경막 내 colistimethate 투여로 치료한 다제 내성 cinetobacter baumannii 뇌실염

홍유아,유진홍,김진진,모은영,안건희,정희경,김진석,이현정,정미향,윤승배 대한감염학회 2009 감염과 화학요법 Vol.41 No.4

Acinetobacter species is a non-fermentative aerobic gram-negative coccobacillus that is an important pathogen found in nosocomial infections. Recently, multi-drug resistant Acinetobacter baumannii (MDR-AB) infections have been increasing and pose a serious problem. Most such infections present as bacteremia, pneumonia, or a wound infection; however, CNS infections are very rare. We herein present a case of ventriculitis caused by MDR-AB in a 37-year old man after a neurosurgical intervention. The patient was successfully treated with intrathecal colistimethate.

5세 남아의 Influenza 종격동기종 및 대엽성 폐렴 1례

오희성,한유진,연은경,선동신,송준환,박경배,박준수,김영통,남해선,최영진,김용배 순천향의학연구소 2009 Journal of Soonchunhyang Medical Science Vol.14 No.3S

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림프부종 치료프로그램이 림프부종이 있는 말기 암 환자의 사지둘레와 신체증상에 미치는 영향

박명희,허수진,최은미,정유니 병원간호사회 2006 임상간호연구 Vol.11 No.2

Purpose: This study was performed to investigate the effects of lymphedema treatment program on extremities circumference and physical symptoms in terminal cancer patients with lymphedema. Method: The subject was 13 patients diagnosed with lymphedema and admitted to C Hospital, hospice unit from March 1 to August 31, 2004. The effects of treatment were evaluated by measuring extremities circumferernce and by assessing physical symptons. Data were analyzed by using repeated measures ANOVA, Scheffé multiple comparisons. Result: The results were as follows: Extremities circumference was reduced significantly 30.8cm after last treatment compared with 33.4cm pre-treatment. Physical sysptom, 'heaviness' was improved significantly 4.2 after last treatment compared with 7.8 pre-treatment and difficulty to mobility was improved significantly 4.5 after last treatment compared with 7.4 pre-treatment. Conclusion: These findings indicate that lymphedema treatment program could be an effective nursing intervention for reducing extremities circumference and improving physical symptoms in terminal cancer patient.

GT rotary file을 이용한 근관성형법과 충전방법의 비교

강유미,진정희,유미경,이세준,이광원 大韓齒科保存學會 2002 Restorative Dentistry & Endodontics Vol.27 No.5

The purpose of this study was to compare the shaping time of two shaping methods and the leakage of three different obturation techniques. Ninty three canaled human molar teeth were used. which were randomly divided into two groups of forty teeth each and ten control teeth. After working length determination. the one group was prepared crowndown technique using rotary root canal instruments of GT rotary files .12/20, .10/20, .08/20 and .06/20 taper(Maillefer Instrument SA. Switzerland). The other group was instrumented with Gates Gildden burs(#1, #2 and #3) to coronal preparation and GT rotary files .08/20 and .06/20 taper to apical preparation. Shaping time was measured. After root canals were instrumented, they were divided to three subgroups and obturated as follows: Subgroup 1, obturated with single cone method : Subgroup 2, obturated with lateral condensation : Subgroup 3, obturated with continuous wave technique. Three subgroups were obturated using non-standardized gutta-percha cone(Diadent, Korea, 06 or .08 taper) and AH-26(Dentsply DeTrey, Germany) as a root canal cement. Ten unobturated teeth served as positive and negative controls. After immersion in 2% methylene blue solution for 1 month, the teeth were washed during 24h. The teeth were determineralized in 10% nitric aciid and dehydrated by immersion in 80, 90 and 100% ethyl alcohol. The teeth were finally cleared and stored in 100% methylsalicylate, and apical dye penetration was evaluated under stereomicroscope(Leica M420, LC, U.S.A) at (×) 8.75 magnification. Liner measurement of dye penetration was assessed with the use of digitalized image analysing system (analySIS, GmbH, Germany), The data were analysed statistically using independent T-test and Two-way ANOVA and Tukey test. The result were as follows: 1. In canal prepared with GT^Trotary file, shaphing time taked more than the group of using Gates Gildden drill to coronal preparation without statistical significant (p>0.05). 2. The group of single cone obturation using canal preparation of GT^TM rotary files showed significantly more apical leakage than those of lateral condensation and continuous wave technique regardless of shaping method (p<0.05). 3. The group of single cone obturation using canal preparation of GT^TM rotary files and Gates Gildden drill showed significantly more apical leakage than those of continuous wave technique regardless of shaping method (p<0.05). 4. Regardless of shaping method. The group of continuous wave obturation showed less apical leakage than those of lateral condensation without statistical significance (p>0.05). 5. The group of single cone obturation using canal preparation of GT^TM rotary files and Gates Gildden drill showed more apical leakage than the group of lateral condensation using sane shaping method without statistical significance (p>0.05).

유치 상아세관에 관한 주사전자현미경적 관찰

김유희,김영진,정경원 大韓小兒齒科學會 1995 大韓小兒齒科學會誌 Vol.22 No.1

유치 상아세관의 형태학적 특징을 관찰하기 위하여 정상탈락기의 유전치, 조기발거한 유전치, 정상탈락기의 유구치와 대조군으로 저기발거한 영구소구치 각 10개를 대상으로 치관부 상아질을 주사전자현미경적 관찰을 통해 치수측, 중앙부, 법랑상아경계부근의 각 부위별 상아세관의 직경과 단위면적당 수를 측정하여 각 군내에서의 부위별 차이와 각 부위에서의 각 군간의 차이을 비교평가하여 다음과 같은 결론을 얻었다. 1. 정상탈락기의 유전치, 조기발거한 유전치, 정상탈락기 유구치, 조기발거한 영구 소구치 각 군내에서의 부위별 상아세관의 직경은 치수측에서 법랑상아경계부근으로 갈수록 작게 나타났다.(p<0.01). 2. 각 군간의 부위별 상아세관의 직경은 조기발거한 영구소구치군이 모든 부위에서 다른 세 군에 비해 크게 나타났다.(p<0.05). 3. 치수측과 중앙부에서 상아세관의 직경은 정상탈락기의 유구치군이 정상탈락기의 유전치군과 조기탈락한 유전치군에 비해 크게 나타났다(p<0.01). 4. 정상탈락기 유전치, 조기발거한 유전치, 정상탈락기 유구치, 조기발거한 영구 소구치에서 부위별 단위면적당 상아세관의 수는 치수측에서 법랑상아경계부근으로 갈수록 작게 나타났다(p<0.01). 5. 각 군의 상아질 치수측, 중앙부, 법랑상아경계부근에서 단위면적당 상아세관 수의 차이는 없었다(p<0.05). The purpose of this study was to evaluate number and diameter of tubules in pulp side, middle side, dentinoenamel junction side of coronal dentin of normal exfoliated anterior primary teeth, early extracted anterior primary teeth, normal exfoliated posterior primary teeth and early extracted permanent premolar. Numbers of sample were 10 teeth in each group. The diameter and number of tubules were counted and measured in ×4000 magnified screen of scanning electron microscope. The comparison of diameter and number of tubules at three level in each group was done. The results of this study were as follow. When the diameters of tubules at three levels were compared, the diameters of tubules were graduately decreased from pulp side close to dentinoenamel juntion side in all groups. At pulp sidem middle side and dentnoenamel junction side, when the diameters of tubules of each group were compared, the diameters of tubules of early extracted permanent premolar were greater than other groups. At pulp side, the diameters of tubules of normal exfoliated posterior primary teeth were greater than that of other two primary teeth groups. When the number of tubules at three levels were compared, the number of tubules were graduately decreased from pulp side close to dentinoinamel junction side in all groups. A pulp side, middle side and dentinoenamel junction side, when the number of tubules of each group were compared, no significant difference was in each group.

Self-drilling 방식의 마이크로임플란트 식립에 의해 발생하는 피질골 스트레인의 유한요소해석

박진서,유원재,경희문,권오원 대한치과교정학회 2009 대한치과교정학회지 Vol.39 No.4

골밀도가 높고 두꺼운 피질골에 마이크로임플란트를 self-drilling 방식으로 식립하는 경우 과도한 수준의 골부하(bone loading)가 발생할 위험이 있으며 이는 인접골의 정상적인 골개형(bone remodeling)에 장애를 초래할 수 있다. 이에, 본 연구에서는 유한요소해석으로 두께 1.0 mm의 피질골에 Absoanchor SH1312-7 마이크로임플란트((주)덴토스, 대구, 대한민국)가 self-drilling 방식으로 식립되는 과정(10회전, 식립깊이 5 mm)을 모사(simulation)하였으며 식립 단계별로 피질골에 발생되는 스트레인을 조사하였다. 식립중 마이크로임플란트 첨부의 절삭연(cutting flute)에 의한 골삭제로 생기는 나사길(threaded groove)의 치수를 얻기 위하여 가토 경골에 마이크로임플란트를 식립/제거한 후 Micro CT (Explore Locus RS, GE Healthcare, Ontario, Canada)를 이용하여 기하형상을 측정하였으며 이를 치밀골의 유한요소모델에 반영하였다. 해석결과, 치밀골에 발생되는 스트레인은 임플란트 식립깊이에 따라 증가하였고, 초기단계에서 나사산에 인접한 골에 국한되던 과부하 부위(스트레인이 4,000μ-strain을 상회하는 영역)가 식립깊이 증가에 따라 인접골 전체, 즉 나사산 인접부는 물론 골(valley) 부위에 접하는 모든 영역으로 확장되었다. 본 연구를 통해, self-drilling 방식으로 마이크로임플란트를 식립할 때 치밀골에 발생하는 스트레인 크기는 생리적인 골개형을 저해할 수 있는 수준임을 확인할 수 있었다. Objective: The aim of this study was to evaluate the strain induced in the cortical bone surrounding an orthodontic microimplant during insertion in a self-drilling manner. Methods: A 3D finite element method was used to simulate the insertion of a microimplant (AbsoAnchor SH1312-7, Dentos Co., Daegu, Korea) into 1 mm thick cortical bone. The shape and dimension of thread groove in the center of the cortical bone produced by the cutting flute at the apical of the microimplant was obtained from animal test using rabbit tibias. A total of 3,600 analysis steps was used to calculate the 10 turns and 5 mm advancement of the microimplant. A series of remesh in the cortical bone was allowed to accommodate the change in the geometry accompanied by the implant insertion. Results: Bone strains of well higher than 4,000 microstrain, the reported upper limit for normal bone remodeling, were observed in the peri-implant bone along the whole length of the microimplant. Level of strains in the vicinity of either the screw tip or the valley part were similar. Conclusions: Bone strains from a microimplant insertion in a self-drilling manner might have a negative impact on the physiological remodeling of cortical bone.

진공증착 장비를 이용한 유기발광 소자 제작

서유석,박훈,홍진수,채희백 순천향대학교 기초과학연구소 2004 순천향자연과학연구 논문집 Vol.10 No.2

We fabricated OLEDs(organic light emitting diodes) by vacuum evaporation. In our experiments, well-known materials are used; indium-tin-oxide(ITO) coated glass for anode, Al for cathode. N,N'-diphenyl-N,N'-bis(3-methylpheny)1,1'-bipheny-4,4'-diamine (TPD) for hole-transport layer, and tris(8-hydrxyquinoline) aluminum (Alq3) for an emissive and electron-measured J-V,L-V and J-Current efficiency I-V-L by using Keithley 236 source-measure unit and Minolta Luminance meter LS-100.

정신분열병과 Neurotensin 수용체 유전자 다형성의 연합 연구

이유상,김형배,한진희,채영규,이정식,이혜순,주연호,김형섭,최인근,양병환 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.6

연구목적: Neurotensin(NT)은 NT수용체와 결합하여 그 효과를 나타내는 neuromodulator 혹은 neurotransmitter로서 대뇌에서 도파민의 분비를 조절하는데 중요한 역할을 한다. 근래의 연구에 의하면 NT와 그 수용체는 대뇌에서 항정신병 약물의 효과를 매개하는 것으로 생각되고 있으며 약물치료를 받지 않은 정신분열병 환자의 뇌척수액에서 NT의 양이 적으로 보고되고 있어 이들은 정신분열병과 깊은 관련을 가지고 있을 것으로 추정된다. 최근 NT수용체의 유전자의 3`인접영역에서 정보가치가 높은 4 염기반복 다형성이 발견되어 이를 유전 표지자로 하여 정신분열병과의 연합을 알아보았다. 방 법: 서로 혈연관계에 있지 않은 정신분열병 환자 120명(남자 91명, 여자 29명)과 정상 대조군 106명(남자 84명, 여자 22명)을 대상으로 하였다. PANSS를 사용하여 양성 및 음성을 알아보았다. 말초혈액에서 DNA를 분리한 후에 중합효소연쇄반응을 사용하여 3`인접영역에 있는 4 염기 반복 다형성을 증폭하였고 silver staining한 후에 유전자형을 관찰하였다. chi-square 검증과 Bonferroni`s correction을 사용하여 환자군과 정상 대조군간의 대립유전자 빈도의 차이를 알아보았다. 또한 양성 및 음성 환자군으로 나누어 차이를 알아보았다. 결 과: 총 23개의 대립유전자가 관찰되었으며, 399bp의 대립유전자(A10)의 빈도가 환자군보다 정상대조군에서 통계적으로 유의하게 높았다(χ²=16.49, df=1, p<0.001). 음성 정신분열병 환자군과 정상대조군 사이의 비교에서는 정상대조군의 A10의 빈도가 환자군보다 유의하게 높았다(χ²=21.33, df=1, p<0.001). 성별 비교에서 남자 정신분열병 환자군은 대조군에 비하여 A10의 분포가 유의하게 적었다. (χ²=13.71, df=1, p<0.001) 결 론: NT 수용체 유전자와 정신분열병사이에 음성연합이 관찰되었다. NT 수용체 유전자가 일부 정신분열병의 발병과정에서 확실하지는 않지만 어떤 종류의 보호기능을 할 수도 있다는 것을 암시한다. Objectives: Neurotensin(NT), of which functions are evoked by its interaction with neurotensin receptors(NTR), coexists with mesolimbic dopamine and regulates endogenous dopamine release. Recent studies have shown that NT with NTR exerts neuroleptic-like activity within the central nervous system and may play an important role in the pathogenesis and in the treatment of schizophrenia. We have examined the gentic association between schizophrenia and tetranucleotide repeat polymorphism in the 3-flanking region of the NTR gene to investigate the possible contribution of the NTR gene to the schizophrenia susceptibility. Methods: Among 23 alleles identified, the subjects were 120 patients(male 91, female 29)with schizophrenia and 106 normal healthy controls(male 84, female 22). They were unrelated native Korean. PANSS was used to determine positive or negative subgroup in the schizophrenic patients. Using polymerase chain reaction and polyacrylamide gel electrophoresis, tetranucleotide repeat polymorphism(CCTT and CTT) in the 3`-flanking region of NTR gene was observed. For a comparison of NTR gene`s allelic frequencies between patients with schizophrenia and normal healthy controls, chi-square test and Bonferroni`s correction was performed. Results: The frequency of A10 allele(base pair size=399)was significantly higher in normal healthy controls than schizophrenia(χ²=16.4902, df=1, p<.000). In the comparison between schizophrenic patients with negative symptoms and normal controls, the frequency of A10 allele was significantly higher in normal healthy control subjects than patients with schizophrenia(χ²=21.33, df=1, p<0.001). In the case of male, the frequency of A10 allele of schizophrenia was significantly higher than normal controls(χ²=13.71, df=1, p<0.001). Conclusions: NTR gene was negatively associated with schizophrenia. NTR gene`s tetranucleotide repeat polymorphism may provide some protective function against schizophrenia.

폐구리염화물용액의 분무열분해반응에 의한 생성분말의 특성에 관한 연구

박희범,최재권,한진아,유재근 호서대학교 반도체제조장비국산화연구센터 2001 반도체장비학술심포지움 Vol.2001 No.-

본 연구의 목적은 폐 구리염화물 용액을 원료로 사용하여 분무열분해 공정에 의해 평균입도가 1 ㎛ 이하이며 입도분포가 균일하고 치밀한 조직을 나타내는 미립의 구리산화물 분말을 제조하는데 있다.또한 본 연구에서는 분무열분해 공정에 의해 생성되는 분말의 특성에 영향을 미치는 반응 온도, 원료용액의 유입속도, 분위기기체 및 공기의 유입속도, nozzle tip 크기 및 원료용액의 농도 등의 반응인자들의 영향을 검토하였다.

한국형 노인주거개발을 위한 이론적 고찰

박유복,최영선,김현정,오이진,박정희 목포대학교 생활과학연구소 2000 생활과학논집 Vol.3 No.-

According to the increase of the number and portion of the elderly people, the elderly housing is an important social welfare factor as the solution of the elderly problem. When we consider the elderly housing of Korea, it should be appropriate to Korean culture and emotion. This study aims to suggest two ways of Korean elderly housing: three-generation housing and the renovation of housing which one elderly person have lived in. Considering that family centrism is remained a lot in Korean consciousness, those two ways should be developed well so as to build a unique Korean housing culture for the elderly.