조선대학교 의과대학 유급제도 개선을 위한 예비조사

박종,박상기,박상학,도남용,송창훈,이승일,임성철 朝鮮大學校 附設 醫學硏究所 1998 The Medical Journal of Chosun University Vol.23 No.1

This is a pilot study to improve the flunk system, a self-reported questionnaire survey was done by 58 professors among a total of 94 professors at Chosun University Medical School in December 1997. The results were as follows : 1. In regard to the student's residence, 69% of professors answered that the current system was appropriate. For a proper method of flunking. 46.6% of the professors agreed to the introduction of retesting by the Academic Affairs Department and 44.8% of the professors agreed to the evaluation of academic achievement of each subject. 2. Sixty-seven point two percents of professors agreed to the changing of time of flunk. 43.1% felt at the end of course, 24.1% felt at midterm, and 25.9% felt that the current system. 3. In regard to flunking, 34.5% of professors thought the current system-if a student receives an F grade in to be one subject, he/she was flunked-was sufficient, but 65.6% of the professors felt needed there improvement. The method of improvement was considered was losing more than two credits-fail(32.8%), and losing more than four credits-fail(10.3%). 4. Eighty-four point five percent of the professors agreed to the necessity of flunking by grade point average(GPA) and 77.6% of the professors answered that the students who must re-register should take all designated subjects. 5. Seventy-two point four percent of the professors opposed summer or winter courses for students who flunk and 51.7% of the professors opposed the necessity of a management system for students. In conclusion, the professors in Chosun University Medical College recognized the necessity of improving the flunk system, especially, the time, method and record keeping. So a concrete follow-up study needed to improve the flunk system.

축구선수의 Detraining과 Retraining이 혈청지질 및 호르몬농도에 미치는 영향

정정화,박재현,채종훈,성혜련,황지인,윤미숙,노금선,윤종관,윤영학,노순덕,정경숙,박일규,김은희,박현태,박상갑 대한스포츠의학회 1999 대한스포츠의학회지 Vol.17 No.1

The purpose of this study was to investigate the effects of detraining and retraining on serum lipid and hormones in soccer players. Subjects were seven male high-school soccer players. V˙O_2max was determined for each subjects by administering a treadmill test(initial speed: 90m/min, grade: 5%, increasing speed per 3 min: 30m/min). Serum lipid(T-C, TG, HDL-C LDL-C) and hormones(epinephrine, norepinephrine, growth hormones, cortisol) were assayed pre and post detraining in 10, 20, 30 days after retraining. The repeated ANOVA was used to determine significant differences. The 0.05 level of significance was as critical level for the study. The results of the study were as follows: 1. V˙O_2max(ml/min) were 3576.3±204.2ml/min pre detraining, 3234.1±198.9 ml/min post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/min) were 3601.4±170.9 ml/min. There were significantly(p<.05) increased in retraining periods. 2. V˙O_2max(ml/kg/min) were significantly(p<.05) decreased from 62.3±2.9 ml/kg/min to 55.9±4.7 ml/kg/min in detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/kg/min) were 62.4±3.4ml/kg/min, 62.7±2.3ml.kg/min, 67.3±7.2ml/kg/min respectively. There were significantly(p<.05) increased in retraining periods. 3. T-C were significantly (p<.05) increased from 166.6±8.5mg/dl to 175.3±10.3 mg/dl in detraining. In 10, 20, 30 days after retraining, T-C were 160.1± 3.2mg/dl, 156.7±3.7mg/dl, 140.3±9.0mg/dl. There were significantly(p<.05) decreased in retraining periods. 4. HDL-C were 61.4±6.6mg/di pre detraining, 5.3±6.6mg/dl post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, HDL-C were 56.9±7.1mg/dl, 56.4±9.2mg/dl, 57.7±9.1mg/dl respectively. There were no significant difference in retraining periods. 5. The hormones(epinephrine. norepinephrine, growth hormone, cortisol) were changed as same patterns. Epinephrine were 26.0±7.0[g/ml pre detraining, 24.6±3.2pg/ml post detraining. In 10, 20, 30 days after retraining, epinephrine were 26.9±5.6pg/ml, 30.6±6.2pg/ml, 29.4±5.6pg/ml respectively. There were no significant difference in retraining periods. In conclusion, HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were decreased, T-C, LDL-C and TG were increased in detraining. But HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were increased, T-C, LDL-C and TG were decreased in retraining.

의과대학 인성교육 모델개발을 위한 예비연구

송창훈,임성철,박종,이승일,도남용,박상기,박상화 조선의대 1998 The Medical Journal of Chosun University Vol.23 No.1

논문 : 국립공원 탐방로 내 위험 급경사지 유지관리 방안 연구

김홍균 ( Hong Gyun Kim ),김태호 ( Tae Ho Kim ),김재학 ( Jae Hak Kim ),곽재환 ( Jae Hwan Kwak ),박성욱 ( Sung Wook Park ),최수원 ( Soo Won Choi ),송영갑 ( Young Karb Song ) 대한지질공학회 2016 지질공학 Vol.26 No.1

국립공원은 주로 산악 지형 내 조성되어 있으므로 산사태에 의한 피해 가능성을 항상 내포하고 있다. 본 연구는 산사태 연구의 일환으로 국립공원 탐방로 내 위험 급경사지를 체계적으로 유지관리하기 위한 방안을 마련하는데 목적이 있다. 국립공원에 특화된 자체 체크리스트를 제작하였으며, 전국 19개 국립공원 183개소 급경사지에 대한 실태조사가 이루어졌다. 실태조사의 최종 목적은 위험 급경사지에 대한 안정화 대책을 마련하는 것으로 현장조사와 안정해석의 과정을 거친다. 일부 급경사지에서는 위험성 판단을 위해 지상라이다 등 특수 장비를 이용한 조사를 시도하였다. 중장기 정비계획을 위한 투자우선순위 공식을 개발하였으며, 현장자료를 이용한 순위 및 위험등급을 산출하였다. 최종적으로 위험 급경사지의 향후 체계적인 관리를 위해 “국립공원 급경사지 유지관리시스템”을 개발하였으며, 모든 현장자료들은 시스템 내 DB화 되었다. National parks, which are located mainly in mountainous areas, are always at risk of damage by landslides. The goal of this study is to establish a method for systematically maintaining hazardous steep slopes along trails in national parks. We produced a checklist suitable for each of the 19 national parks nationwide and investigated 183 slopes. The aim of these investigations is to recommend appropriate slope-stability countermeasures, including field investigations and stability analysis. We made preliminary investigations at specific sites, evaluating the slope hazard using specialized equipment such as terrestrial LiDAR. An investment priority formula was developed, and ranking and hazardous grades were calculated as part of a long-term maintenance plan. Finally, to systematically manage dangerous slopes and to house all the field data within one system, we developed the “Slope Maintenance System in National Parks” based on web server that can show various information for slopes.

C-reactive protein accelerates DRP1-mediated mitochondrial fission by modulating ERK1/2-YAP signaling in cardiomyocytes

( Suyeon Jin ),( Chan Joo Lee ),( Gibbeum Lim ),( Sungha Park ),( Sang-hak Lee ),( Ji Hyung Chung ),( Jaewon Oh ),( Seok-min Kang ) 생화학분자생물학회 2023 BMB Reports Vol.56 No.12

C-reactive protein (CRP) is an inflammatory marker and risk factor for atherosclerosis and cardiovascular diseases. However, the mechanism through which CRP induces myocardial damage remains unclear. This study aimed to determine how CRP damages cardiomyocytes via the change of mitochondrial dynamics and whether survivin, an anti-apoptotic protein, exerts a cardioprotective effect in this process. We treated H9c2 cardiomyocytes with CRP and found increased intracellular ROS production and shortened mitochondrial length. CRP treatment phosphorylated ERK1/2 and promoted increased expression, phosphorylation, and translocation of DRP1, a mitochondrial fission-related protein, from the cytoplasm to the mitochondria. The expression of mitophagy proteins PINK1 and PARK2 was also increased by CRP. YAP, a transcriptional regulator of PINK1 and PARK2, was also increased by CRP. Knockdown of YAP prevented CRP-induced increases in DRP1, PINK1, and PARK2. Furthermore, CRP-induced changes in the expression of DRP1 and increases in YAP, PINK1, and PARK2 were inhibited by ERK1/2 inhibition, suggesting that ERK1/2 signaling is involved in CRP-induced mitochondrial fission. We treated H9c2 cardiomyocytes with a recombinant TAT-survivin protein before CRP treatment, which reduced CRP-induced ROS accumulation and reduced mitochondrial fission. CRP-induced activation of ERK1/2 and increases in the expression and activity of YAP and its downstream mitochondrial proteins were inhibited by TAT-survivin. This study shows that mitochondrial fission occurs during CRPinduced cardiomyocyte damage and that the ERK1/2-YAP axis is involved in this process, and identifies that survivin alters these mechanisms to prevent CRP-induced mitochondrial damage. [BMB Reports 2023; 56(12): 663-668]

한국산 나비 目(Lepidoptera)의 발향린(Androconia)에 관한 주사전자현기경적 연구 III. 네발나비科

박원학,류성만,서경인,이종욱 嶺南大學校 基礎科學硏究所 1992 基礎科學硏究 Vol.12 No.-

한국산 네발나비과에 보고된 77종 중 북한산 12종과 채집하지 못한 21종을 제외한 44종, 670여 개체를 재료로 광학현미경으로 발향린의 유무 및 분포를 확인하였다. 이중 발향린이 관찰된 10종을 대상으로 주사전자현미경으로 그 형태를 비교 연구하였다. 1. 발향린이 관찰된 종은 Brentis ino(R.), Argyronome laodice (P.). A. ruslana (M.). Damora sagana (D.), argynnis paphia (L.), Childrena zenobia (L.), Speyeria aglaja (L.), Fabriciana pallescens (B.), F. adippe (L.), F. nerippe(c.et R. F.) 10종이다. 2. 발향린은 암컷에서는 관찰되지 않았고, 수컷이 앞날개 표면에서만 관찰되었으며, 시맥위에서만 분포한다. 3. 확인, 관찰된 10종의 발향린은 나발막(fimbriae), 경부(neck), 잎새(laminar), 자루병반(foot stalk) 등 발향린의 전형적인 모양을 나타내었으며, 동종내 개체간 변이는 관찰되지 않았다. 4. Argyronome laodice, A. ruslana, Damora sagana, argynnis paphia, Childrena zenobia, Fabriciana pallescens 등 6종에서는 2가지 형태의 발향린이 관찰되었다. 5. 본 연구에서 관찰한 10종은 Subfamily Argynninae아과의 Argynnini족에서만 관찰되었으며, 관찰된 발향린중 Type ⅠⅠ의 형태는 종간에 큰 차이점이 없었고, Type Ⅰ은 많은 형태적 차이를 보이므로 분류학적으로 중요한 형질이라 사료된다. this paper observed through microscope the existance and the distribution of the androconia of the 44 species Nymphalidae among 77 ones that have been reported in Korea, excluding 12 species in North Korea and 21 one's not collected ten species that were observed the androconia among those were chifely compared and studied through Scanning Electron Microscope. 1. The 10 species that observed androconia is Brentis ino(R.), Argyronome laodice (P.). A. ruslana (M.). Damora sagana (D.), Argynnis paphia (L.), Childrena zenobia (L.), Speyeria aglaja (L.), Fabriciana pallescens (B.), F. adippe (L.), F. nerippe(C. et R. F.) 2. The androconia was not found at the female, but only on the dorsal surface of male's fore wings. 3. The androconia of 10 species was not observed intraspecific seasonal variation and individual variation. It was appeared the androconia as general type of fimbriae, neck, laminar and foot stalk. 4. Two types(typeⅠ and Ⅱ) of androconia were observed at the species of Argyronome laodice, A. ruslana, Damora sagana, Argynnis paphia, Childrena zenobia, Fabriciana pallescens. 5. According to this study, the androconia of 10 species observed only Argynnini, subfamily Argynniae. The type Ⅱ of the androconia similar to between species but type Ⅰ was observed multitudes of morphological difference. These difference of type Ⅰ was very important taxonomical characters.

글리세린 처리에 의한 종이의 물성 변화

박세진,차지영,김학상,김봉용 경북대학교 농업과학기술연구소 2006 慶北大農學誌 Vol.24 No.-

This study was carried out to investigate the influence of glycerine on the properties of paper. Two types of glycerine treatment were used. First type, when making handsheets, glycerine was added in the plup slurry. Second type, copying paper was soaked in glycerine solution. Microwave treatment was used for the test of paper degradation. The obtained results were summarized as follows: 1. The glycerin was very effective to improve the property of softness. 2. The glycerine was helpful to increase sizing performance of paper as a fixing agent of sizing emulsion. 3. Curl tester was comparatively useful for the measuring of sizing degree.

미생물을 이용한 페놀 폐수지처리에 관한 연구

박상헌,심학보,이수구,서성조 서울산업대학교 산업대학원 1992 大學院論文集 Vol.1 No.1

본 연구는 혼합 미생물을 이용한 페놀 함유폐수의 생물학적 처리에 관한 연구로서, 높은 페놀 농도에서의 이를 분해시킬 수 있는 균주를 개발하고 페널 함유폐수의 효과적인 처리를 위한 실험연구이다. 각종 공장폐수, 슬러지, 토양 등 40여종의 시료로부터 페놀 분해균을 선별하였으며, 페놀농도를 단계적으로 높여 미생물을 적응시킨 결과, 페놀농도 1,000ppm의 높은 농도에서도 잘 증식하며 페놀을 효과적으로 분해시킬 수 있었다. 혼합 미생물을 분리 동정한 결과, 우점종은Pseudomonas PI인 것으로 나타났다. 회분식 실험에서 초기 페놀농도, 균체량 및 glucose 농도 등을 변수로 실험하였느데, 페놀 분해속도는 시간에 따라 증가함을 나타내었다. 또한 페놀이 완전 제거되는데 소요되는 시간은 초기 페놀 농도에 비례하였으며, 균체 주입량에 다른 초기 MLSS농도의 대수식으로 나타낼 수 있었다. 연속식 활성 슬러지법에 의한 실험에 있어서, 본 실험조건에서 페놀이 완전 제거되는데 필요한 반응기내의 체류시간은 유입 페놀농도 500ppm인 경우 20시간이 소요되는 것으로 나타났다. This investigation was carried out to study the biodegradation of phenol in wastewater using mixed microorganisms. The mixed clutures of phenol degrading microorganisms were selected from various sources such as industrial wastewaters, sludges and soils. The mixed cultures could be adapted to high concentration of phenol by increasing the phenol concentration step by step. The phenol was degraded easily even up to 1,000ppm of phenol using these microorganisms. The predominant bacteria was isolated and characterized as Pseudomonas PI. In a batch system, the removal rate of phenol increased with time due to the lag time of microorganism adapation. The duration time during which phenol could be completely removed was linearly proportional to the initial phenol concentration. And the duration time(td) could be expressed as a funtion of logarithmic initial MLSS concentration(x) as follows. td=?? [8.68-In(x)] In a continuous system, the required residence time to remove phenol completely was found to be 20 hours and 35 hours 500 ppm and 800 ppm of influent phenol concentrations, respectively.

약물 수송 및 분자 영상기법을 위한 나노 기술적 접근

박학수,황성주,박정숙 충남대학교 약학대학 의약품개발연구소 2007 藥學論文集 Vol.22 No.-

Nanotechnology, a multidisciplinary scientific undertaking, involves creation and utilization of materials, devices or systems on the nanometer scale. The field of nanotechnology is currently undergoing explosive development on many fronts. The technology is expected to create innovations and play a critical role in various biomedical applications, not only in drug delivery, but also in molecular imaging, biomarkers and biosensors. Target-specific drug therapy and methods for early diagnosis of pathologies are the priority research areas where nanotechnology would play a vital role. This review considers different nano-technology-based drug delivery and imaging approaches, and their economic impact on pharmaceutical and biomedical industries.

섬유판에서 음향방출원의 위치표정

박익근,김용권,윤종학,노승남,서성원 한국공작기계학회 2003 한국공작기계학회 추계학술대회논문집 Vol.2003 No.-

음향방출 신호를 이용하여 목재 섬유판(fiberboards)의 위치표정의 유용성 유무를 실험적으로 검증하였다. 위치표정의 정확도를 향상하기 위해 신호처리 방법중의 하나인 웨이블릿 변환 디노이징 기법을 활용하여 저주파수인 대칭모드(굽힘파)를 활용하고, 고주파수인 비대칭 모드(팽창파)룰 제거하여 신호를 재구성함으로써 섬유판의 위치표정시 문턱값 통과방법을 사용할 때 발생하는 도달시간차를 최소화 할 수 있음을 확인하였다. 디노이징 기법을 활용한 섬유판의 위치 표정과 굽힘강도에 대한 사상총수를 기초로 하여 목재 구조물 및 문화재의 건전성을 평가 할 수 있을 것으로 기대된다.