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1987년 한국에서 발생한 렙토스피라병의 혈청역학적 조사
이증훈,박영수,이우곤,김석용,정선식,우준희,박성광,박경희,송영욱,김선영,기정일,최두혁,강성귀,김주완,최강원,김우열,최명식,최인학,장우현,윤성열 대한감염학회 1988 감염 Vol.20 No.3
Human leptospirosis was an unfamiliar disease in Korea until 1984 that outbreak of leptospirosis occurred among farmers and soldiers after field works for harvesting rice. During that time, Lee and Jo confirmed the first Korean cases of leptospirosis by serological test, isolation of causative agent and autopy findings. Afterward several outbreaks occurred also during autumn especially after flood in every years and some characterisitcs of leptospirosis in Korea such as clinical manifestations, serotypes and seroepidemiological features has been revealed by many investigators. Because of the major mode of transmission between rodents and human is by direct contact with leptospiral urine of rodents or contaminated soil by the urine, leptospirosis in Korea has been primarily a disease of person in occupations heavily exposed to contaminated soil or infected urine such as farmer, army and etc. Therefore it seems that leptospirosis is one of the main communicable diseases to be controlled urgently in Korea, for an agricultural people account for almost half of total Korean people. For clarifying the seroepidemiological patterns of human leptospirosis in Korea by sex, month region and main reacting serovars of L. interrogans among acute febrile disease occurred in 1987, 1,773 patient's sers with acute febrile episodes were tested by microagglutination test using 19 representative strains of leptospiral serogroup as antigen. All of those sera were collected from 10 collaborative clinics located in Kyunggi, Kangwon, Chungbuk, Chungnam, Chonbuk, Chonnam province and Seoul. The results wee summerized as follows. 1) Among 1,773 sera of patients with acute febrile episodes, 219 (12.4%) were seropositive to L. interrogans, 487(27.5%) to R. tsutsugamushi, 241(13.6%) to R.typhi and 160(90.0%) to Hantaan virus. 2) Among seropositives to L.interrogans, the male outnumbered the female, 65% and 35%. 3) For age distribution, 26.9% of seropositives to L.interrogans were fifties, 19.6% were forties, 9.1% were sixties, 5.9% were thirties and 4.1% were twenties. 4) Eighty three percent of seropositives had occurred between September and October in 1987 with a peak in September. 5) Main leptospiral serovars reactive to patient's sera were Icterohaemorrhagiae(54.3%), Canicola(31.0%), CH-48(13.2%), Tarassovi(0.9%)and Cynopteri(0.5%). 6) For regional distribution, 65.8% of seropositives to L.interrogans were residents from Chonbuk, 12.3% were Chonnam, 7.3% were Chungnam, 5.5% were Kyunggi and 1.4% were Kangwon.
김신현(S. H. Kim),양시원(S. W. Yang),정승채(S. C. Jung),김민기(M. K. Kim),안철주(C. J. Ahn),윤지수(J. S. Yoon),윤영빈(Y. B. Yoon),윤삼손(S. S. Yoon),류시양(S. Y. Ryu) 한국전산유체공학회 2014 한국전산유체공학회 학술대회논문집 Vol.2014 No.5
Combustor development for industrial gas turbine requires extensive experience and massive resources. Due to a recent development of computing power, computational fluid dynamics (CFD) became one of main analysis tools for combustion research. In this paper, both experiment and numerical studies of a lean premixed combustor with an axial-type swirler were conducted. Flow field measurement using PIV was compared with CFD result with various turbulent models. Large eddy simulation (LES) with dynamic Smagorinsky model showed the highest accuracy in recirculation zone prediction. Flamelet progress variable (FPV) method was used to model partially premixed combustion. Reaction zones were visualized by OH concentration from experiment and LES calculation, and they showed good agreement. In addition to the flame shape, complex flow physics inside a lean premixed combustor was observed in LES result. Numerical approach described in this paper will be applied to design Samsung Techwins original combustors.
위암에서 CD40의 발현 및 CD40이 위암세포의 아포토시스에 미치는 영향
김상우 ( S. W. Kim ),윤승규 ( S. K. Yoon ),이학성 ( H. S. Lee ),정우철 ( W. C. Chung ),조영석 ( Y. S. Cho ),이인석 ( I. S. Lee ),최명규 ( M. G. Choi ),정인식 ( I. S. Chung ),박두호 ( D. H. Park ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
<목적> CD40은 종양 괴사 인자 수용체족의 하나로서 B 세포의 생존, 증식 및 분화에 중요한 역할을 하는 것으로 알려져 있으며 여러 악성종양에서도 CD40의 발현이 확인되었다. 그러나 아직까지 위암 조직이나 위암 세포주에서 CD40이 발현되는지, CD40이 위암세포의 아포토시스에 어떠한 영향을 미치는지에 대한 연구는 없다. 본 연구의 목적은 위암 조직 및 위암 세포주에서 CD40이 발현되는지를 조사하고, CD40이 위암세포의 아포토시스에 미치는 영향
암에르고미터 운동시 여유심박수에서의 신체작업능력(PWC%HRR)을 이용한 최대산소섭취량 추정에 관한 연구
정성태,전태원,정덕조,정영수,엄우섭,이동기,윤호섭 한국운동과학회 2000 운동과학 Vol.9 No.1
암에르고미터 운동시 여유심박수에서의 신체작업능력(PWC%HRR)을 이용한 최대산소섭취량 측정에 관한 연구 운동과학. 제 9권 제 1호. (1)-(12), 2000. 본 연구의 목적은 암에르고미터 운동시 여유심박수에서의 신체작업능력(PWC%HRR)을 이용해 최대산소섭취량(O₂_(max))을 추정하는데 있어 그 타당성을 보는데 있다. 이를 위해 본 연구에서는 건강한20대 남자 대학생(21.1±2.77)20명이 참가 하였다. 이들의 안정시 심박수는 5분간 EKG로 측정되었고, 최대산소취량은 암에르고미터에서 50rpm의 속도로 20W에서 운동을 실시하고 매 3분 간격으로 10W씩 증가시켜 피험자가 탈진시까지 운동을 지속시켰다. 여유심박수 계산에 있어서 최대심박수는 수식(HRmax = 210 - age)으로 계산되었다. PWC%HRR의 계산은 점증부하 운동상에서 120≤R≥160의 범위에 발견된 HR과 O₂의 관계식(Y=bx+a)에 의하였다. 강도별 상대적 백분율 범위는 50∼85%사이였으며, 비교대상은 PWC%HRR, O₂R, O₂_(max)이었다. 그 결과 다음과 같은 결과를 얻었다 첫째, %HRR과 O₂R, O₂_(max)간의 회귀분석결과 %HRR은 O₂_(max)보다 O₂R에 가까웠다. 둘째, 각 강도별 PWC%HRR과 O₂R, O₂_(max)간에는 통계적으로 유의한 차이는 없었으나, PWC%HRR은 O₂_(max)보다 O₂R에 보다 가까웠다(P<.05). 셋째, O₂_(max)의 실측치와 PWC%HRR = O₂R에 의한 추정치 사이에는 모든 강도에서 통계적으로 유의한 차이가 없었으나, 상관관계는 PWC%HRR에서 가장 높았다(P<.05). 이상의 결과를 종합해 볼 때 암에르고미터 운동검사 과정에서 만족할 만한 O₂_(max) 발견하지 못했더라도 최소한 60%HRR에 해당하는 심박수가 발견될 때까지 운동을 수행하였다면 일련의 방식에 의해 O₂_(max)의 추정이 가능하다고 본다. The study on Estimation of maximal oxygun uptake through PWC%HRR during Arm Ergometer Exercise. Exercise Science, 9(1): 1-12, 2000. The purpose of this study was to evaluate the validity for estimation of maximal oxygen uptake through PWC%HRR during Arm Ergometer Exercise. The subjects of this study were 20 healthy males(21.2±2.77yrs) college students. Resting heart rate of subjects were recorded by EKG for 5min. the maximal oxygen uptake was determined until subjects were exhausted. The first stage was performed 50rpm, 20W, and then was increased by 10W every 3 minutes on the arm ergometer. HRmax was determined by a numerical formula of HRmax = 210-age. PWC%HRR was assessed by relative equation (Y=bX+a) of HR and V˙O₂ observed in range 120≤R≥160 during the exercise test. Range of relative percentage was between 50% and 85%, comparison factor was examined among PWC%HRR, % V˙O₂R and % V˙O₂_(max). The results of this study are as follows : 1) Result of the regression analysis among PWC%HRR, % V˙O₂R and % V˙O₂_(max), %HRR was equivalent to % V˙O₂R rather than V˙O₂_(max). 2) No significant difference was observed among PWC%HRR, % V˙O₂R and V˙O₂_(max) in the all intensity, But the PWC%HRR was closer to % V˙O₂R rather than V˙O₂_(max)(P<.05). 3) No significant difference was the actual V˙O₂_(max) and the estimation value by PWC%HRR = % V˙O₂R in the all intensity, and the correlation analysis was the most correlated at the estimation value by PWC%60HRR. It was concluded that if the satisfactory V˙O₂_(max) was not found in Arm Ergometer exercise test but heart rate corresponded to 60%HRR, V˙O₂_(max) can be estimated by a series of equation.