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Purge & Trap-GC를 이용한 의약품 필름코팅 정제 중 잔류용제에 관한 연구
장준식,이명자,소유섭,문춘선,이주헌,박희라,김진숙,강경모,이선옥,방성연,유미자,유문균,금오성,이병욱 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-
의약품은 약물을 생체에 적풋하기 위하여 유효성분의 효과가 언제나 일정하게 확보되고 사응에 편리하도록 만들어지는 것이므로 유효썽분 이외에 약효에 영향을 주지 않는 성분이 첨가되는 경운가 많다. 이 때 사용되는 용매들은 제피의 광택 및 건쪼시간의 단축 등을 위하여 휘발점이 낮을 용매들이 주로 사용되어진다. 본 연구는 의약품 필름코팅정제 중 잔류용매 4종(chlorofonr benzen, trichloro ethylen, 1,4-dioxane)에 대한 변형된 pirge & trap-GC 장치를 이용한 동시분석방법을 개발하였으며, 각 표준품의 RSD 값은 chloroform 3.03%, benzen 3.17%, trichloroethylen 3.69% and 1,4-dioxane 3.41%였다. 또한 시중 유통중인 의약품 50종에 대하여 잔류웅매 양을 측정하였으며, 검출되는 잔류용매는 한 건도 없었다. This study nras carried out to develope the analytical method for the mixture of chlorefonn, benzen, trichloroethylen and 1,4-dioxane simultaneously and determine the remainingorgauic solvents in coating tablets by Purge & Trap-GC. The results were as follouFs ; 1. Chloroform, benzen, trio:tloroethylen and 1,4-dioxane separated by tenax #5 trap by HP-624GC column by terrlperature programming. The peaks were separated completely at retentiontime of 6.88min for chloroform, 8.21min for benzen, 10.38miu for trichloroethylen and 11.95minfor 1,4-dioxane. 2. Standard RSD were individually chloroform 3.03%, benzen 3.17%, trichloroethylen 3.69%and 1,4-diorane 3.41%. 3. 60 samples were not detrcted chloroform, benzen, trichloroethylen and 1,4-dioxane.
혼수상태의 외상환자에서 초음파를 이용한 흉부 및 복부손상의 진단
임경수,이강현,이진웅,이부수,황성오,유수영,강성준 대한응급의학회 1995 대한응급의학회지 Vol.6 No.1
The need for rapid diagnosis and treatment of life-threatening thoracic and intra-abdominal injury result in controversy over the appropriate triage of unconscious blunt trauma patients. To aid in early decisions for these patients, a prospective analysis of 98 patients with glasgow coma scale(GCS) scores≤8 was undertaken. Although intra-thoracic and intra-abdominal injuries were frequently identified based on systolic blood ressure, the use of clinical signs alone resulted in more missed injuries than did using the emergency ultrasonography. In normotensive patients(n=34), intra-thoracic injuries was identified in one patient(2.9%), and intra-abdominal injuries were in 7 patients(20.6%). In shock(systolic blood pressure<90mmHg) Pa-tients(n=64), thoracic injuries and intra-abdominal injuries were diagnosed in 8(12.5%) and 27 patients(42.3%), thoracic and abdominal combined injuries were identified in 11 patients(17.2%). The sensitivity, specificity, and accuracy of emergency ultrasonography were 96.3%, 91.7%, 94.9%. This study suggests that all unconscious trauma patients undergo immediate emergency ultrasonography to prevent missing life-threatening injuries.
서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)
김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1
In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.
폴리에틸렌 테레프탈레이트(PET)의 內部摩擦損 및 誘電損의 溫度特性에 關한 相關性 硏究
李準雄,康道烈,金在煥,金鳳洽 光云大學校 1982 論文集 Vol.11 No.-
This paper investigated comparatively the temperature dependence of dielectric α relaxation process and dynamic mechanical α relaxation process. Dynamic mechanical and dielectric loss data on a given polythylene terephthalate (PET) are generally viewed as being directly comparable. This is based on the notion that, if each exhibits a loss peak at about the same temperature and frequency, they must be manifestations of the same process. This supposes that the process couples in the exact same manner with both mechanical and electrical stress fields. That this need be so may be seen from the fact that not only non polar process give rise to dynamic mechanical losses, but also dipolar losses. The results obtained are as follows. 1) Dielectric α peak and dynamic mechanical α peck in PET are observed at almost same temperature correspondently. 2) The elongated sample exhibits the higher α peck at the almost same maximum temperature. 3) The magnitude, location and breadth of the α relaxation in PET are strong function of the degree of crystallinity and also the manner in which a particular degree of crystallinity is attained. And the degree of crystallinity is changed with external conditions, that is, density, annealing. quenching, drawing, orientations and irradiation etc. 4) In the results of observation the absorption peak at 1,788 ?? on infrared spectra, the more bigger concentration of carbonyl dipole group was observed on the elongated sample.
Rat의 복강내에 투여한 5-fluorouracil-polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구
강대영,송규상,최정목,노승무,정경수,오정연,김진향,양준묵,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1
For more effective intraperitoneal chemotherapy, the authers made 5-fluorouracil-polyglycolic acid composite disks(FU-PGA disks) with 5-fluorouracil and polyglycolic acid, a biodegradable polymer. We inserted the FU-PGA disk into the peritoneal cavites of Sprague-Dawley male rats, the control and three experimental groups; one FU-PGA disk insert group(300mg/kg), two FU-PGA disk insert group(600mg/kg), and three FU-PGA disk insert group(900mg/kg). The control group received a similar number of PGA disk inserts. A pharmacokinetic study was performed to measure the 5-fluorouracil concentration in the peritoneal fluid, blood, and tissues(liver, kidney and heart) at 24 hours, 72hours and 168 hours after insertion of the FU-PGA disk. Light and electron microscopic studies were done. The results were as follows: 1) The number of white blood cells and platelets decreased after FU-PGA insertion. The degree was proportional to the duration and amounts inserted. The change in the number of red blood cells varied slightly. 2) Light microscopically, slight changes were noted at 168 hours in the 3 disk insert group (900mg/kg). Mild fatty change and hepatocyte degeneration around the central veins of the liver were noted, with vacuolar degeneration in the proximal convoluted tubules of the kidney. 3) Electron microscopically,the liver showed focal increases of lipid droplets in the hepatocytes, and irregular nuclear membrane with focal nucleolar segregation of the fibrillar and granular elements. Also the double membranous structure of the hepatocytes and Kupffer cells was widened with bleb formation. The kidney showed wide separation of the nuclear double membrane in the proximal convoluted tubular cells and mesangial cells, with vacuolation and myelin figure formation in the mitochondria of the proximal convoluted tubular cells, at 72 hours and 168 hours in the 2 to 3 FU-PGA insert groups. The heart showed focal loss of cristae,vacuolation and myelin figure formation in the mitochondria of the 2 to 3 FU-PGA insert groups. In conclusion, despite the large amont of FU-PGA inserted, the histopathological changes in the liver, kidney and heart were slight, and consonant with the very low amount of 5-fluorouracil concentrations detected in the liver, kidney and heart. The above results suggest that the FU-PGA composite can serve as a new device for releasing drugs in a controlled manner and easily targeted to intraperitoneal organs. This device can improve the efficacy of intraperitoneal chemotherapy for gastric cancer.
測定用 寫眞과 非測定用 寫眞의 組合에 依한 圓筒形 構造物의 全面解析
姜準默,裵淵晟,李鎭德 忠南大學校 産業技術硏究所 1991 산업기술연구논문집 Vol.6 No.2
본 연구는 C.R.P.에서 측정용과 비측정용 사진을 조합하여 원통형 구조물의 전면해석을 시도하고 그의 정확도를 실험적으로 구명한 것이다. 대상물 주위에 원형의 노출 network을 구성하고 측정용과 비측정용 카메라를 이용하여 multi-station photography를 실시하였다. strip과 block을 bundle조정에 의하여 촬영 거리별로 측정용 사진과 비측정용 사진으로 각각 해석하고, 정확도를 비교함으로써 비측정용 카메라의 적용가능성을 입증하였다. 또한 원통형 구조물의 全面을 단시간에 해석하기 위하여 측정용 사진과 비측정용 사진의 조합해석을 시도하고 이의 효용성을 제시하였다. The objective of this study is to suggest the ways of analyzing the entrire-area of cylindrical structure with combination of metric and non-metric photos in C.R.P. and also investigate characteristics of accuracies. For it, circular exposure network was disigned and multi-station photography was executed with metric and non-metric camera respectively. Bundle adjustment was performed to compute three dimensional coordinates of unknown points. By comparing accuracies of results analyzed with metric photos and non-metric photos, we proved applicability of non-metric camera to purpose of measurement. Also, by positioning through combining metric and non-metric pothos, we proved the effectiveness of it and found out characteristics of accuracy of it.
강준묵,이용욱 충남대학교 지역개발연구소 1999 地域開發論叢 Vol.11 No.-
The interest in ocean is being increased by the growth of industry and economy activities. All countries of the world have an acute interest in territorial sea and exclusive economic zone which have their sovereignty and economic power, so they are competing with each other for the profitable zone of jurisdiction. As we adjacent to the district of ocean with china and japan, it is very important for us to decide an accurate territorial base point, still more it must be measured accurately without any friction with them. In this study, we surveyed 4 straight base points and 3 normal base points near by Hondo island and so-huksando island. we analysed surveying accuracy according to broadcast ephemeris and precise ephemeris. Also we analysed the coordinate result of WGS 84 and Tokyo datum for presenting an efficient surveying method of a territorial base point. Because a territorial base point must be measured by the low-water line as UN convention on the law of the sea, it isn't easy to approach. As a result of this, we found that continuos moving survey of OTF is an efficient method to survey safely and quickly in a ship. In case of straight base point comprised of middle-long base line, we could cut down the observation time by using accurate orbit and produce the WGS 84 result within 1 ppm relative accuracy. To produce the Tokyo datum of territorial base point, we analysed the 2 dimension network adjustment based on national standard point and coordinates transformation. With this study, we could decide the territorial base point of the south-west sea using GPS.