미디어 강사의 신문보기

申敏亨(신민형) 관훈클럽 2002 관훈저널 Vol.43 No.4

구강내 백색병소와 편평상피세포암종에서 bcl-2와 NOS₂ 비교발현에 관한 연구

신민,김은철,Shin, Min,Kim, Eun-Cheol 대한안면통증구강내과학회 1999 Journal of Oral Medicine and Pain Vol.24 No.2

The proto-oncogene bcl-2 confers a survival advantage to cells by blocking programmed cell death (apoptosis). Overexpression of bcl-2 probably plays a role in tumorigenesis, and the expression of the bcl-2 protein has been investigated in many kinds of tumors. An increased expression of nitric oxide synthetase(NOS) has been observed in human colon cancer cell lines as well as in human gynecological, breast, and CNS tumors. However there have been only a few reports on the expression of bcl-2 and $NOS_2$ in oral white lesions and cancer. The aim of this study was to investigate the relationship between the expression of Bcl-2 and $NOS_2$ and several pathological parameters such as histological types and layers. We reported desregulation of bcl-2 and $NOS_2$ expression during progression from oral white lesion, lichen planus and leukoplakia to squamous cell carcinoma. The obtained results were as follows: 1. Immunohistochemical analysis with monoclonal antibodies to bcl-2 oncoprotein and $NOS_2$ in formalin-fixed paraffin-embedded tissue sections revealed that bcl-2 expression is restricted to the basal cell layer and $NOS_2$ was mild expressed only in subepithelial inflammatory cells in normal human mucosa. There wasn't specific finding of those in lichen planus and leukoplakia. 2. Bcl-2 immunoreactivity in severe epithelial dysplasia or CIS occurs throughout the epithelium, $NOS_2$ reactivity in most superficial layer were noted. 3. In well-differentiated squamous cell carcinomas, mostly bcl-2 was overexpressed. In moderated and poor squamous cell carcinomas, the expression of $NOS_2$ was increased and that of bcl-2 was decreased. 4. The immunoreactivity of bcl-2 was 12.5% of normal mucosa, 30% of leukoplakia, 44% of lichen planus and 67% of carcinoma in situ. In carcinoma, those were 43%, 50% and 67% according to differentiation, respectively. 5. The immunoreactivity of $NOS_2$ was 25% of normal mucosa, 70% of leukoplakia, 78% of lichen planus and 100% of carcinoma in situ and epithelial dysplasia. In carcinoma, those were higher in moderated(100%) and poor(83%) squamous cell carcinomas than in well differentiated type(71%). 6. The expression of bcl-2 and $NOS_2$ by Western blot was increased highly in lichen planus and leukoplakia. Therefore, the expression of bcl-2 was increased in the white and precancerous lesions and that was decreased by differentiation of carcinoma. However, $NOS_2$ immunoreactivity in carcinoma in situ was lower than those in moderated and poor squamous cell. These findings suggest that the interaction of bcl-2 and $NOS_2$ may be roled importantly in growth and development of carcinoma.

한·중 전통문양의 비교 연구 : 길상 문양을 중심으로

신민 한국공예학회 2001 조형디자인연구 Vol.4 No.2

The patterns, like language and words, has their own indigenous shape depending upon the circumstances in which their users have lived. Thus they have peculiar forms all over the world, and so the Oriental patterns and the Western patterns are distinctively different. However, it can be said that they include not only regional aspects but also religious aesthetics. In Orient, the flourising of the Confucius Buddhist culture has created these patterns by stirring people's imagination abundantly. In this respect, it will be significantly meaningful to make a comparative analysis of the patterns of the two neighboring countries, Korea and China, which have had a close relationship historically. Therefore, this study aims to investigate these two patterns through their comparative analysis with special reference to their lucky physiognomy. As for the patterns showing lucky physiognomy which have been used as a generally popular culture, they were settled as popular arts on the basis of Taoism in China whole they were practically used in the daily life due to the Buddhist arts in Korea. In addition, they symbolize having many sons, living a long life and a wish in China, while in Korea they symbolize a small wish by the unit of family and community. It can be accepted that this represents the basic human desire. It can be finally concluded that these patterns are widely used in food, clothing and housing today, but that they can be developed better when they will be expressed in accordance with modern life so that their true meaning can be brought to modern men.

경추만곡도를 이용한 두개하악장애 환자의 두경부자세에 관한 연구

신민,한경수 원광대학교 치의학연구소 1995 圓光齒醫學 Vol.5 No.2

The purpose of this study was to investigate the relationship between the head and neck posture and the cervical curvature, especially in forward head posture(FHP). Sixty patients with craniomandibular disorders and thirty dental students without any signs and symptoms of craniomandibular disorders participated in this study as patient group and as control group, respectively. The author evaluated the head and neck posture of all subjects by plumb line and CROM(cervical-range-of-motion), and had taken cephalograph in natural head position. On the cephalogragh the angle of cervical inclination formed by true horizontal plane and 4th cervical vertebra(C4) and the radius of cervical curvature from C1 to C5 were measured. A specially designed ruler was used for measuring cervical curvature. Occlusal contact number and force with T-scan system, electromyographic activity of cervical muscles with Bio-EMG, and distance of freeway space with Bio-EGN were recorded, respectively. The collected data were processed by SAS/STAT program. The obtained results were as follows 1. In subjects with longer radius which was less cervical curvature, head positioned more anteriorly than subjects with smaller radius, and they showed slightly straight cervical vertebra. 2. Between the patients and the control group, there were no differences in cervical curvature, in forward head position by plumb line and in CROM. But the patient group had a greater cervical inclination(CVT/HOR) than the control group had. 3. There were positive correlation between cervical curvature and forward head position by plumb line, between forward head position by plumb line and that by CROM in patient group. The cervical inclination (CVT/HOR), however, had negative correlations with cervical curvature, and with forward head position by plumb line, respectively. 4. In case of showing more cervical curvature and more forward head position by plumb line, the head position was defined as forward head posture(FHP). In patient group, subjects without forward head posture showed greater posterior teeth contact force than subjects with forward head posture, but in control group, there were no difference between the two subjects. 5. There were higher electromyographic activity in almost all muscles and smaller freeway space in induced forward head posture than those in natural head position in subjects without forward head posture. In conclusion, head position of patients with craniomandibular disorders were not more anterior than that of normal control persons, but they had tendency to head extension. From the result of this study, forward head posture could be defined as posterior rotation of upper cervical segment with a sliaight lower cervical segment due to loss of normal lordosis.

Ramos B세포의 아포토시스 과정에서 이상 발현되는 Zinc Finger 유전자의 규명

신민선,김수영,동승명,나은영,이석형,박원상,이정용,유남진,신민선 대한병리학회 1998 Journal of Pathology and Translational Medicine Vol.32 No.12

Inhibition of the Jun Aminoterminal Kinase by SP600125 Blocks PMA-Induced 92kDa Type IV Collagenase Secretion

신민,Shin, Min The Korean Academy of Orofacial Pain and Oral Medi 2001 Journal of Oral Medicine and Pain Vol.26 No.2

제 4형 콜라젠을 분해하는 MMP-9은 조직 재생에 중요한 역할을 하기 때문에 주목받아 왔는데, 이전의 문헌들에서 PMA에 의해 이 유전자 발현이 강하게 상승발현된다고 알려져 있다. 비록 MMP-9 발현을 조절하는 PMA의 기전이 잘 밝혀지지는 않았지만, 다른 유전자발현에서의 이 phorbol ester의 효과는 c-raf-1-ERK 신호전달통로의 활성에 관해 연구되어 오고 있다. 하지만 이번 연구에서 저자는 MMP-9 발현에서 PMA의 상승효과에는 대개는 스트레스성 자극과 관련된 JNK1 의존성 신호전달과정이 또한 필요하다는 다른 가능성을 조사하였다. 그 결과 JNK 억제재중 하나인 SP 600125가 UM-SCC-1세포주에서 PMA에 의해 유도된 MMP-9 상승발현을 용량의존적으로 억제하는 것으로 나타났고 72시간동안 전처치를 한 경우에 그의 억제효과가 최대이었다. phorbol ester로 처리한 세포에 GAL4 luciferase reporter와 vector를 주입해서 조사한 결과 PMA가 c-Jun transacting 활성을 상승시켰다. 그뿐 아니라 PMA에 의한 MMP-9 촉진자 활성에는 AP-1 motif가 필요하며 이 motif에 c-Jun이 결합하는 것을 EMSA를 통해 확인하였다. 결론적으로 UM-SCC-1 세포주에서 PMA에 의한 MMP9의 증가된 발현은 이미 밝혀진 ERK 경로뿐 아니라 JNK 경로를 통한 결과임이 밝혀져 이 경로를 차단하는 방법이 또하나의 암치료 방향을 제시해주고 있다.

Biobehavioral Pain Profile을 이용한 구강안면동통 환자의 행동양식에 관한 연구

신민,Shin, Min 대한안면통증구강내과학회 1998 Journal of Oral Medicine and Pain Vol.23 No.4

The aim of this study was to measure effects of the following items to pain and pain behavior reaction in patients with chronic orofacial pain. Items that contribute to the first factor(Environmental Influences) measure environmental sources of information that may affect illness behavior; Second factro(Loss of Control) measure appraisals and attributions perceived to influence personal views aobut pain; Third factor(Health Care Avoidance) measures a variety of avoidant behaviors; Fouth factor(Past and Current Experiences) measures experiences with treatment); Fifth factor(Physiological Responsivity) measures physiological parameters that are experienced in association with pain; Sixth factor(Thoughts of Disease Progression) measures thoughts regarding the etiology and progression of disease in relation to pain. 150 patients that were consist of 40 male and 110 female were participated in this study. The obtained results of this study were as follows : 1. Environmental influences and loss of control scales were recorded high score in patients with chronic orofacial pain 2. "Physician's descriptions of what your pain will be like" and "Physician's facial expression when they ask about your pain" items from the environmental influences were recorded high score. These results indicated that responsibility of doctro is very important to the pain reaction behavior of patients. Also, items from thoughts regarding the etiology and progression of disease in relation to pain influenced to the pain reaction. 3. There were significant defferences on the "nurses' descriptions of what you pain will be like", "physician's and nurses' facial expression when they ask about your pain", "TV and radio", and "Literature" items from the environmental influences between male and female patients. 4. There were no significant differences on the each scale between arthrogenous and combitnation group and significant correlated with all 6 scales.

지구 저궤도에서의 궤도파편 분포 및 진화모델을 이용한 궤도파편 환경 예측 연구

신민,김영록,이재은,박상영,최규홍,김응현,김규선 한국우주과학회 2006 한국우주과학회보 Vol.15 No.2

도시홍수 방재시스템의 가치 추정 연구-광주광역시를 중심으로

신민 한국재난정보학회 2023 한국재난정보학회 학술대회 Vol.2023 No.11

본 논문에서는 다차원법과 CVM을 이용하여, 도시홍수 방재시스템의 가치를 추정하였다. 방재사업은 예산의 편성과 집행 과정 중에 연기 또는 집행 순서가 변경되기도 한다. 이는 즉각적인 효과가 드러나기 어려운 특징 등 때문에 시민 공감을 얻기에 어려우며, 정치적이고 경제적인 요인 등에 의한 것으로 추정된다. 따라서 시민들이 체감하고 있는 방재사업의 가치 규모를 추 정하고자 하였다. 정책 공급자들이 홍수 방재 사업의 추진 결정에 참고하는 가치와 시민들이 생각하는 가치를 다차원법과 CVM으로 각각 추정한 결과, 다차원법으로 산정된 가치보다 시민들의 필요 가치가 낮게 추정되었다. 따라서 정책 수요자들의 공감을 이끌어 내기 위한 노력을 지속해야 할 것이다.

교합안전장치가 근력과 근지구력에 미치는 영향

신민,양춘호 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.6