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( Myung Jin Lee ),( Kye Hyung Kim ),( Jong Youn Yi ),( Su Jin Choi ),( Chung Jong Kim ),( Nak Hyun Kim ),( Kyoung Ho Song ),( Pyoeng Gyun Choi ),( Ji Hwan Bang ),( Wan Beom Park ),( Eu Suk Kim ),( San 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus Myung Jin LEE1, Kye-Hyung KIM1, Jongyoun YI2, SuJin CHOI1, Chung-Jong KIM1, Nak- Hyun KIM1, Kyoung-Ho SONG1, Pyoeng Gyun CHOI1, Ji-Hwan BANG1, Wan Beom PARK1, Eu Suk KIM1, Sang-Won PARK1, Hong Bin KIM1, Nam Joong KIM1, Myoung- Don OH1 Seoul National University College of Medicine, Korea1, Pusan National University School of Medicine, Korea2 Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel Bunyavirus, severe fever with thrombocytopenia syndrome virus (SFTSV). No effective antiviral therapy is proven yet, but clinical use of ribavirin (RBV) has been tried. We investigated the antiviral effect of RBV against SFTSV in vitro. Methods: To test for cytotoxicity of RBV, Vero cells were treated with different concentrations of RBV (3.90 to 500 μg/mL, two-fold dilution) and analyzed by cell viability MTS assay 48h post-infection. To determine antiviral activity of RBV against SFTSV, Vero cells were infected with SFTSV strain Gangwon/Korea/2012 at 100 TCID50 (50% tissue culture infective dose) per well in a 96-well plate, and RBV was added at the concentrations showing no or minimal cytotoxicity. Viral RNAs were extracted from the culture supernatants and quantifi ed using one-step real-time reverse transcription- PCR to amplify the partial large segment of SFTSV. Statistical analysis was done by one-way ANOVA with Tukey`s post hoc test. Results: Cytotoxicity due to RBV was not observed at RBV concentration =31.3 μg/ mL. Viral RNAs at 24h post-RBV treatment were reduced with increasing RBV concentrations (1-32 μg/mL), compared with those of mock-treated cells (P <0.01, Figure). Half maximal inhibitory concentration (IC50) of RBV was 3.69 μg/mL at 24h post-RBV treatment. Conclusions: Our study shows that RBV has antiviral effect against SFTSV in a dose-dependent manner. Further studies are required to evaluate the effi cacy of RBV in SFTS.
심리적 안전이 창의성에 미치는 영향: 성장마인드셋과 조직지원인식의 매개효과를 중심으로
최우수(Choi, Woo-Su),오상진(Oh, Sang-Jin) 한국경영교육학회 2020 경영교육연구 Vol.35 No.5
[연구목적] 본 연구는 불확실한 경영 환경 속 기업에게 혁신 수단으로서 창의성을 제시하기위해, 심리적 안전이 창의성에 미치는 영향과 그 과정에서 성장마인드셋, 조직지원인식과의 관계를 실증하여, 창의성 제고를 위한 실용적 방안을 제시하고자 한다. [연구방법] 국내 기업에 근무하는 다양한 업종의 구성원 총 420명에게 설문지를 배부하여 353명에게 자료를 수집하였다. 심리적 안전, 창의성, 성장마인드셋, 조직지원인식과 관련된 이론 및 선행 연구를 토대로 가설을 설정하였으며, 통계 도구로는 CFA를 통해 신뢰도와 타당성을 검증하였고, 가설검증을 위해 SPSS25, AMOS25, Macro Process3.0을 사용하였다. [연구결과] 연구 모형에 대한 가설 검증 결과 심리적 안전은 성장마인드셋, 조직지원인식, 창의성에 유의한 정(+)의 영향을 주는 것으로 나타났으며, 성장마인드셋과 조직지원인식의 매개효과도 유의한 것으로 나타났다. [연구의 시사점] 본 연구는 기업 현장의 조직문화 요인과 창의성 간의 관계를 동기부여 이론으로 검증했다는데 의의가 크다. 특히, 창의성을 특별한 재능 소유자의 전유물이 아니라 조직 문화의 변화를 통해 구성원들에게 확산시킬 수 있는 혁신의 도구로 제안했다는 점에서 시사점이 있다. [Purpose] This study aims to present creativity as a means of innovation to companies in uncertain business environment, demonstrate the impact of psychological safety on creativity and its relationship with growth mind-set and perceived organizational support in the process, and suggest practical measures to enhance creativity. [Methodology] Data were collected from 353 members. Hypothesis was set based on theories and previous studies related to psychological safety, perceived organizational support, growth mind-set and creativity. The collected data were reviewed for reliability and validity through CFA, and hypothesis verification was performed using SPSS 25, AMOS 25, and Macro Process 3.0 by Bootstrap. [Findings] Psychological safety was found to have a significant positive effect on growth mind-set, perceived organizational support and creativity, and the mediating effects of growth mind-set, perceived organizational support were also significant. [Implications] This study is significant in that it has verified the relationship between organizational culture factors and creativity at corporate sites with the theory of motivation. In particular, creativity is not the exclusive property of a particular talent owner, but it has implications for spreading to members through changes in organizational culture and, through this, proposed as a tool for innovation.
김민지,신수영,송월섭,조수진,최동락,황미진,황진규,박진현,김경,Dennis W. Fell 대구대학교 특수교육재활과학연구소 2011 再活科學硏究 Vol.29 No.1
이 연구는 트레드밀 운동과 키네시오 테이핑의 효과에 따른 폐활량의 변화를 알아보기 위해 26명의 비흡연자가 참가하였으며 키네시오 테이핑을 적용하지 않은 그룹과 키네시오 테이핑을 적용한 두 그룹으로 무작위로 배정하고 각 군들을 주 3회 6주간의 트레드밀 훈련을 실시하였다. 실험 전과 후, 스파이로미터를 사용하여 키네시오 테이핑의 적용 따른 폐활량 변화 효과를 측정하였다. 이 연구의 결과를 종합해보면 키네시오 테이핑을 적용 그룹에서 적용하지 않은 그룹에 비해 FVC, FEV1에서 유의한 증가를 보였다. 이러한 결과는 건강한 성인에서 키네시오 테이핑을 적용한 경우 키네시오 테이핑을 적용하지 않고 트레드밀 운동을 한 경우보다 폐활량의 향상에 효과적이라고 생각되어진다. The purpose of this study was to investigate the variation of vital capacity(VC) according to the effects of kinesio taping with treadmill exercise. Twenty-six non-smokers were participated in this research and these subjects were randomly assigned into two groups. To measure the VC variation effects of kinesio taping, spirometer was used. The collected data were analyzed statistically by using a paired Mauchly test and repeated measure ANOVA. The results of this study were as follows; A group: treadmill with kinesio taping B group: treadmill without kinesio taping. Between A and B, there were significant differences. In the case of A group, there was 11.66% increase of VC, during 3 weeks experiment(p<.01). In the case of B group, there were significant differences, 3.35% increase of VC, during 3 weeks taping intervention(p<.01). After 6 weeks experiment, the improvement of VC shown a significant difference with intergroup (p<.05). From this result, it was revealed that treadmill exercise with kinesio taping was effective to improve VC to healthy adult than treadmill exercise without kinesio taping.
부분 무치악 환자에서 마그네슘 이온주입 임플란트의 성공률에 대한 전향적 임상연구
최수정,유정호,이규복,김진욱 大韓齒科補綴學會 2012 대한치과보철학회지 Vol.50 No.3
Purpose: This study examined the clinical success rate of Mg titanate implants (M Implant system, Shinhung, Korea), which employ a Mg coating method, by evaluating the marginal bone loss and implant stability using radiographs and Osstell, over a 1 year. Materials and methods: The locations of the implants placement were divided into 4 areas; the maxillary and mandibular premolars and molars. In the maxilla, 8 and 9 implants were inserted in the premolar and molar areas, respectively. In the mandible, 11 and 51 implants were inserted in the premolar and molar areas. Marginal bone loss and ISQ of all implants (79) were measured after insertion, mounting the prosthetic appliance, and 1, 3, 6, and 12 months after loading. The marginal bone loss was measured from the radiograph using XCP bite, which was customized, and the implant stability measured using Osstell. Fisher's exact test (α=.05) was used to compare the success rates of each region. Results: The mean marginal bone loss for the upper and lower jaws were 1.537 mm and 1.172 mm. The mobility showed a non-significant reduction or increase according with time. The success rates were accounted for 94.12% and 98.39% in the upper and lower jaws; the premolars and molars were accounted for 100% and 96.67%. The two cases of early failure resulted from failure of primary stability during implant insertion. The late failures were not observed for 1 year after adding a loading to the implants. Conclusion: The Mg titanate implant showed good primary stability and good clinical results in both healing and function. 연구 목적: 부분 무치악 환자에서 Mg titanate implant (M Implant system, Shinhung, Korea)의 보철후 1년간의 방사선사진을 이용한 변연골 흡수량과 Osstell을 이용한 임플란트 안정성 평가 결과를 분석하여 임상적인 성공률에 대해 알아보고자 한다. 연구 재료 및 방법: 38명의 환자에 79개의 임플란트를 식립하여 보철 후 1년 동안 변연골 흡수량, 임플란트의 동요도, 임플란트 식립 위치에 따른 분포 및 성공률, 보철 전후에 따른 성공률을 분석했다. 결과: 변연골의 흡수량은 보철물 장착 후 1년간의 평가에서 상악에서는 평균 1.537 mm, 하악에서는 평균 1.172 mm의 변연골 흡수가 관찰되었으며, 전체적인 상하악의 평균 변연골 흡수량은 1.255 mm로 관찰되었다. 수술 후 시간이 경과함에 따라 ISQ값은 미약하게 감소하였다가 증가하는 경향을 보였으나, 상악과 하악 모두에서 식립 당일 이후 예비 인상일, 최종 보철물의 장착일과 주기적인 평가 기간 동안 ISQ값의 큰 증가나 감소를 나타내지는 않았다. 성공률은 상악에서의 94.12%였고, 하악에서의 98.39%였다. 결론: 본 실험의 결과로 미루어 Mg titanate implant는 임상적으로 양호한 결과를 보여주었다.
Linoleic acid의 酸化에 의한 DNA 損傷作用 및 活性酸素種의 역할
崔守安,姜珍壎 부산교육대학교 과학교육연구소 1987 科學敎育硏究 Vol.12 No.-
The present study was attempted to investigate on the damage of plasmid DNA by lipid peroxidation and the effects of the active oxygen radicals through the reaction of DNA and linileic acid at 37℃ as model systems. The dgree of DNA damage indeced by linoleic acid peroxidation was increased with increasing of linoleic acid content in reaction system. Linoleic acid at concentration above 10 mM induced the nonspecific double strands scission during peroxidation for 3 days, but the POV was below 100 millieq./kg at that time. And, generally, all of the active oxygen scavengers inhibited the DNA damage and the increase of POV by linoleic acid peroxidation, and such effects were greater in singlet oxygen scavengers and superoxide anion scavengers, but not shown in hydroxyl radical scavengers and hydrogen peroxide scavenger after 1 day incubation. From these profiles, it is concluded that singlet oxygen and superoxide anion geatly affected to the DNA damage induced by linoleic acid peroxidation, but hydrogen peroxide and hydroxy 1 redical participated in the early stage of peroxidation.
최훈,박경수,이정렬,엄진섭 江原大學校 産業技術硏究所 2004 産業技術硏究 Vol.24 No.A
In this paper, we proposed an optical balance using a Michelson Interferometer structure. The frequency of the interference signal is changed nonlinearly related with a weight to be measured, and this frequency change is processed by a processor to give a measured weight. Several measurements were performed and the good results were obtained with the fluctuation of about 1g.
최은주,유수진,권정곤 부산대학교 환경문제연구소 1994 環境硏究報 Vol.12 No.-
This study was managed to develope the existing numerical calculation model of near shore current and wave fields where wave and current coexist around shallow water region, and analyse their problems. Until now, nearshore current model that include longshore current and on-off shore current had shown wave characteristic based on regular wave theory. In this study, however, nearshore current characteristic was changed by directional dispersion. So the effect of directional dispersion of multidirectional irregular wave was examined numerically by the basic study of nearshore current calculation due to multidirectional wave that was driving force of pollutant material at shallow water region.
窒素質肥科의 基追肥 施用時期가 이타리안라이그라스의 生育 및 靑草收量과 養分組成에 미치는 影響
崔洙日,崔亨松,陳星桂 又石大學校 1990 論文集 Vol.12 No.-
本 硏究는 冬季休閑畓을 活用한 이타리안 라이그라스의 栽培에 알맞은 窒素質肥料의 基·追肥 施用適期를 알고자 遂行하였던 바 다음과 같은 結果를 얻었다. 1. 窒素基肥施用時期가 늦어질수록 越 草長의 伸長短縮과 靑草收量을 感收시켰고 組蛋白質, 組脂肪, 組灰粉의 含量도 적어 飼料의 質을 低下시켰으며 또한 越冬期 枯死莖 被害와 越冬後의 靑草收量도 減小시켰다. 2. 窒素質肥料의 追肥施用適期 試驗에서도 追肥施用適期가 늦어질수록 生育量 및 追肥施用適期 減小와 節間을 伸長시켰으며 組蛋, 白質, 組脂肪 含量도 적었다. 3. 窒素質肥料의 基追肥 施用適期는 基肥는 播種當日, 追肥는 生育再生後 10日頃이었다. This experiment was carried out to study the effects of different application times on the nitrogen fertilizer, the fresh matter yield and feed efficiency of Italianryegrass under winter cropping on drained paddy field. Plant height, fresh matter yield and content of organic nutrient were decreased. According as the application times of top basal dressing on the nitrogen were late. In the experiment of the application times of top dressing on the nitrogen times of top wintering. Agronomic characters, fresh matter yield, crude protein, crude fat and crude were decreased. According as thd application times of top dressing on the nitrogen fertilizer were late. The optimum application time of nitrogen fertilizer was sowing date in basal dressing and was 10 days after regrowth in top dressing.