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        Development of Predictive Marker for Perineural Invasion and Its Prognostic Value in Oral Squamous Cell Carcinoma: A Preliminary Study

        이광원,김지훈,오규영,윤혜정 대한구강악안면병리학회 2020 대한구강악안면병리학회지 Vol.44 No.3

        Perineural invasion (PNI) is the underestimated metastatic pathway and has been widely recognized as a negative prognostic factor in many human cancers. L1CAM is one of members of the immunoglobulin-like cell adhesion molecule (CAM) family, which play a role in neural development. Moreover, a new role of L1CAM outside the nervous system has been revealed. Overexpression of L1CAM was involved in the tumor progression and LN metastasis in various malignancies. In the present study, presence of PNI and L1CAM expression were examined to define their prognostic values in OSCC. In addition, association of L1CAM expression with presence of PNI was assessed to define the value as a candidate molecule supporting the diagnosis of PNI. We found that presence of PNI significantly correlated with LN metastasis and advanced clinical stage. L1CAM expression also significantly correlated with differentiation, lymph node metastasis, advanced clinical stage, as well as presence of PNI. Our results suggest that L1CAM seems to play a role in tumor progression, possibly through the PNI-related mechanism and could be a molecular marker for supporting the presence of PNI and predicting clinical outcome in OSCC.

      • KCI등재
      • KCI등재
      • KCI등재
      • Throwing athletes에서 어깨 관절의 손상

        이광원,Lee Kwang-Won 대한정형외과스포츠의학회 2003 대한정형외과스포츠의학회지 Vol.2 No.2

        Overhead athletes에서 특히 자주 볼 수 있는 불안정성 SLAP 병변, Internal impingement, 회전근 개 병변 등의 질환은 개별적으로 나타나는 것이 아니라 여러 질환이 동반되어 나타나므로 진단이나 치료에 어려움이 많다. 어깨 관절 손상의 성공적인 치료 및 운동으로의 복귀를 위하여는 각각의 운동의 생역학적인 측면과 개개의 질환의 증상 및 정확한 진단, 병리기전에 대한 확실한 이해가 선행되어야한다. The shoulder is a complex joint and, by virtue of having a large range of motion, is inherently unstable, relying on the surrounding soft tissue structures for stability. The bony joint consists of the glenoid, acromion, and humoral head, while the soft tissues include the glenoid labrum, the glenohumeral ligaments. and coracoacromial ligament as well as the muscles of the rotator cuff, the long head of the biceps, and the scapulothoracic muscles. Dysfunction in any one of these components can cause shoulder problems. The throwing motion involves a series of phases that stress to their limits the dynamic and static restraints of the glenohumeral and scapulothoracic joints. . Therefore, maintaining a balance of proper biomechanical forces is essential to avoiding shoulder injuries in throwing athletes. Over the last decade, signficant advances have been made in the study and understanding of the shoulder mechanics, and pathophysiology of injury. Additionally, advances in surgical techniques, particularly arthroscopy , have aided in the diagnosis of and the developement of less invasive surgical treatments for injuries that do not respond to nonoperative measures. In this article, we reviewed the pathophysiology of injuries , diagnostic techniques, and surgical management of shoulder injuries in throwing athletes .

      • KCI등재후보

        아연도금공정의 안전성평가

        이광원,박문희 한국안전학회 2003 한국안전학회지 Vol.18 No.4

        There are now the plating process that have many hazardous factor cause of the using numerous noxious chemical and bad working environments. The purpose of the study is to make a selection of suitable safety evaluation method that can analyze and righteously find with numerous hazardous factor of the plating process. And another purpose is to systematically adjust the risk of plating process by comprehension of the role of process, equipment, and source material. Therefore, these studies are carried out in the following three investigations of this report. The fast research understands the injurious human health and environment by analyzing hazardous material based on the MSDS. To evaluate the safety of process and compartment, the second research is proposed the security secure counterproposal by using the FMF.A and the HAZOP. The final research is devoted to systematically analyze the hazard by applying for reasonable guide word and doing the HAZOP for hazardous factor in specific process.

      • KCI등재
      • KCI등재
      • KCI등재

        학생자치활동을 통한 민주시민 교육

        이광원 한국사회교과교육학회 2019 사회과교육연구 Vol.26 No.3

        The purpose of this study is to find out the plan to advance citizenship and experience of learner participation through self regulated activities of students. It is aimed at the traditional social studies education to develop the democratic citizenship. However, due to the comprehension-oriented class, there are limitations have not been secured for practical participation. Through the practical participation, formulating the citizenship has been emphasized in recent days. For the cases of elementary school students, such an attempt has significant limitations. Therefore, this study has paid attention to the self regulated activities of students as part of a practical plan of participation activities. For a case of self regulated activities, the experience for citizenship may be experienced through the community problem solving process. And, through the campus activities, it may be an important mean to practice the social participatory activities. Accordingly, as for the preparation of community participation activities of elementary school students, the value of democracy and need for participation are learned through the independent project class in social studies. The experience to participate in education curriculum operation in the school has been confirmed through self regulated activities. Through the foregoing effort, learners may gain the experience in participation in community problem solving and cognitive comprehension on democratic citizenship. This is considered to be a plan to extend the democratic citizenship and willingness to participate for the elementary school students. 이 연구는 학생 자치활동을 통해 학습자 참여 경험과 시민성 신장 방안을 찾고자 시도 되었다. 전통적 사회과 교육이 민주시민성 육성을 일관된 목표로 삼았지만 그 노력에 비해 실천적 참여를 담보하지 못하고 있다는 문제제기가 지속되어 왔다. 최근 다양한 교육장면에서 실천적 참여와 민주시민성 신장에 관한 요구를 받고 있지만 초등학생의 경우 실천 혹은 실천과정을 시민성과 등치시킬 수 없는 한계를 지니고 있다. 이에 본 연구에서는 초등학생의 사회 참여활동의 실천 방안으로 학생자치활동을 주목하였다. 학생 자치활동의 경우 공동체 문제해결 과정을 통해 시민성 형성을 경험할 수 있고, 학교 내 활동을 통해 사회참여활동을 연습할 수 있는 주요한 수단이 될 수 있다. 따라서 초등학생의 공동체 참여활동을 시도하기 위한 준비로 사회과 자치 프로젝트 수업을 통한 민주주의의 가치와 참여 필요성을 학습하고, 자치활동을 통해 학교 교육과정운영에 참여 하는 경험을 제안하고 확인 하였다. 이를 통해 학습자는 민주 시민성에 대한 인지적 이해와 공동체 문제 해결의 참여 경험을 얻을 수 있었다. 이는 초등학생의 참여 의지와 민주 시민성을 신장할 수 있는 또 하나의 방안으로 여겨진다.

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