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이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1
연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.
APT 골조공사의 공사관리 담당자의 업무현황파악에 관한 연구
이두진,홍성우,이명권 경운대학교 산업기술연구소 2001 産業技術硏究論文誌 Vol.3 No.2(C)
With the social demands for tall building, the level of techniques for construction become high and there are various building materials. Also, the construction system become very complicated with the increase of worker. In spite of above facts, the method of construction management depends on the experimental capacity of a construction manager, and there are many unreasonable elements. These elements prevent Well-going in construction process. To solve this problem, it is necessary to make a new system of construction management which is adequate for the condition of company and the contents of construction. In this study, the characteristic of production system and the present condition of construction management were investigated with the help of survey. Thus, the new method of construction management which can clear the previous problems was proposed.
이두진,손재진,최민권 경운대학교 산업기술연구소 2001 産業技術硏究論文誌 Vol.3 No.2(B)
With the social demands for tall building, the level of techniques for construction become high and there are various building materials. Also, the construction system become very complicated with the increase of worker. In spite of above facts, the method of construction management depends on the experimental capacity of a construction manager, and there are many unreasonable elements. These elements prevent well-going in construction process. To solve this problem, it is necessary to make a new system of construction management which is adequate for the condition of company and the contents of construction, In this study, the characteristic of production system and the present condition of construction management were investigated with the help of survey. Thus, the new method of construction management which can clear the previous problems was proposed.
이두진,박찬돈,이상관 경운대학교 산업기술연구소 2001 産業技術硏究論文誌 Vol.3 No.2(B)
The purpose of process planning is to minimize the total duration of building construction. Multi-site scheduling method is one of the solutions of it. But, to use the Multi-site scheduling method, we must synchronize the time of each job. For this reason, Building Structure must be limited. In this paper, put into a formula to calculate the scheduling in the case of Multi-Building Construction without the limitation of the structure. Thus this paper are studied with the view of observation under the condition of the process and the term of works that it is increased a team of the longest works.
李두漢,李振鎬 慶一大學校 1993 論文集 Vol.9 No.1
In this paper, we present the identification of Ojbect-Oriented modeling of computer GO game and report our initial investigations of its programming. Because the GO game has enormous search space and complicated structure, it is difficult to apply traditional techiniques. A proposed model is analogous to intellection of human and a platform for programming to imply precisely structure of GO. We implemented a GO program with this model.
이수영,유두식,정순열,정진상 건국대학교 의과학연구소 1998 건국의과학학술지 Vol.8 No.-
To assess whether the development of plantar foot ulceration could be predicted from the mean plantar foot temperature(MFT), as assessed by digital infrared thermographic imaging(DITI), in patients with or without diabetic polyneuropathy or foot ulceration, 46 feet with no diabetic polyneuropathy(group Ⅰ), 40 feet with diabetic polyneuropathy(group Ⅱ), and 17 feet with diabetic foot ulcer(group Ⅲ) were assessed by DITI in six standard plantar sites and were correlated with laboratory findings (blood sugar, hemoglobin Alc, C-peptide). Total MFT was significantly higher in group Ⅲ(33.18±1.86℃) than group Ⅰ(29.13±1.63℃) or group Ⅱ(30.89±1.51℃). There were increasing tendency of focal MFT in the third metatarsal head and greater toe where revealed higher incidence of foot ulceration. There was a trend toward elevation of glycosylated hemoglobin(HbAlc) in groupⅢ. In conclusion, DITI is a simple, noninvasive method of idenfifying the neuropathic foot at increased risk of ulceration. Patients with high plantar foot temperature are at increased risk of neuropathic foot ulceration.
신규개발된 제초제 metamifop 현탁농축액제에 대한 급성독성평가
이동연,이상훈,백경진,김태원,정두순,임종환,김명석,박병권,윤효인 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-
Metamifop, (R)-2-[4-[(6-chloro-2-benzoxazolyloxyphenoxy]-N-(2-fluorophenyl)-N-methyl propanamide, was newly developed by Dongbu Hannong Chemicals in Korea. In the present study we conducted acute oral toxicity and acute dermal toxicity test. The values of LD_(50) of metamifop was found to be over 5,000 mg/kg for ICR mice. On the other hand, metamifop showed no acute dermal toxicity to SD rats.
현장관리 업무체계의 실태조사 연구 : 시공 중 업무를 중심으로
이두진 경운대학교 산업기술연구소 2002 産業技術硏究論文誌 Vol.5 No.1(B)
With the social demands for tall building, the level of techniques for construction become high and there are various building materials. Also, the construction system become very complicated with the increase of worker. In spite of above facts, the method of construction management depends on the experimental capacity of a construction manager, and there are many unreasonable elements. These elements prevent well-going in construction process. To solve this problem, it is necessary to make a new system of construction management which is adequate for the condition of company and the contents of construction. In this study, the characteristic of production system and the present condition of construction management were investigated with the help of survey. Thus, the new method of construction management which can clear the previous problems was proposed.