음경 흑피증 ( Penile Melanosis )

김윤규(Yun Kyew Kim),엄상철(Sang Cheul Eom),채영수(Young Soo Chae),서기석(Kee Suck Suh),김상태(Sang Tae Kim) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.6

Penile melanosis is a beniign macular hyperpigmentation of the penile shaft and/or glans. Clinically the lesions are irregular in outline and show variegated pigmentation. The main differential diagnostic problem is with acral levtiginous melanoma. A 28-year-old man was seen with slowly growing, asymptomatic, multifocal, and variegated hyperpigmented maculs on the glans penis of 28-year-duration. The post and family history were non-contributory. Hostogologic examination showed acanthosis and basal layer hyperpigrnentation but atypical melanocytes were not seen. Fontana-Masson stain showed increased melanin pigmentation with dendritic elongation of melanocytes in the basal layer of the epidermis. Little is known about the natural history and melnona risk of penile melanosis and we believe that a long-term follow-up is warranted. This patient showed no change during the follow-up period of 2 years and we will continue to monitor him long-term. (Kor J Dermatol 1994;32(6):1082-1085)

한국 청년층에서 UVA - 1의 최소홍반량과 최소색소량 및 8 - MOP 경구 투여 후 UVA - 1 과 UVA - 2 의 최소광독량에 관한 연구

김윤규 ( Yun Kyew Kim ),채영수 ( Young Soo Chae ),서기석 ( Kee Suck Suh ),김상태 ( Sang Tae Kim ) 대한피부과학회 1996 大韓皮膚科學會誌 Vol.34 No.1

Background: Minimal erythema dose(MED), minimal melanogenic dose (MMD) and minimal phototoxic dose(MPD) of UVA-1 in Koreans has not been determined, although MED and MMD of UVB and MPD of UVA-2 in Koreans have been reported. Objective : This study was done to measure the MED and MMDs including minimal immediate tanning dose(MITD) and minimal delayed tanning dose(MDTD) of UVA-1 radiation and compare the MPD of UVA-1 with that of UVA-2. Methods : In this study, a metal halide lamp (SUPUVASUN 3000) and a fluorescent blacklight lamp (Philips TL 20W/09N UVA lamp) were used as the UVA-1 and UVA-2 light sources, respectively. After the determining of Fitzpatrick's skin phototypes, the back skins of young adults were irradiated and the MED, MITD and MDTD of UVA-1 were assessed at 24 hours, 1 hour, and 7 days after irradiation, respectively. The minimal doses of phototoxic reaction, which was induced by oral 8-MOP plus UVA-1 or UVA-2, were assessed visually 72 hours after irradiation. Results : MED,was 61.20+11.50J/cm(mean+S.D.). MITD and MDTD of UVA-1 were 48.00+8.57J/cm and 65.30+12.10J/cm respectively. MPDs of UVA-1 and UVA-2 were 14.88+3.88J/cm and 4.40+1.69J/cm, respectively. Conclusion : In this study, the MED and MMD of UVA-1 radiation and the MPD of UVA-1 and UVA-2 radiation were measured in young adult Koreans. The MITD was less than the MED, and the MDTD was almost the same as the MED. The MPD of UVA-1 was three times higher than that of UVA-2. There vere no significant correlations between the MEDs, MMDs or MPDs and the skin phototypes. (Kor J Dermatol 1996;34(1): 71~77)

피부 콜레스테롤 색전증

김윤규(Yun Kyew Kim),채영수(Young Soo Chae),서기석(Kee Suck Suh),김상태(Sang Tae Kim) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.3

Cutaneous cholesterol embolism is a disease with severe arterosclercsis of the abdominal aorta in which emboli of cholesterol crystals from atheromatous plaques occlude airterioles. We report a case of cutaneous cholesterol embolism in a 61-year-old man who had livedo reticularis on both his feet for 10 days. Histopathologic findings showed needle-shaped cholesterol clefts viithin the lumina of arterioles. The patient died of myocardial infarction 3 months later. (Kor J Dermatol 1904; 32(3): 528-531)

Carbamazepine에 의한 가성림프종 증후군

김현철 ( Hyun Cheol Kim ),김윤규 ( Yun Kyew Kim ),채영수 ( Young Soo Chae ),서기석 ( Kee Suck Suh ),김상태 ( Sang Tae Kim ) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.4

The pseudolymphoma syndrome that may mimic malignant lymphoma clinically and histopathologically has been described as a hypersensitivity reaction to anticonvulsant drugs. It consists of the triad of a fever, generalized rash and lyrnphadenopathy. In some cases, varying degrees of malaise, hepatosplenornegaly, abnormal liver function tests, arthralgias, eosinophilia and blood dyscriasias may also be present. We report a case of pseudolymphoma syndrome due to carbamazepine in a 47-year-old man. He had a diffuse edematous and erythematous patches, papules and vesicles associated with high fever, hepatosplenomegaly and lymphadenopathy. The histopathologic finding slowed a dense atypical mononuclear cell infiltrate of the upper dermis associated with Pautriers microabscess like structures and severe dermal edema. Laboratory findings revealed leukocytosis and an abnormal liver function test. Three weeks after the withdrawal of carbamazepine and treatment with oral prednisolone, his skin lesion and general condition markedly improved. (Kor J Dermatol 1995;33(4): 775-779)

혈액투석시 발생하는 저혈압에 대한 Amezinium Methylsulfate의 효과에 대한 연구

윤일용,이규호,서재석,문치영,김원,박성광,강성귀 의과학연구소 2000 全北醫大論文集 Vol.24 No.2

1. Background : dialysis-induced hypotension is a very common but difficult complication to manage. Amezinium methylsulfate is a developed sympathomimetic agent which was effective in postural hypotension. We studied the effect of amezinium methylsulfate on dialysis-induced hypotension in chronic hemodialysis patients. 2. Methods : Fourteen hemodialysis patients who were maintained on hemodialysis longer than 6 months and had frequent episodes of dialysis-induced hypotension were enrolled in this study. After 4 weeks of observation period, patients were received one tablet (10mg) of amezinium methylsulfate 30 minutes prior to every hemodialysis session for 4 weeks. We compared mean arterial pressure, number of hypotensive episodes between observation and medication period in each patients. 3. Results : The mean arterial pressures during mid-hemodialysis and post-hemodialysis were higher in the medication period compared with observation period (80±6.9 mmHg vs 84±6.9 mmHg in mid-hemodialysis, 83±6.6Hg vs 90±4.7 mmHg in post-hemodialysis) 4. Conclusion : These results show that amezinium methylsulfate is useful to prevent dialysis-induced hypotension in chronic hemodialysis patients. (Key words : Hemodialysis, Hypotension, Amezinium methylsulfate)

족부백선에 대한 1 % 염산 부테나핀 크림의 치료 효과

김상태(Sang Tae Kim),서기석(Kee Suck Suh),김윤규(Yun Kyew Kim) 대한피부과학회 1995 大韓皮膚科學會誌 Vol.33 No.2

Background : Topical 1% butenafine hydrochloride cream, a new benzylamine derivative, has been reported to have antimycotic effect. Objective : An open trial as conducted to assess the efficacy and safety of 1% butenafine hydrochloride cream used once daily in the treatment of tinea pecis. Methods : Of 45 patients with clinically and mycologically proertinea pedis from the department of dermatology at Kosin medical college hospital, 42 patient, who could be monitored to the end of this study were evaluated. They applied 1% butenafine hydrochloride cream once daily until clinical improvement became evident or for 4 weeks and the effects were evaluated clinically and mycologically. Results : 1. From the mycological studies at the initial visit, causative organisms were isolated from 36 patients out of the 42 subjects and Trichophyton rubrum was most comnmon organism. 2. The negative conversion rate of the mycological study( negative microscopy and negative culture) was 90.5%(38/42) after 4 weeks of treatment. 3. The effective treatment vate at 4 weeks was 90.5%(38/42) 4. A adverse effects of using 1% butenafine hydrochloride cream was noted in 1 patient, who had a moderate degree of puritus, out of the 42 subjects. The presritus disappeared soon after the cessation of application of the cream. Conclusion : 1% butenafine lydrochloride cream is effective andafe in the treatment of tinea pedis. (Kor J Dermatol 1995;33(2): 287-293)

Woringer - Kolopp병 ( Pagetoid Reticulosis )

엄상철(Sang Cheul Eom),김윤규(Yun Kyew Kim),채영수(Young Soo Chae),서기석(Kee Suck Suh),김상태(Sang Tae Kim) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.1

Woringer-Kolopp(W-K) disease is a rare, localized, histologically m lignant, but clinically indolent lymphoproliferative disorder. It usually shows only a single slowly enlaging skin lesion mainly on the extremities. Some authors havv. regarded W-K diseas

만성 신부전증 환자의 중중 고혈당에 따른 의식 변화 결정에 대한 연구

위형중,이창범,박성광,강성귀,임천규,박은주,윤경택,한상웅,안유헌,김호중· 대한신장학회 2000 대한신장학회잡지 Vol.19 No.6

악성 흑색종과 멜라닌 세포성 모반의 bc1 - 2 단백의 발현 양상

김현철,김윤규,채영수,서기석,김상태 ( Hyun Cheol Kim,Yun Kyew Kim,Young Soo Chae,Kee Suck Suh,Sang Tae Kim ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.2

Background; The bcl-2 is a newly known oncogene involved in tumorigenisis by blocking apoptosis or programmed cell death. Overexpression of bcl-2 protein has been detected in a variety of human malignancies. However, recent studies of the expression of bcl-2 protein in human melanoma and melanocytic nevus have been controversial. Objective : The purpose of this study was to examine whether there are any differences in the expression of bcl-2 protein between melanocytic nevus and rnalignant melanoma. Methods : Immunohistochemical analysis of bcl-2 protein expression was performed on the formalin-fixed, paraffin-embedded tissue sections of 22 melanocytic nevus and 29 malignant melanomas(20 primary and 9 metastatic) using anti bcl-2 monoclonal antibody with an avidin-biotin peroxidase complex procedure. Results : The results were as follows. 1. The positive rate for bcl-2 protein was observed in 95.4% (21/22) of melanocytic nevus and 95.0%(19/20) of primary malignant melanomas. Therefore, there was no significant difference between the two groups in the positive rate for bcl-2 prtoein. 2. The percentage of stained cells and the staining intensity of bcl-2 protein were significantly increased in melanocytic nevus compared to malignant melanoma(p<0.05). 3. The positive rate for bcl-2 expression of metastatic malignant melanoma[44.4% (4/9)] was significantly decreased compared to that of primary malignant melanoma[95.0%(19/20) ](p<0. 05). But, there was no significant difference betweeen tumor thickness and histological type of malignant, melanoma in the expression of bcl-2 protein. 4. In melanocytic nevus, immunoreactivity of bcl-2 protein gradually diminished or even disappeared towards the deep dermis Conclusion : the bcl-2 expression was decreased in malignant melanoma compared to melanocytic nevus. It. suggests that the loss of bcl-2 expression may play a significant role in the progression and metastasis of malignant melanoma. (Kor J Dermatol 1997;35(2): 284-291)

폐혈색전증에 의한 급성신부전을 동반한 다발성 대칭성 지방종증 1예

이나리,진흥용,박성주,윤일용,권혁진,문치영,김원,박성광,강성귀 대한내과학회 2002 대한내과학회지 Vol.62 No.5

Multiple symmetric lipomatosis (MSL) is a rare disease characterized by the presence of diffuse, non-tender, symmetric deposits of adipose tissue on the neck, back and upper part of the trunk. It has been reported that this disease could be associated with various metabolic abnormalities such as impaired glucose tolerance, hyperuricemia, alcohol consumption, type 4 hyperlipidemia, renal tubular acidosis and thyroid disorder. We present a case of type 2 MSL with pulmonary thromboembolism. He suffered sudden dyspnea and decreased urine output. The causes of dyspnea and acute renal failure (ARF) in this case were dehydration and hemodynamic disturbance due to pulmonary thromboembolism. After thrombolytic and fluid therapy, his condition was improved. He was discharged on warfarin medication and has remained asymptomatic for 12 months.