조혈모세포이식을 받은 급성 골수 백혈병 환자에서 발생한 cyclosporine에 의한 양측 시신경병증

정진권,김한조,박명진,하승주,최경식,이성진,박성희,이상철,이남수,박희숙,원종호 순천향대학교 의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.2

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一般 多重選擇 線型背囊問題에 대한 效率的인 解法

元重淵,鄭聖進 한국경영과학회 1990 韓國經營科學會誌 Vol.15 No.2

An efficient algorithm is developed for the linear programming relaxation of generalized multiple choice knapsack problem. The generalized multiple choice knapsack problem is an extension of the multiple choice knapsack problem whose relaxed LP problem has been studied extensively. In the worst case, the computational complexity of the proposed algorithm is of order 0((n·n_max)^2), where n is the total number of variables and n_max denotes the cardinality of the largest multiple choice set. The algorithm can be easily embedded in a branch-and-bound procedure for the generalized multiple choice knapsack problem. A numerical example is presented and computational aspects are discussed.

一般 多重選擇 線型背囊問題의 擴張問題에 대한 效率的인 解法

元重淵,鄭聖進 한국경영과학회 1992 한국경영과학회지 Vol.17 No.1

An extension of the generalized linear multiple choice knapsack problem[1] is presented and an algorithm of order 0([n·n_max]^2) is developed by exploiting its extended properties, where n and n_max denote the total number of variables and the cardinality of the largest multiple choice set, respectively. A numerical example is presented and computational aspects are discussed.

의료자문을 신청한 골절치료 자체의 합병증에 대한 분석

정인희,원예연,전창훈,안재인,박병문,김병석 대한골절학회 1995 대한골절학회지 Vol.8 No.2

The authors analysed 220 patients (225 cases) of complications including implant failure and refracture in fracture treatment which had been requested for medical consultation by the Korean Automobile, Fire k Marine Insurance Co., Ltd. from July 1984 to December 1992. The results were as follows: 1. The patients were consisted of 178(81%) males and 42(19%) females. 2. The average age of patients was 36.9 years. 3. There were 140(60%) cases of femur, 63(29%) cases of tibia and 12(5%) cases of humerus. 4. The most common previous mode of treatment was plate and screw fixation (183 cases, 83%). 5. There were 171(78%) cases of metal failure, 14 cases of secondary fracture and 14 cases of refracture. 6. Among the causes of complications, improper postoperative care (156 cases, 71%) was the most common causes of complications. 7. It is recommended that in the operative treatment of fracture, orthopaedic surgeon should obey the AO principles and proper postoperative care and also consider the conservative treatment as a good counter part of the operative treatment.

폐결핵환자의 최근 단기화학요법에 대한 임상적 고찰

김재원,정혜영,박효숙,조동일,유재인,유남수,박윤기,배성근 최신의학사 1981 最新醫學 Vol.24 No.1

골형성부전증 10예의 임상적 특징

이형숙,김현주,조재현,이승원,김현아,최준혁,송영준,김대중,이관우,정윤석 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.5

연구배경 및 방법: 골형성부전증은 비교적 희귀한 유전병으로 교원질 대사 장애로 인한 골의 취약성과 다발성 골절 및 척추측만증 등을 특징으로 한다. 유전방식과 표현형의 발현 정도에 따라 다양한 임상 양상을 보이며, 임상적 중증도에 따라 4가지 형태로 분류된다. 지금까지 국내 보고는 분만과정이나 태아 진찰시 골격이상으로 발견된 증례보고가 주였다. 저자들은 비교적 경미한 임상 양상을 보이는 예를 포함한 다수의 골형성부전증 환자들의 전반적인 임상적 특징에 대해 보고하는 바이다. 결과: 2001년 6월부터 2003년 2월까지 골형성부전증으로 진단받은 6 가계, 10예를 대상으로 하였다. 평균 나이는 27.3(5∼56)세였고 소아가 2예였다. 모두 상염색체 우성으로 유전되었으며, 제 I형이 4예, 제 III형이 4예, 그리고 제 IV형이 2예였다. 전 예에서 다수의 골절 경험이 있었고, 골밀도 저하와 골피질 두께 감소 소견이 관찰되었다. 전신의 평균 골밀도는 0.690(0.421∼1.039) g/cm²였다. 골형성지표로 측정된 sAlk는 소아의 경우만 증가되어 있었고, 골흡수지표로 측정된 uDPD의 평균치는 12.9(4.4∼36.3) nM/mM Cr으로 증가된 소견을 보였다. mobility score는 대부분 3,4단계에 속해 있었다. 중증형일수록 진단 시의 mobility score가 낮은 경향을 보였다. 결론: 한국인 골형성부전증 환자의 임상적 특징을 살펴본 결과 기존의 보고된 II형 외에도 I, III, IV형이 다양하게 존재함을 알 수 있었으며, 모든 예에서 상염색체 우성으로 유전됨을 확인할 수 있었다. 또한 모든 예에서 증가된 골흡수로 인한 골밀도 저하와 골절을 확인할 수 있었다. Osteogenesis Imperfecta (OI) is a relatively rare hereditary disease, which is characterized by multiple bone fractures and spine scoliosis, due to the fragility of bone, and is often associated with blue sclerae, deafness and dentinogenesis imperfecta. Four types of OI can be distinguished, according to the clinical findings. Although mutations affecting type I collagen are responsible for the disease in most patients, the mechanism by which the genetic defects cause abnormal bone development remains to be fully understood. Here, the clinical characteristics of 10 OI patient cases are reported, with a review of the literature. All the cases, including 4 type I, 4 type III and 2 type IV, inherited OI as an autosomal dominant trait. All the subjects had multiple old fractures and decreased bone densities. In this study, the biochemical marker of bone formation, serum alkaline phosphatase, was found to be increased only in the pediatric OI patients, while the biochemical marker of bone resorption, urinary deoxypyridinoline, was increased in all cases. The mobility score was found to correlate with the severity of the type on diagnosis (J Kor Soc Endocrinol 18:496∼503, 2003).

다발성 원격전이와 SIADH를 동반한 원발성 충수돌기 악성유암종 (Carcinoid Tumor) 1예

안광진,정현철,노재경,박중원,이화영,서창옥,노준규,이종태,최수임,김병수 대한내과학회 1990 대한내과학회지 Vol.38 No.1

Carcinoid tumors are the most trequently occurring neoplasms of the appendix and small bowel. Most carcinoid tumors of the appendix are incidentally discovered during other surgical procedures. Its natural course is usually benign and the size of the tumor is closely related with the liability of regional or distant metastasis, so this affects the mode of therapy. Lesions less than 2㎝ in greatest dimension are never shown to have metastatic lesions and those larger than 2㎝ are likely to metastasize to regional lymph nodes and occasionally to distant organs such as liver, lung and bones. We experienced a malignant carcinoid tumor of the appendix with metastasis to regional lymph nodes, lung, ribs and thoracic vertebrae, cervical lymphnodes, and the right adrenal gland without liver metastasis. The patient had no signs of carcinoid syndrome but showed hyponatremia which was corrected by fluid restriction, suggesting SIADH. The patient was treated with a combination regimen of 5-fluorouracil and doxorubicin after surgical removal of the appendiceal mass, and a palliative radiotherapy for the osteolytic lesion of the right 12th rib. A review of our experience suggests a more extensive program in disseminated malignant carcinoid tumors is required.

꼭지절단 원추형 페라이트 전파흡수체의 최적설게 및 제작에 관한 연구

김동일,박종구,정세모,원영수,이영구 한국해양대학교 산업기술연구소 2001 연구논문집 Vol.18 No.-

The remarkable progress of electronics and radio communications technology has made our life abundant. On the other hand, the countermeasure of EMC becomes more important socially according to the increased use of electromagnetic waves. It had been required that the absorbing ability of an electromagnetic wave absorber is more than 20 dB, the bandwidth of which is require through 30 MHz to 1,000 MHz for satisfying the international standard about an anechoic chamber for EMI/EMS measurement. From November of 1998, however, the CISPR11 has accepted the extended frequency band from 30MHz to 18 GHz in the bandwidth of EMI measurement. In this paper, we propose the cutting corn-shaped type satisfying the above requirments and carried out broadband design using the equivalent material constants method. Moreover, we have fabricated it and compared its characteristics with simulated one.

농후사료 급여수준이 거세 한우의 증체와 부위별 지방조직의 지방산 조성에 미치는 효과

김내수,원유석,송만강,최양일,최성호,정재경,정정수 한국동물자원과학회 2000 한국축산학회지 Vol.42 No.6

The study was conducted with 60 Hanwoo steer calves(7 month of age, mean body weight 139㎏) for 18 months performance to examine the effect of the feeding levels of concentrates on the growth performance and fatty acid composition of adipose tissues of various locations(subcutaneous, intermuscular and intramuscular fats). The Hanwoo steer calves were randomly allotted into 3 treatments according to the feeding levels of concentrates(85, 100 and 115%), and fed concentrates of Grower(7∼12 month of age), Finisher Ⅰ(12∼16 month of age), Finisher II(17∼20 month of age) and Finisher III(21 ∼25 month of age). The feeding levels of concentrates for the cattle of 85% or 115% were decreased or increased by 15%, respectively, up to 25 month of age based on the similar body weight to the cattle of 100%. The cattle were kept in an individual pen through the experimental period and were fed rice straw ad libitum. The cattle were slaughtered at the ages of 15, 18 and 25 months, and the adipose tissues collected were subjected to analyze the fatty acid composition. Growth of Hanwoo steers was not affected significantly by the feeding levels of concentrates, thus the lowered feed requirement was observed as the feeding levels of concentrates decreased. Overall mean dry matter intake concentrates, daily body gain and feed efficiency of Hanwoo steers up to 25month of age were 5.23㎏ , 0.75㎏ and 6.92, respectively. Fatty acids of palmitic acid(C_(16:0)) stearic acid(C_(18:0)) and oleic acid(C_(18:1)) in the adipose tissues of three locations of Hanwoo steers were dominated. The feeding level of concentrate did not affect the fatty acid composition. Percent composition of myristic acid was lowered in the order of subcutaneous, intermuscular and intramuscular fats. Relatively lowered values of C_(16:0) in the intramuscular and C_(18:1) and unsaturated fatty acids(USFA) to saturated fatty acids(SFA) in the intermuscular fats were observed. But increased tendencies of palmitoleic acid, C_(18:1) and linoleic acid were found from the subcutaneous, intermuscular and intramuscular fats, respectively. On the other hand, percent C_(18:0) slightly decreased but the ratio of USFA to SFA tended to increase with age.

성장월령에 따른 비거세 한우의 도체특성과 육질변화

김내수,원유석,송만강,최양일,정정수,이창림,정재경,임진희 한국축산학회 1999 한국축산학회지 Vol.41 No.6

The current study was undertaken to determine the effects of growing age on the carcass, meat quality and muscle fiber characteristics in Hanwoo bulls during the growing period of 6 to 30 months. A total of 54 heads of Hanwoo bulls (6 heads of 6 months, 12 heads each of 14, 18, 24 and 30 months) were conventionally slaughtered at each age, and then chilled overnight. The carcass characteristics and quality or yield grade (QG or YG) were determined on those carcasses, longissimus muscle (3Kg) was removed from left sides at 1st to 5th lumbar vertebrate and meat qualities or muscle fiber characteristics were evaluated. In the carcass characteristics of Hanwoo bulls, live weight, carcass weight and ribeye area except backfat thickness and dressing percent were increased(P $lt; 0.05) until 24 months of age. The backfat thickness was increased(P $lt; 0.05) from 18 to 24 months of age. The dressing percent was decreased(P $lt; 0.05) from 6 to 14 months, but thereafter slowly increased. Carcasses from 6 or 14 months of age showed A grade of YG, but carcasses from 18 to 30 months showed B grade. In QG, carcasses from 6 or 14 months showed `out of grade' and carcasses from 18 to 30 months showed grade 3 of QG, but the QG was not improved after the 24 months of age. In meat qualities of longissimus muscle, the pH and water-holding capacity tended to be similar except 18 months of age, and the meat color changed to red from 14 to 18 months of age. The shear force was increased(P $lt; 0.05) from 14 to 18 months, but after that decreased(P $lt; 0.05) at 30 months. In proximal analysis, the moisture content was decreased until 24 months of age, but the protein and fat contents tended to increase. In panel test, the flavor score tended to increase but the tenderness or total acceptability score tended to decrease until 30 months of age. In the muscle fiber characteristics, the ratio of white muscle fiber(IIW type) was the largest, and the ratio of intermediate muscle fiber(IIR type) was the smallest except for 6 or 24 months. The ratio of red muscle fiber(IR type) or IIR type tended to decrease, but the ratio of IIW tended to increase until 24 months of age. In the muscle fiber diameter, the IIW type had the largest diameter, but the IR type had the smallest diameter except the I8 or 24 months of age. The diameter of three muscle fiber types tended to increase until 30 months, and the IIW type showed faster increase. In the transmission electron micrographs, muscle fiber from longissimus muscle of 6 months did not show the full development and the A or I band was not fully observed. However, muscle fiber from longissimus muscle of 18 months showed thicker Z-line and the A or I band was fully observed. The longissimus muscle of 24 or 30 months showed the similar morphological pattern of muscle fiber as 18 months of growing age, but the muscle fiber seemed to be fully developed.