Molecular Design and Synthesis of pH-sensitive Polymeric Sensor For Intramolecular Fluorescence Resonance Energy Transfer

홍성우,김건형,안철희,조원호 한국고분자학회 2004 한국고분자학회 학술대회 연구논문 초록집 Vol.2004 No.04

대장암에서 p53 단백 과발현과 전이와의 관계

홍성우,강윤경,나양원,장석효,백인욱,장여구,이혁상 대한소화기학회 2000 대한소화기학회지 Vol.35 No.1

Background/Aims: The long-term survival of patients with colorectal cancer is largely dependent upon the cancer metastasis. The authors analyzed the association between p53 overexpression and metastasis. Methods: We evaluated p53 overexpression in colorectal cancer tissue of 41 patients by immunohistochemical staining method. Twenty patients showed no metastasis over a 5 years period postoperatively. Ten patients had synchronous metastasis and 11 patients showed metachronous metastasis. Results: p53 protein was overexpressed in 35% (7) of the patients (11) with non-metastatic tumors and 71% of the patients with metastatic tumors (p$lt;0.05). The p53 overexpression rates were 11% in cases of right colon cancer, 61% in cases of left colon cancer and 75% in cases of rectal cancer (p$lt;0.05). Excluding the patients with synchronous metastasis, the patients with p53 overexpressed tumors had worse prognosis than those without p53 overexpression, and the 5-year survival rate was 53% in the patients with p53 overexpression and 94% in the patients without p53 overexpression, respectively (p$lt;0.05). Conclusions: p53 overexpression seems to be a good prognostic factor for the cancer metastasis as well as the survival of the patients with colorectal cancer.

Villard de Honnecourt: 스케치북의 저자와 특성

홍성우 한국건축역사학회 1998 건축역사연구 Vol.7 No.3

Even though Gothic architecture, one of the most technologically complex sophisticated structural systems, has been interpreted by art and architectural historians since the nineteenth century, we still cannot entirely comprehend either the medieval builder's constructional technique and structural knowledge or the meaning of Gothic architectural elements. The major reason is that contemporaneous written documentation concerning design methods and constructional techniques of medieval architecture is lacking. In 1955, the Bibliotheque Nationale in Paris exhibited the sketchbook of the thirteenth century architect Villard do Honnecourt. After the exhibition, analysis on the architectural drawings of Villard's sketchbook had reported widely. Most of analysis on Villard, however, has been on his drawing and artistic style, and there has been very little published analysis of his profession and question on the author of the sketchbook. Thus, the purpose of this study is to investigate the characteristics of the sketchbook and identify the artist who drew it. The sketchbook poses a number of unsolved questions. There is no doubt that several hands have contributed some drawing with appropriate captions, particularly in the section devoted to the application of practical geometry to problems of masonry and carpentry. Scholars have assumed and revealed that it was not made by only one person, and it dealt too many different fields and styles. Through this study, the sketchbook drawings consist of five different styles and person (original painter, master1, master2, master3, and the last owner), and they, not Villard, just redrew the original drawings and bound the sketchbook. Therefore, Villard de Honnecourt was just a mentor of the sketchbook and he did not participate any writing and drawing in the sketchbook.

단독주택의 간이스프링클러설비 적용에 관한 연구

홍성우,이영재 한국화재소방학회 2008 한국화재소방학회논문지 Vol.22 No.4

Presently, there is no legal regulation pertaining to the installation, maintenance, management and operation of fire-fighting facilities in single housing in Korea, relying instead on the awareness of the residents which hopefully will prevent fire. Likewise, accident prevention effort is very limiting and weak. Accordingly, this research examines current situation in which fire results, identifies root causes and studies application of regulations and develop design measures centered on the single housing that is most afflicted with fire. As part of the measure to prevent fire that afflict housing, it is necessary to classify single housing as specific target for fire fighting just like the joint housing among the types of the building structures that are classified according to the usage on the "Appendix Chart I of the Enforcement Ordinance of the Construction Law" for management purpose. Moreover, it is necessary to make the installation of fire-fighting facilities such as simple sprinkler facility for residential area, fire extinguisher, warning system and others for the sake of the senior citizens and disabled people who reside in single housing, mandatory. 현재 국내 단독주택은 소방시설의 설치유지 및 관리운영에 대한 법적규제가 없을 뿐 아니라, 거주자의 자율 화재예방 의식에 의존하고 있어 방재에 취약하고 열악한 실정이다. 따라서 본 연구는 주택화재의 가 장 큰 비중을 차지하는 단독주택을 중심으로 화재의 발생현황 및 문제점과 법규적용 및 설계방안을 연구 하였으며, 주택화재의 방재대책으로 "건축법 시행령 별표 1"의 용도별 건축물의 종류 중 단독주택은 공동 주택과 같이 특정소방대상물로 분류하여 관리토록 하여야 할 것이며, 단독주택에 거주하는 고령자, 장애인 등을 고려한 소화기, 경보설비, 주거용 간이스프링클러설비 등의 소방시설 설치를 의무화 하도록 하여야 할 것이다.

롤즈의 정의의 원칙에 관한 고찰

홍성우 圓光大學校 社會思想硏究所 1994 社會思想硏究 Vol.4 No.-

미국의 불법체류 청소년 추방유예제도와 최근의 폐지 논의

홍성우 한국노동연구원 2017 국제노동브리프 Vol.15 No.11

실시간 멀티미디아 스트리밍을 위한 계층 통합 패킷 스케줄링 기법

홍성우,원유집 한국통신학회 2009 韓國通信學會論文誌 Vol.25 No.5

본 연구의 목적은 패킷 스케줄링을 통하여 사용자가 느끼는 QoS 를 극대화함에 있다. 이를 위해 제안하는 중요성 기반 패킷 스케줄링 기법은 패킷 스케줄링의 두 가지 근본적인 문제를 해결한다. 하나는 “무엇을 보내는가” 이고 다른 하나는 “언제 보내는가“ 이다. 대역폭에 적응하기 위해 모든 패킷을 보낼 수 없을 경우에는 일부의 패킷을 선택해서 보낼 수밖에 없다. 이를 위해 효과적으로 프레임 상관관계를 파악하고 프레임의 중요도를 정량화하는 패킷 Significance 개념을 제안한다. Greedy 기법이 패킷 선택 문제에 사용되었고, 패킷 Significance 를 고려하여 간격이 할당되었다. 널리 공개된 MPEG-4 비디오 클립이 실험에 사용되었으며, 네트워크 시뮬레이션 (network simulator version 2)에 디코딩 엔진이 삽입되었고, 성능 평가를 위해 PSNR을 측정하였다. 크기 기반 및 비트 레이트 기반 최선 패킷 스케줄링 기법과 성능을 비교 분석하였다. 본 연구에서 제안하는 중요성 기반 패킷 스케줄링 기법이 성공적으로 더 중요한 패킷에 차별화 된 보호 기법을 적용하였으며, QoS를 크게 향상시키는 것을 확인할 수 있었다.

정책 및 사업평가 : 사회간접자본 확충의 지역적 파급효과 분석 -서해안고속도로 개통을 중심으로-

홍성우,김광구 한국정책학회 2008 한국정책학회 학술대회 Vol.2008 No.1

Matrix Metalloproteinase-2 and -7 Expression in Colorectal Cancer

홍성우,강윤경,이병모,이우용,장여구,백인욱,이혁상 대한대장항문학회 2011 Annals of Coloproctolgy Vol.27 No.3

Purpose: Matrix metalloproteinase-2 (MMP-2) and MMP-7 have been implicated in tumor growth and metastasis. This study aimed to investigate the expressions of MMP-2 and -7 in colorectal cancer and to evaluate their values as prognostic markers. Methods: Immunohistochemical staining for MMP-2 and -7 was done in 144 resected colorectal cancer specimens. Clinicopathological data and survival results were compared with regard to the expression results. Results: The expression rates of MMP-2 in tumor cells in the tumor center and the tumor border were 16.7% and 38.9%,respectively. That of MMP-2 in stromal cells was 27.8%. MMP-7 immunoreactivities of tumor cells in the tumor center and the tumor border were 6.9% and 23.6%. The expressions of MMP-2 and MMP-7 were correlated. MMP-2 expression in stromal cells was more increased in the distal part of the colorectum: 8.8% in right colon cancer, 29.5% in left colon cancer and 36.4% in rectal cancer. MMP-2 expression of tumor cells in the tumor border was correlated with T-stage. MMP-7 expression of tumor cells in the tumor border was increased in case of infiltrative cancer compared with fungating tumor. The expression patterns of MMP-2 and -7 were not correlated with other clinicopathological factors, including tumor markers,node metastasis, distant metastasis, lymphatic invasion, tumor differentiation, and recurrence. No significant associations between the overall and disease-free survival rates and the MMP-2 and -7 expression patterns were noted. Conclusion: The high expression rates of MMP-2 and -7 in tumor borders suggest that MMP-2 and -7 have some role in tumor invasion, but in this study, MMP-2 and -7 did not appear to be significant predictors of prognosis in colorectal cancer.

안드로이드를 이용한 영수증앱 개발 연구

홍성우,홍소희,윤자경,김푸름 한국정보처리학회 2017 한국정보처리학회 학술대회논문집 Vol.24 No.2

종이 영수증으로 인한 환경적, 재정적 손실을 줄이고 소비생활의 편리함을 향상시키고자 영수증앱을 구상하게 되었다.