정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

산도가 장관의 운동성에 미치는 영향

장석종,박해근,김광진,임현재 충남대학교 의과대학 지역사회의학연구소 1982 충남의대잡지 Vol.9 No.2

The effects of hydrogen ion concentration changes on the motility as well as patterns of motility to autonomic drugs was investigated in the isolated duodenum and ileum of rabbits. Motility was recorded on a Physiograph with force transducer by means of Magnus method in sodium lactate Ringer's solution at 37℃ The pH of the Ringer's solution used were nornal (pH 7.4), acidic (7.4-5.5), and alkaline(7.4-9.5), titrated by 0.01 N BCI or 0.01 N NaOH solution respectively. Acetylcholine and norepinephrine as autonomic drugs was treated at normal, acidic, and alkaline Ringer's solution. Obtained results may be summarized as follows. 1. Increased hydrogen ion concentration (or decreased pH) inhibited tie motility of duodenum and ileum and that was proportional to increment of hydrogen ion concentration. 2. Decreased hydrogen ion concentration(or increased pH) enhanced the motility of duodenum and ileum and that at was proportional to decrement of h drocen ion concentration. 3. Effect of acetvlcholine on the patterns of motility in duodenum and ileum was not altered by hydrogen ion concentration changes. 4. Effect of norepinephrine on the patterns of motility in duodenum and ileum was not altered by hydrogen ion concentration changes.

20조갑 이영양증

이진탁(Jin Tak Lee),이창우(Chang Woo Lee),최광호(Kwang Ho Choi),김중환(Joong Hwan Kim) 대한피부과학회 1985 대한피부과학회지 Vol.23 No.3

A 38-year-old female patient presented dystrophic nail changes on her all finger and toe nails for 10 years. On examination, nails were uniformly affected with longitudinal ridging, loss of normal luster and brownish discoloration. This patient has not had any inflammatory skin diseases or systernic illness for the past 10 years. Biopsy examination from the dystrophic nail showed non-specific eczematous changes. The clinical and histologic features of this yatient was considered as the consistent findings with the ty enty-nail dystrophy, occured on the idiopathic base, coined by previous authors.

첨가제를 첨가한 TMA-포접화합물의 상변화에 관한 실험적 연구

김진흥,정낙규,김창오,박호진,강승현,김광일 朝鮮大學校 機械技術硏究所 2002 機械技術硏究 Vol.5 No.2

The purpose of this study is to investigate the propriety of TMA clathrate as a cold storage medium. Particularly, this is to examine the extent of subcooling improvement when the surfactants are added to the TMA clathrate, because water used cold storage material has low phase change temperature and subcooling. this study has been analysed and compared with TMA 30wt% clathrate how phase change temperature, subcooling and specific heat in the various concentrations are changed. This results view to be improved phase change temperature and subcooling of TMA30wt% as a cold storage medium, when it had some surfactant. Additionally, it is that surfactant must be controlled under available solution limit and study for new additive must be lasted to know its effect.

신규로 건설된 군 위댐 호내 어류 군집 및 생태적 특성에 관한 연구

이진웅 ( Jin Woong Lee ),윤주덕 ( Ju Duk Yoon ),김정희 ( Jeong Hui Kim ),박상현 ( Sang Hyeon Park ),백승호 ( Seung Ho Baek ),장광현 ( Kwang Hyeon Chang ),장민호 ( Min Ho Jang ) 한국하천호수학회(구 한국육수학회) 2015 생태와 환경 Vol.48 No.4

To secure water resources, dams are normally constructed on the upper - middle part of streams, and it generates physical disturbances such as habitat alteration and stream fragmentation. Such construction can restrict movement of aquatic organisms, especially for freshwater fish which is one of top predator in aquatic ecosystem, and cause genetic fragmentation and community change. In this study, to investigate impact of habitat alteration after dam construction on freshwater fish, we monitored fish community changes, and compared fish fauna between dam reservoir and inflows. Additionally, movement characteristics and habitat boundaries of four species were identified by radio telemetry method. The study was conducted in the Gunwi Dam which was constructed in December 2010. Radio telemetry was applied to Pungtungia herzi, Zacco platypus (living lotic and lentic), Silurus asotus (lentic preferred species) and Zacco koreanus (lotic preferred species). The number of species was remarkably decreased (4 family, 10 species) comparing with before the dam construction (7 family, 15 species). Specifically, Coreoleuciscus splendidus, Niwaella multifasciata, Liobagrus mediadiposalis, Coreoperca herzi and Odontobutis platycephala that inhabit in the lotic environment were not collected in the study area. A total of 8 species were caught in both the dam reservoir and tributaries except 2 species (C. auratus and S. asotus). Sorenson``s similarity between the reservoir and its tributaries was high (0.842). All of the radio tagged species stayed in the reservoir except S. asotus which moved to the tributary. These species mainly utilized the shallow littoral zone as a habitat. These results could be useful as a baseline data for efficient management of fishes in lakes.

또래학습을 통한 또래교사와 또래학습자의 인지구조 변화 -초등 도형영역에 대하여-

김미정 ( Mi Jung Kim ),이광호 ( Kwang Ho Lee ),이미진 ( Mi Jin Lee ),성창근 ( Chang Geun Sung ) 한국수학교육학회 2013 初等 數學敎育 Vol.16 No.2

본 연구는 또래교수 활동을 통하여 변화된 도형의 개념 및 성질, 도형간의 관계에서 인지구조를 관찰하고 어떻게 정교화 해 가는지에 대해 또래교사와 또래학습자의 인지 구조의 차이를 알아보았다. 연구 문제를 해결하기 위해 보은의 S초등학교 5학년 학생 6명을 대상으로 또래교수와 학습자 3팀을 선정하고 도형영역에 대한 사전·사후검사를 실시하고 자료를 분석하였으며 심층면담을 실시하여 인지구조를 분석하였다. 또래교사와 또래학습자 모두 도형영역에서 인지구조가 변화되었으며 특히 또래교사의 인지구조의 변화가 더욱 뚜렷이 나타났다. 따라서 또래교수활동은 체계적인 계획하에 일관성 있는 교수활동 뿐만이 아니라 학습활동에 더욱더 많은 교사의 지속적인 노력과 지원이 필요하다. The purpose of the study is finding the effective teaching and learning methods on the concepts of figures through exploring the change of students` cognitive structures before and after the peer teaching activities. The difference of the peer teacher`s and student`s cognitive structures was investigated for the activities. Three teams, six students of 5th grade, were selected from the S elementary school in Boyeon. To figure out the students` cognitive structures, pre and post in-depth interviews were conducted and analyzed. Both peer teachers` and learners` cognitive structures were changed. Peer teachers` cognitive structures were changed more positively than peer learners. A consistent systematic planation and continuous teacher support and effort are needed for the activities.

축냉재 포접화합물의 열물성에 관한 실험적 연구 (IV) : 온도 변화 Changing of Temperature

고광옥,임재경,김창오,김진홍,정낙규,하옥남 조선대학교 에너지.자원신기술연구소 2000 에너지·자원신기술연구소 논문지 Vol.22 No.2

The objective of this paper is to investingate the thermal properties of TMA-clathrate applicable to cold storage system for building air-conditioning in order to use energy reasonably. Especially, the test tube experiments are performed by comparing and to analyzing the temperature of phase change, specific heat and subcooling characteristic according to the variation of concentrations and temperature of heat source in TMA clathrate. The result are summarized as follows; 1) temperature of phase change is dropped as the temperature of heat source is lower 2) specific heat of TMA-clathrate is about 24~95 % of pure-water 3) subcooling is smalled as the temperature of heat source is lower. Thus, it apears that TMA-clathrate has thermal properties as the cold storage medium for residential air-conditioning

산업용 조정 피치형 축류송풍기의 성능예측에 관한 연구

구재인(Jae-In Koo),김창수(Chang-Soo Kim),정진택(Jin-Teak Chung),김광호(Kwang-Ho Kim) 한국유체기계학회 2001 유체기계 연구개발 발표회 논문집 Vol.- No.-

In the present study, we studied the method of predicting the on-design and off-design point performance of axial flow fan with adjustable pitch blades. With the change of stagger angle of axial flow fan with adjustable pitch blade, flow rate and pressure can be changed. Because of this merit, adjustable pitch fans are used in many industrial facility. When changing stagger angle or estimating the performance at a wide range of off-design condition, incidence angle changes greatly as the flow rate changes. Therefore, the deviation angle at the blade exit is estimated by the correlation considering the effects of blade design, incidence angle variation. In the loss model, we used known pressure loss model for blade boundary layer and wake, secondary flow, endwall boundary layer and tip leakage flow. The results of modified deviation angle model and experiment were compared for the usefulness of the modified model.

CDMA 시스템의 Ec/Io 개선을 위한 순방향 채널의 전력분배에 관한 연구

김선미,최동유,류광진,박창균 조선대학교 전자정보통신연구소 2002 電子情報通信硏究所論文誌 Vol.5 No.2

This study defined the way to distribute power of forward channel and suggested a new model for prediction power in order to minimize the deterioration of call quality and performance in the CDMA mobile communication system of narrow band using 1.2288MHz of narrow band. Each change in Ec/Io was measured for the factors affecting wireless environment(e.g. the changes in power of overhead channel, the changes in a number of call channel, and the increase in interference from the additional facilities of adjacent base station or other systems) to know the influence on the wireless environment of forward link. The new way for power distribution to a base station in operation and its validity was checked by comparing before and after test.

실업계고등학교 교육 환경 개선 방향에 관한 연구 : 환경 색채 계획을 중심으로

장광집,오현진 경희대학교 디자인연구원 2006 예술· 디자인학연구 Vol.9 No.1

The development of education can be more efficiency with it's educational atmosphere. But because of it's peculiar conservativeness and exclusiveness, budget and time requirement the effort to develop school environment is not working as it should be. The most economical method to develop the school environment is to reform the color scheme of school environment. To applicate the school environmental color scheme effectively, we went out to verify the present status, the outer environment is not harmonize well and because of it doesn't express its own character. The inner environment, the color is painted in unconsiderable color scheme and it effects poorly on student's mental state. Also in survey of satisfaction in color scheme, the students are not satisfy with it. Therefore, the research on school environmental color scheme should be accomplish in priority. Base on this issue, we are proposing basis of environmental color scheme for Vocational High School. This basis will be the basic methodological basis in plan of environmental color scheme for Vocational High School. Through this research, desire to recognize the importance of school environmental color scheme and expect to spread its line gradually by its priority.