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윤승락,김사익,조종수,노정관,나종범,김동귀,최길동 진주산업대학교 산업과학기술연구소 2007 산업과학기술연구소보 Vol.- No.14
Thermomechanical pulp (TMP) and chemical thermomechanical pulp (CTMP) of kenaf cultivated in Korea were manufactured and their fiber properties were investigated. TMP made of the core part of kenaf showed various geometric types of fibers such as rectangular, spindle, and cylindrical forms. The most TMP made of the outer part of kenaf were composed of bast fibers, where no damages on the surface and cutting section of bast fibers was found. CTMP made of the core showed that some fibers were damaged. However, the fibers in CTMP made of the bast were observed not to be damaged. The TMP made of the core showed sound fibers, but the CTMP made of the core showed some damaged fibers. The TMP made of the bast showed curl indexes higher than the CTMP made of the bast, and most of fibers were not damaged in both TMP and CTMP pulps.
조종수,김사익,윤승락,노정관,나종범,김동귀,최길동 진주산업대학교 산업과학기술연구소 2007 산업과학기술연구소보 Vol.- No.14
To investigate the antimicrobial effects of essential oil in the leaves of Chamaecyparis obtusa extractives by paper disc method, the extractives were fractionated into four portions. In antimicrobial test, essential oil in the leaves of Chamaecyparis obtusa was found to have strong inhibitory effects against the growth of Bacillus subtilis and Staphylococcus aureus. A part of analyzed inhibition components of essential oil in the leaves of Chamaecyparis obtusa from GC-MS was supposed to be α,β-pinene, α-terpinolene, camphor, β-myrcene, 1-α-terpinolene, 4-thujen-2-α-yl, limonene, Cardinene.
나종범,김사익,조종수,윤승락,노정관,김동귀,최길동 진주산업대학교 산업과학기술연구소 2007 산업과학기술연구소보 Vol.- No.14
This study was performed to investigate the effect of wax layer of bamboo on leaching of boron compounds. The removal of wax layer increased the loading of boron on bamboo surface. However, it had an effect on increasing the leaching rates of boron compounds during leaching test. The addition of water repellent retarded leaching of boron compounds to some extent from treated samples. Although borate/WRP system did not qualify borate treated wood for ground contact use, it showed a potential to improve performance of borate treated bamboo in above-ground applications not subjected to continuous wetting conditions.
( Dong Lak Choi ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Retransplantation remains the only treatment for the patients with irreversible graft failure after primary transplantation. However, retransplantation carries a significantly higher morbidity and mortality compared with primary transplantation. The most frequent indications for retransplantation are primary non-function, hepatic artery thrombosis, uncontrolled graft rejection and recurrent diseases. The results including survival after liver transplantation remain inferior to those after primary transplantation. Therefore, proper indication, careful selection of operation timing, adequate preoperative preparation, experienced surgical procedures, extensive monitoring and effective perioperative management account for the improvement of the outcome after liver retransplantation
( Dong Lak Choi ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Retransplantation remains the only treatment for the patients with irreversible graft failure after primary transplantation. However, retransplantation carries a significantly higher morbidity and mortality compared with primary transplantation. The most frequent indications for retransplantation are primary non-function, hepatic artery thrombosis, uncontrolled graft rejection and recurrent diseases. The results including survival after liver transplantation remain inferior to those after primary transplantation. Therefore, proper indication, careful selection of operation timing, adequate preoperative preparation, experienced surgical procedures, extensive monitoring and effective perioperative management account for the improvement of the outcome after liver retransplantation
( Dong Chan Kim ),( Dae Won Jun ),( Tae Yeob Kim ),( Joo Hyun Sohn ),( Sang Pyo Lee ),( Kang Nyeong Lee ),( Hang Lak Lee ),( Oh Young Lee ),( Byung Chul Yoon ),( Ho Soon Choi ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Background: Recently, the composition of lipid in liver is more important than the total amount of lipid in NAFLD. Methods: To evaluate the effect of lipoic acid (LA) on lipotoxicity and on the intracellular lipid partitioning, HepG2 was cultured with palmitic acid (PA) or LA. We used TUNEL assay for apoptosis, mitochondrial DNA copy number for mitochondrial function, electromicroscopy for the structure of the mitochondria, fluorescent microscope for the ROS activity, gaschromatography for lipid partitioning. Results: PA significantly increased apoptosis of the cell line (0.5% vs. 19.5%, p<0.05), and LA significantly suppressed apoptosis (19.5% vs. 1.6%, p<0.05). The number of mitochondrial DNA copy was decreased in PA group, and recovered after adding LA (Control: PA: PA+LA= 553± 33.8: 291±14.55: 421±21.05 copies). Electromicroscopy showed significant difference between the groups. ROS activity was significantly increased in the PA group, and decreased in LA group (4180 vs. 4350 vs. 4220 relative fluorescence unit respectively, p<0.05). LA decreased the proportion of saturated fatty acid and increased the proportion of unsaturated fatty acid. Free cholesterol was showed on the cell membrane in LA group. But in PA group, they located in the cytoplasm and cell membrane. Conclusions: LA prevented FFA-induced hepatic lipotoxicity via reversal intracellular lipid composition.
( Dong Shin Kwak ),( Oh Young Lee ),( Kang Nyeong Lee ),( Dae Won Jun ),( Hang Lak Lee ),( Byung Chul Yoon ),( Ho Soon Choi ) 대한간학회 2016 Gut and Liver Vol.10 No.3
Background/Aims: DA-6034 has anti-inflammatory activities and exhibits cytoprotective effects in acute gastric injury models. However, explanations for the protective effects of DA-6034 on intestinal permeability are limited. This study sought to investigate the effect of DA-6034 on intestinal permeability in an indomethacin-induced small intestinal injury model and its protective effect against small intestinal injury. Methods: Rats in the treatment group received DA-6034 from days 0 to 2 and indomethacin from days 1 to 2. Rats in the control group received indomethacin from days 1 to 2. On the fourth day, the small intestines were examined to compare the severity of inflammation. Intestinal permeability was evaluated by using fluorescein isothiocyanate-labeled dextran. Western blotting was performed to confirm the association between DA-6034 and the extracellular signal-regulated kinase (ERK) pathway. Results: The inflammation scores in the treatment group were lower than those in the control group, but the difference was statistically insignificant. Hemorrhagic lesions in the treatment group were broader than those in the control group, but the difference was statistically insignificant. Intestinal permeability was lower in the treatment group than in the control group. DA-6034 enhanced extracellular signal-regulated kinase expression, and intestinal permeability was negatively correlated with ERK expression. Conclusions: DA-6034 may decrease intestinal permeability in an indomethacin-induced intestinal injury model via the ERK pathway. (Gut Liver 2016;10:406-411)
( Dong Chan Kim ),( Dae Won Jun ),( Tae Yeob Kim ),( Joo Hyun Sohn ),( Sang Pyo Lee ),( Kang Nyeong Lee ),( Hang Lak Lee ),( Oh Young Lee ),( Byung Chul Yoon ),( Ho Soon Choi ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background: Recently, the composition of lipid in liver is more important than the total amount of lipid in NAFLD. Methods: To evaluate the effect of lipoic acid (LA) on lipotoxicity and on the intracellular lipid partitioning, HepG2 was cultured with palmitic acid (PA) or LA. We used TUNEL assay for apoptosis, mitochondrial DNA copy number for mitochondrial function, electromicroscopy for the structure of the mitochondria, fluorescent microscope for the ROS activity, gaschromatography for lipid partitioning. Results: PA significantly increased apoptosis of the cell line (0.5% vs. 19.5%, p<0.05), and LA significantly suppressed apoptosis (19.5% vs. 1.6%, p<0.05). The number of mitochondrial DNA copy was decreased in PA group, and recovered after adding LA (Control: PA: PA+LA= 553± 33.8: 291±14.55: 421±21.05 copies). Electromicroscopy showed significant difference between the groups. ROS activity was significantly increased in the PA group, and decreased in LA group (4180 vs. 4350 vs. 4220 relative fluorescence unit respectively, p<0.05). LA decreased the proportion of saturated fatty acid and increased the proportion of unsaturated fatty acid. Free cholesterol was showed on the cell membrane in LA group. But in PA group, they located in the cytoplasm and cell membrane. Conclusions: LA prevented FFA-induced hepatic lipotoxicity via reversal intracellular lipid composition.
( Dong Won Park ),( Oh Young Lee ),( Sung Gon Shim ),( Dae Won Jun ),( Kang Nyeong Lee ),( Hye Young Kim ),( Hang Lak Lee ),( Byung Chul Yoon ),( Ho Soon Choi ) 대한소화기기능성질환·운동학회 2010 Journal of Neurogastroenterology and Motility (JNM Vol.16 No.2
Background/Aims: Irritable bowel syndrome (IBS) is one of the most frequently observed disorders by primary care and practitioners. The aim of this study was to estimate the prevalence of IBS using the Rome II and III criteria in the general Korean population and also to compare sociodemographic differences between subjects diagnosed by these criteria. Methods: Telephone interview surveys were performed with a total of 1,009 individuals in Korea, 15 years of age or older. The questionnaire, based on the Rome II and III criteria, was validated. Results: Among the 1,009 subjects, the prevalence of IBS was 8.0% under the Rome II criteria (81 subjects; 6.4%, male; 9.6%, female), and 9.0% (91 subjects; 7.0%, male; 11.0%, female) under the Rome III criteria. The accordance rate of Rome II and III was 73.5%. Both groups showed highest frequency in the age of 30s (13.9% vs. 15.3% respectively). Female subjects showed a higher prevalence than male subjects under Rome III (91 subjects; 11.0% in female, 7.0% in male; p < 0.05), but not under Rome II criteria. Many patients older than 50 years were added when analyzed under the Rome III criteria, but not under the Rome II criteria (p = 0.017). Conclusions: The Rome III criteria were Less restrictive and showed good agreement with the Rome II criteria. The prevalence of IBS was increased in young women.(J Neurogastroenterol Motil 2010;16:186-193)