우보 (牛步) 하대유 (河大有) 교수 화연기념호 (花宴紀念號), 하대유 교수 약력 (略歷)

연구소자료 전북대학교 의과학연구소 1993 全北醫大論文集 Vol.17 No.1

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행촌 (杏邨) 김상호 (金象皓) 교수 정년 기념호, 행촌 (杏邨) 김상호 (金象皓) 교수 약력 (略歷)

연구소자료 전북대학교 의과학연구소 1997 全北醫大論文集 Vol.21 No.1

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21세기 새로운 시대를 준비하는 원광대학교 의과대학의 교육목표 개정과정

이학승,김요식,송윤강,오재민,양연식,정선관 원광대학교 의과학연구소 2009 圓光醫科學 Vol.24 No.1

교육목적은 대학의 교육이 지향하는 대전제이다. 그러므로 대학교육 목적과 목표가 어떤가에 따라 교육과정과 교육방법이 달라진다. 원광대학교 의과대학의 교육목표는, '지덕겸수'로 요약되는 '과학과 도학을 겸비한 전인교육'의 건학정신과 '학술탐구'와 '덕성함양'의 원광대학교 교육목표와 일치하게 현재까지 유지되었다. 그러나 현행 교육목표의 여러 문제점이 발견되었고, 시대상의 변화에 따라 원광대학교 의과대학에서도 사회적 변화 빛 의료인에 대한 시대적 요구에 걸맞은 의학교육의 목적 및 목표의 재설정 과정을 시작하게 되었다. 그 결과 개정 작업을 통해 새로운 교육목표를 설정하게 되었으며 그 내용은 다음과 같다. 1. 기본진료능력을 지닌 의사를 양성한다. 2. 원불교 교리 이념을 반영한 윤리적, 도덕적인 의사를 양성한다. 3. 평생 학습하는 연구하는 의사 혹은 의과학자를 양성한다. 4. 사회적 책무를 수행하는 리더십을 갖춘 의사를 양성한다. 5. 지역 사회에 공헌하는 봉사정신을 갖춘 의사를 양성한다. Purpose : With the changes to the medical environments and to the medical educational systems, we aimed to evaluate the current mission statement of the School of Medicine, Wonkwang University, and to revise it. Methods : To establish the new goal and mission statement, a Special Committee for the Revision of Medical School Mission and advisory group were organized in 2008. This special committee conducted through five steps of action, which are composed of investigation, education, development, surveillance of various opinions, and announcement. Results : For the development of new goal and mission, the revised, final goal and mission statements decided through the five steps of action. The new mission of Wonkwang University School of Medicine was as follows; 1. Doctor who can diagnose and treat easily 2. Ethical and moral doctor who practice Won Buddhism 3. Doctor or Medical Scholar who studies lifelong study 4. Doctor who has leadership to social responsibility 5. Doctor who goes into service to a local community. Conclusion : The authors expect that the new goal and mission of Wonkwang University School of Medicine would be helpful in giving the guideline on the educational process of medical school and will give the information to reform the medical school system according to the rapidly changing educational environment.

덕암 (德巖) 황인담 (黃仁澹) 교수 화연기념호 (花宴紀念號), 덕암 황인담 교수 약력

연구소자료 전북대학교 의과학연구소 1986 全北醫大論文集 Vol.10 No.1

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증례 ( Case Reports ) : 제 6 차 전북대학교 의과대학 학술집담회 초록 : Mepirizole 유도 십이지장궤양에 관한 실험적 연구

연구소자료 전북대학교 의과학연구소 1985 全北醫大論文集 Vol.9 No.4

고콜레스테롤 혈증 환자에서 Cerivastatin(LIPOBAY, 의과학연구소)의 임상효과 및 안전성에 관한 연구

박성훈,김미연,정수진,이영숙,박창한,변은경,전성희 梨花女子大學校 醫科大學 醫科學硏究所 2001 EMJ (Ewha medical journal) Vol.24 No.3

목적 : Cerivastatin(LIPOBAY)은 최근에 개발되어 사용되기 시작한 HMG-CoA 환원효소 억제제로서 저용량으로 탁월한 콜레스테롤 강하효과를 보이는 약물이다. 저자들은 Cerivatatin(LIPOBAY)의 혈중 콜레스테롤 강하효과를 평가하고 약물의 안전성을 평가하기 위하여 본 연구를 시행하였다. 방법 : 고콜레스테롤혈증 환자 37명(남자 13명, 여자 24명)을 대상으로 하였다. 대상환자는 2주간의 저콜레스테롤 식이 후에도 혈청 콜레스테롤이 240㎎/㎗이상이거나, 관상동맥질환이 있는 환자는 혈청콜레스테롤이 220㎎/㎗이상인 경우 cerivastatin 0.4㎎을 8주간 복용하도록 하였다. 임상적 관찰과 검사실 검사(간기능검사, 일반혈액검사, 혈청지질검사)는 투약개시 후 4주 및 8주 후에 시행하였다. 결과 : Cerivastatin 0.4㎎을 4주간 투여한 후 측정한 LDL 콜레스테롤, 총콜레스테롤, triglyceride, 및 HDL 콜레스테롤은 각각 38%, 28.8%, 11.6% 및 7.8% 감소하였다. 총콜레스테롤/HDL 콜레스테롤 비 및 LDL/HDL비는 각각 20.8% 및 31.1% 감소하였다. 투약 8주후에 측정한 검사소견은 4주후에 비해 유의한 변화를 보이지 않았다. 한명의 환자(2.7%)에서 간기능 검사상 AST, 및 ALT의 지속적인 상승으로 투약을 중지하였다. 결론 : Cerivastatin 0.4㎎/day는 혈청콜레스테롤을 효과적으로 감소시켰으며 심각한 부작용은 볼 수 없었다. 따라서 적극적으로 LDL콜레스테롤을 낮출 필요가 있는 고콜레스테롤혈증 환자에서 cerivastatin은 효과적이고 안전한 약물이라고 생각된다. Objectives : Cerivastain(LIPOBAY) is recently developed HMG-CoA reductase inhibitor which is effective in lowering serum cholesterol levels at microgram does. We evaluated the clinical efficacy and safety of cerivastatin(LIPOBAY) in patients with hypercholesterolemia. Method : Thirty-seven patients(male : 13, female : 24) with hypercholesteolemia defined as baseline serum total cholesterol ≥240㎎/㎗, or ≥220㎎/㎗ in patients with known coronary artery disease were included for this study. After 2 weeks of low cholesterol diet, if the serum total choesterol level meet the criteria, cerivastain 0.4㎎/day was prescribed for 8 weeks. Clinical follow-up and laboratory tests were performed 4 weeks and 8 weeks after medication. Results : After 4 weeks of cerivastain 0.4㎎/day treatment, low density lipoprotein(LDL) cholesterol decreased 38% and total cholesterol decreased 28.8% from baseline. Triglyceride decreased 11.6%, and high density lipoprotein(HDL) cholesterol decreased 7.8% from baseline. Total cholesterol/HDL ratio decreased 20.8% and LDL/HDL ratio decreased 31.1% from baseline. After 8 weeks of treatment, no further significant changes were noted compared with the values at 4 weeks. Cervastatin was discontinued in one patient(2.7%) due to continuous liver enzyme elevation. Conclusion : Cerivastatin 0.4㎎/day is effective in lowering serum cholesterol levels without significant adverse reactions. Cerivastatin is effective and safe for patients with hypercholesterolemia who needs aggressive LDL cholesterol lowering.

관절경을 이용한 전방 십자인대 재건술: : Two Tunnel Method와 One Tunnel Method의 비교 Comparison of Two Tunnel Method with One Tunnel Method

김경순,신규철,김동헌 건국대학교 의과학연구소 1995 건국의과학학술지 Vol.5 No.-

저자들은 1988년 3월부터 1994년 9월까지 진구성 방전십자인대 손상에 대하여 관절경하에서 슬개골-건-골을 이용하여 재건술을 시행한 환자중 1년이상 추시가 가능했던 30례의 환자를 대상으로 결과를 분석하여 다음과 같은 결과를 얻었다. 1) 남자가 많았고 30대가 가장 많았다. 2) 가장 많은 손상 원인은 교통사고였으며 17명의 환자에서 동반손상이 있었다. 3) 수상후 수술까지의 기간은 평균 9개월이었고 3개월부터 18개월까지 고른 분포를 보였다. 4) 가장 많은 동반손상은 내측부 인대 파열이었고 다음은 내측부 반월판 손상이었다. 5) 환자의 임상적 평가는 Lysholm knee scoring scale을 사용하였다. Two tunnel군에서는 최종 평가시 79%에서 양호 이상의 소견을 보였고, One tunnel 군에서는 81%에서 양호 이상의 소견을 보였다. 6) 10명의 환자에서 추시관절경을 시행하였으며 관절경 소견상 이식거늬의 생착과정을 확인할 수 있었다. 저자들은 관절경하에서 슬개골-건-골을 이용한 선방 십자인대 재건술을 시행하여 양호한 결과를 얻었고 향후 장기 추시가 필요할 것으로 사료되며 두 가지 수술 방법에 따른 뚜렷한 차이는 없었다. 또한 추시 관절경 검사는 이식건의 성숙 과정을 관찰하고 환자의 재활치료에 방침을 정하기 위해 필요하리라고 사료된다. Recent Arthroscopic ACL reconstruction methods have been developed as a technical solution to achieve proper positioning of the graft. In this study, ACL tear were treated with BTB autograft using either arthroscopic two tunnel method or one tunnel method. We analyzed the 30 cases who had taken the reconstruction surgery of ACL from March 1988 to September 1994. The results were as follows. In the two tunnel group, 79%(15 patients) were estimated as exellent or good result and 81%(9 patients) in the One tunnel group. Follow-up arthroscopy was perfomed to observe the maturation process of the graft in 10 cases. There was no clinical differences between two groups.

마취기의 일방향성 밸브의 결손이 호기 및 흡기의 가스 농도에 미치는 영향

우남식 건국대학교 의과학연구소 1995 건국의과학학술지 Vol.5 No.-

Recent advances in technology have made it possible to measure all of the respired gases of interest during the administration of an inhaled anesthetic. The results of respiratory gas analysis can provide information about the function of the andsthesia delivery system(machine, vaporizer, circuit, valve, etc.) as well as the patient's respiratory, cardiovascular and metabolic status. The semi-closed circle absorber anesthesia system employs individual inhalation and exhalation unidirectional check valves to guide the flow of gas within the circuit and prevent CO₂rebreathing. The most common malfunction in these unidirectional check valves is one in which the valve disc fails to close. The present investigation was designed to study effect of incompetent unidirectional valves on the changes of the partial pressure of inhaled and exhaled CO₂, the fraction of inhaled and exhaled O₂,arterial O₂saturation, blood pressure and heart rate. An DAMECA anaesthesia machine(Denmark) with a semi-closed circle absorber system was used for the study. All patients were anesthetized with the enflurane or isoflurane combined with nitrous oxide(2 liters/minute) and oxygen(2 liters/minute), and paralized with vecuronium(6-8㎎). Ventilation was controlled with DAMECA ventilator, using a constant tidal volume of 10㎖/㎏ of body weight. Ventilatory rate was adjusted 10-12 times/minutes to maintained the end tidal CO₂of 25~30㎜Hg. After a clinical steady state was achived, measurements were obtained till the partial pressure of expiratory CO₂would reach 50㎜Hg, under two condition: 1) removal of inhalation valve disc: 2) removal of exhalation valve disc. The results were as follows: The removal of exhalation valve shows significant increase of ??(regression equation is Y=1.46×X+26.11) and ??(regression equation is Y=1.15×X+4.59). The removal of exhalation valve shows significant decrease of ??(regression equation is Y= -0.31×X+46.66) and ??(regression equation is Y=-0.22×X+49.29), but these were no clinically significant changes. The removal of inhalation valve shows significant increase of ??(regression equation is Y=0.50×X+27.13) and ??(regression equation is Y=0.11×X+1.14). The removal of inhalation valve shows no significant changes in ?? and ??. There were no significant changes in arterial oxygen saturation, systolic and diastolic blood pressure, and heart rate.

종격동에 발생한 낭포성 림프관종 : Case Report 증례보고

전혜정,최영칠,박정희 건국대학교 의과학연구소 1993 건국의과학학술지 Vol.3 No.-

Cystic lymphangiomas are uncommon neoplasms and are rare in the mediastinum. Approximately seventy-five percent occur within the neck and twenty percent in the axilla with the remaining five percent presenting in the mediastinum and abdomen. Most common type of mediastinal lymphangioma is the tumor extends from the neck into the mediastinum and frequently occurs in young children under age two. It is unusual for lymphangioma to exist in the mediastinum alone, which noted usually in adults. Authors experienced a case of mediastinal cystic lymphangioma in a 54-year-old woman. Chest roentgenogram revealed a large soft tissue mass on the left side of the anterior mediastinum below the aortic arch. CT scan showed well defined and thin walled water density mass lying in the anterior mediastinum on left which did not displace or compress the adjacent mediastinal structure. The mass was totally resected.

활성산소의 독성과 그 임상응용

조병일 건국대학교 의과학연구소 1993 건국의과학학술지 Vol.3 No.-

Acute, servere increases in arterial blood pressure cause sustained cerebral arteriolar dilation, abnormal reactivity to carbon dioxide and to changes in blood pressure, abolition of the endothelium dependent dilation from acetylcholine, discreate morphological lesions of the endothelium and vascular smooth muscle, and breakdown of the blood-brain barrier to plasma proteins. The dilation, abnormal reactivity, and morphological abnormalities are inhibited by tase-inhibitable reduction of nitroblue tetrazolium applied to the brain surface was detectable both during hypertension and one hour after hypertension subsided. Nitroblue tetrazolium reduction is also reduced by topical application of arachidonate. The results are consistent with the view that acute hypertension induces generation of superoxide anion radical in association with accelerated arachidonate metabolism via cyclooxygenase. This radical enters cerebral extracellular space via the anion channel and gives rise to hydrogen peroxide and hydroxyl radical. All three radicals are capable of causing vasodilation by relaxation of cerebral vascular smooth muscle. The hydroxyl radical is the most likely candidate for vascular wall damage. The significance of this mechanism in chronic experimental hypertension or its relevance to human disease is not known.