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흰쥐에서 염화비닐 폭로수준에 따른 소변내 thiodiglycolic acid 농도의 변화
왕승준,차봉석,노재훈,신동천,김명수,전근재 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.4
Objectives : It is the objective of this research to identify the variation of thiodiglycolic acid(TdGA) in urine with vinyl chloride monamer(VCM) exposure levels through methylation. Methods : After rats were exposed to vinyl chloride monomer of 4 levels, 0㎎/㎥, 50㎎/㎥, 150㎎/㎥, 500㎎/㎥, respectively, of which urine was sampled in each sampling time of 0 hour, 2 hours, 4 hours, 8 hours, 16 hours, 36 hours, 48 hours. After urine had been methylated with diazomethane in the preliminary experiment and the peak of 146 m/z had been verified, the main experiment was done. Results : In the variation of TdGA with sampling times, concentration of TdGA increased rapidly in 4 hours and then decreased after 8 hours. When the variation of urinary TdGA concentration in urine according to exposure level of VGM was verified through Kruskal-Wallis statistical method at each sampling time, the significant increment with the exposure levels at 2 hours, 4 hours, 8 hours after exposure was clarified. Conclusion : TdGA concentration in urine with increment of VCM exposure level increased, especially significantly at 2 hours, 4 hours, 8 hours of sampling time.
전근재(G . J . Jeon),임승길(S . K . Lim),이현철(H . C . Lee),김경래(K . R . Kim),허갑범(K . B . Huh) 대한내과학회 1988 대한내과학회지 Vol.35 No.6
N/A We studied 59 patients who had received a diagnosis of graves' disease or myxedema by dual photon absorptiometry from August 1986 to July 1987 at the Department of Internal Medicine, Yonsei University Severance Hospital. The results were summarized as follows: 1) Patients with Graves' disease of a mean duration of 19.2 weeks demonstrated an average of 9.37 mg/dl Ca and 4.29 mg/dl P in their blood samples while the 24 hr urine specimen showed 194.26 mg/dl 24 hr of Ca and the P revealed 520.36 mg/24 hr, which is higher than those of myxedema. 2) The patients with Graves' disease revealed a prevalance of osteoporosis in the following, Ward's triangle 18,8%, femora) neck 20.8%, trochanter 25%, but the spine, while observed at 22.9% in hyperthyroidism, also was detected at 18.2% in myxedema. 3) In females with Graves' disease, the values of BMD were relatively lower than those of the control group but showed a greater at traction to osteoporosis than the males. 4) Most womon in their postmonopaunal poriod showed a strong tondency to develop osteoporosis in the femoral neek but they demonstrated a greater relationship to the spine. 5) Even after treatment, the BMD revealed a tendency to continue increasing, however, there was still a possibility for incomplete recovery. Excess thyroid hormones lead to negative bone mineral balance. The revealed bone loss was clinically significant in postmenopausal women despite its short dyratuib abd ut aooeared ti be at keast oartuakkt reversubke after treatment.
심방중격결손증 환자에서 도플러심초음파와 심도자술을 이용한 폐혈류량과 체혈류량의 비교
오미희(Mee Hee Oh),전근재(Geon Je Jeon),민병철(Byoung Chul Min),박금수(Keum Soo Park),최경훈(Kyung Hoon Choe) 대한내과학회 1989 대한내과학회지 Vol.37 No.3
N/A The measurement of systemic flow (Qp) and pulmonary flow (Qs) is clinically important in the management of adult patients with an atrial septal defect. In clinical practice, this is usually assessed by oximetry, radionuclide technique. 1n previous experimental and pediatric studies, the ratio of pulmonary to systemic flow (Qp/Qs) was accurately estimated by Doppler echocardiography in various cardiac shunt lesions. The purpose of this study was to assess the accuracy of pulsed Doppler echocardiography in adult patients with atrial septal defect. In 10 patients and 10 normal persons, blood flow was measured in the right and left ventricular outflow tracts by pulsed Doppler echocardiography and compared with the oximetric measurement. The results were as follows; 1) In 10 patients without heart disease, the correlation (r) between systemic (Qs) and pulmonary (Qp) blood flow was 0.91 (y=0.88 x±0.8) and the Qp/Qs ratio ranged from 0.85 to 1.14 (mean 0.96±0.09). 2) In 10 patients with an atrial septal defect, the mean Qp/Qs ratio measured by oximetry was 1.68J0.46 and by pulsed Doppler echocardiography was 1.56±0.30 (p=NS). In these patients, the correlation between the Qp/ Qs ratio determined by oximetry and pulsed Doppler echocardiography was significant (r=0.89, y=0.58x±0.58). 1n adult patients with artial septal defect and high quality echocardiograms, the magnitude of the pulmonary to systemic flow ratio can be assessed by noninvasive and simple pulsed Doppler echocardiography.
Neuroleptic Malignant Syndrome 에 동반된 급성신부전증 1 예
이광훈,최승옥,진소영,김원천,배선우,전근재 대한내과학회 1988 대한내과학회지 Vol.35 No.5
Neuroleptic malignant syndrome is characterized by muscular rigidity, hyperthermia, altered consciousness, and autonomic dysfunction, and it appears to be an idiosyncratic reaction to major tranquilizers, all of which interfere with dopamine transmission in the hypothalamus and basal ganglia of the central nervous system. Usually the syndrome develops early in the course of treatment of when the dose of the drug is increased. Acute renal failure, one of the serious complications in neuroleptic malignant syndrome, develops very rarely. Myoglobinuria, following rhabdomyolysis, is responsible for the renal impairment. We report a case of neuroleptic malignant syndrome with myoglobinemic acute renal failure after ingestion of a large amount of various antipsychotic drugs for suicide. The patient recovered after treatment by hemodialysis, administration of bromocriptine and other conservative measures.
결핵성 뇌막염 진단에 있어서 뇌척수액 Adenosine Deaminase 활성도에 관한 연구
배선우(Seon Woo Bae),김원천(Won Tsen Kim),전근재(Geun Jae Jeon),성낙억(Nak Uk Sung),최경규(Kyung Gui Choi),최일생(Il Saing Choi) 대한내과학회 1988 대한내과학회지 Vol.34 No.4
N/A The prognosis of tuberculous meningitis is closely linked to the stage at which treatment is started. The cerebrospinal fluid findings, however, are often ambiguous, It has been suggested by recent investigations that ADA activities in cerebrospinal fluid may help differentiate tuberculous meningitis from aseptic meningitis. In this study, cerebrospinal fluid adenosine deaminase activities were measured in 23 cases of tuberculous meningitis, 9 cases of aseptic meningitis, 9 cases of purulent meningitis, 24 cases of miscellaneous neurologic conditions and 23 cases of normal controls. The results obtained were as follows: 1) The mean ADA activity in tuberculous meningitis was 17.39±10,34 U/L, in bacterial meningitis 7.87±8.52 U/L, in aseptic meningitis 2.83±1.92U/L, in miscellaneous neurologic conditions 2.80±5.61U/L and in control 1,09±0.51U/L. 2) The ADA activitiies in tuberculous meningitis showed significantly higher values than in other groups (P<0.001), 3) Cerebrospinal fluid ADA activities differentiated tuberculous meningitis from those with aseptic meningitis being higher than 4.5U/L in all and higher than 6.5U/L in 96% case of tuberculous meningitis, but lower than 6,5U/L in aseptic meningitis and less than 3.5U/L in normal controls. 4) In tuberculous meningitis, ADA activities showed significant correlation with protein in cerebrospinal fluid (P<0.01), but in other groups, no significant correlation with available routine parameters in cerebrospinal fluid. It is suggested that measurement of ADA activity in cerebrospinal fluid is a available test which is relatively easily performed for diagnosis of tuberculous meningitis, especially differential diagnosis with aseptic meningitis.
탄광부 진폐증 환자에서 맞춤형 호흡 재활 치료 프로그램의 임상적 효용성
정희 ( Hee Cheong ),이정민 ( Jeong Min Lee ),박인기 ( In Ki park ),김종규 ( Jong Kyu Kim ),전근재 ( Geun Jae Jeon ),김주령 ( Ju Ryung Kim ),김지홍 ( Ji Hong Kim ),최병용 ( Byoong Yong Choi ) 대한내과학회 2014 대한내과학회지 Vol.87 No.6
Background/Aims: It is unknown whether pulmonary rehabilitation (PR) is an effective intervention to manage coal worker pneumoconiosis (CWP). We evaluated the efficacy and safety of an individualized PR program in 53 patients with CWP hospitalized in two medical institutions. Methods: The PR program consisted of upper and lower extremity exercises to improve exercise endurance and skeletal musculoskeletal strength. All subjects performed treadmill and ergometer exercise with steady loading weights three times/week for 12 weeks. The following tests were performed before and after the study to investigate the efficacy of the PR program: modified Borg scale, pulmonary function test, mid-thigh circumference, maximum muscular strength, 6-min walk distance (6MWD), and the St. George’s Respiratory Questionnaire (SGRQ), Korean version. Results: Forty patients (75.5%) completed their PR programs. They improved significantly on the modified Borg scale, mid thigh circumference, maximum muscular strength, 6MWD (all p < 0.000), and SGRQ (p = 0.007), however, no significant improvement was observed on the pulmonary function test. A significant improvement in dyspnea (p = 0.004) and 6MWD (p = 0.002) was observed in 12 patients with forced expiratory volume in 1 sec < 60%. The PR program with smoking cessation resulted in significantly more improvement on the 6MWD (p < 0.0001) and the SGRQ score (p = 0.002), as compared to those of patients who did not quit smoking. Conclusions: Our results show that an individualized 12-week PR program improves exercise capacity and quality of life for patients with CWP. (Korean J Med 2014,87:690-697)
간 , 담도 및 췌장 : 치료받지 않은 간암환자의 평균 생존기간 및 예후인자에 관한 고찰
장우익(Woo Ik Chang),권상옥(Sang Ok Kwon),이광훈(Kwang Hoon Lee),이흥재(Hong Jai Lee),전근재(Geun Jae Jeon),임채선(Chae Seon Lem),김남동(Nam dong Kim),심영학(Young Hak Shim),홍인수(In Soo Hong) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.2
N/A The survival period and prognostic factors of hepatocellular carcinoma were evaluated in 84 untreated patients confirmed by ultrasound-guided aspiration cytology or histopathology. The results were as follows: 1) In 82 untreated patients, the mean survival period was 16.5 weeks from diagnosis to death. 2) The survival period correlated to age, ascites and weight loss but it did not correlated to bilirubin, albumin, a-FP and the individual groups of Childs classification, 3) According to size and shape the ultrasonographic findings of hepatoma were classified, however the survival period did not correlate to them and also cytologic differentiation. 4) The revised staging system by Primark and staging system by Okuda were not significantly correlated to the survival period.