열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

니켈담지촉매의 제조과정에서 액상산화의 효과

최재석,임태훈,홍성안,이호인 한국공업화학회 2004 응용화학 Vol.8 No.1

The deactivation of reforming catalyst in the DIR-MCFC was reported to be affected by dispersion, loading amounts, kind of support and so on. In this research, we checked the resistivities of catalysts prepared by the different methods, and examined the effect of liquid phase oxidation. The oxidized catalyst in a liquid phase showed the increased activity and dispersion even though the nickel species was supported by deposition-precipitation method. In order to investigate the role of the oxidation, TGA, TPR and XRD analyses were conducted. The increase in activity was ascribed to the strong metal-support interaction which was induced by liquidphase oxidation.

Prostacyclin synthase 유전자의 C1117A 다형성과 이형협심증과의 관련성

성인환,임대승,김정희,이재환,최시완,정진옥 대한내과학회 2004 대한내과학회지 Vol.66 No.4

목적 : Thromboxan A2의 혀관수축반응을 저해하는 prostacylin synthase exon 8 C117A의 변이가 관동맥 연축과 관련성이 있는지를 알아보고자 하였다. 방법 : 1998년 1월 1일부터 2000년 12월 31일까지 충남대학교병원 순환기내과에서 관동맥조형술과정맥내 에르고노빈 유발검사를 시행하여 관동맥 연축이 확진된 이형협심증 환자군(45예)과 정상 대조군(59예)을 대상으로 중합효소 연쇄반응법 및 restriction fragment length polymorphism을 이용하여 분석하였다. 결과 : Prostacyclin synthase exon 8 C117A 유전자형의 빈도는 대조군에서 A/A : A/C : C/C =3.4% : 30.5% : 66.1%, 이형협심증 환자군에서 A/A : A/C : C/C = 8.9% : 42.4% : 48.9%로 두 군간에 유의한 차이가 없었다. 대조군에 비해 변이형 협심증 환자군에서 남자의 비율과 흡연률이 높았지만, prostacyclin synthase exon 8 C117A 유전자형에 따른 군에서 당뇨병, 고혈압, 흡연, 고지혈증, 비만 등의 유의한 차이는 없었다. 결론 : 한국인에서 prostacyclin synthase exon 8 C117A 유전자 다형성과 관동맥 연축이 있는 이형협심증과의 유의한 연관성은 발견할 수 없었다. Backround : Coronary artery spasm plays an important role in the pathogenesis of variant angina(VA). Prostacyclin is one of the endothelium derived relaxing factors. The association between the novel single nucleotide polymorphism in the prostacyclin synthase gene and VA is not known. Therefore, we investigated the association between VA and the polymorphysm in the prostacyclin synthase gene. Methods : We compared 45 variant angina patients who had positive intravenous ergonovine test by coronary angiography with 59 control subjects who had negative intravenouis ergonovine test and normal coronary angiogram. Using the polymerase chain reaction-single-strand conformation polymorphism analysis, we identified a single nucleotide polymorphism, C117A, in exon 8. This nucleotide change did not cause an amino acid change in codon 373. Results : There was no significant difference in characteristics between the control group and the VA group, and there was no significant difference in the genotype distributions between the control group and the VA group. Conclusion : The C117A polymorphism in exon 8 of the prostacyclin synthase gene is not associated with variant angina.

특발성 좌심실빈맥(Idiopathic Left Ventricular Tachycardia)의 성공적인 전극도자절제술을 위해 단극전기도(Unipolar Electrogram)가 유용한가?

최기준,남기병,강덕현,홍명기,송재관,김재중,박성욱,박승정,박종훈,김유호 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

Staphylococcus lugdunensis에 의한 감염성 심내막염 1예

최성호,박현구,변승운,구동회,강호석,장항제,김양수,우준희,김영휘,최상호 대한감염학회 2006 감염과 화학요법 Vol.38 No.5

Staphylococcus lugdunensis is a coagulase-negative staphylococcus (CNS) that is commonly found on the human perineal skin. Contrary to other CNS, S. lugdunensis is a rare contaminant in cultures and has the potential to cause clinically significant infections, including infective endocarditis. Infective endocarditis due to S. lugdunensis have been known to resemble endocarditis due to S. aureus because of its aggressive clinical course and high mortality. We report a case of infective endocarditis caused by S. lugdunensis in a 21-year-old woman. She was cured of the infection with surgical and antibiotic therapy. S. lugdunensis에 의한 감염성 심내막염은 국내에서보고가 없었던 매우 드물지만 다양한 합병증과 높은 사망률을 보이는 감염증이다. 저자들은 S. lugdunensis가 수술적 치료와 항생제 치료로 완치된 감염성 심내막염 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

리사이클을 위한 평판 유리 파쇄 장치 개발

최성대,정선환,김잠규,김우재,김용선 한국공작기계학회 2008 한국공작기계학회 춘계학술대회논문집 Vol.2008 No.-

At a point time, when demand is gradually increasing on LCD and PDP market all over the world, demand on glass which is key part of LCD and PDP is increasing, too. Hence, glasses are being cut by requested size for satisfaction on demands, the remain glass is making problems. This study is for designing installation of handling these remained glasses effectively and easily.

原料의 種類와 形態에 따른 Aspergillus oryzae 麴의 生理活性 및 酵素力

최성현,정재홍,이상덕,손화영,성창근,오만진,김성렬 충남대학교 농업과학연구소 1997 농업과학연구 Vol.24 No.2

CNU O4-5 isolated from conventional Meju, which is used as raw material for making a soybean fermentation food, identified as an Aspergillus oryzae. To make koji, Aspergillus oryzae CNU O4-5 was cultured for 3-4 days at 30℃ with various grain materials such as flour, soybean powder, flour+soybean powder(1:1), soaked soybean and rice. The koji was evaluated for analyze the angiotesin converting enzyne(ACE) inhibition, antioxidative activity, superoxide dismutase(SOD) activity, amylase and protease activity, α-amylase and glucoamylase activities of flour koji wee higher than those of the koji soybean powder. However neutral and alkaline protease activities of flour koji were lower than those of flour+soybean powder and soybean koji. Amylase and protease activities of kojies of soaked soybean and rice showed very low level. The range of the ACE inhibition rate by hot water fraction of the kojies, which are cultured with various gain materials, were from 45% to 54%. The antioxidative activity of ethanol-fraction of koji, which is made by using the soybean powder or soaked soybean, prolonged for 6 days in lard at 60℃. The SOD activity of grinded fraction of koji, which is made by using the flour or soybean powder, was same as 2,000 units per g of each koji.

Ficin의 酵素化學的性質에 관한 硏究

崔甲晟,徐在信 順天大學校 1985 論文集 Vol.4 No.1

One of ficin, isolated from Fig latex, was conducted to investigate some chemical properties of enzyme. The results are as follows; 1. The activity of crude ficin was 2.3 unit/mg and milk clotting activity was 8.33x10-²unit/mg 2. The hydrolytic activity to substrate was 6.8%, which is thought to be of low value. 3. While activities of enzyme after adding 10?? Mcysteine and those concentration of 2-mercaptoe thanol were high. 10-³M-Na₂S₄O?? was the strongest inhibitor among others. 4. The value of enzyme activity was the highest when the concentration of casein solution was 3%.

임신 제 일삼분기와 제 이삼분기 초음파의 태아기형 진단의 유용성에 대한 고찰

최승도,최규연,이정재,정성윤,이임순,이권해 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.2

Objective: Ultrasonographic screening between 9 and 13 weeks for fetal structural abnormalities using transvaginal sonography in unselected population. Visualization of detailed fetal anatomy in the first trimester has improved as a result of technological progress in ultrasound machines and the introduction of transvaginal sonography(TVS). Our study aims to evaluate the accuracy of TVS as a screening tool for detecting fetal malformations in a nonselected population of pregnant women. For this purpose we compared the results obtained by using second trimesster TA scanning with those obtained using TVS at 9-14 weeks' gestation. Methods: From March 2001 to February 2003, 620 unselected consecutive pregnant women were recruited at their initial visit at Soonchunhyang university hospital, department of obstetrics and gynecology and offered a TVS scan at the average gestational age of 9-13 weeks in addition to the TA screening usually performed between 22-26 weeks. To fulfill the technical requirements of a screening test, ultrasonographic examinations were performed by skillful operators with different degrees of experienced using adequate instruments Aloka SSD 5500 (Aloka Co. Ltd., Tokyo, Japan) provided with either a 3.5-5MHz TA probe or a 5-7.5MHZ TV probe) in a fixed scanning time of maximum 30 min, generally considered sufficient for a complete fetal anatomic survey. Results: During the study period we found in our unselected population an overall prevalence of target abnormalities of 2.2%(24 malformed fetuses out of 600 screened). In the fetuses examined by TVS, 16 abnormalities were detected whereas 8 were not; of these, 6 were detected at transabdominal rescreening at 22-26 weeks and the remaining 2 were observed after birth. A nuchal region abnormality was the most frequent type of malformation detected in the early scan, including six cases of nuchal edema, two cases of cystic hygroma associated with hygroma associated with hydrops, three cases of hydronephrosis, one case of fetal neck teratoma, one case of cleft lip. Conclusion: This study has demonstrated the potential of screening a low risk population for fetal abnormalities at 9-13 weeks of gestation using transvaginal sonography and rescreened via transabdominal sonography at 22-26 weeks. Larger studies are required to establish the clinical value of the first trimester scan.

수증기 개질반응용 니켈촉매에 첨가된 리튬의 효과

최재석,윤정숙,임태훈,홍성안,이호인 한국공업화학회 2005 응용화학 Vol.9 No.1

In the direct internal reforming type molten carbonate fuel cell, alkali carbonates used as electrolyte in the cell are transported to reforming catalyst of which activity drastically decreases. In our previous work, the deactivation of the nickel catalyst was studied with increasing the amount of added lithium. Unexpectedly, the increase of activity was observed with a small amount of lithium less than 1wt%. The results of TPR, XRD and chemisorption showed no significant difference between the fresh catalyst and the Li-added one, implying that lithium did not cause the change of morphological property of the supported nickel. To elucidate the effect of lithium the methanation of CO was applied to the catalysts, which was considered as the reverse reaction of the key elementary step of methane steam reforming. It can be seen by an online mass spectrometer that the small injection of CO/H₂ mixture into the Li-added catalyst reactor at 650 ℃ showed the longer tail of produced methane than into the fresh one. The delay should be originated from the effect of lithium, which determined the overall rate on the Li-added catalyst.