 도핑시킨 NPB/Alq₃ 복층소자에서 엑시톤 확산

송석태,채희백,한찬수 순천향대학교 기초과학연구소 2011 순천향자연과학연구 논문집 Vol.17 No.2

Red dye DCJTB was doped 2% with thickness 1nm in NPB(40nm)/Alq₃(60nm) bilayer in order to investigate the diffusion of exciton. The location of the dopant layer was varied from the junction of NPB/Alq by 5nm. The emission zone was distributed narrow in Alq side near the junction. The diffusion length of exciton was 15nm ± 5nm which was confirmed from the measurements of Rubrene doped NPB(40nm)/Alq₃(60nm) bilayer system.

單症性 健康念慮症의 臨床經驗

韓辰熙,柳太烈,趙伯紀,李鍾六 서울醫大 1990 精神醫學 Vol.15 No.2

在來市場 再整備 戰略의 方向 : 미국·일본의 소매시장 활성화 전략을 중심으로

한희경,김정태,오덕성 忠南大學校 地域開發硏究所 1997 地域開發論叢 Vol.9 No.-

The purpose of this is to present effective strategy of rehabilitations, renewals on traditional retail markets which have been pressed from emerging of new types of retail shops, increased income, changing of consumer's merchandising pattern. For this study, the cases of America, Japan were chosen and analyzed according to effective ways of rehabilitations, renewals on traditional retail markets. The results were as follows. ① The strategy in Japan rehabilitations depending on tenant's participation present architectural guidelines our situation consisting of petty market and organization. ② The strategy in America give functional mix, tenant mix, strategical market, markets with regional character in markets renewal which were applied to out situation associated with clearance.

하악골 후방이동시 중안면부 연조직의 변화양상에 대한 임상통계학적 연구

한대희,김수남,민승기,김태성,성헌모 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.3

Prediction of the soft tissue changes following hard tissue movement is very important from the esthetic view point for patients who have orthognathic surgery. There are many cephalometric analysis of facial bone and soft tissue on the lower lip and chin region but few soft tissue analysis on the midface after mandibular setback surgery. This study was performed to obtain whether the mandibular posterior movement has influence on the midface and the predictable ratio of post-operative measurement values of the soft tissue changes following mandibular setback surgery. Fifteen patients (8 males and 7 females) who had undergone mandibular setback surgery were selected and analyzed the soft tissue movement on the upper lip and the cheek region. Post-operative changes of the soft tissue measurements after mandibular surgery were examined on pre- and post-operative cephalo-metrics and the ratio of changes were analyzed after drawing the reference line on the face with the barium sulfate solution. The reference lines were perpendicular to the intercanthal line from infraorbital foramen and lateral canthus. The results obtained were as follows : 1.There were tendancy of anterior movement of soft tissue adjacent the nose after mandibular surgery 2.There were incerased tendancy of the amount of anterior movement from the nasal crease to the cheek region. 3.The amount of anterior movement of the soft tissue was larger below the palatal plane compared with above the palatal plane in the cheek region. 4.The upper lip length was increased and moved posterior direction after mandibular setback surgery 5.The lower lip was moved posterior direction by posterior movement of the mandibular structure 6.Soft tissue of the midface around the nose moved anterior direction after mandibular setback surgery but there was no correlation between the amount of mandibular setback and the amount of the soft tissue changes

他科醫師의 精神科 諮問에 대한 期待度

韓辰熙,柳太烈,李秀晶 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.1

To investigate physicians' expectations to the role of psychiatric consultation, the authors conducted 18-item questionnaire on 117 nonpsychiatric physicians of two university affiliated general hospitals(St. Mary's Hospital and Kang Nam St. Mary's Hospital) in Seoul. The results were as follows : 1) Physicians rated, in general, high scores on items related with `evaluation function ' and `direct service function' of psychiatric consultation, whereas they rated low on `mediating function' items. 2) `Evaluate mental status', `Help physicians understand psychological aspects of a patient's illness', ` Arrange to transfer patient to psychiatric ward', `Evaluate psychogenesis' and `Make suggestions about management of patient on the ward' are those which phisicians valued most important of all 18 items. 3) There was a tendency that resident group manifested low item scores compared to faculty members, and items of `Arrange to transfer patient to psychiatric ward' and `Recommand additional diagnostic work-up' showed significant difference in mean scores between groups. 4) Physicians in medical services showed significant high mean scores on items such as `Arrange to transfer patient to psychiatric ward', `Make suggestions about management of patient on the ward', `Evaluate psychogenesis' and `Work with patient's family' as compared to surgeon group.