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      • SCOPUSKCI등재

        흰쥐에서 카드뮴과 니켈이 혈압에 미치는 효과

        차봉석,왕승준,Cha, Bong-Suk,Wang, Seung-Jun 대한예방의학회 2001 Journal of Preventive Medicine and Public Health Vol.34 No.2

        카드뮴과 니켈이 혈압에 미치는 영향과 더불어 복합적 노출이 혈압에 미치는 영향을 평가하고자, 250 g 정도의 흰쥐를 대조군과 노출군(두 농도의 카드뮴 노출군, 니켈 노출군, 복합노출군)에 각각 10마리씩 할당하고 염화카드뮴과 염화니켈을 생리식염수에 녹여 일주일간 매일 복강 내에 투여한 후 1, 5, 10, 20, 30일 경과 후 혈압의 변화를 관찰하였다. 각각 5회씩 혈압을 측정하였으며 최고치와 최저치를 제외한 3회 측정치의 평균값을 이용하여 각 시간대에서 각 물질간에 혈압의 차이가 있는지 확인하기 위하여 일요인 분산분석을 실시하였으며 시간을 반복측정요인으로 보고 반복측정된 이요인 분산분석을 실시하였다. 혈압의 변화에 있어서 0.1 mg/kg bw의 염화카드뮴 투여 후 1, 5, 10일 째에서 대조군과 통계적으로 유의한 차이를 보여 주었으며 같은 농도의 염화니켈은 전기간 동안 통계적으로 유의한 차이를 보여 주지 못했다. 이 농도에서 동시 노출시 대조군과는 1, 5, 10일째에서 통계적으로 유의한 차이(p<0.05)를 보여 주었으며 염화카드뮴 투여군과는 5일째에서, 염화니켈 투여군과는 5, 10일째에서 통계적으로 유의한 차이를 보여 주었다. 1.0 mg/kg bw의 염화카드뮴 투여 후 1, 5, 10, 20일째에서 대조군과 통계적으로 유의한 차이를 보여 주었으며 같은 농도에서 염화니켈의 경우, 1, 5일째에서 대조군과 통계적으로 유의한 차이를 보여 주었다. 이 농도에서 동시 노출시에는 대조군과 전 시간대에서 통계적으로 유의한 차이를 보여 주었으며 염화카드뮴 투여군과는 10, 20, 30일째에서, 니켈 투여군과는 5, 10, 20, 30일째에서 통계적으로 유의한 차이를 보였다. 결과적으로 카드뮴이 니켈에 비하여 혈압의 상승효과가 크며 복합 노출시 혈압의 상승이 오랫동안 지속되었다. Objective : To verify the separate and combined effects of cadmium and nickel on blood pressure in rats. Methods : Following the daily administration of cadmium chloride$(CdCl_2)$ and nickel chloride$(NiCl_2)$ to rats both individually and in combination with intraperitoneal injection method for one week, systolic blood pressure of the tail was measured at 1 day and 5, 10, 20, 30 days after administration. Each substance was injected into the rats with 0.1 mg/kg bw and 1.0 mg/kg bw concentration. Results : After 0.1 mg/kg bw $CdCl_2$ was injected, a statistically significant difference was found as compared with the control group(only saline) after 1, 5 and 10 days. After 0.1 mg/kg bw $NiCl_2$ was injected, a statistically significant difference was not found compared with the control group. After 0.1 mg/kg bw $CdCl_2$ and 0.1 mg/kg bw $NiCl_2$ were injected simultaneously, a statistically significant difference was found as compared with the control group after 1,5 and 10 days and compared with 0.1 mg/kg bw $CdCl_2$ group after 5 days and as compared with 0.1 mg/kg bw $NiCl_2$ group after 5 and 10 days. After 1.0 mg/kg bw $CdCl_2$ was injected, a statistically significant difference was found as compared with the control group after 1, 5, 10 and 20 days. After 1.0 mg/kg bw $NiCl_2$ was injected, a statistically significant difference was found as compared with the control group after 1 day and 5 days. After 1.0 mg/kg bw $CdCl_2$ and 1.0 mg/kg bw $NiCl_2$ were injected in combination, a statistically significant difference was found after 1, 5, 10, 20 and 30 days as compared with 1.0 mg/kg bw $CdCl_2$ after 10, 20 and 30 days and as compared with 1.0 mg/kg bw $NiCl_2$ after 5, 10, 20 and 30 days. Conclusion : It was found that the effect of $CdCl_2$ on blood pressure was much more than $NiCl_2$ and a high concentration $CdCl_2\;and\;NiCl_2$ in combination delayed the recovery of blood pressure.

      • SCOPUSKCI등재

        직장인의 스트레스와 사회적 지지의 상관성에 관한 연구

        차봉석,장세진,박종구,Cha, Bong-Suk,Chang, Sei-Jin,Park, Jong-Ku 대한예방의학회 1992 Journal of Preventive Medicine and Public Health Vol.25 No.4

        The effects and roles of social support and stressors (stressful life events and chronic strains) on psychosocial distress were examined in a model with data from a sample of the white-collar workers (N=416) in Korea. The findings of this study present that mean levels of psychosocial distress were higher in the female, youth, unmarried and divorced, and low economic status (monthly income). The analysis also shows that, as expected, stressful life and chronic strains as stressors are positively related to occurrence of psychosocial distress, and social support is negatively related to psychosocial distress. Further, the contribution of social support to predicting psychosocial distress is greater in magnitude than that of stressful events, chronic strains, and seciodemographic variables. There is no evidence that social support buffers the impacts of stressors on psychosocial distress, rather social support takes a role of mai or direct effects on psychosocial distress. Therefore, the strength of the social support is an important and meaningful strategy to prevent from stress and mental, physical illness.

      • SCOPUSKCI등재

        농약의 복합투여가 백서의 혈장 콜린에스테라제 활성도 및 요중 파라-니트로페놀 배설에 미치는 영향

        차봉석,박정균,박종구,장세진,Cha, Bong-Suk,Park, Jung-Gyun,Park, Jong-Ku,Chang, Sei-Jin 대한예방의학회 1992 Journal of Preventive Medicine and Public Health Vol.25 No.2

        The effects of multiple exposures to pesticides on plasma cholinesterase(ChE) activities and urinary p-nitrophenol excretion were evaluated in rats. Rats were received single dose i.p. with $LD_{50}/100(mg/kg)$ of organophosphorous(OP), organophosphorous-organochroline(OP-OC), organophosphorous-carbamate(OP-CAB), organophosphorous-organoarsenate(OP-OA) pesticides for 4 consecutive days. In repeated administration of pesticides, plasma ChE activities were decreased, but urinary p-nitrophenol were increased after the first injection and then decreased gradually The recovery rates of ChE activities and p-nitrophenol excretion at 48 hours after the fourth Injection were delayed in comparision with the baseline value of 24 hours before the first injection. Statistical significances were found between OP and other groups except OP-OA group after the second injection in plasma ChE activities, but in urinary p-nitrophenol excretion there was statistical significance only between OP and OP-CAB.

      • SCOPUSKCI등재

        직업적 특성, 사회심리적 스트레스 및 호모시스테인의 관련성

        차봉석,고상백,장세진,Cha, Bong-Suk,Koh, Sang-Baek,Chang, Sei-Jin 대한예방의학회 1998 Journal of Preventive Medicine and Public Health Vol.31 No.4

        This study was carried out to assess the relationship between jobstrain, psychosocial distress and homocysteine. The study design was cross-sectional, and included 152 industrial workers in middle sized city. A self-adminstered questionnaire measured general characteristic, job strain and psychosocial distress. Blood was drawn into EDTA tube, and total plasma homocysteine was measured by HPLC. Homocysteine in the high job demand group was sagnificantly higher than that in the low job demand. Cholesterol in the high job control group was significantly higher than that in the low job control. Homocysteine was significantly higher in the high job strain group than that in the other group. Folate and vitamin B12 showed a significantly negative correlation with homocysteine. Multiple regression analysis was used to determine whether the psychosocial distress and other variable contributed to explaining the homocysteine. Stress correlates with the homocysteine.

      • SCOPUSKCI등재

        산업재해 요양기관 이용자의 정신건강에 관한 연구

        차봉석,박종구,Cha, Bong-Suk,Park, Jong-Ku 대한예방의학회 1986 예방의학회지 Vol.19 No.2

        Our study was designed to identify the difference in the mental health status among hospitalized patients due to occupational diseases and accidents and pre-employment physical examinees, and to identify the relationship between mental health status and socio-demographic variables, and to provide information useful to non-psychiatric clinicians in caring of such patients. Samples were comprised of 189 pneumoconiotic patients, 132 industrial accident-induced patients and 122 pre-employment physical examinees who were interviewed with 90-item symptom cheklist (SCL-90). The following results were obtained: 1) Mean scores of symptom dimension on socio-demographic subgroup showed higher tendencies in older aged, male, lower educated, miner, married, mining residence, and pneumoconiotic patients. 2) Mean scores of total samples on all symptom dimensions were as follows in the order of their magnitudes; Depression, Somatization, Obsessive-compulsive, Anxiety, Psychoticism, Interpersonal sensitivity, Phobic-anxiety, Hostility, and Paranoid ideation. 3) The highest mean scores on each socio-demographic subgroup were as follows; Depression in younger aged and Somatization in older aged; Depression in male Somatization in female; Somatization in lower educated and depression in higher educated; Somatization in miners and depression in non-miners; Somatization in married and Depression in unmarried; Depression in all kind of residences; Somatization in patients and Depression in pre-employment physical examinees(normal). 4) In consequence of stepwise multiple regression, the important socio-demographic variables were age, occupation, diagnostic classification, and residence. Age was the most imprtant variable in Somatization, Depression, Obsessive-compulsive, Anxiety, Phobic anxiety, Paranoid ideation, and Psychoticism. Occupation was the most important one in Interpersonal sensitivity and Hostility and also had significant realtionships with all symptom dimensions.

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