폐렴간균(Klebsiella pneumoniae)과 그 외의 다른 세균에 의한 화농성 간 농양의 임상적 비교

진흥용,이식,박주형,최유진,이흥범,이수택,안득수 대한감염학회 2001 감염 Vol.33 No.3

Background : There are increasing reports of hepatic abscess cause by K. pneumoniae, especially in Asia and its more frequent occurrence in diabetes mellitus but the reason remains unclear. This study was conducted to clarify the different clinical presentations between patients with K. pneumoniae (KP group) and those with non-K. pneumoniae (non-KP group) hepatic abscess. Methods : A retrospective clinical survey was done from April 1997 to February 2001. The medical records of 20 adults with culture-confirmed pyogenic liver abscess who had attended Chonbuk National University hospital were reviewed. Results : Hepatic abscess caused by K. pneumoniae accounted for 10 (50%) of 20 patients with pyogenic liver abscesses. Compared to KP group, non-KP group showed higher proportions of polymicrobial infections (50% vs 20%) including E. coli, Proteus sp., Enterobacter sp., Citrobacter sp., P. aeruginosa, viridans streptococcus, Enterococcus, and Bacteroides sp.. Although, the clinical presentations of the two groups were similar, but KP group showed higher association with diabetes mellitus, lower hepatobiliary diseases, and larger abscess formation than non-KP group. Conclusion : K. pneumoniae was one of the most important causative organism in pyogenic liver abscess. Clinical findings were similar between K. pneumoniae heatic abscess and non-K. pneumoniae-induced abscess, though, K. pneumoniae-induced hepatic abscess was more frequently associated with diabetes mellitus and single large abscess. (Korean J Infect Dis 33:202∼205, 2001)

Morphologic Changes in Autonomic Nerves in Diabetic Autonomic Neuropathy

진흥용,백홍선,박태선 대한당뇨병학회 2015 Diabetes and Metabolism Journal Vol.39 No.6

Diabetic neuropathy is one of the major complications of diabetes, and it increases morbidity and mortality in patients with both type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). Because the autonomic nervous system, for example, parasympathetic axons, has a diffuse and wide distribution, we do not know the morphological changes that occur in autonomic neural control and their exact mechanisms in diabetic patients with diabetic autonomic neuropathy (DAN). Although the prevalence of sympathetic and parasympathetic neuropathy is similar in T1DM versus T2DM patients, sympathetic nerve function correlates with parasympathetic neuropathy only in T1DM patients. The explanation for these discrepancies might be that parasympathetic nerve function was more severely affected among T2DM patients. As parasympathetic nerve damage seems to be more advanced than sympathetic nerve damage, it might be that parasympathetic neuropathy precedes sympathetic neuropathy in T2DM, which was Ewing’s concept. This could be explained by the intrinsic morphologic difference. Therefore, the morphological changes in the sympathetic and parasympathetic nerves of involved organs in T1DM and T2DM patients who have DAN should be evaluated. In this review, evaluation methods for morphological changes in the epidermal nerves of skin, and the intrinsic nerves of the stomach will be discussed.

액와부 상완신경종 차단시 액와동맥초내압의 변화

진흥용 중앙대부설한국의과학연구소 1984 한국의과학 Vol.16 No.2

Lost in Translation? Measuring Diabetic Neuropathy in Humans and Animals

진흥용,문성수,Nigel A. Calcutt 대한당뇨병학회 2021 Diabetes and Metabolism Journal Vol.45 No.1

The worldwide diabetes epidemic is estimated to currently afflict almost 500 million persons. Long-term diabetes damages multiple organ systems with the blood vessels, eyes, kidneys and nervous systems being particularly vulnerable. These complications of diabetes reduce lifespan, impede quality of life and impose a huge social and economic burden on both the individual and society. Peripheral neuropathy is a debilitating complication that will impact over half of all persons with diabetes. There is no treatment for diabetic neuropathy and a disturbingly long history of therapeutic approaches showing promise in preclinical studies but failing to translate to the clinic. These failures have prompted re-examination of both the animal models and clinical trial design. This review focuses on the functional and structural parameters used as indices of peripheral neuropathy in preclinical and clinical studies and the extent to which they share a common pathogenesis and presentation. Nerve conduction studies in large myelinated fibers have long been the mainstay of preclinical efficacy screening programs and clinical trials, supplemented by quantitative sensory tests. However, a more refined approach is emerging that incorporates measures of small fiber density in the skin and cornea alongside these traditional assays at both preclinical and clinical phases.

A Case of Graves’ Disease Combined with Hantaan Virus Infection

진흥용,김소영,박지현,백홍선,박태선,강선미 대한의학회 2009 Journal of Korean medical science Vol.24 No.1

Graves’ disease (GD) is generally presented by thyrotoxicosis with hyperthyroidism, and it is an organ-specific autoimmune disease induced by thyroid-stimulating hormone receptor autoantibodies. However, among diverse etiologies, viral infections have been suggested to trigger or to be involved in the pathogenesis of GD. Hantaan virus infection causing hemorrhagic fever with renal syndrome (HFRS) is common in South Korea and its pathogenesis is suggested to be an immunologic mechanism. We have experienced a patient who was diagnosed as HFRS with thyrotoxicosis. So we herein report the case as GD combined with the hantaan virus infection.

Lost in Translation? Measuring Diabetic Neuropathy in Humans and Animals (Diabetes Metab J 2021;45:27-42)

진흥용,문성수,Nigel A. Calcutt 대한당뇨병학회 2021 Diabetes and Metabolism Journal Vol.45 No.3

Response

천적과 친환경농자재를 이용한 목화진딧물의 방제

진흥용,Jin, Heung-Yong 전국농업기술자협회 2008 농업기술회보 Vol.45 No.1

심혈관계, 신장 합병증이 동반된 환자의 당뇨병 약물 치료

진흥용 대한내과학회 2023 대한내과학회 춘계학술대회 Vol.2023 No.0

빈혈이 있는 당뇨병환자에서 말초신경병증 동반여부와 혈중 에리트로포에틴의 농도

진흥용,정수진,박지현,백홍선,박태선,김종화 대한당뇨병학회 2007 Diabetes and Metabolism Journal Vol.31 No.2

Background: Peripheral neuropathy is a common complication of diabetes mellitus, contributing the greatest morbidity and mortality and impairing the quality of life. Recently the receptor of erythropoietin (Epo) was proven to be expressed in neuronal cell and recombinant human Epo (rhEpo) has been shown to have neuroprotective and neurotrophic potential in peripheral neuropathy. But there is no report about baseline Epo level in blood before rhEpo treatment with diabetic peripheral neuropathy.Methods: From Jan. 2000 to Sep. 2006, diabetic patients were reviewed about Epo level in blood, anemia, and peripheral neuropathy in Chonbuk National University Hospital. And we compared the mean value of baseline Epo level in diabetic patients with anemia according to the peripheral neuropathy. Results: The mean value of Epo of patients with peripheral neuropathy was lower than that of patients without peripheral neuropathy (16.3 ± 7.1 vs 26.1 ± 29.7 mU/mL, P < 0.05). There was no significance in the correlation between hemoglobin and Epo level in diabetic patients with anemia irrespective of presence of peripheral neuropathy (r = -0.02, P = 0.81).Conclusion: We suggest that decreased Epo level in blood is possible to be an additional cause in the development of peripheral neuropathy. However, simultaneously another possibility that neuropathy causes reduced Epo level should be considered, so further studies are warranted in this field. (J Kor Diabetes Assoc 31:151~156, 2007) 연구배경: 당뇨병환자에서는 신장손상 및 신기능저하, 자율신경계 손상, 그 외 여러 가지 규명되지 않은 기전에 의해 빈혈이 동반되더라도 Epo가 증가되지 않는 상대적 감소현상을 보인다고 알려져 있다. 그러나 Epo는 잘 알려진 골수에서의 조혈작용 외에도 신경세포내의 Epo 수용체에 작용하여 신경을 보호하는 효과도 가지고 있다고 보고되고 있다. 이러한 면에서 당뇨병성 말초신경병증이 발생한 경우 신경보호효과가 있는 Epo의 혈중내 감소정도와 상관관계 여부에 대해서 알아보고자 하였다. 방법: 본 연구에서는 2000년 1월부터 2006년 9월까지 전북대학병원에 내원한 당뇨병환자 중 당뇨병성 말초신경병증을 진단받은 환자와 말초신경병증이 동반되지 않은 환자를 구분하여 이중 혈중 Epo값이 측정된 환자들만을 조사하였다. 대조군은 말초신경병증이 동반되지 않은 당뇨병환자 중 나이, 혈색소, HbA1c값이 말초신경병증 환자들의 평균값과 유사한 환자들을 선별하였다. 결과: 조사된 당뇨병환자 중 말초신경병증과 빈혈이 동반되어 있으면서 혈중 Epo값이 측정된 환자는 76명이었고 평균값은 16.3 ± 7.1 mU/mL였다. 말초신경병증은 없고 빈혈이 동반된 환자 중 혈중 Epo값을 확인 할 수 있었던 환자는 78명이었으며 평균값은 26.1 ± 29.7 mU/mL였다 (P < 0.05). 조사된 Epo 평균값은 당뇨병이 없는 빈혈 환자들에서 보고된 혈중 Epo 농도보다 낮았고 말초신경병증이 동반된 환자들에서 더욱 낮은 농도를 보였다. 또한 말초신경병증의 동반여부에 상관없이 조사되었던 빈혈이 있는 당뇨병 환자들에서 혈색소 농도에 따른 혈중 Epo의 반응은 상관관계가 없었다 (r = -0.02, P = 0.81).

당뇨병성 족부궤양 환자에서 vancomycin에 의한 범혈구 감소증 1예

진흥용,정수진,박지현,박태선,백홍선 대한당뇨병학회 2006 Diabetes and Metabolism Journal Vol.30 No.5

Diabetic foot ulcer is a common complication in diabetic patients and the outcome of foot ulcer depends on the severity of ulcer and combined infection such as osteomyelitis. So antibiotics targeting Gram positive cocci including Staphylococcus aureus have been used frequently. However, during the antibiotic therapy, diverse adverse reactions could be happened including red man syndrome, chest pain, hypotension, thrombocytopenia, neutropenia and drug eruption. Among these reactions, hematologic adverse events such as pancytopenia are rare and it could be lethal if happened. This article reports a case of pancytopenia associated with vancomycin in treating 저자들은 감염된 당뇨병성 족부 궤양 환자에서 vancomycin 사용 후 발생한 범혈구 감소증 환자를 경험하였 기에 이런 상황에 자주 접하는 내분비 의사들에게 주의와 함 께 항생제 사용의 신중함을 당부하기 위해 보고하는 바이다.