그레이브스병에서 치료에 따른 폐동맥압의 변화

남택만,조한수,이진서,송영림,김두만,두영철,박철영,정인경,홍은경,이성진,오기원,김현규,유재명,최문기,유형준,박성우 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.5

연구배경: 갑상선기능항진증에 의한 갑상선중독증 환자들은 호흡곤란을 호소하며, 그 원인으로 호흡근의 근력 약화, 좌심실부전으로 인한 폐모세혈관의 울혈, 기도저항의 증가, 갑상선종으로 인한 기관의 압박, 호흡기능 이상 등이 거론되고 있다. 폐동맥고혈압이 동반된 그레이브스병 환자가 여러 증례가 보고되었으며, 폐동맥고혈압 환자에게서 갑상선 자가항체와 갑상선기능저하증의 빈도가 높음이 알려지면서 갑상선중독증이 동반된 그레이브스병 환자에게서 관찰되는 호흡곤란의 한 원인으로 폐동맥압 증가가 작용할 가능성이 제시되고 있다. 이에 저자 등은 그레이브스병 환자를 대상으로 폐동맥압을 측정하고 치료 전후의 폐동맥압의 변화를 전향적으로 연구하였다. 방법: 갑상선중독증이 동반된 그레이브스병 환자와 정상 갑상선기능을 나타낸 대조군을 대상으로 갑상선기능검사 및 갑상선 자가항체를 측정하고, 심초음파를 이용하여 치료 전후로 폐동맥압을 측정하여 폐동맥압과 갑상선기능 및 갑상선 자가항체와의 관계, 폐동맥압의 변화 등을 관찰하였다. 결과: 1. 연구대상은 대조군 10명 (남녀비 1:9, 관해 상태의 그레이브스병 3명, 갑상선종 3명, 정상인 4명), 그레이브스병 환자 26명 (남녀비 7:19)이었다. 2. 대조군과 치료 전 그레이브스병 환자의 폐동맥압은 각각 23.5±2.32 mmHg, 29.6±10.3 mmHg이었고, 치료 전의 폐동맥압과 혈청 갑상선자극호르몬 결합억제 면역글로불린 (TBII) 농도는 유의한 양의 상관관계를 보였다. 3. 26명의 그레이브스병 환자 중에서 10명 (38.5%)이 폐동맥고혈압 (기준: 폐동맥압 > 30 mmHg)으로 진단되었다. 4. 치료 전후로 폐동맥압을 측정한 13명은 폐동맥압이 치료 전 29.6±10.3 mmHg에서 치료 후 폐동맥압 22.2±6.48 mmHg로 의미있게 감소하였다. 결론: 갑상선중독증을 보이는 그레이브스병 환자의 약 40% 정도에서 폐동맥고혈압이 발견되어 폐동맥고 혈압은 그레이브스병에 흔하게 동반하는 질환으로 생각된다. 향후 그레이브스병 환자에서 관찰되는 폐동맥압의 증가와 관련한 병인, 발생기전 및 임상적 의의 등에 대한 연구가 필요할 것으로 생각된다. Background: Exertional symptoms, dyspnea and impaired effort tolerance are common in patients with Graves' disease. Proposed explanations include: high-output left heart failure, ineffective oxygen utilization and respiratory muscle weakness. In addition, pulmonary hypertension has also been reported in patients with Graves' disease. A high prevalence of hypothyroidism and positive thyroid autoantibody were also observed in patients with pulmonary arterial hypertension. Therefore, the pulmonary artery pressure in patients with Graves' disease was evaluated. Methods: Two-dimensional and Doppler echocardiographic examinations (Hewlett Packard Sonos 2500) were performed to determine the pulmonary artery (PA) pressure in 26 Graves' disease patients, both before and after treatment (23 patients with propylthiouracil and 3 with RAI), and in 10 euthyroid controls. The changes in the PA pressure after treatment were evaluated in 13 patients with Graves' disease, who became euthyroid after treatment. Results: The pulmonary artery pressure was increased in the untreated Graves' disease patients compared to the normal controls (23.5±2.32 vs. 29.6±10.3 mmHg). 38.5% of the Graves' disease patients (10/26) showed pulmonary arterial hypertension (PA>30 mmHg) and the serum TBII level was higher in the Graves' disease patients with pulmonary arterial hypertension than in those with normal PA pressure (P<0.05). In the Graves' patients who became euthyroid after treatment, the PA pressure was significantly decreased. Conclusion: 38.5% of the untreated Graves' disease patients showed pulmonary arterial hypertension, and the pulmonary artery pressure was significantly decreased in those who became euthyroid after treatment. The pathogenesis and clinical importance of pulmonary arterial hypertension in Graves' disease requires further studies (J Kor Soc Endocrinol 18:465∼472, 2003).

전력전자상거래(VSEM)를 위한 웹기반 미터링/과금 시스템의 보안성 분석

송영기,강환일,장우석 명지대학교 산업기술연구소 2007 産業技術硏究所論文集 Vol.26 No.-

This paper focuses on the analysis for the security of web based metering system for VSEM(Value Storage Electricity Meter). We analyze security problem of existing system for authentication using smart cards for consumer, key value authentication, integrity and non-repudiation between the data of consumers and supplier in VSEM server. And we also propose the security model to solve the problem.

뇌동맥류의 진단에 대한 전산화단층촬영 뇌혈관조영술과 고식적 뇌혈관조영술의 비교

송상현,윤수한,안영환,안영민,조기홍,조경기,김선용,서정호 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.10

Cerebral angiography has been essential for the diagnosis of the intracranial aneurysms but. is sometimes accompanied by serious complications. Resolution of CT angiography was up-graded greatly to represent the three-demensional structure of vesseles since helical CT had been introduced. We have compared 26 cases of CT angiography and 28 cases of conventional angiography in terms of specificity and sensitivity for the diagnosis detectable aneurysm diameter. configurational diagnosis and diagnostic confidency. All results showed no statistical difference between CT angiography and conventional angiography. These should suggest that CT angiography could be replaced with conventional angiography for the diagnosis of ruptured aneurysms and even of unruptured aneurysms. resulting in the introduction of first screening modality of unruptured aneurysms.

객체지향 기법을 이용한 다중 스레드 프로그램 기법에 관한 연구

송기범,박영옥,이준 조선대학교 동력자원연구소 1995 動力資源硏究所誌 Vol.17 No.2

The Software which uses object-oriented method has the advantage of extensibility, independence and easy maintenance, but has the disadvantage of decrease of system performance. Object-oriented software provides parallel process of objects, and then to improve of system performance we categorize objects into active and passive ones and then use active one. Therefore we implement active and passive objects with object-oriented language, propose multi threaded programming method using thread library for real time process.

류마치스성 제1-2경추 아탈구 : 증례보고 Report of A Case

송상현,윤수한,조기홍,안영환,안영민,조경기 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.10

Authors report a case of one-stage transoral decompression and posterior fusion in rheumatoid atlantoaxial subluxation. A 63-year-old man developed a rheumatiod atlantoaxial subluxation with mild weakness of all extremities which developed relatively suddenly 3 months after the initial symptom of neck pain. Skeletal traction followed by transoral decompression and occipitocervical fusion was performed on the same day. Postoperative course has been uneventful and revealed favorable fusion state of occipito-atlanto-axis. The pertinent literature on theumatoid atlanto-axial subluxation is reviewed and discussed.

Glucose Oxidase가 척수지각신경절세포에 미치는 영향과 천마의 효과에 관한 연구

송호준,이용석,손영우,이강창,정종길,신민교,홍기연 대한본초학회 2002 大韓本草學會誌 Vol.17 No.2

Objectives : To clarify the cytotoxic effect of glucose oxidase(GO) and protective effect of gastrodiae Rhizoma (GR) on spinal sensory ganglion(DRG) neurons, neurotoxicity mediated by GO was measured by MTT assay and neurofilament enzymeimmuno assay(EIA). Methods : DRG neurons were cultured in the media containing various concentrations of GO for 3 hours. In addition, neuroprotective effects of GR, on GO-induced neurotoxicity in DRG neurons were examined after DRG neurons were preincubated with various concentrations of GR for 2 hours before 15mU/ml GO for 3 hours. Results : GO decreased remarkably cell viability in dependently in these cultures, and also RG increased cell viability and amount of neurofilament in DRG neurons damaged by GO. Conclusion : It is suggested that GO has toxic effect in cultured mouse DRG neurons, and also RG was effective in the protection of GO-induced neurotoxicity in these cultures.

유동성 레진의 두께가 미세누출에 미치는 영향

송기강,조영곤 大韓齒科保存學會 2005 Restorative Dentistry & Endodontics Vol.30 No.5

본 연구는 2급 복합레진 수복 시 다양한 두께의 유동성 레진 이장이 법랑질 또는 상아질 치은측 변연부의 미세누출에 미치는 영향을 평가하기 위하여 시행하였다. 발거된 상, 하악 대구치의 근심 또는 원심면에 2급 와동을 형성하고 혼성 복합레진만으로 충전한 군 (대조군)과 유동성 레진을 치은측에 0.5 ㎜ (실험 1군), 1 ㎜ (실험 2군), 2 ㎜ (실험 3군) 두께로 이장한 후 복합레진을 충전한 군으로 분류하였다. 각 군은 5℃와 55℃에서 500회 열순환을 시행한 후 2% methylene blue에 24시간 동안 침적시켜 광학 입체현미경하에서 변연부의 색소 침투를 관찰하였다. 본 연구의 결과 유동성 레진의 다양한 두께는 복합레진 수복물의 변연부 미세누출에 영향을 미쳤다. 복합레진을 이용한 구치부 2급 와동 수복 시 법랑질 또는 상아질 변연에서 0.5 ㎜ 두께로 유동성 레진을 적용하는 것이 미세누출 감소에 효과적인 것으로 나타났다. This study investigated the effect of thickness of flowable resin lining on marginal leakage in class II composite restorations. 80 experimental teeth were prepared with class II preparations with enamel margin or dentin margin. Each group was devided into four groups according to flowable resin lining thickness ; Control group - no flowable resin lining, Group 1 - 0. 5 ㎜ flowable resin lining, Group 2-1 ㎜ flowable resin lining, Group 3 - 2 ㎜ flowable resin lining. The cavities were restored using Scotchbond Multi- Purpose adhesive system, Filtek Flow and Filtek Z 250 composite resin. Following one day storage in distilled water, the restored teeth were thermocycled for 500 cycles and immersed in 2% methylene blue for 24 hours. The results of this study were as follows: 1. Ranking of mean microleakage scores at the enamel margins was Group 1 < Control = Group 2 < GrouP 3. The microleakage of Group 3 was significantlv higher than that of Control, Group 1 and Group 2 (p < 0. 05). 2. Ranking of mean microleakage scores at the dentin margins was Group 1 < Group 2 < Control < Group 3. The microleakage of Group 3 was significantly higher than that of Control, Group 1 (p < 0. 05). 3. Compared with microleakage between the enamel and dentin margins, enamel margin group were significantly lower than dentin margin group.

상속성과 병행성 통합에서 오는 상속 변칙 분석에 관한 연구

박영옥,송기범,이준 조선대학교 전자정보통신연구소 2001 電子情報通信硏究所論文誌 Vol.4 No.2

The integration of concurrent and object-oriented programming paradigm hae been a goal of researchers for over a decade. The concurrent object-oriented programming languages used for development of various concurrent applications. However, concurrency and inheritance have conflicting characteristics, thereby inhibiting their simultaneous use without heavy breakage of encapsulation. This conflicting phenomenon is known as inheritance anomalies, have been limited in applicability and have not addressed all the issues that synchronization raises. In this paper, we introduce the behavior description equation is introduced for the solution for the conflicting phenomenon between inheritance and object-based concurrency. As a result, we can solve the several inheritance anomalies without redefining object methods. Therefore this paper offers flexible concurrency model with an emphasis on the reuse of both synchronization and function code.

하수 염소 소독시 소독부산물 발생 특성

백영석,송민형,정경훈,권동식,이기공 한국물환경학회 2004 한국물환경학회지 Vol.20 No.3

This study was performed to investigate the disinfection efficiency and the formation characteristics of disinfection by-products(DBPs) by chlorination in the sewage effluent. The effluent was sampled from the sewage treatment plants operated in the activated sludge process and the advanced sewage process. The type of DBPs investigated were Trihalomethanes(THMs), Dichloroacetonitrile(DCAN), Chloral hydrate(CH), Dichloroacetic acid(DCAA), Trichloroacetic acid(TCAA). Major findings are as follows. First, the optimum injection concentration for chlorination in sewage effluent were found to be in the range 0.5 ~ 1.0 ㎎ Cl₂/L. Also, It was found that the chlorine dosage in the effluent of activated sludge process was higher than in the effluent of advanced sewage process. Second, the maximum formation concentration of THMs were 12.7 μg/L. The THMs formation reaction was finished in a short time of several seconds and chloroform was mainly formed. Also, it was found that the concentration of ammonium nitrogen is higher, the concentration of THMs is lower. Third, it was found that DCAA and TCAA were mainly formed as DBPs by disinfection.

Influence of fiber length and its distribution in three phase poly(propylene) composites

Seong, Dong Gi,Kang, Chul,Pak, Seong Yeol,Kim, Chai Hwan,Song, Young Seok Elsevier 2019 Composites Part B, Engineering Vol.168 No.-

<P><B>Abstract</B></P> <P>We explored how the fiber lengh affects physical properties of three phase polymer composites. The composites including glass fibers, graphites and poly(propylene) were produced via injection molding. The fiber length and its distribution were analyzed before and after molding. Two different fiber lenghs (i.e., 2 mm and 10 mm) were adopted in this study. The morphological analysis of the samples was carried out to evaluate the fiber orientation depending on the fiber length. The thermal, mechanical, and viscoelastic behaviors of the composites were analyzed experimentally. The finding revealed that the longer fiber reinforced composites showed higher viscoelastic properties, Young's modulus, and melting temperature but showed less uniform distribution of fibers. In addition, numerical simulation was conducted to help understand the experimental results.</P>