高等學校 學生들의 生理學的 誤槪念

鄭玩鎬,車喜英,姜錫本 한국교원대학교 과학교육연구소 1993 청람과학교육연구논총 Vol.3 No.1

The major purpose of this research was to identify high school students' misconceptions on physiology. Misconceptions of scientific concepts have been believed to be very persistent and difficult to be overcome through regular classroom activities. Therefore, to find out students' misconceptions and students' cognitive structure must be very important to design instructions as well as curriculum. In order to find out high school students' misconceptions on physiology, a open-ended form of questionnaire on the physiology of several biological areas was developed and sent to fifty-three high school students. Their responses were collected and analyzed. From the analysis of all the Korean text books, it was found that some concepts were not described correctly. At the same time, the terminology used in the text books was different from book to book. These incorrect presentations and inconsistent use of terminology would have been the source of students' misconceptions on biology. Although the pattern of misconceptions that Korean students have in the area of photosynthesis was generally similar to one by foreign students, the misconceptions arose from biological terminology such as excretion and elimination were found to be specifically developed in Korean students who use Korean language. Although there a few special misconceptions in fragmentary lower-level concepts, there were some misconceptions in comprehensive and fundamental higher-level concepts. This probably could have resulted from the fact that too many concepts were included in current Korean textbooks and the entrance examination items were only knowledge level which need only be memorized line by line. Therefore, the content and concepts should be very carefully chosen in the text books.

한국인에게서 그레이브스병 약물치료의 적정기간

이형숙,이동훈,정희선,이종우,김정은,신승수,정윤석,이관우,김현만 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.1

연구배경: 그레이브스병의 치료에는 항갑상선제, 수술 및 방사성 요오드법이 선택되어 사용되고 있다. 이중 항갑상선제는 가장 많이 선호되고 있으나 낮은 관해율과 높은 재발율로 장기간 치료기간이 요구된다. 저자들은 그레이브스병 환자에게서, 선택되는 치료법의 선호도와 각 치료법의 관해율을 조사하고자 본 연구를 시행하였다. 또한 본 연구에서는 항갑선제 치료의 적정기간을 평가하고자 하였다. 방법: 아주대학교병원에 내원한 환자 중 1년 이상 추적관찰이 가능한 205명의 그레이브스병 환자를 대상으로 조사하였다. 항갑상제군, 수술군 및 방사성 요오드군은 각각 170명, 29명 그리고 6명이었다. ROC curve를 이용하여 약물치료의 예후예측인자를 분석하였다. 결과: 1) 그레이브스병 환자의 치료 방법의 선택은 항갑상선제군, 수술군 및 방사성 요오드군 각각 170명(83.0%), 29명(14.1%) 그리고 6명(2.9%)으로 항갑상선제 치료가 가장 선호되었다. 2) 그레이브스병의 관해율은 항갑상선제군, 수술군 및 방사성 요오드군에서 각각 60.0%(102/170명), 96.5%(28/29명) 그리고 83.0%(5/6명)으로 수술군이 가장 높았다. 3) ROC curve의 AUC는 치료기간과 진단시 TBII가 각각 0.709 및 0.648이었고 적절한 약물투여 추적 관찰기간은 26개월이었다. 결론: 그레이브스병의 일차 치료법으로는 항갑상선제가 선호되고 있으나 수술 및 방사성 요오드 치료군에 비해 상대적으로 낮은 관해율을 보였다. 따라서 항갑상선제 치료로 26개월 이상 관해가 되지 않을 경우에는 치료 방법의 변경을 고려하는 것이 관해율을 높이는데 도움이 될 것으로 생각된다. Background: Graves' disease in an organ specific autoimmune disease. Three kinds of therapeutic modalities (antithyroid drugs, ablation with radioactive iodine and subtotal thyroidectomy) are frequently performed for the management of this disease. The most popular therapeutic policy for the disease in Korea is antithyroid treatment. We analysed and compared the remission rates of all three modalities for Graves' disease, and evaluated the antithyroid modality to determine the correct duration of treatment. Subjects & Methods : The medical records of 205 patients with Graves' disease were reviewed. For the evaluation of the antithyroid modality medical treatment, antithyroid drugs were administered for more than 1 year. The prognostic factors associated with remission were analysed by means of an ROC curve. Results: 1) Of the 205 patients, proportions that received medical therapy, subtotal thyroidectomy and radioiodine therapy were 83.0, 14.1 and 2.9%, respectively. 2) The remission rates of the medical therapy, surgery and radioiodine therapy were 60.0, 96.5 and 83.0%, respectively. 3) The remission rate of the medical therapy was associated with the duration of medication and TBII activity. The determined proper duration for the antithyroid treatment was 26 months from the ROC curve analysis. Conclusion: The above results suggest that the proper duration of antithyroid treatment for Graves' disease is 26 months, after which time the subtotal thyroidectomy or radioiodine therapy should be considered if the disease has not remitted (J Kor Soc Endocrinol 18:24∼31, 2003).

Cornell Potential Parameters for S-Wave Heavy Quarkonia

Hee Sok Chung,이정일,강대경 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.52 No.4

We compute derived quantities for various values of the model parameter of the Cornell potential model for the S-wave heavy quarkonia with radial quantum numbers n=1, 2 and 3. Our results can be used to determine leading and relative-order-v² nonrelativistic quantum chromodynamics matrix elements for S-wave charmonia and bottomonia such as ψ(2S), ηc(2S) and Υ(nS) for n=1, 2 and 3. These matrix elements will be essential ingredients for resumming relativistic corrections to processes involving those S-wave heavy quarkonium states. We compute derived quantities for various values of the model parameter of the Cornell potential model for the S-wave heavy quarkonia with radial quantum numbers n=1, 2 and 3. Our results can be used to determine leading and relative-order-v² nonrelativistic quantum chromodynamics matrix elements for S-wave charmonia and bottomonia such as ψ(2S), ηc(2S) and Υ(nS) for n=1, 2 and 3. These matrix elements will be essential ingredients for resumming relativistic corrections to processes involving those S-wave heavy quarkonium states.

한국인 정상 성인에서 성장호르몬의 분비능

정윤석(Yoon Sok Chung),김현만(Hyeon Man Kim),이은직(Eun Jig Lee),정재희(Jae Hee Chung),이경미(Kyung Mi Lee),박석원(Seog Won Park),조홍근(Hong Keun Cho),이현철(Hyun Chul Lee),허갑범(Kap Bum Huh),박유경(Yoo Kyoung Park),김희선(Hee Son 대한내과학회 1994 대한내과학회지 Vol.47 No.3

N/A Objectives: Growth hormone secretory capacity of adults decrease with aging, Growth hormone secretory capacity and prevalence of growth hormone deficiency in Korean adults were studied. Methods: History, physical examination, and routine blood tests were performed to roule out ill patients among ordinary subjects. Anthropometry, nutritional history, serum insulin-like growth factor-1 (IGF-1) levels, L-dopa stimulation tests, and urinary growth hormone levels were measured in 309 Korean adults, ages 20-87 years. Results: The mean serum IGF-1 levels were 258,2+6. 8 ng/ml. The mean serum IGF-1 levels of adult males were significantly higher than those of the females. The serum IGF-1 levels decreased with aging. The prevalence of growth hormone deficiency defined by serum IGF-1 levels (< 150 ng/ml) were 0.0% in the 3rd decade, 5.5% in the 4th decade, 12.2% in the 5th decade, 10.0% in the 6th decade, 32.1% in the 7th decade, 48.1% in the 8th decade, respectively. The serum IGF-1 levels were positively correlated with total energy expenditure, but negatively correlated with body fat mass. The peak serum growth hormone levels after L-dopa stimulation and urinary growth hormone levels of the younger subjects were significantly higher than those of the older subjects, There were goad correlations among serum IGF-1 levels, peak growth hormone levels after L-dopa stimulation, and urinary growth hormone levels. Conclusion: Growth hormone secretory capacity decreased significantly with aging, and growth hormone deficiency was found in about 1/3 of subjects aged over 60 years.

HBV : O-009 ; Poor durability of entecavir effectiveness: Extended data of the five year`s treatment experience

( Chung Hwa Park ),( Hee Yeon Kim ),( Do Seon Song ),( Myeong Jun Song ),( Nam Ik Han ),( Young Sok Lee ),( Si Hyun Bae ),( Jong Young Choi ),( Seung Kew Yoon ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-

Background: Entecavir, first-choice antiviral agent for treatment of chronic hepatitis B (CHB), is well known of its efficacy during treatment, but still its durability of effectiveness after withdrawal is still uncertain. Here, the extended data of the entecavir durability is reported. Methods: Retrospective study was done from adult patients who took entecavir for at least 3 months, prescribed from Jan., 2006 and stopped before Dec., 2010. Complete virologic response (CVR) was defined as serum HBV DNA < 300 copies/mL and virologic relapse (Vr) as ≥ 104 copies/mL after achieving CVR. Results: Among total 1366 patients, CHB patients without decompensation who took entecavir as a first-line antiviral therapy, whose CVR was achieved followed by a period of consolidation and who had follow-up lab data after cessation were 53 (3.8%). The consolidation period varied throughout the patients from 0 to 1030 days. Cumulative relapse rates at months 3, 6, 9 and 12 after cessation of entecavir were 15%, 56%, 78%, 80%. Age and DNA titer at starting antiviral therapy was shown to be the predictive factors for relapse. None of the patients of age over 50 showed durable effectiveness (p=0.02), and DNA titer over 108 copies/mL showed higher relapse rates (p=0.013). Conclusions: Effectiveness of entecavir is not so durable in either HBeAg-positive or negative patients, and is not even dependent on consolidation duration. Treatment duration may even need to be extended in patients over fifty or whose serum HBV DNA titer is ≥ 108 copies/mL at initiation.

한국인의 이소골 계측

김희남,이호기,박기현,정명현,김원석,정인혁 대한이비인후과학회 1998 대한이비인후과학회지 두경부외과학 Vol.41 No.8

경미한 미란성 식도염에서 식도 운동 및 위산 역류의 양상

정인식,김재광,김병욱,박재명,김보경,최황,최명규,선희식,최지현,박두호,한석원,문성배,김상우,정규원 대한소화기내시경학회 1999 Clinical Endoscopy Vol.19 No.5

Background/Aims: The major complications of reflux esophagitis are stricture formation and Barrett's esophagus. In Korea, the incidence of these complications is low and most patients with reflux esophagitis undergo a mild clinical course. The purpose of this study was to investigate patterns of acid reflux and esophageal motility in mild reflux esophagitis in Korea. Methods: Using conventional manometry and 24-hour ambulatory pH monitoring, we were investigated esophageal motility and patterns of gastroesophageal reflux in 41 patients with reflux esophagitis Savary-Miller (S-M) Ib using on endoscopy. The total supine, and upright reflux periods, as well as frequency and duration of reflux episodes were determined from the 24-hour pH monitoring record using standard software. Pathologic reflux was defined when the percentage of the total time with pH less than 4 (acid exposure time) exceeded 4%. Results: Pathologic reflux was observed in 17 patients (41.5%), who were categorized into upright refluxers (70.6%), supine refluxers (11.8%), and combined refluxers (17.6%). Patients with reflux esophagitis did not differ in lower esophageal sphincter pressure from the normal subjects. There were two patients (4.9%) with a lower esophageal pressure ≤ 10 mmHg and four patients (9.8%) with hiatal hernia. Failed peristalsis was seen in 4 patients (9.8%). Conclusions: A high proportion of upright reflux and low incidence of esophageal peristaltic dysfunction may contribute to the low incidence of stricture formation and Barrett's esophagus in patients with mild reflux esophagitis in Korea.

위장관 이물 118 예에 대한 고찰

정명선,최규용,김재광,최명규,박순민,선희식,한남익,한석원,윤종구,김성수,채현석,최주연 대한소화기학회 1999 대한소화기학회지 Vol.33 No.4

Background/Aims: Most of foreign bodies in the gastrointestinal tract are passed spontaneously, bu 10-20% of those needs treatment. We evaluated the role of endoscopy for removal of foreign bodies in the gastrointestinal tract. Methods: We investigated retrospectively 118 cases with foreign bodies in the gastrointestinal tract. They had been treated at Holy Family Hospital, The Catholic University of Korea, from January, 1990 through December, 1996. Results: The age ranged from 3 month to 78 years. Patients under 15 years were 76 cases and male was more prevalent than female (M:F= 1.68:1). Half (59 cases) of the patients had no symptom. Two most common foreign bodies were coins (45 cases) and sharp materials (18 cases) in children, while gastric bezoars (15 cases) and bones (10 cases) in adults. The most common location was esophagus (61 cases). In eighty-eight cases (74.6%), foreign bodies were removed by rigid or flexible endoscopy or anoscopy. Conclusions: Rigid and flexible endoscopy are useful tools for removal of foreign bodies in the gastrointestina tract.

Free Paper Session : LC & Liver Fibrosis ; Experiences in autologous bone marrow mesenchymal stem cell transplantation for decompensated Liver cirrhosis patients (초)

( Chung Hwa Park ),( Pil Soo Sung ),( Hee Yeon Kim ),( Sun Hong Yoo ),( Do Seon Song ),( Myeong Jun Song ),( Nam Ik Han ),( Young Sok Lee ),( Si Hyun Bae ),( Jong Young Choi ),( Seung Kew Yoon ) 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3(S)

Optimal interval of follow up imaging after complete response in patients with hepatocellular carcinoma under Milan criteria (초)

( Hee Yeon Kim ),( Jong Young Choi ),( Myeong Jun Song ),( Chung Hwa Park ),( Si Hyun Bae ),( Seung Kew Yoon ),( Sang Wook Choi ),( Chang Don Lee ),( Young Sok Lee ) 대한간학회 2010 Clinical and Molecular Hepatology(대한간학회지) Vol.16 No.3(S)