Slide Session : OS-IFD-07 ; Infectious Disease : In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus

( Myung Jin Lee ),( Kye Hyung Kim ),( Jong Youn Yi ),( Su Jin Choi ),( Chung Jong Kim ),( Nak Hyun Kim ),( Kyoung Ho Song ),( Pyoeng Gyun Choi ),( Ji Hwan Bang ),( Wan Beom Park ),( Eu Suk Kim ),( San 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus Myung Jin LEE1, Kye-Hyung KIM1, Jongyoun YI2, SuJin CHOI1, Chung-Jong KIM1, Nak- Hyun KIM1, Kyoung-Ho SONG1, Pyoeng Gyun CHOI1, Ji-Hwan BANG1, Wan Beom PARK1, Eu Suk KIM1, Sang-Won PARK1, Hong Bin KIM1, Nam Joong KIM1, Myoung- Don OH1 Seoul National University College of Medicine, Korea1, Pusan National University School of Medicine, Korea2 Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel Bunyavirus, severe fever with thrombocytopenia syndrome virus (SFTSV). No effective antiviral therapy is proven yet, but clinical use of ribavirin (RBV) has been tried. We investigated the antiviral effect of RBV against SFTSV in vitro. Methods: To test for cytotoxicity of RBV, Vero cells were treated with different concentrations of RBV (3.90 to 500 μg/mL, two-fold dilution) and analyzed by cell viability MTS assay 48h post-infection. To determine antiviral activity of RBV against SFTSV, Vero cells were infected with SFTSV strain Gangwon/Korea/2012 at 100 TCID50 (50% tissue culture infective dose) per well in a 96-well plate, and RBV was added at the concentrations showing no or minimal cytotoxicity. Viral RNAs were extracted from the culture supernatants and quantifi ed using one-step real-time reverse transcription- PCR to amplify the partial large segment of SFTSV. Statistical analysis was done by one-way ANOVA with Tukey`s post hoc test. Results: Cytotoxicity due to RBV was not observed at RBV concentration =31.3 μg/ mL. Viral RNAs at 24h post-RBV treatment were reduced with increasing RBV concentrations (1-32 μg/mL), compared with those of mock-treated cells (P <0.01, Figure). Half maximal inhibitory concentration (IC50) of RBV was 3.69 μg/mL at 24h post-RBV treatment. Conclusions: Our study shows that RBV has antiviral effect against SFTSV in a dose-dependent manner. Further studies are required to evaluate the effi cacy of RBV in SFTS.

이창래의 Native Speaker의 한글번역본 비교연구 : 번역가의 두 가지 다른 시선

이형진 ( Hyung Jin Lee ) 韓國世界文學比較學會 2011 世界文學比較硏究 Vol.36 No.-

This paper intends to analyze different perspectives of the two translators, reflected into the two versions of Korean translation of Native Speaker (1995), the first novel written by the Korean-American novelist Chang-rae Lee. As literary translation is a product of another form of the translator`s personal reading of the text, different versions of translation often indicate different perspectives of translators toward the original text, and these differences become more important to understanding the meaning and value of the work, more than endless debates regarding mistranslation of the text. Hyun`s Korean translation of 1995 attempts to situate Lee`s novel under the umbrella of Korean literature, considering the theme of the novel as Korean immigrants` nostalgia for Korean culture and identity. This perspective leads to more natural translation with the frequent use of Korean cultural equivalents, trying to remind Korean readers of cultural connection to the author. However, Chung`s translation of 2003 views Lee`s novel as part of contemporary American literature which deals with the alienated life of immigrants in the multi-cultural society of America in which these immigrants are required to create a new kind of hybrid identity. This perspective is reflected in Chung`s careful attention to word choice, sentence structure and stylistic characteristics, often found in poetry translation. However, this difference does not exclusively derive from the translators` personal views on the novel. Rather, it has been critically influenced by the elevated status of the writer as one of the most representative contemporary American writer, not anymore Korean-American writer. Also, more careful attention in Chung`s translation to the writer`s style and literary identity leads to the translator`s efforts to keep Lee`s linguistic elegance and literary style intact in the translation, often creating poetic effect. Literary translation is never a form of perfect and omniscient reading of the text by a translator, and, in this sense, analyzing translators` perspectives reflected in the translations of the same novel provides a valuable tool to understanding the text from different perspectives.

폐내 기관지 낭종

이석열,이숭진,박형주,이철세,이길노,김윤정,나주옥 순천향의학연구소;Soonchunhyang Medical Research Institute 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

A 33-year-old female was admitted to our hospital due to removal of lung mass which indicentally detected Chest radiography. Chest computerized tomography revealed lung parenchymal cystic lesion. Open thoracotomy was done for diagnosis and therapy. Cystic lesion was communicated to bronchus and wedge resection including cystic lesion was done. Bronchogenic cyst is congenital disease and mainly locate in mediastinum. It is rare in lung parenchyme. Herein we report a case of intrapulmonary bronchogenic cyst.

갱년기 여성의 호르몬 대치 요법에 대한 수용율

이임순,장진영,이정재,이순곤,이권해,이해혁,김승형 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2

Purpose: We have evaluated the compliance of hormone replacement therapy. Method: There are 185 climacteric women who are divided into three groups (Group I, Group II, Group III). Group I is given conjugated equine estrogen(CEE, 0.625mg, day 1-30) plus medroxyprogesterone acetate(MPA, 5mg, day 1-12). Group II is given conjugated equine estrogen (CEE, 0.625mg, day 1-30) plus medroxyprogesterone acetate (MPA, 2.5mg, day 1-30), Group III is given only conjugated equine estrogen(CEE, 0.625mg, day 1-30). Results: 1) The compliance rate of hormone replacement therapy during three months is 77.9% including each Group I : 77.7%, Group Ⅱ : 76.1%, Group Ⅲ :80.4%. 2) The compliance rate of hormone replacement therapy during six months is 60.7% including each Group Ⅰ:52.9%, Group Ⅱ: 56.4%, Group Ⅲ: 79.5%. 3) The compliance rate of hormone replacement therapy during nine months is 49.7% including each Group Ⅰ: 45.5%, Group Ⅱ:41.7%, Group Ⅲ: 64.3%. 4) The compliance rate of hormone replacement therapy during a year is 44.4% including each Group Ⅰ: 40.2%, Group Ⅱ:35.3%, Group Ⅲ: 59.5%. Conclusion : It is vital that we maximize compliance if patients are to receive the full benefits from hormone replacement therapy. We think that physicians who prescribe hormone replacement therapy for climacteric women should enough explain the purpose, risks, and side effect of treatment for maximizing compliance of hormone replacement therapy.

하동카올린의 탄소환원법에 의한 질화거동

이형복,이홍림,이형직,임헌진 연세대학교 산업기술연구소 1985 논문집 Vol.17 No.2

Nitridation behavior of Hadong Pink Kaolin was studied over the temperature range of 1250-1350℃ in N₂-H₂atmosphere. Carbon was used as a reducing agent. Mullite, α-quartz, Si₂N₂O, X-phase, 15R-AIN, SiC and cristobalite were formed as intermediate products during reaction. But the final product was almost β-Sialon phase, when the reaction proceeded longer than 10hr at the C/H.K.(SiO₂) ratio larger than 3.

비만세포주에서 Histamine 유리에 관한 연구

김형룡,국윤아,신민,이홍수,원진숙,김형민,이영미,정헌택,이혜숙,안녕형 원광대학교 생명공학연구소 1995 생명공학연구소보 Vol.3 No.1

관상동맥 질환에서 SDF-1α의 농도

김보영,박용규,박형서,노상필,정승현,이유선,이정우,이재환,최시완,정진옥,성인환 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

Atherosclerosis is now viewed as an inflammatory disease of the vascular system. Expression of several chemokines, including monocyte chemoattractant protein(MCP)-1, MCP-4, RANTES(regulated on activation normal T-cell expressed and secreted), and interleukin-8(IL-8) are increased in human atherosclerotic plaques compared with normal vessels. They are involved in the pathogenesis of atherosclerosis and plaque rupture by activating and directing leukocytes into the atherosclerotic lesions. However, some are involved in homeostatic functions such as normal leukocyte traffic and growth regulation. SDF-la is a multi-functional cytokine that is involved in myelogenesis, hematopoiesis, angiogenesis and injured gastric mucosal regeneration in the gastric ulcer patient. SDF-la is recently shown to be highly expressed in atherosclerotic plaques and a potent platelet agonist. At least in high concentrations, SDF-la may mediate antiinflammatory and matrix stabilizing effects in unstable angina. Many studies are going on to know the function of SDF-la in coronary artery diseases. I investigated the difference of the plasma level of SDF-la between control group and coronary artery disease group. Total 75 subjects were enrolled. The diagnosis of coronary artery disease was confirmed in all patients by coronary angiography. Control subjects in this study were confirmed normal by coronary angiography. Clinical profile and risk factors were also reviewed. Control subjects in this study were 27 (M=10, F=17). Plasma for the study was collected before the angiography and centrifuged. SDF-la analysis was performed by ELISA. Plasma level of SDF-la is significantly increased in patients with stable angina(n=20) and unstable angina group(n=28) compared with healthy control group(n=27). the risk factors do not influence the plasma level of SDF-la in coronary artery diseases. In this study, plasma level of SDF-la is increased in patients with stable angina and unstable angina groups compared with healthy control group(P<0.05). the risk factors do not influence the plasma level of SDF-la in coronary artery diseases.

한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

Eysenck의 성격차원과 수면특성의 관계

이형영,국승희,윤진상,신일선 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.5

연구목적 : 수면은 생리적 현상이므로 이를 성격과 관련짓기 위해서는 생물학적 이론에 기초한 성격평가도구의 선택이 바람직하다. 따라서 본 연구는 생물학적 성격차원이론을 체계화한 Eysenck의 성격차원과 수면특성의 관계를 알아보고자 하였다. 방 법 : 종합대학교 남녀학생 532명을 대상으로 주중 수면습관과 수면장애를 묻는 설문지, Eysenck의 성격차원 검사를 실시하여 509명의 자료를 얻었다. 네가지 성격차원(정신병적 경향성, 신경증적 경향성, 외향성, 허위성)점수, 주중 수면습관과 수면장애의 기술 통계치를 산출하였으며, 이들 성격차원과 수면특성(주중 수면습관, 수면장애)의 관계를 알아보기 위해 Pearson의 적률상관을 산출하였다. 결 과 : 연구대상자의 네가지 성격차원 점수와 주중 수면습관은 정상범위였고, 가장 빈도가 높은 수면장애는 입면의 어려움이었으며, 가장 빈도가 낮은 수면장애는 몽유였다. 정신병적 경향성과 주중 취침시각, 기상시각, 수면잠복기, 깨는 빈도, 수면의 규칙성, 낮잠과 깜박잠의 빈도와 지속시간 및 입면의 어려움을 포함한 수면장애는 정적 상관이 있었고, 수면의 질, 일주기 리듬의 점수는 유의미한 부적 상관이 있었다. 신경증적 경향성과 수면습관 및 수면장애의 관계도 이와 유사하였다. 외향성은 수면의 질 및 일주기 리듬의 점수와 정적 상관이 있었으나 수면장애와는 관계가 없었다. 허위성은 일주기 리듬의 점수와 정적 상관이 있었으며, 수면잠복기, 수면의 규칙성, 낮잠과 깜박잠의 빈도 및 지속시간, 수면장애와 부적 상관이 있었다. 결 론 : 정신병적 경향성과 신경증적 경향성이 높을수록 수면습관이 더 좋지 않았고, 수면장애의 빈도가 높았다. 외향성이 높을수록 수면의 질이 좋았고, 아침형에 근접하였다. 허위성이 높을수록 아침형에 근접하고, 수면이 더 규칙적이었으며, 주간의 졸음이 적었고, 수면장애의 종류 및 빈도가 적었다. 이러한 결과는 Eysenck의 성격차원과 수면특성이 밀접한 관련이 있음을 시사한다. Objectives : In order to evaluate the possible relationship between sleep and personality characteristics, it is desirable to adopt the personality theory with biological basis because sleep is a physiological phenomenon. The purpose of this study was to investigate their possible relationship using the personality dimensions of Eysenck, which is well known as a biological personality theory. Methods : Sleep Questionnaires regarding the weekday sleep habits and the sleep disorders and Eysenck's Personality Questionnaire were administered to 532 university students. Data analysis was based on 509 students who gave reliable information. Firstly, the descriptive statistics of the scores on four personality dimensions(psychoticism, neuroticism, extraversion, lie) and sleep characteristics were obtained. Secondly, the possible relationships between each personality dimension and sleep characteristics(the weekday sleep habits and sleep disorders) were tested by calculating Pearson's product moment correlations. Results : The four personality dimensions' scores and weekday sleep habits of subjects were within a normal range. The highest frequency of sleep disorder was induction difficulty of sleep and the lowest was sleep walking. Psychoticism was positively correlated with bedtime, rise time, sleep latency, number of awakening, regularity of sleep, frequency and duration of nap and doze, frequency of sleep disorders, while negatively correlated with the quality of sleep, and the score of circadian rhythm. The correlations between neuroticism and sleep characteristics were similar to those of psychoticism. Extraversion was positively correlated with the quality of sleep and the score of circadian rhythm, while not correlated with sleep disorders. Lie was positively correlated with the score of circadian rhythm, but negatively correlated with sleep latency, regularity of sleep, frequency and duration of nap and doze, and sleep disorders. Conclusions : The higher psychoticism and neuroticism, the poorer sleep habits and the higher frequency of sleep disorders. The higher extraversion, the better quality of sleep and the closer morningness. The higher lie, the closer morningness, the more regularity of sleep, the less sleepiness of daytime, and the less frequency of sleep disorders. These findings suggest that there exist the close relationships between Eysenck's personality dimensions and sleep characteristics.

셀룰라 이동 통신 시스템에서 경로 손실 데이터베이스를 이용한 이동국의 위치와 속도 추정 방식

李相憲,鄭遇坤,崔炯辰 성균관대학교 1998 학술회의지원논문목록집 Vol.1998 No.-

차세대 셀룰라 이동통신 시스템은 기지국의 소형화와 서로 다른 크기의 기지국의 복합형태인 계층구조 셀룰라 형태를 가지게 되는데 이에 따른 시스템의 컨트롤은 이동국의 정확한 위치와 속도에 관한 추정을 전제로 한다[13]. 본 논문에서는 지금까지 연구되어온 이동국의 위치 추정 기법인 AOA(Angle of Arrival)와 TOA(Time of Arrival)및 TDOA(Time Difference of Arrival)의 방법을 설명하고 그 문제점을 분석하였고, 반사와 회절이 심하여 이동국의 위치 및 속도 추정이 어려운 마이크로셀 환경에서는 서비스 지역내 경로손실값의 이상 지역 데이터 베이스를 이용하여 이동국의 위치를 추정하는 방법을 제안하였다. 속도의 추정은 위치의 추정치로부터 시간에 대한 변화값으로 얻었다. 오차를 최소화하기 위하여 시스템의 Causality를 만족하는 범위 안에서 이동평균(Moving Average) 방법의 Smoothing을 적용하여 그 성능을 개선하였다. 또한 이산 지역 데이터 베이스의 탐색지역을 줄이는 방법을 제안함으로 시스템의 구현을 간단하게 할 수 있는 방안을 제시하였다. To achieve the required services in the next-generation cellular telephone systems, the size of the cell become smaller and/or is of mixed macrocells and microcells. To more efficient system control, we make use of the mobile position and velocity information, provided that the mobility information is relatively accurate. In this paper, we propose an improved version of path-loss measurement algorithm introduced in literature[11]. In microcellular structure with servere multipath fading, reflection and refraction make mobile position and velocity estimation very difficult. In the proposed method, the pre-recorded path-loss informations, called the discrete position data vase, are searched to estimate the position. Velocity estimation is obtained as a difference of the position values with respect to the time difference. Moving average is applied to smooth the estimated velocity and to reduce the error in the estimates. We also propose a method to simplify system implementation by reducing search area for discrete area datebaase.