Comparative occurrence of ischemic stroke with the rhythm versus rate control strategy in a national prospective cohort of atrial fibrillation

( Jae Guk Kim ),( Young Soo Lee ),( Ki-woon Kang ),( Eue-keun Choi ),( Myung-jin Cha ),( Jung-myung Lee ),( Jin-bae Kim ),( Junbeom Park ),( Jin-kyu Park ),( Tae-hoon Kim ),( Jae-sun Uhm ),( Jaemin Sh 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.1

Background/Aims: Comparative occurrence of ischemic stroke for rhythm versus rate control strategy in patients with non-valvular atrial fibrillation (NVAF) is still inconclusive. The purpose of this study was to investigate whether the rhythm control strategy is associated with a lower risk of ischemic stroke compared to the rate control strategy in NVAF patients. Methods: The CODE-AF registry prospectively enrolled 6,280 consecutive patients who were treated for NVAF at 10 tertiary referral centers in South Korea. Of these, 2,513 NVAF patients (age, 67 ± 10 years; male, 61.8%) were clinically followed up for over 1-year and divided into rate and rhythm control groups. Results: Those treated with the rhythm control strategy were younger and had less proportions of underlying disease compared to those treated with the rate control strategy. After the propensity matching analysis, those treated with the rhythm control strategy had similar baseline characteristics including the CHA₂DS₂-VASC score compared to those treated with the rate control strategy. The rate of oral anticoagulation, all bleeding, and hospitalization were also similarly between the two groups. The incidence rate of ischemic stroke in the rhythm control group was significantly lower than in the rate control group (0.7 vs. 6.9 per 1,000 person-years, p = 0.011). Conclusions: The rhythm control strategy demonstrated a beneficial effect to lower the risk of ischemic stroke during a 1-year follow-up compared to the rate control strategy.

Gender-related Differences in Management of Nonvalvular Atrial Fibrillation in an Asian Population

Lee, Jung Myung,Kim, Tae-Hoon,Cha, Myung-Jin,Park, Junbeom,Park, Jin-Kyu,Kang, Ki-Woon,Shim, Jaemin,Uhm, Jae-Sun,Kim, Jun,Park, Hyung Wook,Lee, Young Soo,Choi, Eue-Keun,Kim, Chang-Soo,Joung, Boyoung,K The Korean Society of Cardiology 2018 Korean Circulation Journal Vol.48 No.6

<P><B>Background and Objectives</B></P><P>Gender-related differences in health care utilization for atrial fibrillation (AF) are increasingly recognized. However, large cohort data for examining gender-related differences in AF are lacking in Asian populations.</P><P><B>Methods</B></P><P>The Registry for Comparison Study of Drugs for Symptom Control and Complication Prevention of AF (CODE-AF Registry) is a prospective observational cohort-study that enrolled participants at 10 tertiary hospitals in South Korea. Baseline characteristics retrieved from the CODE-AF Registry were analyzed.</P><P><B>Results</B></P><P>A total of 6,274 patients were recruited (mean age 67±11 years, mean CHA<SUB>2</SUB>DS<SUB>2</SUB>-VASc score 2.7±1.7, 63% male, 65% paroxysmal AF) from June 2016 to April 2017. Women underwent less electric cardioversion (12.3% vs. 19.6%, p<0.001), less radiofrequency ablation (12.4% vs. 17.9%, p<0.001), and less antiarrhythmic drug therapy (44.7% vs. 49.5%, p<0.001), despite having more severe symptoms (symptom class III or IV, 45.8% vs. 37.5%, p<0.001). Among patients with a CHA<SUB>2</SUB>DS<SUB>2</SUB>-VA score of 2 or more, a slightly higher proportion of women were taking oral anticoagulants than men (85.7% vs. 81.9%, p=0.002), and non-vitamin K antagonist oral anticoagulant (NOAC) use was more prevalent in women than men (70.4% vs. 62.3%, p<0.001). Insufficient NOAC dosing was very common, more so in women than men (61.5% vs. 56.3%, p<0.001).</P><P><B>Conclusions</B></P><P>Female patients with AF were treated more conservatively and rhythm control strategies were used less frequently than in males, even though the female patients with AF had more severe symptoms. While insufficient NOAC dosing was common in both sex, it was significantly more frequent in women.</P>

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

공업계 고등학교 남 ·여학생의 진로의식 비교 연구

노재정,유병항,차명수 경성대학교 생산기술연구소 1996 생산기술연구지 Vol.3 No.-

The purpose of this thesis is to get data which need to set up the positive directions for Coeducational Technical High School. To attain these data, Technical High School boy and girl students' consciousness of career was examined, and then their consciousness levels of career, choices of career, views for getting a job, and states of career education were compared and analyzed. The main points to accomplish the purpose of this thesis are as follows : 1. Do Technical High School students' motives of entrance and major choice indicate a meaningful difference by both sexes? 2. Do Technical High School students' self-consciousnesses indicate a meaningful difference by both sexes? 3. Do Technical High School students' consciousnesses of career indicate a meaningful difference by both sexes?

흰쥐에서 염화비닐 폭로수준에 따른 소변내 thiodiglycolic acid 농도의 변화

왕승준,차봉석,노재훈,신동천,김명수,전근재 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.4

Objectives : It is the objective of this research to identify the variation of thiodiglycolic acid(TdGA) in urine with vinyl chloride monamer(VCM) exposure levels through methylation. Methods : After rats were exposed to vinyl chloride monomer of 4 levels, 0㎎/㎥, 50㎎/㎥, 150㎎/㎥, 500㎎/㎥, respectively, of which urine was sampled in each sampling time of 0 hour, 2 hours, 4 hours, 8 hours, 16 hours, 36 hours, 48 hours. After urine had been methylated with diazomethane in the preliminary experiment and the peak of 146 m/z had been verified, the main experiment was done. Results : In the variation of TdGA with sampling times, concentration of TdGA increased rapidly in 4 hours and then decreased after 8 hours. When the variation of urinary TdGA concentration in urine according to exposure level of VGM was verified through Kruskal-Wallis statistical method at each sampling time, the significant increment with the exposure levels at 2 hours, 4 hours, 8 hours after exposure was clarified. Conclusion : TdGA concentration in urine with increment of VCM exposure level increased, especially significantly at 2 hours, 4 hours, 8 hours of sampling time.

흰쥐에 있어서 Ethanol과 Phenobarbital이 트리클로로에틸렌 대사에 미치는 영향

이경종,노재훈,김치년,조명화,차봉석,문영한 大韓産業醫學會 1993 대한직업환경의학회지 Vol.5 No.1

Trichloroethylene is widely used for organic solvent in many industries. There are many workers who are exposed to trichloroethylene in Korea. If workers are exposed to trichloroethylene after ingestion of ethanol or phenobarbital, there might be an increased risk of toxicity due to combined exposures of chemicals. This study was performed to find out the influences of ethanol and phenobarbital on the levels of trichloroethylene in rats. Trichloroethylene was administered orally at the doses of 150, 750, 1,500, and 3,000mg/kg after pretreatment of 4g/kg ethanol or 80mg/kg phenobarbital. Trichloroethylene in blood was not detected at 12 hours after oral administration of trichloroethylene. Administered amount of trichloroethylene and its total blood concentration had a positive relationship. The level of blood trichloroethylene was decreased faster in ethanol and phenobarbital pretreated groups than in the control group. Amounts of urinary free trichloroethanol were larger at the doses of 150, 750, and 1,500mg/kg of trichloroethylene with pretreated phenobarbital group than in the control group. Total amounts of urinary conjugated trichloroethanol were larger in pretreated ethanol and phenobarbital groups than in the control group. In the phenobarbital pretreated group, there was a increasing tendency of excertion of urinary trichloroacetic acid. These results showed that intake of ethanol and phenobarbital may alter the metabolism of trichloroethylene in rats.

노인의 영적 간호요구

최미혜,김경희,김귀옥,김기숙,김수강,김정신,김춘숙,노흥진,박지연,성혜연,오명선,이선희,이원옥,이윤영,이현수,장명재,차혜경,채정선,홍상희 중앙대학교 의과대학 간호학과 간호과학연구소 2001 중앙간호논문집 Vol.5 No.1

This study was designed to exam the aged's needs for spiritual nursing care. The purpose was to serve as a basis for the development of spiritual nursing practice. The major findings are as follows : 1. The degree of needs for spiritual nursing care as area was that needs of love and relationship mean 22.0, needs of meaning and object mean 28.2, needs of forgiving mean 13.5. Total needs for spiritual nursing care mean 63.7, which was on the upper middle level. The needs of meaning and object was rated highest. 2. Among the general characteristics of the subjects, needs of love and relatiohship wasn't significanlty different. 3. Among the general characteristics of the subjects, needs of meaning and object was significantly different according to two factors : age(F=7.260, p=0.001), religion(F=5.275, p=0.001). Higher needs of meaning and object was possessed by the older than the younger, by the one who have religion than the other. 4. Among the general characteristics of the subjects, four factors made a significantly difference to needs of forgiving : sex(t=-2.851, p=0.006), age(F=8.201, p=0.001), religion(F=6.928, p=0.000), disease(t=2.327, p=0.024). Higher needs of forgiving was possessed by man than woman, by the older than the younger, by the one who have religion than the other, by the one who have disease than the other.

LETTER TO THE EDITOR : Interval Cancers after a Negative Colonoscopy Finding in a Korean Population: A Small Step for Gastroenterologists but One Giant Leap for Koreans

( Jae Myung Cha ) 대한장연구학회 2014 Intestinal Research Vol.12 No.2

REVIEW : Colonoscopy Quality is the Answer for the Emerging Issue of Interval Cancer

( Jae Myung Cha ) 대한장연구학회 2014 Intestinal Research Vol.12 No.2

Colonoscopy is currently regarded as the gold standard and preferred screening method for colorectal cancer (CRC). Recently,however, a limitation of colonoscopy in the prevention of CRCs has been identified, particularly in the right-sided colon, andthe problem of so-called interval cancers has emerged. The prevalence of interval cancer is estimated to be between 4% and 8%of CRCs detected. Although the exact etiology of interval cancer remains unknown, factors implicated in the development ofinterval cancers include missed lesions at the time of colonoscopy, incomplete resection of previous neoplastic lesions, differenttumor biology, and serrated pathway of carcinogenesis. However, recent evidence suggests that interval cancers are relatedto the training of the endoscopist and quality of the colonoscopy rather than tumor biology. Therefore, the importance of adequatetraining and continuous monitoring of the colonoscopy quality, which are amenable to improvement, cannot be overstatedin order to prevent the risk of interval cancers. In this study, the current literature regarding the prevalence and potentialfactors related to interval cancers and colonoscopy quality-related issues are reviewed. (Intest Res 2014;12:110-116)

Physicians Should Provide Shared Decision-Making for Anti-TNF Therapy to Inflammatory Bowel Disease Patients

Cha, Jae Myung,Park, Dong Il,Park, Sang Hyoung,Shin, Jeong Eun,Kim, Wan Soo,Yang, Suk-Kyun KOREAN ACADEMY OF MEDICAL SCIENCE 2017 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.32 No.1

<P>Shared decision-making may increase the effectiveness of inflammatory bowel disease (IBD) treatment, as different anti-tumor necrosis factor (anti-TNF) administrations may have different effects on the quality of life (QOL). Patient preference is integral to the selection of anti-TNFs and their routes of administration, however, previous studies on the patient preference to anti-TNFs are inconsistent and limited. We evaluated the predictive factors for preferences to anti-TNF administrations in IBD patients between March and August in 2015. Consecutive adult IBD patients who received care at one of four university hospitals in Korea were invited to participate in this study. Patients were administered questionnaires about their preferences regarding anti-TNF therapy and QOL. During the study period, 322 IBD patients completed the questionnaires. IBD patients preferred intravenous anti-TNFs to subcutaneous anti-TNFs (2.4:1), and 58.4% of patients preferred shared decision-making. When comparing subcutaneous anti-TNF therapy with intravenous anti-TNF therapy, patients with higher income levels, patients who experienced adverse events with prior medication and patients with a longer disease duration preferred subcutaneous anti-TNF therapy over intravenous anti-TNF therapy (<I>P</I> = 0.043, <I>P</I> = 0.000, and <I>P</I> = 0.029, respectively). In a logistic regression analysis, high income level (odds ratio [OR] 2.0; 95% confidence interval [CI] 1.1–3.5; <I>P</I> = 0.026) and an adverse event with prior medication (OR 4.0; 95% CI 2.2–7.2; <I>P</I> = 0.000) and were found to be independent predictors for preference to subcutaneous anti-TNF therapy. Therefore, physicians should share decision-making with their IBD patients regarding the mode of anti-TNF administration.</P>