정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Breeding of Tetraploid in Codonopsis lanceolata (Sieb. et Zucc.) Trautvetter by Colchicine Treatment

Kim,Ik-Hwan,Kim,Hag-Hyun,Hong,Eui-Yon,Yun,Jong-Sun,Yun,Tae,Hwang,Ju-Kwang,Lee,Cheol-Hee 한국자원식물학회 2003 Plant Resources Vol.6 No.3

Present studies were carried out to produce tetraploid plants by colchicine treatment using seeds, seedlings and shoot tips of Codonopsis lanceolata. Three tetraploid plants of C. lanceolata were produced from seeds which absorbed 0.1 % colchicine solution for 12 hours, and 0.5% colchicine solution for 1 and 6 hours from seedlings, respectively. But tetraploid was not produced from shoot tips treated by colchicine solution. Compared to diploid, tetraploid plants had larger stomata, but less number of stomata. Fresh weight of tetraploid plants was 1.4∼3.6 times heavier than diploid plants.

Breeding of Tetraploid in Platycodon grandiflorum (Jacq.)A. DC. by Colchicine treatment

Kim,Ik-Hwan,Kim,Hag-Hyun,Hong,Eui-Yon,Yun,Jong-Sun,Yun,Tae,Hwang,Ju-Kwang,Lee,Cheol-Hee 한국자원식물학회 2003 Plant Resources Vol.6 No.3

Present studies were carried out to produce tetraploid plants by colchicine treatment using seeds, seedlings and shoot tips of Platycodon grandiflorum in Campanulaceae. The most successful colchicine treatment for tetraploid production in P. grandiflorum was soaking treatment using 0.01 and 0.5% colchicine solution for 1 hour and 12 hours, respectively. Morphological characteristics of both diploid and tetraploid were similar, but tetraploid plants had more leaves. Compared to diploid, tetraploid had the larger stomata, but less number of stomata. Fresh weight of tetraploids was 20∼40% heavier than that of diploid.

유도 '되치기 본'의 개선 방안에 관한 연구

김의환,김도준,김규수,김관현,김종달,최종삼,조용철,박순진,윤익선,안병근,정 훈,김미정,한성철 龍仁大學校 武道硏究所 1999 武道硏究所誌 Vol.10 No.1

The purpose of this study was to reform practically a Korean Judo's Doechigi-Bon(Forms of Counterattack, judo's Gaeshi no Kata, Judo's Uradori no Kata, Judo's Gonosen no Kata) that was established in 1955 Korea, according to changing of techniques by Judo's modernization, in order to have Judo's carefulness and systematic diffusion. Reform procedure of Judo's Doechigi-Bon was 1st stage, Questionnaire survey 303 judokas, 2nd stage, Technical seminar by judo experts(12 judo professor) 4 times, 3rd stage, wording report for reform, 4rd stage, Discussion and judgement of Teaching and Judgement commission of Korean judo Association(KJA), 5th stage, Public hearing for reform in KJA, 6th stage, Report and decision of board of directors in KJA, 7th stage, public publication of Judo News(No.53) in KJA. Basic principle of reform of Judo's Doechigi-Bon were as table 1. Table 1. Basic principle of reform of Judo's Doechigi-Bon ------------------------------------------------------------------------------- Items Reformed Key Points of Judo's Doechigi-Bon ------------------------------------------------------------------------------- 1. Structure 1) Grand classification : Classified by 3 parts(1,2,3Gyo) 2)Medium classification : Te waza, Goshi waza, Ashi waza devided per each part(Gyo) 3)Sub-classification : Classified five techniques per each part(Gyo) 2. Contents 1) Selected established techniques as possible 2) Considered rationalty and overlapping of counterattack techniques 3. Decision of Conterattack techniques 1) Refered to results of Basic Questionnaire survey 2) Priority to decisions of Judo expert technical seminar -------------------------------------------------------------------------------- Reformed Korean Judo's Doechigi-Bon(Forms of Counterattack techniques-KJA, 1999) are as follows: 1. Gyo; ① Uki otoshi -> Uchi mata ② Harai goshi -> Harai goshi gaeshi ③ O soto gari -> O soto gake ④ Ko uchi gari -> Sasae tsurikomi ashi ⑤ O uchi gari -> Ko soto gari 2. Gyo; ① Ippon seoi nage -> Okuri eri jime ② Tsuri domi goshi -> Uki waza ③ Okuri ashi harai -> Okuri ashi harai ④ Ko soto gari -> Tai otoshi ⑤ Hiza guruma -> Hiza guruma 3. Gyo; ① Kata guruma -> Sumi gaeshi ② Tai otoshi -> Ko soto gari ③ Hane goshi -> Harai tsurikomi ashi ④ Uchi mata -> Tai otoshi ⑤ Tomoe nage -> O uchi gari

혼합 식물추출물에 대한 차응애의 감수성 검정

김창승(Chang Seung Kim),김도익(Do Ik kim),국용인(Yong In Kuk),현규환(Kyu Hwan Hyun),김상수(Sang Soo Kim1) 한국차학회 2016 한국차학회지 Vol.22 No.1

The acaricidal activity of the mixed plant extracts of Gleditsia japonica var. koraien, Camellia sinensis, Cinnamomum cassia, and Lantana camara, toward the tea red spider mite, Tetranychus kanzawai Kishida was evaluated in laboratory bioassays. Treatments with mixtures 1 and 3 were effective against the adult females of T. kanzawai and yielded 87.0 and 85.6% adulticidal activity at 7 days after treatment, respectively. Mixture 3 revealed 78.7% adulticidal activity. However, mixtures 4 and 5 had lower adulticidal activity than the other treatments. The adult females of T. kanzawai treated with mixtures 1 and 3 produced only 22.5-22.8% as many eggs as did the control females. The residue of the plant extracts tested had low adulticidal activity (16.3-27.2%). All of the plant extracts tested were ineffective against the eggs of T. kanzawai. Treatments with mixtures 1 and 3 were effective against the nymphs of T. kanzawai and led to emergence rates of 20.7 and 25.3%, respectively. These results suggest that mixtures 1 and 3 might be used for the control of T. kanzawai.

영어 연어의 형태와 기능

金益煥 한국영어교육연구학회 2002 영어교육연구 Vol.- No.24

Collocation refers to combinations of two lexical items which make a semantic contribution to discourse. According to the analysis of collocations in English, words do not combine randomly but follow rules and principle. A major direction in vocabulary studies today is researching multiword units through corpus evidence to establish their frequency and behavior. Lexis should not be considered as individual words in isolation but should be viewed as integral part of discourse. This phenomenon is one of the most important trends in vocabulary studies. Some studies show that collocational or idiomatic meanings are processed faster than literal meanings. This may be seen as evidence that fixed expressions are stored and retrieved as single words. Chunking may facilitate language learning process. Multi-word units are so common in normal language that they may well be the basic organizing principle in language production. They are certainly known to the vast majority of native speakers. In general, studies of collocation focus on more on their formal properties and collocations provides stylistic variety and lend emphasis to statements. The functions of collocation can be classified according to the way in which they contribute to the content and structure of a text. In some aspects, lexis is closely related with grammar, meaning and phonelogy. In other respects, lexis is independent of the above three areas. It can be said that lexis has relation with the three fields. The ability to use collocations in English effectively will lead to the enhancement of communicative competence by learners of English.

영어접사의 생산성에 관한 연구

김익환 계명대학교 국제학연구소 2004 국제학논총 Vol.9 No.-

The productivity of a given affix is defined as the possibility to coin a new complex word with this affix. Possible words need to conform to the word-formation rules of a language whereas actual words are often idiosyncratic. This paper also discussed how complex words are stored and accessed in the mental lexicon, which is crucial for an understanding of the notion of productivity in word-formation. Productive processes are characterized by many low-frequency words and thus do not depend on the storage of many individual words, whereas unproductive processes show a preponderance high-frequency forms. We have seen that apart from constraint on usage, structural constraints play an important role in word-formation. Possible words of a given morphological category need to conform to very specific phonological, semantic, and syntactic requirements. Finally, token-blocking was discussed, which is a general psycholinguistic mechanism which prevents complex forms from being formed if a synonymous word is already present in the speaker's lexicon.

영어 핵심어휘의 특성과 원형이론

金益煥 한국영어교육연구학회 1999 영어교육연구 Vol.- No.19

This paper examined various syntactic, phonological, morphological characteristics of core vocabulary in English. The study also investigated how grasping the meaning involves knowing the prototype, and the ranking of items in relation to it. Advantages and problems of the prototype theory were presented and discussed. Core relates to meanings of a particular word which are most central, primary, or invariant. A prototype is a best instance example of a concept. The distinction between core and non-core vocabulary is an important feature of the basic structure of the lexicon of a language. It is useful framework for discussing stylistic and expressive effects in vocabulary use. When humans group objects into categories, they set up a prototype - the most typical example. The prototype theory has implications that when people grasp the meaning of a word, they automatically activate their subconscious ranking system. The findings of this study show that core words are distributed over a range of different spoken and written text. They tend to be more irregular. Core words serve the needs of the most general expression. Core vocabulary has greater relevance to teaching vocabulary in the initial rather than advanced stages of language learning. Prototype theory explains how people cope with extended usages and metaphor. It also raises a few questions about how prototypes are acquired. Understanding the prototype is in fact a more complex process than was once thought, since prototype effects may have different causes.

제 이 언어 습득연구에 대한 접근법

김익환 계명대학교 국제학연구소 1999 국제학논총 Vol.4 No.-

<Abstract>Much of the research into second language acquisition has focused attention on what learners learn during their acquisition process. In recent years the research has began to address the problem of how learners go about learning a second language.The major purpose of this paper is to investigate three approaches to language acquisition research : the neurolinguistic, linguistic, and psycholinguistic traditions. Each of the major approaches has contributed different knowledge to understanding language learning process. Although each approach explains several aspects of language acquisition, each is suited to account for one aspect in a systematic way. The neurolinguistic approach providies the best account of how the phonological system is acquired. The linguistic approach with the aid of the universal grammar provides the best account of how the syntactic system is acquired. The psycholinguistic approach provides the best account of how the lexical system is acquired and represented in the brain. In principle, each of the three approaches serves the same function in explaining first and second language learning.Each approach influences the kind of theory or model of second language acquisition. From that viewpoint, all the approaches are fundamental to a description of the process. This paper is an attempt to establish an integration of competing perspectives. The explanation for how learners learn a second language needs to be an interdisciplinary enterprise.

어휘의 사용과 의미 구조

김익환 계명대학교 국제학연구소 2000 국제학논총 Vol.5 No.-

Language has been viewed as communicating meanings through the medium of concepts. On this view, each lexical item is associated with a concept Knowing a ward involves various kinds of word knowledge. Increasing knowledge of one word knowledge aspect could help improve knowledge of related aspects. The different kinds of word knowledge are interrelated. Frequency is related to formality in that more frequent words tend to be less formal, and tend to be more formal. Thus, greater awareness of formality is likely to be somewhat related to awareness of a word's frequency of occurrence, even if this awareness is unconscious. Words have a core meaning that is relatively universal and is likely to be acquired before other figurative meanings, prototype theory has been developed to explain how people deal with fuzzy meaning. The theory proposes that the mind uses a typical "best example" of a concept. This paper surveyed some of the important research findings about meaning organization and register knowledge. Register is a complex set of informations that is affected by many different factors. Register is connected with the paradigmatic issue of getting things done with language. This paper also examined association research that indicates the nature of meaning organization. Word association studies suggest that words are organized in the mind. This organization changes as one matures or as one's language proficiency increases.