임상 간호원의 업무 스트레스 요인에 관한 연구

최미혜 최신의학사 1987 最新醫學 Vol.30 No.10

인슐린 의존형 당뇨병으로 진단 받은 청소년의 질병에 대한주관적 인식 유형

최미혜,권은경,김수강 한국아동간호학회 2006 Child Health Nursing Research Vol.12 No.3

=A Study on Subjective Perception of Their Diseaseby Adolescents with IDDM*

골연하 결손부에서 조직유도재생술의 장기적 방사선학적 변화 관찰

최미혜,박진우,서조영,이재목,Choi, Mi-Hye,Park, Jin-Woo,Suh, Jo-Young,Lee, Jae-Mok 대한치주과학회 2007 Journal of Periodontal & Implant Science Vol.37 No.2

Periodontal surgery as part of the treatment of periodontal disease is mainly performed 1) to gain access to diseased areas for adequate cleaning; 2) to achieve pocket reduction or elimination; and 3) to restore the periodontal tissues lost through the disease; i.e., a new attachment formation of periodontal regeneration. To accomplish the latter, often referred to as the ultimate goal of periodontal therapy, a number of surgical procedures have been advocated throughout the years. Clinical studies have demonstrated that considerable gain of clinical attachment and bone can be achieved following guided tissue regeneration (GTR) therapy of intrabony defects. The aim of this study was to analyse the radiographic bone changes 2-year after GTR using a bone graft material and nonresorbable membrane. Patients attending the department of periodontics of Kyungpook National University Hospital were studied. Patients had clinical and radiographic evidence of intrabony defect(s), 33 sites of 30 patients aged 32 to 56 (mean age 45.6) were treated by GTR with a bone graft material and nonresorbable membrane. Baseline and 2-year follow-up radiographs were collected and evaluated for this study. Radiographic assessment includes a bone fill, bone crest change, defect resolution, and % of defect resolution. Pre- and post-treatment differences between variables (maxilla and mandible, defect depth, defect angle, bone graft materials) using the paired t-test were examined. We observed $2.86{\pm}1,87mm$ of bone fill, $065{\pm}0.79mm$ of crestal resorption, $3.49{\pm}2.11mm$ of defect resolution, and $44.42{\pm}19.51%$ of percentage of defect resolution. Mandible, deeper initial defect depth, narrower initial defect angle showed greater bone fill, defect resolution, and % of defect resolution. But no difference was observed between xenograft and allograft. Outcome of GTR as a therapy of intrabony defect was better than other therapy, but herein, good oral hygiene maintenance as a anti-infective treatment and periodic recall check of patients are essential.

Gene expression pattern during osteogenic differentiation of human periodontal ligament cells in vitro

최미혜,노우창,박진우,이재목,서조영 대한치주과학회 2011 Journal of Periodontal & Implant Science Vol.41 No.4

Purpose: Periodontal ligament (PDL) cell differentiation into osteoblasts is important in bone formation. Bone formation is a complex biological process and involves several tightly regulated gene expression patterns of bone-related proteins. The expression patterns of bone related proteins are regulated in a temporal manner both in vivo and in vitro. The aim of this study was to observe the gene expression profile in PDL cell proliferation, differentiation, and mineralization in vitro. Methods: PDL cells were grown until confluence, which were then designated as day 0, and nodule formation was induced by the addition of 50 μg/mL ascorbic acid, 10 mM β-glycerophosphate, and 100 nM dexamethasone to the medium. The dishes were stained with Alizarin Red S on days 1, 7, 14, and 21. Real-time polymerase chain reaction was performed for the detection of various genes on days 0, 1, 7, 14, and 21. Results: On day 0 with a confluent monolayer, in the active proliferative stage, c-myc gene expression was observed at its maximal level. On day 7 with a multilayer, alkaline phosphatase, bone morphogenetic protein (BMP)-2, and BMP-4 gene expression had increased and this was followed by maximal expression of osteocalcin on day 14 with the initiation of nodule mineralization. In relationship to apoptosis, c-fos gene expression peaked on day 21 and was characterized by the post-mineralization stage. Here, various genes were regulated in a temporal manner during PDL fibroblast proliferation, extracellular matrix maturation, and mineralization. The gene expression pattern was similar. Conclusions: We can speculate that the gene expression pattern occurs during PDL cell proliferation, differentiation, and mineralization. On the basis of these results, it might be possible to understand the various factors that influence PDL cell proliferation, extracellular matrix maturation, and mineralization with regard to gene expression patterns. Purpose: Periodontal ligament (PDL) cell differentiation into osteoblasts is important in bone formation. Bone formation is a complex biological process and involves several tightly regulated gene expression patterns of bone-related proteins. The expression patterns of bone related proteins are regulated in a temporal manner both in vivo and in vitro. The aim of this study was to observe the gene expression profile in PDL cell proliferation, differentiation, and mineralization in vitro. Methods: PDL cells were grown until confluence, which were then designated as day 0, and nodule formation was induced by the addition of 50 μg/mL ascorbic acid, 10 mM β-glycerophosphate, and 100 nM dexamethasone to the medium. The dishes were stained with Alizarin Red S on days 1, 7, 14, and 21. Real-time polymerase chain reaction was performed for the detection of various genes on days 0, 1, 7, 14, and 21. Results: On day 0 with a confluent monolayer, in the active proliferative stage, c-myc gene expression was observed at its maximal level. On day 7 with a multilayer, alkaline phosphatase, bone morphogenetic protein (BMP)-2, and BMP-4 gene expression had increased and this was followed by maximal expression of osteocalcin on day 14 with the initiation of nodule mineralization. In relationship to apoptosis, c-fos gene expression peaked on day 21 and was characterized by the post-mineralization stage. Here, various genes were regulated in a temporal manner during PDL fibroblast proliferation, extracellular matrix maturation, and mineralization. The gene expression pattern was similar. Conclusions: We can speculate that the gene expression pattern occurs during PDL cell proliferation, differentiation, and mineralization. On the basis of these results, it might be possible to understand the various factors that influence PDL cell proliferation, extracellular matrix maturation, and mineralization with regard to gene expression patterns.

여성의 자기의식, 신체 이미지가 반복되는 미용수술 행위에 미치는 영향

최미혜,김경희,김주덕 한국미용학회 2008 한국미용학회 추계학술발표회 Vol.2008 No.1

노인의 영적 간호요구

최미혜,김경희,김귀옥,김기숙,김수강,김정신,김춘숙,노흥진,박지연,성혜연,오명선,이선희,이원옥,이윤영,이현수,장명재,차혜경,채정선,홍상희 중앙대학교 의과대학 간호학과 간호과학연구소 2001 중앙간호논문집 Vol.5 No.1

This study was designed to exam the aged's needs for spiritual nursing care. The purpose was to serve as a basis for the development of spiritual nursing practice. The major findings are as follows : 1. The degree of needs for spiritual nursing care as area was that needs of love and relationship mean 22.0, needs of meaning and object mean 28.2, needs of forgiving mean 13.5. Total needs for spiritual nursing care mean 63.7, which was on the upper middle level. The needs of meaning and object was rated highest. 2. Among the general characteristics of the subjects, needs of love and relatiohship wasn't significanlty different. 3. Among the general characteristics of the subjects, needs of meaning and object was significantly different according to two factors : age(F=7.260, p=0.001), religion(F=5.275, p=0.001). Higher needs of meaning and object was possessed by the older than the younger, by the one who have religion than the other. 4. Among the general characteristics of the subjects, four factors made a significantly difference to needs of forgiving : sex(t=-2.851, p=0.006), age(F=8.201, p=0.001), religion(F=6.928, p=0.000), disease(t=2.327, p=0.024). Higher needs of forgiving was possessed by man than woman, by the older than the younger, by the one who have religion than the other, by the one who have disease than the other.

북한이탈 대학생의 적응 스트레스 및 대처 경험에 관한 질적 연구

최미혜 한국학교사회복지학회 2016 학교사회복지 Vol.0 No.35

This study is a qualitative research which refers to identify the adjusting process and the stress response, and also to seek life experience and meaning in terms of coping strategies of North Korean defectors among undergraduate students in Korea. This study recruited 8 participants using snowballing sampling approaches are college students who are North Korean defectors at 4 different universities in Seoul and Kyoung-gi-do. Collected data through in-depth interviews from 8 participants has derived 20 theme clusters and 4 categories using Colaizzi's phenomenological method of data analysis. The 4 main categories consisted of, ‘the first step to a new beginning', ‘the pains of my past still remains in my heart' ‘experiencing stress of the difference between compare and contrast’, and‘coping efforts and great resources hidden inside me’. To be specific, the results shows communication problems, cultural heterogeneity, the difference of education background and approach, relationship problems and south Koreans’prejudices, economic problems, emotional problems and fear for the future as their stress. It also shows economic coping experiences, active behavioral attitude in relationship, volunteer work, nobleness and patience, academic efforts, social supports, and having a dream as their coping experiences and potential resources. This results of the study lead us to find the stress responses of North Korean defectors among undergraduate students in their view, and it is valuable to understand their unique coping skills and internal strengths and resources. Theses attempts will devote to providing basic data in oder to develop social welfare services and policies including effective and successful adjustment to college life. 본 연구는 북한이탈 대학생의 대학생활에 관한 적응과정과 스트레스가 무엇인지를 밝히며 그에 대처하는 삶의 경험과 의미를 탐색하는 질적 연구이다. 본 연구의 참여자들은 서울특별시와 경기도에 소재하는 4개의 대학에 재학 중인 남녀 북한이탈 대학생 8명이며, 눈덩이 표집방법으로 실시하였다. 심층면접으로 얻은 자료를 Colaizzi의 분석방법을 이용하여 4개의 범주와 20개의 주제모음이 조직화하였다. 4개의 주요범주는 ‘새로운 시작의 발걸음’, ‘여전히 아픈 과거의 상처들’, ‘차이와 다름의 경계에서 겪는 스트레스’, 그리고 ‘대처하는 노력과 잠재된 자원’으로 제시되었다. 좀 더 구체적으로는 북한이탈 대학생이 겪는 스트레스로는 의사소통의 어려움, 문화적 차이에서 오는 이질감, 교육의 배경과 방법의 차이, 관계의 어려움과 편견, 어려운 경제적 상황, 정서적 고통, 미래에 대한 두려움 등이며, 이들이 보여준 대처 경험과 잠재적 자원은 경제적인 노력, 적극적 대인관계의 대처, 자원봉사, 당당함과 인내심, 실력을 위한 노력, 주변의 지지, 꿈을 가짐 등으로 나타났다. 본 연구결과는 북한이탈 대학생이 겪는 스트레스를 그들의 입장에서 파악하며, 또한 이들이 대처하는 삶의 독특한 방식이나 내재적인 힘과 자원을 이해하는데 가치가 있다. 이런 시도는 이들의 효과적이고 성공적인 남한 대학생활의 적응을 위한 복지적 서비스와 정책을 모색하는데 기초적인 자료를 제공하는데 기여할 것이다.

연구포스터 발표 : 고농도의 당이 치주인대세포의 세포활성에 미치는 영향

최미혜,김현숙,박진우,이재목,서조영 대한치주과학회 2005 대한치주과학회 학술대회자료집 Vol.2005 No.2

급성 림프구성 백혈병 환아에서 항암화학요법 후 사용되는 Filgrastim과 Lenograstim의 효과 비교

최미혜,강래영,김귀숙,박경호,손인자,오정미 한국병원약사회 2008 병원약사회지 Vol.25 No.4

Granulocyte colony-stimulating factor(G-CSF) has been incorporated into the treatment regimens of many patients in an effort to decrease the risk of neutropenic complications, including febrile neutropenia after myelosuppressive chemotherapy regimens. In doing so, it could significantly reduce incidence and severity of neutropenic infection, thus decreasing morbidity and health care expenditure. Two formulations of recombinant human G-CSF(rhG-CSF), one non-glycosylated(filgrastim) and one glycosylated(lenograstim), are available. This study was undertaken to compare the hematologic effects of filgrastim and lenograstim after chemotherapy in children with acute lymphoblastic leukemia(ALL). From September 2005 to August 2006, 157 cases(87 filgratim, 70 lenograstim) with acute lymphoblastic leukemia who had received G-CSF after chemotherapy at Seoul National University Hospital department of pediatrics were studied. We retrospectively analyzed the duration of G-CSF treatment, neutropenia and the frequency of neutropenic fever, IV antibiotic treatment. There was no significant difference in duration of GCSF treatment(5.3±3.7 vs 4.6±3.1 days, filgrastim vs lenograstim, Mean±SD), time to absolute neutrophil count(ANC) recovery to above 500/mm3(5.1±3.7 vs 4.7±3.0 days), febrile days(2.3±1.6 vs 2.3±1.5 days), and duration of antibiotic treatment(6.0±3.0 vs 5.7±2.7 days) Also, frequency of neutropenic fever and antibiotic treatment were similar in both groups. In summary, in terms of their clinical effect on neutropenia, the two G-CSF preparations appeared to have identical activity. A large-scale randomized prospective studies are necessary to confirm and evaluate the efficacy of two types of G-CSF.

청소년의 성허용성과 가족기능 및 부모와의 의사소통

최미혜,김경희,권혜진,김수강 한국아동간호학회 2005 Child Health Nursing Research Vol.11 No.1

Purpose: This study was done to examine the relationship between sexual permissiveness, family function and parent-adolescent communication among adolescents. Method: A descriptive correlation approach was used and the participants were 956 male and female students. Data were collected by questionnaire survey using convenience sampling. The instruments were the Family APGAR Questionnaire by Smilkstein(1978), PAC by Olson and Barnes(1982), and the Premarital Sexual Permissiveness Questionnaire by Reiss(1967). Data were analyzed using the SPSS 10.0 program with descriptive statistics, Pearson correlation coefficients, t-test, and ANOVA. Results: Family function was significant according to school record, economic status, living arrangement of parent. Parent-Adolescent Communication was significant according to religion, economic status, having a boy/girl friend, and experience of sexual intercourse. Sexual permissiveness was significant for all except economic status. Correlation among the variables showed that parent-adolescent communication was negatively correlated to sexual permissiveness(r=-.127, p=.000) and positively to family function(r=.368, p=.000). Conclusion: The findings suggest that parent-adolescent communication and family function are associated with sexual permissiveness, and the findings of this study are expected to make a contribution to creating an ideal sexual culture for youth.