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      • KCI등재

        혈소판 응집능에 미치는 인슐린의 in vitro 효과에 관한 연구

        조재현,강호철,이태희,정민영,양승원,박철주,선영덕 대한내과학회 1996 대한내과학회지 Vol.51 No.1

        Objectives: It has been suggested that functional abnormalities of platelets play a role in the pathogenesis of diabetic macro- and microangiopathy. Platelets obtained from diabetic patients have been shown to exhibit increased sensitivity to aggregating agents. It was reported that insulin influence on platelet and the long term insulin deficiency might account for the enhanced platelet aggregability frequently observed in diabetic patients. Our aim in this study was to clarify the influence of insulin on platelets in vitro. Methods: We investigated the effects of insulin on platelets response by incubating PRP(platelet rich plama) at 37℃ with different concentrations of the insulin for 5 or 30 min before adding the aggregating agents. Insulin final concentratons were 40, 100μIU/ml, assuming that the basal insulin concentration of PRP is 10 μIU/ml. The responses of platelets to ADP(adenosine diphosphate) and collagen were examined under basal conditions and after the addition of insulin, and they were quantified as the maximal aggregation(M) and T_(1/2)(time consumed to reach 50% of the maximal aggregation). Results: 1) The subjects aged 27.4±2.5(mean±SE) years with body weight 62.5±6.3 kg. 2) The maximal aggregation of the control platelet in response to ADP(60.3±2.7%) was significantly reduced after PRP incubation for 30 min with 40 μIU/ml insulin(52.7±2.7%, 100 μIU/ml insulin(48.7±3.2%) (p$lt;0.01). 3) The T_(1/2) of the control platelet in response to ADP(30.9±1.9sec) was significantly increased after PRP incubation for 30 min with 40pIU/ml insulin (36.6 ±1.7sec), 100 p μIU/ml insulin(38.3±1.7sec) (p$lt;0.01). 4) The maximal aggregation of the control platelet in response to ADP(60.3±2.7%) was significantly reduced after PRP incubation for 5 min with 100 μ IU/ml insulin(56.9±2.5%), PRP incubation for 30 min with 100 μIU/ml insulin(48.7+3.2%)(p$lt;0.01). 5) The T_(1/2) of the platelet incubated for 5 min in response to ADP(31.9±2.1sec, 32.5±2.0sec) was significantly increased after 30 min of incubation(36.6 ±1.7sec, 38.3±1.7sec) at 40μIU/ml, 100μIU/ml insulin concentration(p$lt;0.01). 6) The maximal aggregation of the control platelet in response to collagen (63.9±2.8%) was significantly reduced after PRP incubation for 30 min with 40 p IU/ml insulin(58.3±3.0%), 100μIU/ml insulin(55.1±3.3%) (p$lt;0.01). 7) The maximal aggregation of the control platelet in response to collagen(63.9±2.8%) was significantly reduced after PRP incubation for 5 min with 100 μIU/ml insulin(57.8±2.9%), PRP incubation for 30 min with 100 μIU/ml insulin(55.1±3.3%)(p$lt;0.01). Conclusion: Insulin reduces the platelet response to ADP, collagen in vitro, especially in 30 min PRP incubation at same concentration.

      • The Effect of Highly Concentrated Oxygen(40%) on Heart Rate(HR) While Performing Addition Tasks in a Graphic Driving Simulator

        Cheol-Kee,Min,Doo-Hwan,Ji,Soon-Cheol,Chung,Jin-Kyu,Kang,Seunghee,Hong,Shun'ichi,Doi,Byung-Chan,Min 대한인간공학회 2012 대한인간공학회 학술대회논문집 Vol.2012 No.5

        In this study, it was observed how the supply of highly concentrated oxygen(40%) could affect HR while performing the addition tasks in a vehicle graphic simulator. The subjects of this study were 17 males in their twenties, and the addition tasks were performed in oxygen concentration(21%, 40%). For the performance of double-digit addition tasks in the straight course of two-lane road, its data was extracted by 30sec section from the start of the task and was analyzed. The test was proceeded in the order of Control (5min), Driving (2min), Driving + Task (1min), and Rest (10min). As a result of analyzing HR, there was a significant difference (p<0.01) between 21% oxygen concentration and 40% oxygen concentration, and HR increased during 21% oxygen concentration. Also, the significant difference between stimuli(Control, Driving, Driving+Task) was recognized, and as a result of the posteriori test, compared with Control, HR increased in Driving+Task, showing a significant difference(p<0.01). That is, the sympathetic nerve of the drivers were activated while performing the addition tasks during driving performance. Especially, when highly concentrated oxygen(40%) was presented, HR reduced. And thus, it was found out that highly concentrated oxygen(40%) had a positive effect on performing addition tasks while driving.

      • KCI등재

        확장된 인터리빙을 사용하는 BICM-OFDM의 주파수 다이버시티

        최민철(Min Cheol Choi), 김창중(Chang-Joong Kim), 이호경(Ho-Kyoung Lee) 대한전자공학회 2010 電子工學會論文誌-TC (Telecommunications) Vol.47 No.7

        본 논문에서는 확장된 인터리빙이 추가된 BICM-OFDM 시스템의 주파수 다이버시티를 분석한다. 확장된 인터리빙이란 기존의 인터리빙 방법에서 인터리빙의 범위(depth)를 ?배 확장한 것을 의미한다. 확장된 인터리빙을 사용하면 ?개의 다중경로를 갖는 채널에서 다이버시티 효과를 min(d<SUB>free</SUB>, L)에서 min(d<SUB>free</SUB>, KL)로 증가 시킬 수 있다. 여기서 d<SUB>free</SUB>는 길쌈 부호의 자유거리이다. 또한 이를 다중경로의 개수가 변하는 개폐 채널(on-off channel)에 적용하고 모의실험을 통하여 성능이 개선됨을 보인다. In this paper, we analyse the frequency diversity of BICM-OFDM with extended interleaving. The extended interleaving is an interleaving which is added to the existing BICM-OFDM system to extends the interleaving depth by ? times to the previous interleaving depth. Using the extended interleaving, the diversity order of the proposed system over ?-tap frequency selective channels is increased from min(d<SUB>free</SUB>, L) to min(d<SUB>free</SUB>, KL), where d<SUB>free</SUB> is minimum Hamming distance of the convolutional code. Simulation is also performed to show that the performance of the proposed system is better than that of the existing system even if the channel is an on-off channel in which the number of multi-paths is varying.

      • 유화처리 바이오디젤이 도포된 콘크리트의 침투깊이 판정

        백철 ( Baek Cheol ), 김태우 ( Kim Tae-woo ), 이재진 ( Lee Jae-jin ), 이동윤 ( Lee Dong-yun ), 한민철 ( Han Min-cheol ), 한천구 ( Han Cheon-goo ) 한국건축시공학회 2017 한국건축시공학회 학술발표대회 논문집 Vol.17 No.2

        This study is to provide a evaluation method for the penetration depth of emulsified refined bio diesel(ERBD)applied to a surface of the concrete by using water absorption capability of the concrete. The concrete applied with ERBD was immersed at water for 1 min., 5min., and 10 min. and then was checked the brightness with elapse of time. Test results indicated that there was clear difference between ERBD part and non ERBD part in concrete specimen after measuring the brightness until 120min.

      • Views of physiatrists and physical therapists on the use of gait-training robots for stroke patients

        Kang,,Chang,Gu,Chun,,Min,Ho,Chang,,Min,Cheol,Kim,,Won,Hee,Do,,Kyung The Society of Physical Therapy Science 2016 JOURNAL OF PHYSICAL THERAPY SCIENCE Vol.28 No.1

        <P>[Purpose] Gait-training robots have been developed for stroke patients with gait disturbance. It is important to survey the views of physiatrists and physical therapists on the characteristics of these devices during their development. [Subjects and Methods] A total of 100 physiatrists and 100 physical therapists from 38 hospitals participated in our questionnaire survey. [Results] The most common answers about the merits of gait-training robots concern improving the treatment effects (28.5%), followed by standardizing treatment (19%), motivating patients about treatment (17%), and improving patients' self-esteem (14%). The subacute period (1–3 months post-stroke onset) was most often chosen as the ideal period (47.3%) for the use of these devices, and a functional ambulation classification of 0–2 was the most selected response for the optimal patient status (27%). The preferred model was the treadmill type (47.5%) over the overground walking type (40%). The most favored commercial price was $50,000–$100,000 (38.3%). The most selected optimal duration for robot-assisted gait therapy was 30–45 min (47%), followed by 15–30 min (29%), 45–60 min (18%), ≥ 60 min (5%), and < 15 min (1%). [Conclusion] Our study findings could guide the future designs of more effective gait-training robots for stroke patients.</P>

      • SCOPUSKCI등재

        대장내시경검사의 전처치로서 항콜린제 사용에 관한 연구 : 전향적, 이중맹검법으로

        박경남,한동수,이민호,최호순,박준용,손주현,이오영,함준수,전용철,송승찬,기춘석,윤병철,이종희 대한소화기내시경학회 1997 Clinical Endoscopy Vol.17 No.3

        Background: Use of antispasmodic medication prior to colonoscopy is controversial but someone believes antispasmodic may improve visualization of colonic mucosa and ease colonoscope insertion. So, we designed a study to assess the effect of premedication with the antispasmodic, hyoscine-N-butyl bromide(Buscopan') on the performance of colonoscopy. Methods: This study was prospective, double blinded, randomized, controlled study, One hundred three consecutive patients were randomized to receive intravenous buscopan lml(n=52) or placebo(n=51) combined with our standard initial medication(me- peridine 50 mg and midazolam 2 mg). Insertion of colonoscopy was timed, and 100 mm visual analogue scales (VAS) were used for asscssing difficulty of procedure, colonic motility, frequency of positional change, frequency of external compression, difficulty of assistance and degree of discomfort experienced by the patients. Results: There were no significant differences of intubation time between buscopan group(mean time, 7.23 min., range 2~15) and placebo group(7.07 min., range 3-25), (p=0.83) and withdrawal time between buscopan group (6.46 min., range 2-22) and placebo group(6.76 min., range 2 25), (p=0.69). Also, there was no significant differences in intubation time between males and females(buscopan; males 7.00 min., females 7.60 min., p=0.34, placebo; males 7.0~5 min., females 7.08 min., p 0.44). The VAS scores checked by endoscopist(p=0.29), assistant(p=0.32) and patient (p=0.15) were not significantly different in both groups. There were no significant differences in intubation time, VAS scores nf endoscopist, assistant, and patients. Conclusion: Premedication with intravenous bu.opan has no advantage on colonoscopy procedure. Use of antispasmodic medication prior to colonoscopy was not considered as recommendable agent.

      • PE-020 : Comparison of Renal Safety between Entecavir and Tenofovir for the Treatment of Chronic Hepatitis B: A Two Year Retrospective Study

        ( Hyun Jung Kim ), ( Sung Kyun Na ), ( Young Min Choi ), ( Hoe Soo Jang ), ( Young Nam Kim ), ( Eun Kwang Choi ), ( Hyun Woo Kim ), ( Byung-cheol Song ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

        Aims: Entecavir (ETV) and tenofovir (TDF) are most commonly used anti-viral agents for the treatment of chronic B hepatitis (CHB). We evaluated renal safety between two antiviral agents. Methods: Of 549 patients who received ETV or TDF as a first-line treatment, 285 patients (ETV, n=139 vs. TDF, n=146) were analyzed retrospectively. We compared the frequency of renal impairment, defined by creatinine increase (ł 0.3mg/dL) or GFR reduction (ł 15%) and GFR change at 2 years. Results: The frequency of creatinine increase was 0.8% and 9.2% in ETV and TDF groups, respectively (p=0.002). The frequency of GFR reduction (ł 15%) was higher in TDF group (14.2%) than in ETV group (6.8%) (p=0.048) The frequency of renal impairment at 2 years was higher in TDF group compared with ETV groups (17.0% vs. 6.8%, p=0.01). TDF treatment, baseline albumin, GFR and diabetes mellitus were independent risk factors for renal impairment. The GFR decreased from 76.6 ml/min/1.73m2 to 74.0 ml/min/1.73m2 in ETV group (p<0.0001) and from 76.2 ml/min/1.73m2 to 72.0 ml/min/1.73m2 in TDF group (p< 0.0001). GFR change between two groups was not different at 2 years. (p=0.16) In subgroups with high GFR ( > 76 ml/min/1.73m2), GFR was not different between two groups at 2 years. (p=0.97) However, in patients with low GFR (< 76 ml/min/1.73m2), GFR was higher in ETV group than in TDF groups. (p=0.005) at 2 years. Conclusions: TDF treatment might be associated with renal function deterioration. Therefore, before choosing antiviral agents, efficacy and risk factors for renal impairment should and should be considered.

      • 동적 신장 신티그래피 검사 시 사용되는 Gates 법과 Modified Gates 법의 사구체 여과율 비교에 관한 고찰

        함준철,반영각,박민수,조석원,임한상,김재삼,이창호,Ham,,Jun-Cheol,Bahn,,Young-Kag,Park,,Min-Soo,Cho,,Seok-Won,Lim,,Han-Sang,Kim,,Jae-Sam,Lee,,Chang-Ho 대한핵의학기술학회 2012 핵의학 기술 Vol.16 No.1

        사구체 여과율은 신기능의 평가 및 신 질환의 조기 발견 및 만성 신 질환 환자의 경과 관찰에 중요한 지표가 된다. 본 연구에서는 동적 신장 신티그래피의 Gates법과 Modified Gates법을 채혈을 이용한 MDRD법 공식을 기준으로 그 차이를 비교, 분석하고자 한다. 2010년 11월부터 2011년 8월까지 본원에 내원하여 신장 신티그래피 검사를 시행한 45명의 환자를 대상으로 시행하였다. 이 중 20명의 환자는 AGUS(Philips Medical System, Cleveland, OH, USA) 장비의 Gates법과 MDRD법(Modification of Diet Renal Disease) 공식에 의한 사구체 여과율 값을 비교하였으며, 20명의 환자는 INFINIA (General Electric Healthcare, Wisconsin, MI, USA) 장비의 Modified Gates법과 MDRD법 공식에 의한 사구체 여과율 값을 비교하였다. 마지막으로 경과 관찰 시 MDRD법 공식에 의한 사구체 여과율 변화가 없는 환자 5명을 대상으로 Gates법과 Modified Gates법을 비교하였다. Gates법과 Modified Gates법 모두 MDRD법 공식에 의한 사구체 여과율 값과 높은 상관 관계를 보였으며($p$<0.01, r=0.903, r=0.867), Gates법의 대응 차 평균은 $2.05{\pm}2.54mL/min/1.73m^2$로 나타났고, Modified Gates법의 대응 차 평균은 $25.2{\pm}3.71mL/min/1.73m^2$로 나타났다. 마지막으로 5명의 환자에서 실시된 Gates법과 Modified Gates법의 비교는 높은 상관 관계를 보였으며($p$<0.05, r=0.949), 대응 차 평균은 $20.4{\pm}8.84mL/min/1.73m^2$ 로 나타났다. Gates법과 Modified Gates법 및 MDRD법 공식에 의한 사구체 여과율 값은 서로 높은 상관 관계를 보였다. 동적 신장 신티그래피 검사 시 사용되는 Gates법과 Modified Gates법의 상관 관계를 인지하고 검사를 진행 한다면, 진단능을 향상시켜 정확한 신기능의 평가가 이루어질 것으로 사료된다. Purpose: Glomerular filtration rate is an important index for assessment of renal function, early discovery of renal disease, and progress observation of chronic renal disease patients. In the present study, the objective is to conduct a comparative analysis of differences between Gates and Modified Gates method in dynamic renal scintigraphy based on MDRD (Modification of Diet Renal Disease) formula using blood collection. Materials and Methods: Renal scintigraphy was performed for 45 patients who visited our hospital between November 2010 and August 2011. For 20 patients of those tested, glomerular filtration rates from Gates method and MDRD formula using AGUS equipment, were compared. For the other 20 patients, glomerular filtration rates from Modified Gates method and MDRD formula using INFINIA equipment. Finally, Gates and Modified Gates method were compared for 5 patients who indicated no change in glomerular filtration rates from MDRD formula during progress observation. Results: Glomerular filtration rates from both Gates and Modified Gates method showed a high correlation with those from MDRD formula ($p$<0.01, r=0.903, r=0.867), with a paired difference mean for Gates method of $2.05{\pm}2.54mL/min/1.73m$, and that for Modified Gates method of $25.2{\pm}3.71mL/min/1.73m$. Finally, the values for Gates method and those for Modified Gates method showed a high correlation for the five patients ($p$<0.05, r=0.949), with a paired difference mean of $20.4{\pm}8.84mL/min/1.73m$. Conclusion: Glomerular filtration rates from Gates method, Modified Gates method and MDRD formula showed mutually high correlations. If the tests are performed with recognition for the correlations between Gates and Modified Gates method used in a dynamic renal scintigraphy, then an accurate assessment of renal function is considered possible with an improved diagnostic ability.

      • SCOPUSKCI등재

        임상연구 : 무릎 관절경 수술 시 Ketorolac 투여가 압박띠 사용에 따른 혈압 변화에 미치는 영향

        김운영 ( Yoon Young Kim ), 신연식 ( Youn Sik Shin ), 민두재 ( Doo Jae Min ), 이윤숙 ( Yoon Sook Lee ), 김재환 ( Jae Hwan Kim ), 박영철 ( Young Cheol Park ) 대한마취과학회 2007 Korean Journal of Anesthesiology Vol.52 No.5

        Background: The use of a tourniquet can produce pain and cause increased blood pressure. Ketorolac is known to have analgesic effects at the peripheral and central levels, however, its effect on the increased blood pressure due to a tourniquet is unknown. Therefore, the effects of ketorolac on the tourniquet-induced changes in the systolic, and diastolic blood pressures (SBP & DBP), as well as the heart rate (HR), were investigated. Methods: ASA physical status I and II patients, who were scheduled for knee arthroscopic surgery using a tourniquet, were assigned to control (n = 20), K30 (n = 20) and K60 groups (n = 20). Anesthesia was maintained with enflurane, N2O and O2. Either 30 or 60 mg ketorolac was injected 10 min prior to tourniquet inflation in both the K30 and K60 groups. The changes in the SBP, DBP and HR were measured before and 10, 20, 30, 40, 50, and 60 min after tourniquet inflation. Results: There were no differences in the baseline SBP, DBP, and HR values. The SBP was higher than the baseline value at 10, 20, 30, 40, 50, and 60 min in the control and at 30, 40, 50, and 60 min in the K30 groups, but only at 60 min in the K60 group. At 60 min, the SBP was lower in the K60 than the control group. The DBP was higher than the baseline value at 50, and 60 min in the control, but not in the ketorolac groups. Conclusions: A 60 mg ketorolac injection prior to tourniquet inflation can attenuate the tourniquet induced increase in blood pressure in knee arthroscopic surgery patients. (Korean J Anesthesiol 2007; 52: 511~5)

      • SCOPUSKCI등재

        무릎 관절경 수술 시 Fentanyl 투여가 압박띠 사용에 따른 혈역학적 변화에 미치는 영향

        이윤숙 ( Yoon Sook Lee ), 김재환 ( Jae Hwan Kim ), 차문호 ( Moon Ho Cha ), 민두재 ( Doo Jae Min ), 김운영 ( Woon Young Kim ), 장문석 ( Moon Seok Chang ), 박영철 ( Young Cheol Park ) 대한마취과학회 2009 Korean Journal of Anesthesiology Vol.56 No.1

        Background: The use of a tourniquet can produce pain and increase in blood pressure. It is known that fentanyl reduces central sensitization, however its effect on blood pressure increase due to tourniquet is unknown. So we investigated the effect of fentanyl on tourniquet-induced changes of mean arterial blood pressure (MBP), heart rate (HR), and cardiac index (CI). Methods: ASA physical status I and II, who were scheduled for knee arthroscopic surgery using a tourniquet, were assigned into control (n=30) and fentanyl group (n=30). Anesthesia was maintained with enflurane, N2O and O2. Fentanyl was injected 1.5 ug/kg at 10 min before inflation of the tourniquet in the fentanyl group. Changes of the MBP, HR, CI were measured before and 10, 20, 30, 40, 50, 60 min after inflation of the tourniquet. Results: There were no differences in the baseline values. MBP was increased at 40, 50, 60 min in the control group. At 60 min, MBP was lower in the fentanyl than the control group. HR was decreased at 10 min in the fentanyl group. CI was decreased in all groups after tourniquet inflation. At 60 min, CI was more decreased in the control than the fentanyl group. Conclusions: Fentanyl injection prior to tourniquet inflation can attenuate the tourniquet induced hemodynamic changes in the knee arthroscopic surgery patients. (Korean J Anesthesiol 2009;56:6~10)

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