중등학교 교과서의 농업·농촌 기능 분석 및 반영 방안

서우석,강대구,정진수,김절용,김재호,이윤조 한국농업교육학회 2007 농업교육과 인적자원개발 Vol.39 No.2

구강 편평세포암종에서 E-cadherin 및 β-catenin 발현의 변화 : Correlation with Histologic Features and p53 Expression

서진건,권창석,박진배,윤혜경,김우형,이희철 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.4

Objective : Altered expression of cell adheion molecules is associated with biologic behavior of tumor. The aim of this study is to evaluate the expression pattern of E-cadherin, β-catenin and p53 protein according to histologic grade and invasion pattern of squamous cell carcinoma of the oral cavity and the relationship between E-cadherin, β-catenin and p53 protein expression. Methods and Material : The materials were fifty seven cses of squamous cell carcinoma, and clinicl parameers such as age, sex, tumor location, stage and recurrence were recorded. Histologic review was done based on histologic grade and invasion pattern(nodular vs infiltrative). Immunohistochemical stains for E-cadherin and β-ca tenin were interpreted based on staining pattern as los of membranous expression and cytoplasmic expression and p53 protein expression was defined as positive if more than 10% of nuclei were reactive. Statistical analysis between E-cadherin, β-catenin and p53 protein expressions and histologic grade and invasion pattern and the relationship between E-cdherin, β-catenin and p53 protein expressions were perfomed. Results : There wa positive correlation between higher histologic grade and infiltrative pattern. Loss of membranous expression and cytoplasmic expression of E-cadherin were noted in 33.3% and 57.9%, respectively, and loss of membranous expression of E-cadherin showed increaing tendency in poorly differentiated carcinomas, however, there was no significant difference of cytoplasmic expression rate of E-cadherin according to histoogic grade. Altered expression of E-cadherin was more frequent in poorly differentiated carcinomas. Loss of membranous expression and cytoplasmic expression of E-cadherin were more frequent in carinomas with infiltrative pattern than in carcinomas with nodular pattern, but their diferences were not significant, Loss of membranous expression and cytoplasmic expression of β-catenin were observed in 19.3% and 80.7%, respectively. Loss of membranous expression of β-catenin howed no positive correlation according to histologic grade and invasion pattern, but cytoplasmic expression rate of β-catenin was higher in poorly differentiated carcinomas and in carcinomas with infiltrative pettern. p53 protein expression rate was 45.6%, and showed invreasing tendency in poorly differentiated carcinomas, but no significant relationship with invasion pattern. There was an inverse relationship of loss of membranous expression and cytoplasmic expression of E-cadherin and β-catenin. Altered expression of E-cadherin was related to cytoplasmic expression of β-catenin, however, there were no significant relationship between altered expressions of E-cadherin and β-catenin and p53 protein expression. Conclusion : In squamous cell carcinomas of the oral cavity, altered expression of E-cadherin and β-catenin was more frequent in poorly differentiated carcinomas and in carcinomas with infiltrative pattern and there was positive correlation betwween altered expression of E-cadherin and β-catenin. These findings suggest that altered expressions of E-cadherin and β-catenin may have a role in the development of squamous cell carcinomas with aggressive biologic behavior. but altered explosions of E-cadherin and β-catenin. These findings suggest that altered expressions of E-cdherin and β-catenin my have a role in the development of squmaous cell carcinomas with aggressive biologic behavior. But altered expression of E-cadherin and β-catenin might not be related to p53 protein expression. Further study on genetic mutation related to altered expression of E-cadherin and β-catenin will be needed

간헐적 복통과 혈변이 동반된 성인의 맹장-결장 회전결여증 1예

정서진,박성흠,윤서구,박치구,최경우 대한대장항문학회 1998 Annals of Coloproctolgy Vol.14 No.3

폐비닐여재를 적용한 부착성장식 공법의 유기물 및 영양염 제거 특성

서종환,김진우,안철우,이철승,박진식,김수생 동아대학교 환경문제연구소 2003 硏究報告 Vol.25 No.2

This study was carried out to demonstrate the removal characteristics of organic materials & nutrients in attached growth process applied Synthetic Wasted Polyethylene Media which is reused from wasted vinyl in rural. The results are as follows: 1. Removal efficiencies were indicated COD_(cr), 91.4, 92.4, 93.9%, T-N 56.9, 61.4, 65.1% and all T-P 45% or more with HRT 10, 12, 14 respectively. 2. It is indicated BOD volume load 0.18~0.40kg/ ㎥ ·d, COD volume load 0.28~0.53kg/ ㎥ ·d and NH₄-N volume load 0.12kg/ ㎥ ·d respectively. In conclusion, It is showed activated sludge process is replaced with this process applied Synthetic Wasted Polyethylene Media and this process is considered the methods that solve wasted vinyl troubling in a rural.

관상동맥 누공에 의한 급성 심근 경색 1예

서유승,최재웅,송창섭,조용범,양진수,박준섭,정인수 대한내과학회 2003 대한내과학회지 Vol.65 No.2

관상동맥 동정맥루 기형은 매우 드문 질환으로 치료가 불필요한 경우가 대부분이나 coronary steal 현상으로 인해 증상이 발생하거나 합병증이 발생한 환자에 대해선 치료를 요한다. 최근에는 시술에 적합한 누공을 가진 선택된 환자군을 대상으로 카테터를 이용한 중재적 시술이 시행되어 수술적 치료와 유사한 결과를 얻고 있다. 저자들은 젊은 남자에서 관상동맥 동정맥루 기형과 동반된 급성 심근 경색증을 진단하여 비 수술적 방법인 카테타 코일 색전술로 성공적 치료 후 증상 및 심근 재관류에 호전을 보인 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. We report a case of coronary fistula between the left anterior descending and main pulmonary artery complicating acute non-Q wave myocardial infarction. A 27-year-old man visited emergency department because of severe chest pain lasting two hours. The electrocardiogram showed ST segment elevation in precordial leads V3~6. Cardiac enzymes were as follows;CK-MB:36.44 IU/L T-T:0.489 ng/mL, CPK:542 IU/L, and LDH:475 IU/L. The thallium-201 dipyridamole stress perfusion scan showed perfusion defect and reversed redistribution in the anteroseptal wall. The coronary angiogram revealed coronary artery fistula between the proximal left anterior descending artery and main pulmonary artery without significant stenoses of coronary arteries. The result of ergonovine test was negative. After micro-coil embolization to the coronary fistula, symptoms were improved. Follow-up thallium-201 scan showed normalized blood flow in the left anteroseptal wall.

3개 대학병원의 주 진단 코딩사례 평가

서순원,김광환,부유경,서진숙,서정돈,윤석준,이영성,이무식,정희웅 한국의료QA학회 2002 한국의료질향상학회지 Vol.9 No.1

Background : Coding of principal diagnosis is essential component for producing reliable health statistics. We performed this study to evaluate the current practice of principal diagnoses determination and coding, and to give some basic data to improve coding of principal diagnosis. Method : Nineteen medical record administrators(MRAs) of 3 university hospitals participated in coding principal Dx. From August 1, 2001 to August 31, 2001. From each hospital, 10 medical records of patients with high frequency disease were selected randomly. Each 10 medical records were grouped into three(A,B,C). Then, these 30 medical records were given to each MRAs for coding. At the same time questionnaire was given to each of them. Questions were to prove how they decide and code the principal diagnosis among many current diagnoses ; how they decide and code the principal diagnosis when day see irrelevant diagnosis recorded as the principal diagnosis in medical record, when only tentative diagnoses were recorded without final diagnosis, and when different diagnoses were recorded in different sheets of same record. Agreement of coding among 3 hospitals were compared and survey results were analysed with SAS 6.12. Results : Agreement of coding was found in medical records 5-6 of each 10 medical records. Causes of disagreement were as follows. Difference of clinician’s opinion from each hospital; mixed use of guideline from KCD-3 and guideline from DRG; difference in 4th digit classification according to the absence of pathology report in the medical record; difference of abbreviations among hospitals. 57.9% of decided principal diagnosis after consulting to KCD-3 guideline. When there were difficulties in determining the principal diagnosis, 42.1% of MRAs decided principal diagnosis after discussion with the physician, 26.3% after discussion with fellow MRAs. Conclusion : There were differences in coding among hospitals. To minimize the difference, we suggest the development of disease-specific guidelines for coding in addition to the current general guideline such as KCD-3. To do this, Coding Clinic which can produce guidelines is needed.

패밀리레스토랑 수요 결정요인분석 - 절단된 가산자료 모형의 적용

서진우 釜山 大學校 經營 經濟 硏究所 2009 經營 經濟 硏究 Vol.28 No.1

폐광산 주변의 목본 식생 현황 및 오염 토양에 대한 목본 종자의 발아 특성

서경원,손요환,김래현,구진우,노남진,경지현,김정규 한국환경농학회 2006 한국환경농학회지 Vol.25 No.1

실시간 응용프로그램을 위한 최악 실행 시간 분석

元裕憲,徐鎭哲,李俊東 弘益大學校 科學技術硏究所 1999 科學技術硏究論文集 Vol.10 No.1

Worst-case execution time(WCET) is part of the timing analysis of real-time systems. The goal of timing analysis is to validate that a real-time computer system fulfills the specified temporal requirements of a given application in all predicated situation. In this paper, We illustrate a new language, Timing-C, and design a timing tool for predicting WCET in it. Timing-C is added time constraint and a few restriction in the subset of C. Using Timing-C, programmer need not learn a new language and can demonstrate program's timing activity.

NaOH 첨가에 따른 음식물찌꺼기 고온 혐기성 산발효

안철우,이철승,서종환,박진식,문추연,장성호,김수생 한국환경농학회 2004 한국환경농학회지 Vol.23 No.4

본 연구는 음식물찌꺼기의 혐기성 산발효에 있어 여러 조건들 중 온도가 효율적인 가수분해와 산발효에 미치는 영향을 검토하기 위해 고온(55℃)과 중온(35℃)에서 각각 실험을 수행하여 다음과 같은 결론을 얻을 수 있었다. 음식물찌꺼기의 혐기성 산발효시 산생성 효율을 높이기 위한 전처리 과정으로 음식물찌꺼기에 NaOH를 투입한 결과 가수분해효율을 표현한 가용화 정도(Solubilization)가 0.01 g NaOH/g TS이하로 투입된 경우 0.01 mgSCOD_(prod)/mgICOD_(inf)이하를 나타내었으나, 0.05 g NaOH/g TS이상을 투입했을 때는 0.07~0.09 mgSCOD_(prod)/mgICOD_(inf)로 나타났다. 따라서 음식물찌꺼기에 NaOH를 투입하여 효율적인 가수분해가 이루어지기 위해서는 g TS당 0.05 g이상의 NaOH가 투입되어야 할 것으로 판단된다. 음식물찌꺼기를 NaOH로 전처리한 후 고온(55℃) 산발효를 실시했을 때 0.05 g NaOH/g TS 투입시 SCOD의 증가치 3,800 mg/L로 최대의 가용화와 산생성에 효과적인 pH 5.95를 얻을 수 있었다. 0.05 g NaOH/g TS를 투입하여 중온(35℃)에서 산발효를 실시한 경우와 비교하여 SCOD 증가치가 약 5배 정도 높았고, 최대 가용화에 이르는 시간도 중온의 2/3 정도로 짧아 음식물찌꺼기의 가용화에는 고온이 효과적인 것으로 나타났다. NaOH 0.05 g NaOH/g TS로 전처리된 음식물찌꺼기의 산발효 결과 고온(55℃) 및 중온(35℃)에서 각각 반응시작 후 72시간에 12,600 mg/L, 120tlrksdp 9,800 mg/L의 VFA농도를 나타내어 동일기질을 이용하여 산발효를 실시했을 때 중온보다는 고온에서 미생물의 활성증대와 유기물의 가수분해가 촉진되어 VFA생성이 효율적인 것으로 판단되었다. 고온에서 NaOH에 전처리된 음식물찌꺼기를 산발효 시켰을 때 VFA가 가장 높았던 시점을 기준으로 VFA의 조성을 조사한 결과 acetic acid가 45.9%, butyric acid가 26.7%, propionic acid가 13.9% 등으로 총 유기산 발생량의 86.5%를 차지하였다. This study showed that thermophilic anaerobic acid fermentation of food wastes had an enhanced hydrolysis capability and improvement of acidification efficiency. Influence of pH on the anaerobic hydrolysis and acidogenesis was investigated to determine the proper alkalinity in the thermophilic fermentation of food wastes. The results of putting NaOH as alkali to evaluate hydrolysis and acid fermentation efficiency in acid fermentation process of food wastes showed that the food wastes pretreated with 0.05 g NaOH/g TS had the maximum 12,600 mg/L of VFAs concentration during HRT 3 days in 55℃ hermophilic condition and the maximum 9,700 mg/L of VFAs concentration during HRT 5 days in 35℃ mesophilic condition. The accomplishment of high VFAs concentration resulted from that the main component of food wastes such as cellulose, lignin and etc. is performed active chemical decomposition by alkali in thermophilic condition. The major components of VFAs produced from the thermophilic acid fermentation process of food wastes were the short chain fatty acids such as acetic acid, butyric acid, and propionic acid.