우리나라 카드뮴 폭로 근로자들의 혈중, 요중 카드뮴과 누적폭로 추정량에 따른 신장장해 평가

강성규,양정선,김기웅,장재연,정호근 大韓産業醫學會 1995 대한직업환경의학회지 Vol.7 No.1

88 workers exposed to cadmium were examined at the 12 factories using or producing cadmium in order to know the present state of cadmium exposure and renal dysfunction in 1992. Cadmium in blood and in urine were measured and compared by the 3 exposure level of cadmium in air. Cadmium in blood of low, moderate and high exposure group were 2.5, 3.8 and 7.6 ㎍/L, respectively. Cadmium in urine were 1.8(1.3), 3.8(2.6) and 7.9 ㎍/L(6.1 ㎍/g creatinine), respectively. However, there was no relationship between urinary cadmium and β₂-microglobulin. Cumulative exposure estimate(CEE) was calculated by multiplying the mean ambient cadmium level of the factory and working duration. CEE has a high correlation with cadmium in blood and urine, but no relation to β₂-microglobulin. Because working durations were relatively shorter than European workers', the highest CEE was just 300 ㎍·year/m³, which was not enough to induce renal tubular dysfunction. This study, however, suggested the possibility that renal tubular dysfunction caused by cadmium could be happened in Korea in the near future.

골절단을 이용한 급속 치아이동 후 치수 및 치주조직 변화

강경화,김은철,이선경,임채웅,마쓰다 기꾸,태기출,김상철 대한치과교정학회 2004 대한치과교정학회지 Vol.34 No.2

본 연구는 골절단을 이용한 치아-치조골 분절의 급속 치아이동 후 치수, 치주인대 및 치조골의 변화를 유성견에서 평가하고자 하였다. 하악 제4소구치의 근심, 원심, 치근단 부위에서 피질골을 절단하여 치아-골 분절을 형성하고 하악 제3소구치를 발거하면서 협측, 설측 부위의 피질골을 삭제하였다. 1주 휴지기 부여에 따라 휴지기군과 비휴지기군으로 나누어 치아의존형 견인장치로 6일 동안 견인하고 강화기를 거친 후 0주, 1주, 2주, 4주, 6주, 8주에 희생시켜 치수, 치주인대 및 치조골의 조직 변화를 임상적, 방사선적, 조직학적 및 면역화학적으로 평가하여 다음과 같은 결과를 얻었다. 1. 치아이동 양과 강화기 동안의 조직 치유 양상에서 휴지기 유무에 따른 차이는 없었다. 2. 견인측에서 골형성은 강화기 8주까지 계속되었는데 강화기 1-2주에 가장 활발하였으며 6-8주간의 변화는 적었다. 3. 비휴지기군의 강화기 1주에서 치조골 흡수 및 파골세포 출현, 염증세포 침윤이 가장 많았으며, 특징적으로 파상아세포가 압박측의 치주인대와 치수 내에 나타났다. 4. TGF-β는 치조골의 골기질 및 골모세포, 파골세포, 치수 내 파상아세포에서 강양성 발현을 보인 반면 치수, 백악모세포, 무세포성 백악질에서 경미한 양성 발현을 나타내는 부위 특이성이 있었다. 5. TGF-β는 견인측 치주인대의 치조골에 인접한 혈관 및 치주인대세포, 골모세포에서 강화기 초기 1-2주에 주로 발현되었으며 6주 이후에는 발현이 크게 감소하였다. The movement of tooth-bone segments by osteotomy can simultaneously shift tooth and surrounding alveolar bone in a relatively short period. The purpose of this study was to evaluate the tissue changes in pulp, periodontal ligament, and alveolar bone in rapid tooth bone movement with osteotomy. The mandibular 3rd premolar of a dog was extracted and cortical bones of the buccal and lingual area were eliminated, and then cortical bones around the mesial and distal area of root, and below the root apex of the mandibular 4th premolar were osteotomized. After a one week latency period, a tooth-borne distraction device was activated for 6 days. And pulp, periodontal ligament and alveolar bone were evaluated clinically, radiologically, histologically and immunohistochemically at 0, 1, 2, 4, 6, 8 weeks of the consolidation period and conclusions were reached as follows. 1. Latency period didn't affect total amount of tooth movement and healing process of tissue during consolidation period. 2. Bone formation continued through 8 weeks of consolidation in distracted side, with a high peak at 1-2 weeks, and the lowest at 6-8 weeks of consolidation. 3. At 1 week of consolidation, alveolar bone resorption, osteoclast appearance and inflammatory cell infiltration were the most active, and dentinoclasts characteristically appeared on the pulp and pressure side of the periodontal ligament. 4. The expression of TGF-β was area-specific, as it was strong-positive at bone matrix, osteoblast, osteoclast of alveolar bone, and dentinoclast inside pulp, but weak in pulp, cementoblast and acellular cementum. 5. The expression of TGF-β was generally observed at the initial 1-2 weeks of consolidation at vessels, periodontal ligament cells, and osteoblast near alveolar bone on the distraction side of the periodontal ligament, and was significantly decreased after 6 weeks of consolidation.

국내 카드뮴 취급 사업장의 카드뮴 폭로 실태 평가

강성규,홍정표,김기웅,장재연,정호근,정규철 大韓産業醫學會 1994 대한직업환경의학회지 Vol.6 No.2

Twenty-four factories registered at the Ministry of Labor as factories using or producing cadmium in 1991 were investigated to know the present state of occupational exposure to cadmium in 1992. Nine factories among 24 stopped using or changed to other substances and 1 factory didn't produce any more, but delivered it to other factories through imports. Therefore, only 14 factories were producing or using cadmium. But, alloying materials were supplied to about 20 and more factories, however, they couldn't be investigated because of limited information. Three factories had less than 50 workers were 3,6 had 50-300 and 5 had more than 300. About 167 workers were exposed to cadmium. According to the classification by process, there were 4 alloy processes, 2 refinary, 2 elctroplating, 2 dry cell making, 1 industrial battery making, 1 duplicator drum making, 1 recycling of battery and 1 copper refinary. 8 factories used metal cadmium, 3 cadmium oxide, 2 cadmium sulfide, and 1 cadmium hyroxide. One factory was importing cadmium stearates only and supplying them to the PVC making factories. The amount of metal cadmium producing in 2 refinary factories was about 50-65 ton per month. The other cadmium compounds were imported. According to exposure level of cadmium air of the 10 factories examined, each factory could be divided into high, moderate and low exposure groups. 1 battery recycling factory and 3 alloy factories were in the high exposure group and their mean air concentrations were 0.06679, 0.05481, 0.02492, and 0.003㎎/㎥, respectively. Refinary and industrial battery making factories were in the middle exposure group and their mean air concentrations were 0.00773 and 0.00613 ㎎/㎥, respectively. Finally, low exposure group were copper smelting, dry cell case making, duplicator drum making and electroplating factory and their mean air concentrations were 0.00096, 0.00071, 0.00057 and 0.00054 ㎎/㎥ respectively.

다단계하프변환을 이용한 타원 영상 검출

강창원,이정재,이웅기 조선대학교 기초과학연구소 1997 自然科學硏究 Vol.20 No.1

This paper considers the problem of detecting elliptical curves using multistage Hough transform. The proposed approach is based on the polar and pole definition of conics and its advantage lies in avoiding the propagation of parameter estimation error over the successive stages of the Hough transform. The Proposed method is capable of detecting partially visible ellipses, overlapping ellipses, and groups of concentric ellipses. It presints techniques aimed at improving the efficiency and reducing the memory size of the accumulator array. A set of experimental results is presinted to demonstrate these capabilites of the suggested approach.

개선된 하프변환을 이용한 훼손된 타원 검출

강창원,양환석,이정재,김남중,이웅기 조선대학교 기초과학연구소 1997 自然科學硏究 Vol.20 No.1

This paper considers the problem of detecting elliptical curves using Advanced Hough transform. Storage and efficiency problems are over come by decomposing the problem into two stages. The first stage uses a novel constraint as the basis for a Randomined Hough transform to detect the ellipse centre while the second stage finds the remaning parameters using simple but efficient focusing implementation of the Advaned Hough transform. The method is applicable in many situations where previous Hough transform schemes would fail. Results are demonstrated for comolicated image data containing several occluding ellipses.

産母의 血液所見이 新生兒 臍帶血中 血色素値에 미치는 影響

孫基勇,林英子,姜熙雄 金原出版 1969 小兒科 Vol.10 No.9

Trichloroethyene 처리한 흰쥐의 이물질 대사효소의 활성도에 관한 연구

김기웅,강성규,최병순,이종성,김종성,문영한 大韓産業醫學會 1994 대한직업환경의학회지 Vol.6 No.2

Trichloroethylene(TRI) is one of the most widely used organic solvent in many industries. It is used a degreasing agent, extract and dillution solvents. TRI is metabolized by liver microsomal cytochrome P450 to reactive intermediates, which are considered responsible for its hepatotoxicity. Cytochrome P450 is a key enzyme in the first step of TRI metabolism resulting in chloral hydrate(CH) formation, which is a rate-limiting step in TRI metalbolism. This study was performed to find change of hepatic cytochrome P$%) levels and of electron transport system for P-450 dependent reaction. Injections of TRI were done to the male Sprague Dawley rats(mean body wights, 170±10g) in corn the dosage of 150,300,600 ㎎/㎏ for 2 days. The results of experiments are following: 1. The contents of microsomal protein, cytochrome P450 and b5 are tended to be decreased with increasing amount of TRI, but not signifcantlly(p>0.05). 2. The activity of NADPH-cytochrome P450 reductase is slowly decreased by increasing amount of TRI, but not significantlly(p>0.05). On the other hand, the activity of NADH-b5 reductase is increased with increasing amount of TRI(p<0.05). 3. The activity of 7-ethoxyresolufin O-deethylase did not show any critical changes(P>0.05). This result suggests that the inductive pattern of TRI may not be related to P 450IA1 and P450IIB.

합성피혁제조업체 근로자들에 있어서 N-methylformamide 배설속도에 관한 연구

김기웅,최병순,강성규,문영한 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.1

This study was conducted to examine the excretion rate of dimethylformamide(DMF) from the workers exposed to DMF. The study was done at two synthetic leather factories located in Kyeonggi-do from the period of May 2 to 30, 1996. N-methyl-formamide (NMF) concentrations in urine were measured and compared by the three exposure level of DMF in air. The mean concentration of the Low (dry and winder part), Moderate (rinsing part) and High (mixing and coating part) exposure group were 3.99±3.54, 10.19±5.69 and 32.10±7.87㎎/㎥ during workshift of 8 hours, respectively. The mean concentration of urinary N-methylformamide (NMF) were 2.13±2.58, 11.16±4.98 and 26.24±7.35㎎/g creatinine, respectively. The concentration of NMF in urine could reach to maximum in 3 hours and was reduced nearly to zero in about 18 hours after exposure to DMF.

핵간안근마비를 보인 중추신경계 크립토콕쿠스병 1례

이지영,김재일,김기선,강문철,이창민,양대웅,이근호,김상준 대한신경과학회 1997 대한신경과학회지 Vol.15 No.5

스티렌 폭로 근로자들의 기중 및 혈중 스티렌과 요중 만델산의 관계 분석

정호근,강성규,양정선,김기웅,이종성,조영숙,박인정 大韓産業醫學會 1994 대한직업환경의학회지 Vol.6 No.1

The concentration of styrene in air in blood and mandelic acid in urine were checked for the 60 workers with normal liver function, exposed to styrene. Styrene in air were sampled with personal air sampler at least 4 hours and analyzed by gas chromatography. Blood and spot urine were collected at the end of shift with a vacuum tube and a polythylene bottle and analyzed by gas chromatography and high performance liquid chromatography. Means of air and blood styrene and urine mandelic acid were 8.16 ppm(geometric mean), 0.199 mg/L, and 0.519 g/g creatinine, respectively. The concentration of styrene in air and mandelic acid in urine were high in the FRP factories and low in polymerization factory. Styrene in blood showed large difference by the working process. Styrene in air showed a good correlation with mandelic acid in urine(r=0.6369) and styrene in blood(r=0.6371). The mandelic acid in urine and styrene in blood corresponded to exposure of 50 ppm styrene were 0.890 g/g creatinine and 0.434 mg/L. However, hippuric acid in urine did not show any correlation with styrene in air. Urine mandelic acid excretion expected ratio showed a tendency to decrease according to obesity index and to increase with alcohol consumption.