교정력의 즉시 부하가 미니스크류의 제거 회전력에 미치는 영향의 평가

선승범,강윤구,김성훈,모성서,국윤아 대한치과교정학회 2007 대한치과교정학회지 Vol.37 No.6

교정치료에서 고정원의 조절은 교정 장치의 선택과 적용에서 가장 중요한 요소 중 하나이다. 이 연구의 목적은 교정용 미니스크류의 식립 즉시 교정력을 적용한 군과 교정력을 적용하지 않은 군의 제거회전력 측정과 조직학적 분석을 통해 즉시 교정력을 가한 미니스크류의 고정원으로서의 안정성을 확인하여 식립 후 교정력을 적용 수 있는 시기의 선택에 도움을 주고자 하는 것이다. 외경 1.6 mm, 길이 8 mm인 총 40개의 타이타늄 미니스크류를 10마리 가토의 경골에 식립하였다. 20개의 미니스크류 실험군은 식립 직후부터 6주동안 지속적인 200g의 교정력을 적용하였고 나머지 20개의 미니스크류 대조군은 교정력을 적용하지 않았다. 제거 회전력은 디지털 토크 게이지를 이용하여 측정하였으며 t-test를 이용하여 통계처리 하였고, 조직표본은 미니스크류를 제거한 후 H-E 염색하여 조직 소견을 관찰하였다. 제거회전력은 실험군과 대조군에서 통계학적으로 유의성 있는 차이를 보이지 않았으며, 조직학적으로 두 군간의 차이는 없었다. 본 연구의 결과는 교정용 미니스크류에 즉시 교정력을 가하더라도 안정적인 고정원으로 활용할 수 있다는 점을 제시한다. Objective: The purpose of this experimental study was to evaluate the effect of immediate orthodontic loading on the stability at the bone-implant interface of titanium miniscrews in a rabbit model. Methods: Forty titanium miniscrews (1.6 mm diameter, 8 mm length) were inserted in the tibiae of 10 rabbits. Twenty test group miniscrews were subjected to continuous orthodontic forces of 200g immediately after implantation for a period of 6 weeks. The remaining 20 control group miniscrews were left unloaded for the same follow-up interval. Removal torque values were recorded using a digital torque gauge. An independent t-test was performed. Results: All the miniscrews were stable, and exhibited no mobility or displacement throughout the experimental period. Histologically, miniscrews were well-integrated into bone. No statistically significant differences in removal torque data were found between the loaded test and the unloaded control groups. Conclusions: These findings suggest that titanium miniscrews can be used as anchoring units for orthodontic tooth movement immediately after insertion.

A transcervical amniotic fluid collector: a new medical device for the assessment of amniotic fluid in patients with ruptured membranes

Lee, Seung Mi,Romero, Roberto,Park, Joong Shin,Chaemsaithong, Piya,Jun, Jong Kwan,Yoon, Bo Hyun Walter de Gruyter GmbH 2015 Journal of perinatal medicine Vol.43 No.4

<B>Abstract</B><P>To describe a new device for the transcervical collection of amniotic fluid (AF) in patients with ruptured membranes, and to compare the concentration of proteins in fluid retrieved by transabdominal amniocentesis and the transcervical AF collector.</P><P>Paired AF samples were collected in patients with preterm prelabor rupture of membranes (PROM) (n=11) by transabdominal amniocentesis and with the transcervical AF collector (Yoon’s AF Collector™). Three proteins known to have high concentrations in AF [α-fetoprotein (AFP), β-human chorionic gonadotrophin (β-hCG), and prolactin] were measured.</P><P>(1) There was a significant correlation between the concentrations of analytes in AF obtained by transabdominal amniocentesis and by the transcervical AF collector (r=0.94, P<0.001 for AFP; r=0.96, P<0.001 for β-hCG; r=0.72, P<0.05 for prolactin); (2) Bland-Altman plots showed no evidence of heteroscedasticity between transabdominal or transcervical AF concentrations of these markers.</P><P>There was a strong correlation between the concentrations of proteins in AF collected by amniocentesis or with the transcervical device.</P>

아침형-저녁형의 측정을 위한 한국어판 조합척도의 교차 타당화

이형영,윤진상,국승희 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.2

연구목적 : 일주기 리듬의 유형을 분류하는 설문지는 일주기 리듬을 연구하고, 교대근무의 적응력을 예측하기 위해 개발이 필요하다. 본 연구에서는 Smith 등 (1989)의 조합척도를 한국어판으로 표준화한 윤진상 등(1997)의 한국어판 조합척도(Korean translation of Composite Scale : KtCS)를 실제 직장인들에게 적용할 수 있는 지를 확인하고자 하였다. 방 법 : 간호사 115명(순환교대 근무자 85명, 주간고정 근무자 70명)과 여대생 247명을 대상으로 KtCS와 생활습관 설문지(Life Habit Questionnaire : LHQ)를 배포하였다. 간호사 군과 여대생 군 각각에 대해 KtCS 점수의 분포도를 검증하고 백분위 10이하의 점수를 받은 군을 저녁형, 백분위 90이상의 점수를 받은 군을 아침형, 그 중간의 점수를 받은 군을 중간형으로 정의하였다. 두 군 각각에서 KtCS 점수의 내적 일치도를 구하고, 요인 분석을 하였으며, 일주기 리듬의 유형에 따른 생활습관의 차이를 분석하였다. 결 과 : 간호사 군과 여대생 군 각각의 KtCS 점수는 부적으로 편포되어 있었으나 유의하지는 않았고, KtCS의 평균점수에서도 유의한 차이가 없었다. 간호사 군에서 Cronbach alpha는 .836이었으며, “취침과 가상의 선호시간”, “아침의 각성”, “기상시간”의 세 요인이 추출되었는데, 문항 11이 요인 1에 추가적으로 부하된 경우 외에는 본 연구의 여대생 군 및 윤진상 등 (1997)의 요인분석 결과와 거의 동일하였다. 여대생 군에서 KtCS의 내적 일치도는 Cronbach alpha .787이었고, “취침과 기상의 선호시각”, “기상시각”, “아침의 각성” 세 요인이 추출되었다. 또한 간호사 군과 여대생 군 각각의 생활습관에서도 일주기 리듬간에 유의한 차이가 있었다. 즉 각성, 수행, 업무 혹은 학습효과가 최고조에 이르는 시간대는 저녁형이 가장 늦고, 다음이 중간형, 아침형 순이었으며, 오전 학습효과는 아침형이, 저녁의 학습효과는 저녁형이 가장 높았으나, 오후의 학습효과에서는 저녁형과 아침형 간에 유의한 차이가 없었다. 취침시각과 기상시각은 저녁형이 가장 늦었지만, 총 수면시간에서는 저녁형, 중간형, 아침형 간에 유의한 차이가 없었다. 결 론 : 간호사에서 KtCS의 심리측정 속성은 여대생에서의 분포도, 내적 일치도, 타당도가 매우 유사하였고, 윤진상 등(1997)의 연구결과와도 유사하여서, KtCS 활용의 일반화 가능성이 시사된다. Objectives : It is necessary to develop a questionnaire to classify the circadian rhythm for studying circadian rhythms and predicting shift work adaptability. This study attempted to confirm the general applicability of “Korean translation of Composite Scale : KtCS)” by Jin-Sang Yoon et al(1997), a Korean version of Composite Scale(CS) by Smith et al(1989). Methods : KtCS and Life Questionnaire(LHQ) were administered to 155 nurses(65 rotating shift nurses,, 70 nurses on a fixed day schedule) and 247 female university students. We tested the distribution of KtCS scores and then subjects were categorized on the basis of their KtCS scores into evening(E), intermediate(I), and morning(M) types. Cut-off points for these categories were set at the 10th and 90th percentiles. We obtained the results of the internal consistency and the structure of factors of KtCS. We also compared the difference of life habits according to the circadian rhythm types. Results : In both groups, nurses and female university students, the distributions of KtCS score were negatively skewed but not significantly and the KtCS mean score was not significantly different. In nurses, Cronbach's alpha was 0.836, and three extracted factors were ‘preferred times of performance and going to bed’, ‘rising time’ and ‘morning alertness’. In female university students, Cronbach's alpha was 0.787, and the same three factors as nurses were confirmed. However, only item 11 was loaded to factor 1 for the nurse group, whereas it was loaded to factor 2 for the student group. Life habits significantly differed among the three circadian rhythm types. The time of perceived peak alertness(mental and physical) was the latest in the E-type. The quality of academic performance during the morning was the highest in the M-type, and during the evening it was the highest in the E-type, but during the afternoon there was no significant differences among the three types. The bedtime and the rising time were latest in E-type, but the sleep lengths were not significantly different among the three types in both groups. Conclusion : The psychometric properties of KtCS in nurses were very similar to those of female university students and the previous findings of Jin-Sang Yoon et al(1997). This result supports that KtCS can be generally applied.

체력단련이 숨참기동안 및 회복기의 혈압과 심박동수에 미치는 영향

이영만,윤봉영,윤성수,김준곤,이상렬,김성호,배계숙 최신의학사 1984 最新醫學 Vol.27 No.11

고온 접촉식 탐상용 초음파 탐촉자 개발 및 평가

김기복,김병극,이승석,윤남원,윤동진,안윤국 한국비파괴검사학회 2003 한국비파괴검사학회지 Vol.23 No.1

고온(500℃) 환경에서 접촉식 탐상이 가능한 초음파 탐촉자를 개발하고 평가하였다. 고온용 탐촉자는 Curie 온도가 600 ℃ 이상인 bismuth titanate 계열의 압전세라믹 소자, 텅스텐 분말과 inorganic binder를 혼합한 후면재, 알루미나 튜브, 전면재, 하우징 등으로 구성되었다. 기본 공진주파수가 각각 1.04 및 2.08 ㎒의 2 종류 탐촉자를 제작하였으며 각종 고온용 커플런트의 온도특성을 시험하였다. 개발된 고온용 탐촉자를 이용하여 강재 시편을 대상으로 시편에서의 초음파 반사신호를 측정한 결과 시편의 온도가 증가함에 따라 반사신호의 크기는 감소하였다. 고온에서 반복측정 실험결과 500℃에서 연속적인 접촉식 초음파 탐상이 가능한 것으로 나타났다. Piezoelectric ultrasonic transducers for high temperature contact measurement were developed. These high temperature ultrasonic transducers (HTUT) consisted of bismuth titanate piezoceramic element whose Curie temperature is higher than 600℃, a backing material of the mixture of tungsten powder and inorganic binder, an inner alumina tube, a wear plate and a housing. The operational frequencies of the HTUT were 1.04 and 2.08 ㎒, respectively. Various commercially available couplant for high temperature were evaluated and compared. As a couplant for high temperature ultrasonic testing between HTUT and test specimen, gold epoxy was selected. The peak amplitude of pulse-echo signals from steel test specimen decreased with increasing temperature. The operational temperature of the HTUT reached up to 500℃ at which the continuous contact measurement was possible.

C3H 생쥐에서 자외선 B의 집중조사와 분할조사가 표피내 랑게르한스 세포의 회복에 미치는 영향

구상완,한승경,박윤기,조무연 ( Sang Wahn Koo,Seung Kyung Hann,Yoon Kee Park,Moo Yon Cho ) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.4

N/A The Effect on the Recovery of Epidermal Langerhans Cells in C3H Mice after Single and Fractionated Exposure of Ultraviolet B Irradiation Sang-Wahn Koo, M.D., Seung Kyung Hann, M.D., Yoon-Kee Park, M.D., Moo Yon Cho, M.D. Department of Dermatology, Yonsei University College of Medicine Seoul, Korea The study was undertaken to see the recovery in epidermal Langerhans cells in relation to time after UVB irradiation through different amounts and ways of exposure in C3H mice. We irradiated the ears of C3H mice with UVB 200mJ/㎤ and 400mJ/㎤ in a single dose at one time and 5 fractionated doses for 5 days and 10 fractionated doses for 10 days and performed biopsies on the ears of the control and experimental groups after, 2, 7, 14, 21 days of irradiation and stained them by the immunoperoxidase method. The results are summarized as follows. 1. A more significant decrease in the number of Ia-positive epidermal Langerhans cells was observed in single-dose-exposed group than fractionated-dose-exposed groups on the second day of irradiation. 2. On the seventh day of exposure, the number of the Ia-positive epidermal cells in single-dose-exposed group returned to normal, but in fractionated-dose-exposed groups the number of Langerhans cells decreased most remarkably. 3. In fractionated-dose-exposed groups, the number of Langerhans cells returned to normal on the 14th or 21st day of expposure. (Kor J Dermatol 29(4) : 459-465, 1991)

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

複合 韓藥劑 淸籬滋坎湯의 抗癌效果 및 作用機轉 糾明

Cho, Kyung-Sam,Kim, Si-Young,Park, Jai-Kyung,Choi, Seung-Hoon,Chung, Se-Young,Yoon, Hwi-Joong 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Kyung Sam Cho¹Si Young Kim¹, Jai Kyung Park²,Seung Hoon Choi³,Se Young Chung⁴, Hwi Joong Yoon¹¹College of Medicine, ²East-West Medical Research Institute, ³College of Oriental Medicine, ⁴College of Pharmacology, Kyung Hee University,Seoul, Korea. The Anti-cancer Effect of Oriental Medicine Chung-Ri-Ja-Gam-Tang in the Mouse with Metastatic Lung Cancer. Proceedings of International Symposium on East-West Medicine, Seoul. 231-243, 1999.-The oriental medicine Chung-Ri-Ja-Gam-Tang is an herbal medicine which has been used for pulmonary diseases and known as having immune stimulatory effects. It has been known effective in lung cancer. So we studied the effects and the mechanisms of this herbal medicine it the mouse with metastatic lung cancer. The metastatic lung cancer of the mouse was produced with melnoma cell line(B16BL/6).5×10□/mouse tumor cells were injected intravenously to the CDF1 mouse via tail vein. The mice were divided 4 groups. The first group was treated with 50mg/kg extract of Chung-Ri-Ja-Gam-Tang per oral for 10 days after cancer cell injection, second group treated with saline after cancer cell injection, the third group with medicine without cancer cell, and the last group with saline only. After 10 days treatments some of the mice were scarificed and the lung and spleen was removed. The survival duration, weight change, the number of metastatic cancer nodule of the lung, the NK cell activity, the capacity of cytokines(INF-γ,INF-α,IL-2) production and the proliferation activities of mouse lymphocytes were measured. The surival times of the group 1 mice were longer and the weight loss was less than the group 2 significantly. The number of the metastatic nodule of the lung were decresed in the group 1 than the group 2. The production of INF-γ,was increase in group 2 than group 3 and 4, IL-2 production was increased in group 1 than group 2,3,4 significantly. There was no difference in TNF- α production and proliferation activity of lymphocyte in each group. The NK cell activity was significantly increased in group 1 than group 2,3,4. We conclude that the Chung-Ri-Ja-Gam-Tang has the effect of increasing the NK cell activity of the CDF1 mouse with metastatic lung cancer(B16BL/6). And it is suggested that the increased production of the IL-2 is the mechanisms of enhanced NK cell activity.

군산 구(舊)조계지의 필지변화와 주거건축에 관한 연구

윤도선,홍승재 대한건축학회 2004 대한건축학회논문집 Vol.20 No.1

The characteristic and change of dwelling architecture of Japanese and plot transition were analyzed with the old international settlement in Gunsan. By learning about one side of modern history that was broken off in the historical form of dwelling and observing the dwelling environment that have been changing historically, it can be significant as the basic material of observing our dwelling today. Along with prior investigations and studies related to the late 19th century (opening of port period) urban dwellings, the urban tissue was analyzed through documents about the history of Gunsan city and other cities that were occupied by Japan. In addition, along with survey investigation based on the cadastral map, construction management register and aerial map, I also worked on drawing up dwellings and urban tissue. As for the time range, the urban tissue of Gunsan, before opening of port, and after opening of port from 1899 to 1945 during the Japanese Occupation, was studied. And, the urban tissue was studied up to the current 2002, where the plot transition is changing or continuously maintained. As for the district subjected for study, the established international settlement district of Gunsan during the early stage of opening of port, was established as spacial range, focusing on Yeonghwa-dong which was the center of international settlement district, which was abolished in 1913. This was the first district in Gunsan to be planned with grid streets structure, and this could be said to be the main dwelling that keeps the characteristic of Japanese dwellings. The old international settlement of Gunsan has become the center of urban tissue development of the current Gunsan, and the initially established street pattern influenced the form and plot of dwellings. The dwellings have been changing with correlation to the current plot. As the plot line is fixed according to the line divided within a long building(長屋), the form is changed through a small scale of subdivided plots combining, in the process of new construction by removing the existing structures again. The plot is changing of possessing one-way improvement only by facing the street, as the bare grounds (alleyway) disappeared. The dwellings in this district, long buildings or machiyas(町屋), have developed with precedent pattern according to the street, and the dwellings have developed in the direction of inner household. In addition, as for the dwelling space, there was change in the use and extension, due to the factors such as difference in style, change in life style and modernization of accommodation system.

학교불소용액 양치사업 평가에 관한 조사연구

윤신종,신승철 단국대학교 치의학연구소 1991 논문집 Vol.3 No.-

The author have surveyed 1634 school children for experimental group and 886, for control, through the oral examination and questionaires, the school based fluoride mouth rinsing program that had been done for several years at some elementary schools for pilot projects. Questionaires were proposed to parents of students, teachers and school nurses also. The obtained results were as follows. 1. It was estimated that the fluoride mouth rinsing program were well performed for several years in the initial periods of the projects as about 30% of caries reduction effect. But there were less efforts as years progresses and now only 40% of schools were continued at the program. 2. The most school children and parents of students were in favor for fluoride mouth rinsing program on the other hands, teachers and school nurses disliked or were indifferences. So comprehensive readjustment were needed to promote the school based fluoride mouth rinsing program. 3. In order to pormote and to spread to all over the Korea, the authorities of the Ministry of Health and Welfare and the Ministry of Education as well as dentists and school teachers should be take part in the program. And it should be needed that the department of oral health wer established to control the school based fluoride mouth rinsing program, in Korea.