Vibrio vulnificus에 의한 패혈증 3예

김신무,김유현,신상희,오재세,강숙희,윤여안,이화재,김영옥 대한임상병리사협회 1986 임상병리사회지 Vol.18 No.1

양측성 알도스테론 분비 선종 1 예

김동규,김규태,이상조,신형식,김학양,유재영,배수동,임성희,김병태,김종혁,송숙희 대한내과학회 1991 대한내과학회지 Vol.41 No.5

Primary aldosteronism is a condition in which chronic aldosterone excess exists independently or semiindependently of the renin-angiotensin system, resulting in hypertension and hypokalemia. The most common cause of primary aldosteronism is unilateral aldosterone-producing adrenal cortical adenoma. The indiopathic aldosteronism showing bilateral adrenocortical hyperplasia accounts for the bulk of the remaining cases. Only rare cases of primary aldosteronism are known to be due to multiple aldosterone-producing adrenocortical adenoma. We report a case of primary aldosteronism due to bilateral adenomas, which was diagnosed preoperatively by abdomen CT and then confirmed by operation and pathological findings.

봄철 익산지역 환경대기 중 수용성 이온성분의 일별 침적량

김남송,강공언,김정숙,김현아,신지혜,김병수,최석진 원광대학교 대학원 2008 論文集 Vol.40 No.-

Deposition samples were collected in wet gauge and dry gauge containers at downtown of Iksan city, located southwest of the Korean peninsula, from April 20 to May 1, 2004. The volume of 30-50㎖ deionized water was added for wet gauge before sampling, but dry gauge was installed in the dry state with no deionized water adding. These samples were collected twice a day during daytime and nighttime and were analyzed for anions(Cl^(-), NO^(3-), SO₄^(2-)) and cations (NH₄^(+), Na^(+), K^(+), Mg^(2+), Ca^(2+)) using ion chromatography. Data quality was checked by the data obtained from re-injection of standard solution, Dionex cross check standard solutions, and random several deposition samples, and measured data was estimated to be reliable. Considering the deposition sample volume, the sampling time, the surface area of sampling container, and the ion concentration measured, the deposition amounts were calculated in mg/㎡/day. The sum of ion dry deposition amounts for dry gauge and wet gauge was 9.1±6.7 mg/㎡/day and 26.5±9.1 mg/㎡/day, respectively. A significant increase in deposition amount during rainfall days and Asian yellow dust period was observed for both wet gauge and dry gauge, especially during rainfall days having no difference of deposition amount between in wet gauge and in dry gauge. The mean deposition of all ions measured in this study were higher in wet gauge than in dry gauge because of the surface difference of the sampling container. The mean deposition amount of NH₄^(+), SO₄^(2-), and NO^(3-) in wet gauge were found to be about 27.6 times, 5.5 times, and 3.4 times higher. than that in dry gauge, while the rest of the chemical species were equal or a little higher in wet gauge than in dry gauge. Dominant species in dry gauge were SO₄^(2-) and Ca^(2+), accounting for 14.7% and 47.3% of the total ion dry deposition, whereas those in wet gauge were SO₄^(2-) and NH₄^(+), accounting for 27.7% and 27.1% of the total ion dry deposition, respectively.

곰쓸개 복용 후 발생한 육안적 혈뇨와 신유두부 괴사증 1예

김우진,한민석,김수항,박인형,박진석,선제형,홍세인,박옥영,신정현,이숭,신병철 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.3

Renal papillary necrosis occurs most commonly in association with urinary tract infection, diabetes mellitus, sickle cell disease, vascular disease, and analgesic nephropathy. Clinical presentation may be related to symptoms of pyelonephritis such as flank pain, renal colic, hematuria, Proteinuria, recurrent fever. The necrotic tissue may be sloughed off, and the diagnosis can sometimes be made by finding piece of renal medullary tissue in the urine. Pyelography may demonstrate cavities and sinuses in the resion of papillae. Anuria & oliguria can lead to the acute renal failure, and especially prognosis and progress may be affect influenced by urinary infection. We report a case of renal papillary necrosis with ingestion of bear gallbladder. On pyelography, Persistent contrast is diagnostic clue of renal papillary necrosis. This case is not be related to urinary tract infection, but occurred acute renal failure. Expectant treatment was gone.

무증상의 현미경적 혈뇨를 동반한 성인 환자에서 신조직 검 사의 유용성

김형종,최훈영,김동기,김현진,장제현,김현욱,최규헌,이호영,한대석,강신욱 대한신장학회 2003 대한신장학회잡지 Vol.22 No.6

양극성 기분장애에서 세로토닌 수용체 유전자의 다형성(102T/C)에 관하여

지익성,신석철,왕성근,이선우,신용재,김충수,김상국,최하석,오승용,류택근,이영호 대한생물치료정신의학회 1999 생물치료정신의학 Vol.5 No.2

Plenary Session 2 : PS-2-1 ; Outcomes of hepatitis B virus recurrence after liver transplantation: a multicenter analysis in Korea

( Hee Yeon Kim ),( Jong Young Choi ),( Dong Goo Kim ),( Myoung Soo Kim ),( Soon Il Kim ),( Shin Hwang ),( Sung Gyu Lee ),( Kwang Woong Lee ),( Kyung Suk Suh ),( Young Seok Han ),( Dong Lak Choi ),( Se 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-

Background: The outcome of hepatitis B virus (HBV) infection after liver transplantation (LT) was improved by hepatitis B immunoglobulin (HBIG) and nucles(t)ide analogue (NUA). However, HBV recurrence after LT is critical because the recurrence is occasionally accompanied by a progressive destruction of graft and poor survival. The aims of this study were to investigate the significance HBV recurrence and identity factors associated with HBV recurrence. Methods: From October 1999 to February 2011, a total of 2684 consecutive LT recipients who underwent HBV-associated LT were retrospectively enrolled from 7 transplantation centers in Korea. Results: Prophylaxis regimens were HBIG monotherapy (67.7%) or a combination of HBIG with NUA (22.3%). The recurrence rate of HBV was 6.1% (164 recipients) during mean follow-up duration of 10.9 years. The median time from transplantation to recurrence was 2.1 years (0.1-7.9 years). Of the 1,071 patients with hepatocellular carcinoma (HCC) prior to LT, 155 patients (14.5%) had HCC recurrence after transplantation, and 48 patients (31.0%) had HBV recurrence. Of the 48 patients with recurrence of both HBV and HCC, 25 patients (52.1%) experienced HBV recurrence after HCC recurrence. In the multivariate analysis, pretransplant HCC, pretransplant HBV DNA above 5.5 log copies/mL was independent clinical factors influencing HBV recurrence after LT. The mortality rate among the recipients with HBV recurrence was 34.1% (56 recipients). Mean overall survival was 6.4 years in the HBV-recurrence group and 9.9 years in the HBV-nonrecurrence group (p<0.001). HBV recurrence was not an independent prognostic factor for overall survival. HCC recurrence was the most important factor for overall survival. Conclusions: The overall outcome of LT in HBV-related liver disease was excellent with the current prophylaxis regimen Choon Hyuck David Kwon,8 Suk-Koo Lee8 Pretransplant HBV DNA and HCC were important factors for HBV recurrence. HBV recurrence after LT did not significantly influence on the overall survival without combining of HCC recurrence.

한국인에서의 mefloquine(Lariam^�)내약성에 관한 연구

기현균,김연숙,정숙인,김춘관,김신우,김성민,백경란,송재훈 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.3

목적 : Mefliquine은 가장 널리 사용되는 말라리아의 화학적 예방약이지만 경련, 정신병 증상 등의 심각한 신경학적 부작용을 포함한 여러 가지 부작용을 일으킬 수 있다. 이러한 부작용은 인종간에 차이가 있는 것으로 알려져 있으나 아직까지 우리나라에서는 mefloquine에 대한 내약성에 관한 구체적인 자료가 없다. 이에 저자 등은 한국인에서의 mefloquine의 내약성을 전향적으로 조사하였다. 방법 : 1997년 6월부터 1999년 4월까지 삼성서울병원 여행의학 클리닉에 내원한 총 180명의 열대열 말라리아 위험지역으로 여행하고자 하는 여행객들을 대상으로 하였으며 이들은 여행 1주전부터 귀국 후 4주까지 mefloquine을 주 1회 복용하였다. 이들에게 여행자 수첩을 배부하고 약제 복용 후 발생한 증상을 기록하도록 하였고 동시에 여행자들에 대한 전향적 관찰 및 병록지 검토를 시행하였으며 귀국 후 3개월째 전화조사를 시행하여 mefloquine복용 당시의 부작용과 동반증상 여부에 관하여 평가하였다. 성적 : 총 180명의 여행자가 연구에 포함되었으며 이중 166명에 대하여 평가를 시행하였다(166/180, 92.2%). 연구대상 중 남자가 104명(104/166, 62.7%), 여자가 62명이었고(62/166, 37.3%) 평균연령은 36.4세였다(36.4±15.2). Mefloquine은 평균 6주간 투여하였다. 평가에 포함된 여행자 166명 중 4명에서 부작용이 나타났으며(2.4%) 부작용 발현건수는 6건이었다(3.6%). 나타난 부작용은 현기증이 2건(1.2%), 비정상적인 꿈, 수면장애, 기분저하, 발열이 각각 1건씩 발생하였다. 이중 증상과 약제와의 관련성이 있는 경우는 1명에서만 나타났으며(0.6%) 투약을 중지한 후 증상이 소실되었다. 나머지 3명의 여행자는 모두 mefloquine을 처음 복용할 당시에 일시적인 증상이 있었으나 부작용과의 인과관계는 확실하지 않았고 증상은 곧 소실되었다. 연구대상 환자 중 말라리아가 발병한 증례는 없어 100%의 예방효과를 보였다. 결론 : 총 166명의 연구대상 중에서 mefloquine에 대한 내약성이 불량한 경우는 1예 였으며(0.6%), 심각한 신경학적, 정신과적 부작용은 나타나지 않았다. 이러한 결과는 한국인 여행객들의 mefloquine에 대한 내약성이 우수함을 시사한다. Background : Mefloquine is the most commonly used chemoprophylactic agent against malaria. Many kinds of adverse reactions of mefloquine including neuropsychiatric adverse reactions, have been reported. It has been thought that the incidence of mefloquine-related adverse reactions may be different among the races. Since data on Korean people are not available, we investigated the incidence of mefloquine-related adverse reactions in Korean travelers prospectively. Methods : We gave a notebook to each visitor to Travel Medicine Clinic of the Samsung Medical Center, who had a plan to take a trip to the endemic area of malaria by Plasmodium falciparum. The study duration was from June 1997 to April 1999. They took mefloquine weekly from I week before the trip to 4 weeks after the trip. They wrote any adverse reactions on the notebooks by themselves. We surveyed the travelers by clinical observation, reviewing the medical records and telephone interview at 3 months after the trip. Results : One hundred eighty travelers were included in the study and 166 of them were evaluable (166/180. 92.2%). One hundren four travelers were male (104/166, 62.7%). The mean age of travelers were 36.4 years (36.4±15.2 years). The median duration of chemoprophylaxis were 6 weeks. Four of the enrolled travelers had adverse reactions (4/166, 2.4%) and six episodes of adverse reactions were occurred (6/166, 3.6%) : dizziness (2 cases), bizzare dream (1 case), sleep disturbance (1 case), mood change (1 case), and febrile sense (1 case). Only one traveler with persistent dizziness stopped mefloquine, and then dizziness was relieved. The other symptoms were transient, which were relieved despite continuation of mefloquine. No case of malaria was found in this study. Conclusion : Only one episode of adverse reactions was thought to be related to the mefloquine (0.6%). No case of severe neuropsychiatric adverse reactions was observed. This study suggests that mefloquine tolerance in Korean travelers is excellent.

광주광역시 치매의 유병률과 위험인자의 도시-농촌 지역 비교

신일선,김재민,윤진상,김석재,양수진,김웅장,이승현,강순아,곽지영,이형영 大韓神經精神醫學會 2002 신경정신의학 Vol.41 No.6

연구목적 : 본 연구의 목적은 광주광역시의 도시 및 농촌 지역에 거주하는 노인에서 치매의 유병률과 위험인자를 조사하고자 하였다. 부가적으로 이 두 지역간에 치매의 유병률과 위험인자를 비교하고자 하였다. 방 법 : 광주광역시의 전형적인 도시와 농촌지역의 65세 이상의 노인(N=1,598)을 대상으로, 2단계의 역학연구를 수행하였다. 1차 선별 단계에서는 38명의 훈련된 연구보조원이 대상노인을 면담하여, 사회인구학적 특징을 조사하고 한국판 간이정신상태검사(Korean version of Mini-Mental State Examination ; MMSE-K)로 평가하였다. 2차 임상 진단 단계에서는 1차 단계에서 MMSE-K 점수가 24점 이하인 노인(N=431)을 대상으로, 전문연구팀의 임상적 평가를 통해 치매를 진단하고 원인질환별로 알쯔하이머병(Alzheimer's disease ; AD), 혈관성 치매(vascular dementia ; VaD) 및 기타 치매로 분류하였다. 대상노인에서 치매의 유병률을 측정한 후, 광주광역시 전체 노인의 연령보정 유병률을 산출하였다. 전체 대상에서 AD의 위험인자를 조사한 후, 도시와 농촌군으로 나누어 분석을 다시 시행하였다. 결 과 : 1차 및 2차 단계의 참가율은 각각 71.0%(N=1,134) 및 83.2%(N=410) 였다. 연구 참여 노인(N=1,134)에서 전체 치매, AD 및 VaD의 유병률은 최소 각각 9.7%, 5.2%, 1.8%였다. 광주광역시 전체 노인의 연령 보정 유병률은 각각 10.7%, 5.7%, 1.9%인 것으로 산출되었다. AD의 독립 위험인자는 고령, 여성, 무학이었다. 도시와 농촌에 따른 유병률의 차이는 파악되지 않았다. 그러나 AD의 위험인자는 지역에 따라 차이가 있었다. 도시 노인에게는 무학만이, 농촌 노인에게는 고령과 여성인 경우가 독립 위험인자였다. 결 론 : 광주광역시 노인에서 치매의 유병률은 높았고, 이는 국내 다른 지역에서 수행된 선행연구 결과와 유사하였다. 알쯔하이머형 치매의 위험인자는 도시와 농촌에 따라 다른 결과를 보였다. 본 연구 결과는 한국에서의 치매의 실태를 반영하며, 치매의 적절한 관리와 예방을 위해서는 지역성 특성이 고려되어야 함을 시사한다. Objectives : The purpose of this study was to investigate the prevalence rate and risk factors of dementia in an urban and a rural sample of older persons in the metropolitan Kwangju area, Republic of Korea. In addition, the prevalence rate and risk factors of dementia between the two samples were compared. Methods : A two-phase epidemiological study of residents aged 65 or over(N=1,598) was conducted in a highly developed, urban and a non-contiguous, poorly developed, rural area of metropolitan Kwangju. In the first(screening) phase, 38 trained research assistants collectively peformed in-home interviews for all participants. Detailed sociodemographic characteristics were gathered and the Korean version of Mini-Mental State Examination (MMSE-K) was administered. In the second (diagnosing) phase, diagnosis of dementia was established for those scoring 24 or less on the MMSE-K in the screening phase(N=431), and etiological types of dementia were classified to Alzheimer's disease(AD), vascular dementia(VaD) or miscellanous type by two teams of experts. Prevalence rate of dementia was determined in the participants, and age-standardized prevalence rate adjusted by age distribution in metropolitan Kwangju was estimated. For AD, the risk factors were investigated in all participants, and analyses were repeated for the urban and rural samples separately. Results : The participating rates in the first and second phases were 71.0%(N=1,134) and 83.2%(N=410), respectively. In the participants, the prevalence rates of dementia(all types), AD and VaD were 9.7%, 5.2% and 1.8%, respectively. The age-standardized prevalence rates were 10.7%, 5.7% and 1.9%, respectively. Aging, female gender and no education(complete lack of formal education) were identified as independent risk factors for AD. No difference between the urban and rural samples was observed in the prevalence rates of dementia(all types), AD and YaD. However, risk factors for AD differed between these areas. In the urban sample, no education was the only significant factor ; whereas, aging and female gender were identified as risk factors in the rural sample. Conclusion : A high prevalence rate of dementia was observed among old persons in metropolitan Kwangju, consistent with previous studies conducted in other Korean areas. The risk factor profi1es for AD differed between urban and rural settings. The results of this study reflect the current status of dementia in Korea and suggests that appropriate management and prevention strategies for dementia should be tailored toward the geographic settings.

탄화수소를 환원제로 하는 배연 탈질공정에서 금속이온교환된 ZSM-5 촉매들의 촉매활성 비교연구

김재천,한상현,신병선,정석진 경희대학교 산학협력기술연구원 1998 산학협력기술연구논문집 Vol.4 No.-

In this study, in order to make up its drawbacks in the Cu-ZSM-5 catalytic system, some of transition metals or alkaline earth metals were cocation-exchanged in Cu-ZSM-5. Among various cocation-ion-exchanged XSM-5 catalysts, Mg/Cu-ZSM-5 was found to be the most active and durable in NOx reduction even with high oxygen content as well as in the presence of water vapor. The role of Mg in ZSM-5 is supposed to prevent the dealumination of aluminium ions the in supercage even at harsh hydro-thermal conditions, and also it seems to stabilize the Cu ions in the structure. In order to prepare commercially available catalysts, Mg/Cu-ZSM-5 catalysts were wash-coated on the surface of honeycomb type monolith, and tested in terms of catalytic activities. As a results, it was found that the catalyst prepared by the wash-coating showed satisfactorily high NOx conversion for the practical in the SCR process.