정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

군비통제 검증관련 기구 및 법령에 관한 연구

백진현(白珍鉉),제성호(諸成鎬) 한국전략문제연구소 2002 전략연구 Vol.9 No.2

Verification is one of the most difficult. important and complicated issues in the process of arms control. Verification is not just a technical. military issue but a complex process involving economic. financial and political dimension as well. Despite the complexity and importance of verification. there has been little in-depth studies about verification: its concept, nature. functions. and its specific methods and strategy. Particularly. there has been almost nothing on the domestic. institutional aspect of verification. This study is concerned with the domestic institutional aspect of verification. As a result of the inter-Korean summit and consequent resumption of dialogue between North and South Korea. there has been growing interests for verification as an essential process of arms control. Against this backdrop. the study intends to focus on the issue of verification. in particular what should be the most effective and efficient domestic system to implement the task of verification and what legislations are required to this effect. Verification, in general. has at least four functions. These functions include: first. insurance against significant surprise or "breakout" (in other words. sudden unilateral abrogation of an existing agreement): second, confidence-building between the adversaries: creation of political support for arms control: and fourth. guidance for drafting better arms control treaties. Our approach to verification in the North-South arms control negotiation should bear these four functions in mind. In particular. the following four principles should be stressed. First. despite North Korea's negative attitude toward verification in general. any arms control agreements with North Korea must include an effective verification provision. without which they cannot obtain the needed domestic support. Second. however. it is important for the South to be flexible about the specific methods of verification. given North Korea's sensitivity to verification. Third, gradualism and pragmatism should be a guiding principle in negotiation on verification. Too ideal or ambitious approach to verification. such as demanding a strict form of challenge inspection in the absence of minimal element of confidence. can easily lead to the collapse of arms control negotiation. Fourth. no efforts should be spared to obtain the domestic support for the relevance and validity of the adopted arms control methods. What kind of domestic institutional mechanism is needed in deciding and implementing verification strategy? There can be two kinds of approach to this question. The first is to make use of the existing standing committee of National Security Committee (NSC). which requires no new legislation or establishment of new institution. The standing committee of NSC would be in charge of arms control and verification affairs which involve and affect the interests of various government department and agencies. The second approach is to set up the Arms Control Commission under the office of Prime Minister. and let this commission in charge of planning, deciding. and implementing arms control matter. This option obviously requires new legislation. but such new institution may be useful when arms control would become a serious. real issue. Finally. whichever option is adopted. the current Office of Arms Control and Verification and Inspection Agency within the Ministry of Defence should be strengthened and restructured when North-South arms control proceeds in earnest.

일산화탄소 및 고압산소의 폭로가 흰쥐의 제2형 폐포세포와 사구체에 미치는 영향에 관한 연구

백두진,정호삼,이계훈,황세진,전영호,전영희 한양대학교 의과대학 1997 한양의대 학술지 Vol.17 No.2

The present study was performed to investigate the ultrastructural changes of the type Ⅱ pneumocyte in the lung and that of the glomerulus in the kidney after carbon monoxide(CO) or hyperbaric oxygen (HBO) exposure. The male Sprague-Dawley rats, weighing about 200gm, were used as experimental animals. The animals were divided into CO exposure group, air exposure after CO exposure group, HBO exposure group and HBO exposure after CO exposure group. After single CO and HBO exposure (3790ppm), the specimen of lung and kidney were obtained. According to routine method, EM preparations were made and observed with electron microscope. The results obtained were as follows ; 1. Slight disruption of the mitochondrial membrane was observed in alveolar type Ⅱ pneumocyte, after single CO exposure. 2. In all experimental groups except CO exposure group, decrease in number and atropy of rough endoplasmic reticulum, disruption of double membrane and crista of mitochondria and vacuolar degeneration of lamellar bodies in alveolar type Ⅱ pneumocytes were observed. 3. In all experimental groups, fusion of the pedicles of podocytes, and obliterations of the endothelial fenestrations were observed. These results suggested that CO and HBO exposure may induced the ultrastructural damages in the alveolar type Ⅱ pneumocyte and the glomerulus.

NSIP와 BOOP의 고해상전산화단층촬영 소견과 비교

백상현,박재성,차장규,홍현숙,김대호,박성진,조준희,이혜경,최진수 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.2

Purpose: BOOP and NSIP also share similar clinical features such as subacute flu-like illness, the finding of bronchoalveolar lavage, the result of pulmonary function test and more favourable outcome than usual interstitial pneumonia(UIP). The author try to compare the HRCT findings of NSIP with BOOP by pattern and distribution of diseases. Materials and Methods: HRCT findings of histopathologically proven NSIP(Group Ⅰ; 6, Group Ⅱ; 7, Group Ⅲ; 2) in 15 patients(5 male, 10 female, age range, 39-69 years; mean age, 53 years), BOOP in 15 patients(6 male, 9 female, age range, 26-76 years; mean age, 52 years) were reviewed retrospectively. Results: The common pattern of the two diseases was admixed consolidation, ground glass attenuation & reticular densities with/without architectural distortion(NSIP; 53.3%, BOOP; 46.7%). The main component of the pattern wan predominantly consolidation(NSIP; 46.7%, BOOP; 73.3%) and ground glass attenuation(NSIP; 40.0%, BOOP;20.0%). Architectural distotion was more provinent finding with NSIP(mild ; 3, moderate ; 4, severe; 2) compared with BOOP(mild; 7, moderate; 2, severe; 0). The predominant overall distribution was lower lung, peribronchovascular & peripheral lung field in both of the two entities(NSIP;73.3%, BOOP; 73.3%). Peribronchovascular involvement was more common with NSIP(100%) than BOOP(80%), whereas peripheral involvement was more common with BOOP(93.3%) than NSIP(80%). Conclusion: The HRCT findings of NSIP and BOOP were similar in pattern and distribution. But NIP manifested more frequently ground-glass attenuation, whereas BOOP showed more frequently consolidation. Architectural distortion was more severe with NSIP than BOOP. NSIP invoved more frequently peribronchovascular space and BOOP were more common in peripheral lung field.

Daunomycin이 Mouse 간장의 Alkaline Phosphatase 활성에 미치는 영향

백두진,김훈기,정호삼 한양대학교 의과대학 1987 한양의대 학술지 Vol.7 No.2

Daunomycin is a member of the anthracycline class of antitumor antibiotics. And it was isolated from cultures of Streptomyces peucetius in 1963. Cemically, it was found to consist of a pigmented aglycone (daunomycinone) bound to an aminosugar, daunosamine. The biochemical mode of cytotoxic action of daunomycin results from its binding to DNA possibly by intercalation between the base pairs, thereby inhibiting the DNA polymerases. The author has investigated the effect of daunomycin on the mouse liver histochemically observing the change in the activity of alkaline phosphatase. The animals treated with 16 mg per kg of daunomycin wee sacrified at 6, 12, 24 and 36 hours after drug administration. The animals of control group were administered only water for injection. The liver specimens were fixed in 10% neutral formalin at 4℃ and sectioned at 16? In thickness in a frozen cryostat. The activity of alkaline phosphatase was evaluated histochemically by Gomori's method. The results were as follows. 1. The activity of alkaline phosphatase was moderate positive at the periportal and intermediate zones and trace positive at the centrilobular zone of the hepatic lobule in 6 hours daunomycin treated group. Ad the time goes by, the activity of alkaline phosphatase was decreased in the hepatic lobule. At 24 hours after administraton of daunomycin, negative reaction at the centrilobular zone, trace positive at the intermediate zone and weak positive at the periportal zone of the hepatic lobule were seen. Consequently, it is suggested that daunomycin decreases the activity of alkaline phoshatase in the liver, due probably to its cytotoxic effect on the hepatocyte.

Mitomycin이 Mouse의 肝細胞 내 Pyronin 好性顆粒에 미치는 影響

鄭鎬三,李圭植,白斗鎭 한양대학교 의과대학 1985 한양의대 학술지 Vol.5 No.1

Mitomycin, one of the mitosane antibiotics, is isolated from Streptomyces caespitosus which has anticancer effect. It is well known that mitomycin inhibites DNA synthesis in mammalian cells. The major machanism accounting for the inhibitory effect of mitomycin is interference of the template activities of the DNA by cross linking to DNA double helix. The auther has investigated the effect of mitomycin on the liver of mice, observing the distribution and disaggregation of the pyroninophilic granules in the hepatic parenchymal cells. A total of 52 healthy mice of ICR strain (the weight 20g) were divided into two groups; The control and the mitomycin treated groups. All experimental animals were given food and water ad libitum. The animals of the mitomycin treated groups were administered 4mg per kg of body weight of mitomycin diluted in the water for injection by intraperitoneal injection. The animals of the MC treated groups were sacrified at intervals of 6, 12, 24 and 36 hours after administration of mitomycin Histochemical preparations were stained with the methyl green-pyronin method for the pyroninophilic granules in the hepatic parenchymal cells. A marked reduction or disappearance of the pyroninophilic granules were observed in the entire hepatic lobule at 24 hours after administration of mitomycin. Consequently, it is suggested that mitomycin causes the loss of pyroninophilic granules in the hepatic parenchymal cells of the liver in the mitomycin treated mice.

Clozapine 투여후 설사와 혈소판 감소증이 나타난 환자 1례

김진희,이창욱,김정진,김우선,백인호 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.3

The clozapine has been used to the treatment of schizophrenic patients unresponsive to conventional antipsychotics, but to administration of clozapine has been restricted because of its propensity to cause agranuloytosis. So side effects associated with the administration of clozapine have probably not been fully elucidated. The authors describe a case of a male schizophrenic who developed prefuse diarrhea, spiking fever and thrombocytopenia associated with the administration of clozapine. Discontinuance of clozapine therapy resulted in improvement of diarrhea and fever followed by normalization of the platelet count. Previous reports of adverse hematologic side effects and gastroenteric reaction induced by clozapine administration are also discussed. We suggest that the physician must keep in mind these side effects and administer clozapine cautiously.

국가대표 선수들의 Personality 특성에 관한 비교연구 : 개인, 대인 경기 선수들 중심으로

김진호,백옥미 경희대학교 체육과학연구소 1995 體育學論文集 Vol.23 No.-

This research has been carried out to help improve players' competitive ability and scout for them through a precise grasp of their personalities and study of their unique personality characteristics. Forty-two male and forty-nine female National Amateurs who are residing in Tea-Reung Players' Village have been subjects of this research. 1.Comparison in each Personality Factors between the sports. In Factor F (Impulsion), Shooting marked a high average score of 6.99 score, Considerable differences(p<0.05) were found among Basketball, Weight Lifting and Shooting in Duncan's post- verification result. In Factor Ⅰ (Strength), Archery scored a high average mark of 7.58 scored. In Factor Ⅰ, (Reliance), Shooting gained a high average score of 7.11 scored, In factor Q1, (Progress), Archery scored a high average mark of 7.82 scored 2.Comparison in each Personality Factors between Individual and Personal Sports. In Factor G (Perfection), Individual Sports marked 6.02 scores and In Factor I (Strength), Individual 5.76 scores and In Factor L (Reliance), Individual 7.05 scores and in Factor M (Reality), Individual 5. 94 scores and in Factor N (Utility), Individual 7.04 scores and finally in Factor Q3 (Restraint), Individual 5.23 scores From the above results, it was discovered that Individual Sports players marked higher scores than Personal Sports ones. 3.Comparison in each Personality Factors between male and female. In Factor C (Stability), male marked 7.00 points and in Factor I (Strength), female 6.14 5 and in Factor M (Reality), female 5.98 and in Factor O (Guilty), female 5.90 and In Factor Q1 (Progress), female 5.94 and finally in Factor Q2 (Strain), female cored 5.99 points As in the above results, female players marked relatively higher average points than male ones in all Factors except in Factor C where male marked higher scores than female. 4.Comparison in each Personality Factors between careers. In Factor A (Cordiality), players with more than twelve-year careers marked the highest points of 6.75 and in Duncan's post-verification result, there were remarkable differences (p< 0.05) between players with 8 to 12-year careers and players with more than 12-year careers. In factor Q2 (Independence), players with 8 to 12-year careers gained the highest points of 5.92 and In Duncan's post-verification result, there were noticeable differences (p<0.05) between players with 8 to 12-year careers and players with more than 12-year careers. 5.Comparison in each Personality Factors between occupations. Among 16 factors, noticeable differences were indicated in Factor G (Perfection) and in Q3 (Restraint). In factor G (Perfection), the rest(middle-school) marked the highest scores of 6.76 and in Duncan's post-verification result, there were considerable differences (p<0.05) among high-school, under-graduate (graduate) and the rest (middle- school) players. In Factor Q3 (Restraint), professional players gained the highest scores of 6.25 and in Duncan's post- verification result, remarkable differences (p<0.05) were found among professional, the rest and high-school players. 6.Comparison in each Personality Factors between blood types. Among 16 factors, noticeable differences (p<0.05) were Indicated in Factor C (Stability) and in Q4 (Strain). In Factor C (Stability), blood type AB marked the highest score of 7.20 and in Duncan's post-verification result, there were remarkable differences (p<0.05) among blood type O, B and AB. In Factor Q4 (Strain), blood type B scored the highest average points of 6.12 and in Duncan's post-verification result, there were considerable differences (p<0.05) between blood type B and AB.

항정신병 약물치료하에서 주관적 안녕감을 평가하는 한국형 척도의 개발

윤진상,국승희,이형영,이철,백인호 대한신경정신의학회 2000 신경정신의학 Vol.39 No.6

연구목적 : 본 연구의 목적은 1994년 Naber 등이 개발한 38문항의 '항정신병 약물치료하에서 주관적 안녕감을 평가하는 자가평정척도(a self-rating scale to measure subjective well-being under neuroleptic tre-atment : SWN)'를 문항수를 줄이고 문항내용을 수정하여 한국형으로 개발하고자 하였다 방 법 : 204명의 정신분열병 환자들에게 22문항의 KmSWN과 General Health Questionnaire/Quality of Life-12(GHQ/QL-12)를 실시하였고, 사회인구학적 및 임상적 특징을 조사하였다. 자료분석에는 척도에 대한 반응과 정보가 신뢰로운 176명의 자료를 포함시켰다. 첫째, KmSWN의 신뢰도와 타당도를 평가하였다. 둘째, KmSWN총점과 사회인구학적 및 임상적 특징의 관계를 조사하였다. 끝으로 KmSWN의 총점을 예측하는 변인들을 알아보기 위해 KmSWN총점과 유의한 상관이 있는 변인들을 독립변인으로 하고 KmSWN총점을 종속변인으로 하여 단계적 중다회귀분석을 실시하였다. 결 과 : 22문항의 KmSWN중 세문항은 내적 일치도가 낮아서 추후분석에서 제외되었다. 19문항의 KmSWN(KmSWN-19)은 반분신뢰도(.91), 문항간 상관의 평균(.38), 내적 일치도(Cronbach alpha .92)가 높았다. 요인분석에서는 '불만족', '신체 및 정신기능', '정서조절 및 자기통제'의 3개요인이 추출되었다. KsSWN-19총점과 GHQ/QL-12총점간의 상관은 -.83으로 공존타당도가 높았다. 사회인구학적 및 임상적 특징중 연령, 용돈, 사회경제적 수준, 과거 입원횟수, 투약에 대한 순응 투약에 대한 만족도는 KmSWN-19 총점과 정적 상관이 있었던 반면, 질병의 심도, 파킨슨 증상의 심도, 지연성 운동장애의 심도, 투약횟수 및 투약을 빠뜨린 횟수는 KmSWN-19 총점과 부적 상관이 있었다, 단계적 중다회귀분석결과, KmSWN-19총점을 유의하게 예측하는 변인은 투약의 만족도, 투약을 빠뜨린 횟수 및 용돈이었으며, 변량의 24%를 설명하였다. 결 론 : KmSWN-19는 정신분열병 외래환자의 주관적 안녕감을 측정하는 자기평정척도로서 신뢰롭고, 타당하며 실용적임이 확인되었다. 아울러 KmSWN-19는 항정신병 약물과 관련한 주관적 안녕감에만 특이한 척도가 아니라, 척도에 응답할 수 있는 모든 정신분열병 환자나 기타 정신증 환자들에게 적용할수 있는 일반적 척도임이 시사되었다. 한편, KmSWN-19총점에 대해 독립변인들의 설명변량이 크지 않는 점을 주관적 안녕감 혹은 삶의 질의 평가에서 개인의 가치나 신념, 성격특성 같은 개인내적 특성을 고려해야 할 필요성이 있음을 시사한다. Objective : The purpose of this study was to develop the Korean modification of SWN(KmSWN), based on the original 38-item SWN(a self-rating scale to measure subjective well-being under neuroleptic treatment)by Naber et. al. In 1994, but containing the reduced number of items and the modified content. Methods: The KmSWN with 22 items and General Health Questionnaire/Quality of Life-12(GHQ/QL-12) were administered to 204 out-patients with schizophrenia. Also, their socio-demographic and clinical characteristics were investigated. Data analyses were conducted based on 176 patients whose responses to the scale, as well as whose related informations, were reliable. First, the reliability and validity of KmSWN were assessed comprehensively. Second, the relationships between the total score of KmSWN and the sociodemographic and clinical characteristics were examined. Finally, in order to identify the predictable variables on the total score of KmSWN, the stepwise multiple regression analysis was conducted, where the inde-pendent variables were already shown significant correlations with the total score of KmSWN. Results : Three of 22 items of KmSWN were excluded from the following analysis due to their poor internal consistency. KmSWN comprised with 19 items(KmSWN-19) showed high levels of spilt-half reliability(.91), mean of inter-item correlations(.38) and internal consistency (Cronbach alpha .92). Factor analysis of the KmSWN-19 revealed that a three-factor solution accounted for 100% of total explained variance. The three factors were interpreted as 'diss-atisfaction','physical and mental functioning', 'emotional regulation and self-control', The concurrent validity of KmSWN-19 with GHQ/QL-12 was very high(-.83). Of the socio-demographic and clinical characteristics, age, disposable money, socioeconomic level, number of previous hospitalizations, compliance with medication and satisfaction with medication were positively correlated with the total score of KmSWN-19, while severity of illness, severity of parkinsonism, severity of dyskinesia, administration frequency of medication and omission number of medication were negatively correlated. However, the total score of KmSWN-19 was not correlated with medication, the omission number of medication and the disposable money were significantly contributed to the total score of KmSWN-19, and they explained 24% of the variance. Conclusions : The above findings indicated that KmSWN-19 was a reliable, valid and pra-ctical self-rating scale to measure subjective well-being in out-patients with schizophrenia. Moreover, KmSWN-19 seemed to be a general scale applicable to all the schizophrenic or other psychotic patients if they were able to complete it, rather a specific scale only for the patients undergoing the neuroleptic treatment. Based on the results of the predictable variables on the total score of KmSWN-19, one may argue that intra-individual characteristics such as value, belief and personality traits, although they were not evaluated in this study, should be considered in assessing subjective well-being or the quality of life.

일산화탄소 폭로후 고압산소 재폭로시 흰쥐 신장 및 심장의 SOD 활성 변동에 관한 연구

전영희,백두진,황세진,박준숙,정호삼 한양대학교 의과대학 1997 한양의대 학술지 Vol.17 No.1

Carbon monoxide is generated from the incomplete combustion of carbon-containing materials. Carbon monoxide cause muscle necrosis leading to myoglobinuria and acute renal failure. The hyperbaric oxygen exposure is increased production of active free radicals. Free radicals which promoted peroxidation of unsaturated fatty acids may destroy essential cellular components and itself cytotoxic materials. Superoxide dismutase, one of the protective mechanisms against tissue damage, catalyzed the dismutation of superoxide anion to less toxic product. The author performs the present study to investigate on Mn-SOD and Cu, Zn-SOD immunoreactivities in kidney and heart carbon monoxide (CO) and hyperbaric oxygen (HBO) exposure. The animals were divided CO exposure group, air release after CO exposure group, HBO exposure group and, CO and HBO exposure group. The specimen were sectioned in 16㎛ with cryostate. The Mn-SOD and CuZn-SOD immunohistochemistry was performed in renal corpuscle, proximal and distal convoluted tubules of kidney and, in sarcoplasm and sarcolemma of heart muscle. The results obtained were as follows: 1. The immunoreactivity of Mn-SOD were increased in renal corpuscles and distal convoluted tubules, were similar to control group in proximal convoluted tubules. 2. The immunoreactivity of Cu, Zn-SOD were increased than that of control group in renal corpuscles and distal convoluted tubules, were same that of the control group in proximal convouted tubules. 3. The immunoreactivity of Mn-SOD were increased at all experimental group of sarcoplasms of heart muscle. 4. The immunoreactivity of Cu,Zn-SOD were increased than that of control group in sarcolemma of heart muscle. These results suggest that the immunoreactivity of SOD after CO or HBO exposure is greatly increased in kidney and heart.