THE WORLD OF CREATIVE WRITING : Centering Around Lyrics Written by Son Kil-Yong

Son, Kil Young 서경대학교 1982 論文集 Vol.10 No.-

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

전자식 안정기용 자여식 직렬공진 인버터의 설계 및 구현

손영대,김종길 동서대학교부설연구소 1998 연구소 논문집 Vol.3 No.-

Analysis, design and practical implementation of a self-excited electronic ballast for bulb-type fluorescent lamps are presented in t his paper. The proposed topology is based on a self-excited electronic ballast which connects half-bridge series resonant inverter to converntional rectifier output. That is, by using the self-excited drive circuit with current transformer, it can cause the improvement of switching characteristic and controllability, and the circuit's simplicity and miniaturization eventually. Therefore, it has the advantage of cost-effectiveness and easiness of implementation. Experimental rsults from the ballast system with 00W bulb-type pluorescent lamps have demonstrated the feasibility of the proposed self-excited electronic ballast.

급박 하지 허혈증에 대한 비수술적 치료의 장기 추적 결과

최재영,손민수,이길연,이상목,고석환,홍성화,윤층,오수명,박호철 대한혈관외과학회 2003 Vascular Specialist International Vol.19 No.1

슬라이딩 섹터에 근거한 제어기 설계

배상현,손영수,한종길 조선대학교 전자정보통신연구소 2001 電子情報通信硏究所論文誌 Vol.4 No.2

A sliding sector is defined as a subset the state space, inside which some norm of state decreases with zero control input. The variable structure controller with sliding sector is designed to transfer the system state from the outside to the inside of the sliding sector in a finite time and enable the system state stay inside the sliding sector, and the resulted VS control system is quadratically stable. The simulation results are its effectiveness.

들깨 종자 코팅의 폴리머 및 고형물질이 발아력에 미치는 영향

강점순,손병구,최영환,안종길 밀양대학교 농업기술개발연구소 2000 農業技術開發硏究所報 Vol.4 No.1

The purpose of seed coating is to make seedling mechanization possible by enlarging the seed size. The objective of this study was to determine the optimum of polymer and particulate matters for seed coating in perilla. There were significant differences of percent germination and germination speed in accordance with the coating polymer and the concentration. Among the coating polymer, germination of seeds using polyvinyl alcohol (PVA) was generally smooth, and followed by polyvinyl pyrrolidone (PVP), hydroxyethyl cellulose (HEC), and methyl cellulose (MC). The germination rate was also different according to the coating particulate matters. Generally, percentage germination and germination speed of seeds using the mixture of diatomaceous earth, talc and bentonite were higher and faster than using other coating materials, respectively. However, percentage germination using limestone was low, and percent germination of coated seeds with coating material showed the tendency of decreasing more than that of the seeds just added with coating particulate matters.

신속하고 균일한 묘출현 증진을 위한 종자전처리 기술

조동,손병구,강점순,최영환,안종길 密陽産業大學校 農業技術開發硏究所 1998 農業技術開發硏究所報 Vol.2 No.1

Preplant seed hydration treatments, particularly at low water potential, mobilized seed's resources that are utilized for rapid and synchronous germination, improved emergence rare, and larger stand size and yields. Seed priming is ideally suited to combat or lessen the impact of a number of soil and climatic constraints, including cold and wet conditions, thermoinhibition, drought, and incidence of diseases. The priming treatment is versatile enough to be integrated with other preplant physiological and non-physiological treatment to combat other internal and external constraints. These include chilling to break the primary dormancy, permeation with hormones to prevent the induction of secondary dormancy, and treatment with pesticides and beneficial microbes to combat seed and seedling diseases during stand establishment. The success or failure of priming treatment are influenced by a complex interaction of factors including plant species, osmeticum, water potential of the priming agent, during of priming, temperature, seed vigor, and dehydration and storage conditions following priming. Seed priming treatment under controlled temperature conditions, allows seeds to imbibe water and go through the initial stages of germination without radicle protrusion through seed coat. The use of a matricum for solid matrix priming(SMP) follows the same principals as for solution osmotic priming. The choice in mainly based on choosing a material wherein water uptake by the seed can be more closely regulated. Concentration of the matricum or osmoticum can be altered to fine-tune water relations The other factors that effect the results from seed priming, aeration, temperature, duration, light. dehydration, and storage are dependent on the species being primed. All crop seeds need air to germinate, thus optimizing aeration during priming. Germination rate and uniformity can be improved by priming for a vast array of crops as evidenced. The numbers of different species commercially primed and available to producers is quite small. The reasons for this might include the high charges to the grower of primed seed, lack of knowledge and or experience by growers of the results obtained from priming. Finally, more practical and essential subjects such as seed vigor and priming effectiveness, effects of dehydration after priming, storage conditions, and the ideal combination of matrix-solid, water, and seeds in SMP treatments are in need of further studies.

슬라이딩 섹터를 갖은 가변구조제어를 이용한 추적제어

배상현,한종길,손영수 朝鮮大學校 電子情報通信硏究所 2003 電子情報通信硏究所論文誌 Vol.6 No.2

제어이론의 중요한 문제는 유한시간 안에 정해진 수준의 오차 안에서 상태가 원하는 궤적을 따라 이동하도록 플렌트를 제어하는 것이다. 본 논문은 슬라이딩 섹터를 이용한 새로운 추적제어 방식을 제안하며, 슬라이딩 섹터에 라아프노프 함수를 이용하여 안정도를 분석한다. 시스템에 컴퓨터 시뮬레이션을 통하여 제안한 슬라이딩 섹터 제어가 채티링을 줄일 수 있는 것을 확인한다. A problem of major importance in control theory is that of controlling the plant in order to have the state tracking a specific reference trajectory within a prescribed level of tracking error in a finite time. In this paper, new methods of the tracking control using the sliding sector is proposed. This paper analyzes the stability, using Lyapunov function on the sliding sector. Through the computer simulations for the system, it is verified that sliding sector control is capable to reduce the chattering.

Head-Space SPME에 의한 생체시료 중 메스암페타민류 분석(Ⅲ)

박미정,최상길,손행자,최화경,최영남,허상철,박종서,정희선 內務部 國立科學搜査硏究所 2002 國立 科學 搜査 硏究所 年報 Vol.34 No.-

Hydropriming 처리가 오이종자의 발아성에 미치는 영향

조동,최영환,손병구,감정순,안종길 密陽産業大學校 農業技術開發硏究所 1998 農業技術開發硏究所報 Vol.2 No.1

본 연구는 오이종자의 발아율 향상과 발아촉진을 위해 처리가 간편하고, 처리비용을 절감할 수 있는 hydropriming의 실용화를 위해 필수적인 요인에 관한 실험을 수행하였다. 오이 종자의 발아촉진에 최적 priming 처리제는 50mM ·NaN03였다 유근장 및 유근 건물 중은 priming 처리제 종류에 따라 유의적인 차이는 없었으나, priming 및 hydropriming 종 자는 무처리보다는 높았다. 그러나 50mM NaN03와 hydropriming 처리간 발아력 증진 효과가 동일하여 오이종자에서 물을 이용한 hydropriming은 처리비용을 절감할 수 있어 합리적인 종자처리였다 오이 종자의 hydropriming 적정 처리온도는 20℃, 처리시간은 24시간이였다. Hydropriming시 적정 용액량은 종자 2g에 대한 용액량 10m 공급처리가 발아율 향상. T50,MDG 단축 및 유근생장에 효과적 이였다. 인위노화 종자는 발아율이 감소하였고 발아속 도는 지연되었으며, 비정상적인 발아는 증가하였다. 활력이 저하된 노화종자를 hydropriming 처리는 발아율이 향상되었고, 조기 발아하였다 또한 비정상인 발아는 감소되었으며, 유근생장이 촉진되어 종자력이 부분적으로 회복되었다. 이러한 경향은 노화일수록 경과된 종자일수록, 부적당한 발아조건인 15℃ 명확하게 나타났다. Various hydration treatments have been devised to improve the rate and uniformity of seed germination as well as seed viability. Hydropriming and priming, the imbibition of seeds in distilled water and osmotic solutions respectively, are useful techniques for early establishment of uniform seedlings. In this study, the optimum conditions were determined for hydropriming cucumber seeds. Effects of hydropriming were compared those of osmotic priming. Seeds, hydroprimed or primed with distilled water and 50 mM NaN03 at 20℃ for 24 hour, showed shorter number of days to 50% of the final germination percentage(T50) , and mean number of days to germination(MDG) than those untreated seeds. Nor did the ratio between the amount of seed to the volume of solution affect percent germination. But, hydorprimed with 10 ml distilled water showed improving the rate of germination than other treatment seeds. Hydropriming the aged seeds did improve percent germination at 15℃ and 25℃ . The T50 and MDG values were reduced significantly by hydropriming the aged seeds regardless of germination temperature. In addition to being simple and inexpensive, the quicker germination of hydropriming at low temperature. The effectiveness of hydropriming seeds caused some increase in the percentage of normal seedlings.