위치기반서비스를 위한 Push-to-Talk 기술

김상태(Sang Tae Kim),김영철(Young Cheol Kim),차현철(Hyun Chul Cha),김현덕(Hyun Deok Kim) 한국통신학회 2010 한국통신학회 학술대회논문집 Vol.2010 No.2

Carbamazepine에 의한 가성림프종 증후군

김현철 ( Hyun Cheol Kim ),김윤규 ( Yun Kyew Kim ),채영수 ( Young Soo Chae ),서기석 ( Kee Suck Suh ),김상태 ( Sang Tae Kim ) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.4

The pseudolymphoma syndrome that may mimic malignant lymphoma clinically and histopathologically has been described as a hypersensitivity reaction to anticonvulsant drugs. It consists of the triad of a fever, generalized rash and lyrnphadenopathy. In some cases, varying degrees of malaise, hepatosplenornegaly, abnormal liver function tests, arthralgias, eosinophilia and blood dyscriasias may also be present. We report a case of pseudolymphoma syndrome due to carbamazepine in a 47-year-old man. He had a diffuse edematous and erythematous patches, papules and vesicles associated with high fever, hepatosplenomegaly and lymphadenopathy. The histopathologic finding slowed a dense atypical mononuclear cell infiltrate of the upper dermis associated with Pautriers microabscess like structures and severe dermal edema. Laboratory findings revealed leukocytosis and an abnormal liver function test. Three weeks after the withdrawal of carbamazepine and treatment with oral prednisolone, his skin lesion and general condition markedly improved. (Kor J Dermatol 1995;33(4): 775-779)

기저세포암 , 편평 세포암 , 각화극세포종 및 모낭 상피종의 bcl - 2 단백 발현 양상

김현철 ( Hyun Cheol Kim ),장민수 ( Min Soo Jang ),채영수 ( Young Soo Chae ),서기석 ( Kee Suck Suh ),김상태 ( Sang Tae Kim ) 대한피부과학회 1996 大韓皮膚科學會誌 Vol.34 No.5

Background: The bcl-2, gene is a newly described oncogene involved in tumorigenesis by blocking apoptosis, or programmed cell death and overexpression of bcl-2 protein has been reported in several malignant tumors such as lymphoma, breast cancer, and lung cancer. Though keratinocyte-derived skiri tumors are one of the most common human tumors the detailed molecular mechanism of the keratinocytic tumors is not clear. Also, the differentiation between basal cell carcinoma(BCC) and trichoepithelioma(TE) is sometirnes difficult clinically and histologically. Objective : The purpose of this study is to examine whether there is difference in staining pattern of bcl-2 protein in BCC, TE, squamous cell carcinoma(SCC), and keratoacanthoma(KA). We also evaluated the diagnostic value of expression pattern of bcl-2 protein in distinguishing BCC and TE. Methods : Routine paraffin sections of formalin-fixed forty-four tissues (19 BCC, 9 SCC, 10squamous cell carcinoma in situ : 5 actinic keratosis [AK] and 5 Bowen disease [BD], 5 keratoacanthoma, and 6 (TE) were labeled with anti-bcl-2 monoclonal antibody using a avidin-biotin peroxidase complex. Normal skin for bcl-2 protein served as negative controls. Results : The results were as follows. l. In normal skin, bcl- 2 positivity was observed in the epidermal basal layer, the basal layer of follicular infundibuium, the mesenchymal cells of the follicular papillae, and the eccrine glands. 2. All cases of BCC and TE showed a positive cytoplasmic staining for bcl-2 proein, but all cases of SCC, AK, BD, and KA were negative. 3. In staining pattern, of bcl-2 protein, BCC showed diffuse staining throughout the tumor lobules. In TE, the basaloid cells lining the periphery of each tumor nests and the papillary mesenchymal bodies stained strongly. Conclusion : This study shows that BCC express bcl-2 protein, whereas SCC are negative. Our results indicate that proteon from apoptosis mediated by bcl-2 protein may be involved in the neoplastic growth mechanism of BCC. In addition, the ohserved findings in expression pattern of bcl-2 protein in BCC and TE may be of a diagnostic help in distinguishing the borderline cases. (Kor J Dermatol 1996;34(5): 739-746)

GPS 위치정보를 이용한 멀티미디어 관광 콘텐츠 제공 서비스

김영철(Young Cheol Kim),김상태(Sang Tae Kim),차현철(),김현덕(Hyun Deok Kim) 한국IT서비스학회 2009 한국IT서비스학회 학술대회 논문집 Vol.2009 No.3

위치기반 서비스는 사용자의 위치를 자동으로 인식하여 사용자의 위치를 고려한 맞춤형 서비스를 제공하며, 일반적으로 위치정보 획득을 위해 GPS(Global Positioning System)를 이용하고 있다. 본 논문에서는 GPS 수신기를 통해 수신된 정보로 부터 차량의 위치정보를 인식하고, 이를 사전에 설정된 관광 차량의 이동경로와 비교 분석하여 안내 방송이 필요한 각 관광지까지의 거리와 소요시간 등을 실시간으로 인식한다. 또, 이러한 인식결과를 이용하여 사전 또는 실시간으로 설정된 관광지의 멀티미디어 관광 콘텐츠를 영상과 음성으로 재생하여 관광객에게 제공하게 된다. 특히, 각각 사용 언어가 다른 사용자가 동시에 서비스를 이용하더라도 별도의 음성채널을 통하여 서비스를 제공하며, 사용자 수신기에서 채널을 선택하여 이용하므로 사용자 편의성을 높일 수 있다.

차량 탑재용 지능형 다국어 방송시스템

김영철(Young Cheol Kim),김상태(Sang Tae Kim),차현철(Hyun Chul Cha),김현덕(Hyun Deok Kim) 한국통신학회 2010 한국통신학회 학술대회논문집 Vol.2010 No.2

All - Trans - retinoic Acid와 Ursolic Acid가 배양된 인체 진피 섬유모세포에서 자외선 A 조사에 의한 AP - 1 ( Fos / Jun ) 활성도에 미치는 영향

김현철,양준성,채영수,서기석,김상태 ( Hyun Cheol Kim,Joon Sung Yang,Young Soo Chae,Kee Suck Suh,Sang Tae Kim ) 대한피부과학회 1997 大韓皮膚科學會誌 Vol.35 No.6

Backgrpund : Recently, UVB irradiation was found to activat,e AP-1, which is known to be a major enhancer factor of the collagenase gene. However, tbe effect of UVA irradiation on the activity of AP 1 in derrnal fibroblasts is unclear. Although all trans-retinoic acid(tRA) has been known to prevent. the AP 1 and collagenase stimulatory effect of UVB irradiation, the effect of tRA and ursolic acid(UsA) on the enhancement of AP-1 activity hy UVA irradiat.ion is unknown. Objective : In this stuc y, the effect of UVA irradiation on the AP-1 activity in cultured human dermal fibroblasts was studied. The effect. of tRA and UsA on the enhancement of AP-1 act,ivity by UVA irradiation was also investigated. Methods : Confluent human dermal fibroblast.s were irradiated with 15J/cm of UVA. Drugs were administered and kept in a culture rnedia for 12 hrs before or immediately after UVA irra diation. Nuclear protein extracts were isolated 12 hrs after UVA irradiation and were subjected to gel retardation assay ising oligolabeled DNA probe for AP l binding site. Results : 1. The activity of AP -1 was increased by UVA irradiation and prominent activation was detected at 6 and 12 hrs postirradiation. 2. Compared to the UVA irradiated group, tRA and the high concentration(10-5M) of UsA administered before or al ter UVA irradiation inhibited the increase of AP-1 activity. Conclusion : These res ilts suggest that UVA irradiation enhance the AP-1 activity, which is known to be a major er hancer factor of the collagenase gene, and tRA and UsA dov,nregulate the 1JVA induced AP-l ctivit.y enhancement. (Korean J Dermatol 1997;35(6): 1136-1142)

악성 흑색종과 멜라닌 세포성 모반의 bc1 - 2 단백의 발현 양상

김현철,김윤규,채영수,서기석,김상태 ( Hyun Cheol Kim,Yun Kyew Kim,Young Soo Chae,Kee Suck Suh,Sang Tae Kim ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.2

Background; The bcl-2 is a newly known oncogene involved in tumorigenisis by blocking apoptosis or programmed cell death. Overexpression of bcl-2 protein has been detected in a variety of human malignancies. However, recent studies of the expression of bcl-2 protein in human melanoma and melanocytic nevus have been controversial. Objective : The purpose of this study was to examine whether there are any differences in the expression of bcl-2 protein between melanocytic nevus and rnalignant melanoma. Methods : Immunohistochemical analysis of bcl-2 protein expression was performed on the formalin-fixed, paraffin-embedded tissue sections of 22 melanocytic nevus and 29 malignant melanomas(20 primary and 9 metastatic) using anti bcl-2 monoclonal antibody with an avidin-biotin peroxidase complex procedure. Results : The results were as follows. 1. The positive rate for bcl-2 protein was observed in 95.4% (21/22) of melanocytic nevus and 95.0%(19/20) of primary malignant melanomas. Therefore, there was no significant difference between the two groups in the positive rate for bcl-2 prtoein. 2. The percentage of stained cells and the staining intensity of bcl-2 protein were significantly increased in melanocytic nevus compared to malignant melanoma(p<0.05). 3. The positive rate for bcl-2 expression of metastatic malignant melanoma[44.4% (4/9)] was significantly decreased compared to that of primary malignant melanoma[95.0%(19/20) ](p<0. 05). But, there was no significant difference betweeen tumor thickness and histological type of malignant, melanoma in the expression of bcl-2 protein. 4. In melanocytic nevus, immunoreactivity of bcl-2 protein gradually diminished or even disappeared towards the deep dermis Conclusion : the bcl-2 expression was decreased in malignant melanoma compared to melanocytic nevus. It. suggests that the loss of bcl-2 expression may play a significant role in the progression and metastasis of malignant melanoma. (Kor J Dermatol 1997;35(2): 284-291)

항암제 내성 유방암 MCF7/adR 세포주에 대한 보정방암탕과 홍삼산성다당체의 세포고사 유도효과

안귀인,박철환,이은옥,이효정,이재호,김관현,이연희,장유성,김상태,김성훈,Ahn, Gyu-In,Park, Cheol-Hwan,Lee, Eun-Ok,Lee, Hyo-Jung,Lee, Jae-Ho,Kim, Kwan-Hyun,Rhee, Yun-Hee,Jang, Yu-Sung,Kim, Sang-Tae,Kim, Sung-Hoon 대한약학회 2006 약학회지 Vol.50 No.4

This study was undertaken to determine whether the 9 herbal complex induces apoptosis in human breast cancer MCF-7 cells and adriamycin-resistant MCF7/adR cells. Ethanol extracts of Bojungbangamtang (BBTE) and acidic polysaccharide of Red Ginseng (GIN) induced cell death in both MCF-7 and MCF7/adR cells. Ethanol extracts of Bojungbangamtang and acidic polysaccharide of Red Ginseng also induced $G_2/M$ cell cycle arrest and increased TUNEL positive cells in MCF7/adR cells. In addition, flow cytometric analysis revealed the decreased expression of P-glycoprotein (P-gp) in ethanol extracts of Bojungbangamtang and acidic polysaccharide of Red Ginseng treated MCF7/adR cells. Similarly, decreased protein levels of P-glycoprotein and multidrug resistance associated proteins-1 were also determined by immunocytometry in ethanol extracts of Bojungbangamtang treated MCF7/adR cells. Taken together these data indicate that ethanol extracts of Bojungbangamtang and acidic polysaccharide of Red Ginseng inhibit the function of ABC transporters such as multi drug resistance associated proteins (MRPs) and P-glycoprotein as well as induce apoptosis in MCF7/adR cells. Thus, these data suggest that ethanol extracts of Bojungbangamtang and polysaccharide of Red Ginseng can be candidates for the treatment of multidrug-resistant MCF7/adR cells.

Itraconazole로 치료된 원발성 피부 효모균증 1예

김현철,김영진,채영수,서기석,김상태 고신대학교 의학부 1996 高神大學校 醫學部 論文集 Vol.11 No.1-2

Cryptococcosis is a systemic disease caused by yeast-like fungus Cryptococcus neoformans. It usually involves brain and meninges. However, the primary cutaneous cryptococcosis involving skin alone is rare. Amphotericin B and fluorocytosine have both been reported to be effective as the mainstay of treatment. However, the use of amphotericin B and fluorocytosine should be restricted owing to their adverse effect. We report a case of primary cutaneous cryptococcosis in a 12-year-old male, who had erythematous hard nodules with ulcers and crusts on the face and neck for five months. Physical examination and laboratory findings other than skin lesion were within normal limits. Histopathologic features of the nodule showed many spores with thick capsules and chronic inflammatory infiltrates composed of lymphocytes, histiocytes and giant cells. A tissue culture of the lesion on Sabouraud's media without cycloheximide at 37℃ showed moist, smooth, mucoid cream colored colonies 3 days later and revealed encapsulated yeast cells in India ink preparations. Our patient was successfully treated with oral itraconazole without side effect.

Itraconazole로 치료된 원발성 피부 효모균증 1예

김현철,김영진,채영수,서기석,김상태 高神大學 醫學部 1996 高神大學醫學部 論文集 Vol.11 No.1-2