Serum TSH Level in Healthy Koreans and the Association of TSH with Serum Lipid Concentration and Metabolic Syndrome

( Yeo Kyung Lee ),( Jo Eun Kim ),( Hyun Ju Oh ),( Kyung Sun Park ),( Soo Kyung Kim ),( Seok Won Park ),( Moon Jong Kim ),( Yong Wook Cho1 ) 대한내과학회 2011 The Korean Journal of Internal Medicine Vol.26 No.4

Background/Aims: The proper treatment of subclinical hypothyroidism and the normal range of serum thyroid stimulating hormone (TSH) concentration are intensely debated. However, few reports have investigated TSH concentrations in Asian ethnic groups. Therefore, the present study was designed to define the TSH reference range in a Korean population and to investigate the metabolic significance of TSH concentration. Methods: We enrolled patients who underwent medical examination at the CHA Bundang Medical Center. Anthropometric data were evaluated, and serum TSH, free T4, and lipid profiles were assayed. Results: A total of 7,270 subjects were included. Mean TSH concentration of the study population was 1.82 ± 0.95 mU/L, and we observed a sex-related difference in TSH concentration (male, 1.67 ± 0.87 mU/L; female, 2.02 ± 1.01 mU/L; p < 0.01). When the 2.5 and 97.5 percentiles were calculated, 95% TSH reference limits were 0.52-4.29 mU/L. TSH concentration was higher in elderly subjects, during winter, in postmenopausal women, and in obese males. Moreover, TSH showed significantly positive correlations with serum total cholesterol, triglyceride, and low density lipoprotein cholesterol regardless of sex, age, season, obesity, or menopausal status (all p < 0.01). Finally, TSH concentration was positively related to the prevalence of metabolic syndrome. Conclusions: We demonstrated the association between TSH concentration within the normal reference range and serum lipid levels. TSH concentration varies according to sex, age, season, and body mass index (only in males). Moreover, high normal TSH levels were significantly associated with an increased prevalence of metabolic syndrome, which may be of importance when evaluating subjects with high normal TSH concentration.

문학,문화 : 디지털 시대 도시의 생태학적 전망

이경래 ( Kyung Lae Lee ),박규현 ( Kyou Hyun Park ),조연정 ( Yeon Jung Cho ) 경희대학교 비교문화연구소 2012 비교문화연구 Vol.26 No.-

City`s Ecological Landscape in the Digital Age Lee Kyung-Lae, Park Kyou-Hyun, Cho Yeon-Jung We all know how beautiful our wild and it`s importance to our living planet Earth. But did you realise the speed at which man himself is damaging it`s unique natural habitat. We are well on our way to destroy our forests, plants, wetlands. We are polluting our oceans and seas. This way, we`re driving numerous animal species, plant species and many others into extinction. Everyone should be aware of the importance of our natural environment. We live in the period of echocide. Why we need nature to survive and how we can deal with the environmental problems we face. This paper has the purpose to reform city`s environment. Because, Metropolis and megalopolis are the principal cause of environmental disruption. To reform the city is needed to consider digital technology in our age. In the face of economic and cultural globalization, many have argued that we live an increasingly placeless world. However, as a growing number of cities participate and compete in key marketplaces of advanced capitalism, the spectacle of the city is more than ever a significant medium of communication in its own right. In doing so, this work is focused specifically on the dimension of city`s media environment. To that end, the paper examined U-City and U-Eco city. In this study, we will introduce the study on model of U-Eco City as one way for the eco-freindly future city.

4D 특수영상에서의 캐릭터 개발과정 제작 공동 작품 연구

조현경(Cho, Hyun-Kyung) 한국만화애니메이션학회 2015 만화애니메이션연구 Vol.- No.41

영상을 통한 콘텐츠 유통 활성화는 안성지역 활성화 콘텐츠 산업에서 선순환 구조 구축의 필수조건이다. 2015년 국책 사업을 통해 안성지역 지자체에서 제작되고 있는 특수 영상 콘텐츠 제작의 애니메이션은 지역경제를 활성화시키기 위해 시에서 추진되고 있는 핵심 사업이다. 이 연구는 영상 콘텐츠 개발의 과정에서의 기획고찰과 디자인 작품 제작을 통해 시각적 제안을 하고자 한다. 캐릭터 개발 과정의 창의성 및 독창성을 비롯하여 심미적인 평가와 작품의 타당성, 비평성의 연구는 매우 중요하기에, 점차 활성화되고 있는 특수 영상(3D,4D)에서의 지방자치단체의 일반 기존 제작되어진 캐릭터와는 다른 방향의 캐릭터 개발 발전 방향을 위해서 실질적 개발의 비쥬얼이 제시되어져야 할 연구 과제일 것이다, 아울러 개발 진행 단계와 각 단계별로 평가 기준과 실질적 분석의 기획단계의 과정을 통해 제안된 작품이 주요 결과로서 제시되었다. 각 캐릭터 시안의 대한 기획과정의 연구들이 본론에서 제시되고, 결론부분에서 작품 완성 디자인이 중요하게 다루어 졌으며, 개발 사례에 대한 기획방향과 제시된 특수영상의 캐릭터의 특징들을 자세히 제시하였다. 실질 개발 과정에서의 선택과 평가가 객관적이고 결과 지향적이어야 하기에 특수영상의 실질적 캐릭터 작품을 기획과 결과 과정을 제시하며 발표하는 논문은 중요한 요청을 가지며, 제시된 디자인 결과물로서 실질적 가치 개발 창출에 의미를 가짐으로서 가시적 성과에 기여할 것으로 기대한다. In Kyung–GI DO, An-sung, Each local autonomous entity developed the character design to inform the public relations and revitalize local economy and culture. consequently, These have got benefits with marketing local speciality related to their an-sung character; we call it name is arum, pung-mul, duck-bugi who korea traditional face characters. On the contrary, Most of old characters which have been fallen off their formative qualities became a reason that unfit (4D,3D) special film at local doom movie theater. This thesis aims to study on the character of ‘namsadang’group what have been produced in ansung-si, that the show up to people about an-sung 4D Contents what local actually character and to make it more competitive through 3D,4D spacial character project developing process. It is need for new various characters, that (3D,4D-VFX)-Graphics of new an-sung‘namsadang’group. that will be total different and new development. total VFX; 4-Dimantion visual graphics released in next an-sung local festival, Business prospects are bright and receiving benefits are increasing. As seen in the case of the character of in 2015, it can be a measure to earn benefits as a higher value-added business if it is managed in the local autonomous entities. In this thesis, I propose what the of character in the local special graphics; VFX style characters design. also I was show up to‘4D contents character;’;‘namsadang’group; creative processing including planing. It is possible to be ranged from special 4D series animation, a feature-length special effct cartoon film, character products, and even local doom Theme parks show up film. which are all expected high profits. These profits will be returned back to the an-sung local autonomous entity, who can use them to develop new contents, one of foundations in local economy. As a result, it is helpful to make local traits and effective tourist attractions.

Clinical Significance of Classification of Graves` Disease According to the Characteristics of TSH receptor Antibodies

(Won Bae Kim),(Hyun Kyung Chung),(Young Joo Park),(Do Joon Park),(Hong Kyu Lee),(Bo Youn Cho) 대한내과학회 2001 The Korean Journal of Internal Medicine Vol.16 No.3

N/A Background:It has been widely accepted that the epitope (s) and/or functional characteristics of thyrotropin receptor antibodies (TSHRAb) from Graves` patients are heterogenous among patients. However, the clinical significance of such heterogeneity has not been systematically evaluatedyet. We were to elucidate and find the clinical significance of heterogeneity for TSH receptor antibodies in Graves` disease. Methods:We measured stimulating TSHRAb (TSAb) activities using CHO-hTSHR cells, FRTL-5 cells and chimeric receptor expressing cells (Mc1+2 and Mc2), specific blocking TSHRAb (TSBAb) activities using Mc2 cells and TBII activities using porcine thyroid membrane in 136 patients with untreated hyperthyroid Graves` disease. Results: Based on various TSHRAb activities from each patient, the patients could be categorized into 7 subgroups by cluster analysis; 1) Group 1 (n=41) was characterized by moderate TSAb activities bothin CHO-hTSHR cells and in FRTL-5 cells, typical TSAb epitope, rare blocking antibodies and high TBII activities. 2) Group 2 (n=16) was characterized by the presence of blocking TSHRAb in most patients, albeit the other characteristics were the same as those in Group 1. 3) Group 3 (n=19) patients had low TSAb activities bothin CHO-hTSHR cells and in FRTL-5 cells, seldom had blocking TSHRAb, but they had high TBII activities. 4) Group 4 (n=30) could be categorized as `mild disease` group, as they had low activities in all kinds of TSHRAb assay and had low antim icrosomal antibody activities. 5) Group 5 (n=14) was characterized by moderate TSAb activities with atypical epitope (s), rare blocking TSHRAb and moderate TBII activities. 6) Group 6 (n=10) patients had veryhigh TSAb activities with typical epitopes, seldom blocking TSHRAb and low TBII activities. 7) Group 7 (n=6) was characterized by very high TSAb activities with atypical epitopes and high TBII activities. Pretreatment serum thyroid hormone level was low only in group 4 patients compared to the other 6 groups (p<0.05). The size of goiter was significantly larger in those in group 1 and group 3 (p<0.05) compared to the other 5 groups. The prevalence of clinically significant ophthalmopathy was higher in group 2 patients than the other 6 groups (50%vs.27.5%,p=0.06). Among 6 kinds of TSHRAb activities, only the blocking TSHRAb activity was significantly associated with the presence of ophthalmopathy in multivariate analysis. Conclusion:These results suggest that the differences inepitopes for TSAb or the presence of blocking TSHRAb is not a major factor in determining the degree of thyrotoxicosis in Graves` disease. Although the pathogenic mechanism is not clearyet, we suggest that patients with ophthalmopathy have different TSHRAb repertoire from those without ophthalmopathy in Graves` disease.

야생동충하초로부터 우량균주선발(II)

방극소(Keuk-So Pang),홍경환(Kyung-Hwan Hong),조덕현(Duck-Hyun Cho) 한국자원식물학회 2001 한국자원식물학회지 Vol.14 No.2

2000년 5월 중순부터 10월까지 채집하였다. 이 중 2속 4종을 확인하였고 6균주를 분리하여 모두를 자실체 유도실험에 이용하였다. 그 결과 동충하초 [Corcyceps miliraris(CHO-7410)] 1균주, 눈꽃동충하초[isaria japoica (CHO-6713, CHO-7413)] 2균주를 상업적이나 의약품개발에 있어서의 시료등 각 산업에있어서 전반적으로 이용가치가 충분히 있다고 사료되어 우량균주로 선발하였다. Many Cordyceps spp. were collected for excellent strains selection at near Wanju-kun from May to October, 2000. They were identified. As the resulting, They were 2 genera and 4 species. 6 strains were got through 4 species culture. 6 strains are Cordyceps militaris f. albino, C, gracilaides, C. militaris and Isaria japoica. Among them, 4 species used for induction of artifitial fruiting body. 3 strains of them were selected for excellent strains. excellent strains are Cordyceps militaris and Isaria japoica.

40세 이하 관상동맥 질환자에서 장기적 임상 관찰

이승욱,정명호,박종철,박형욱,조상희,김원,김계훈,이상현,강경태,조장현,김남호,김건형,안영근,조정관,박종춘,강정채 全南大醫大 2001 전남의대학술지 Vol.37 No.2

서울올림픽 이후의 體育施設 活用施設 活用方案 意識實態 調査硏究

趙庚旭,金昌範,金顯俊 忠北大學校 平生體育硏究所 1990 平生體育硏究所 論文集 Vol.4 No.-

The research material of this study is randomly chosen out of an area of large cities, small and medium cities, and towns. The object persons are totaled to 852; male 519 and female 333. 1. More than falf of the answers say that they are in good health condition. And they want take part in individual and easy sport games. And they cannot take part in sports or games because they have no spare time or facilities. So, to give many chances, we have to make some effective plan to prolong the spare time and we have to locate the sports facilities near the dwelling place. And we have to make a standard for the sports facilities according to the population and have to keep it. They usually use the public sports facilities. To popularized the socio-physical training, the public sports facilities take more important role than other elements. And to make the best use of the vacant space, the adminisrtative cooperation is needed. And we have to formulate thesystem which can prepare the nongovernmental organized sports facilities. 2. Most people want the entire opening of the Olypic facilities to the individual, and they show very positive attitude to the Olympic facilities and its environment. Also, they need a guide who can help their recreation. But almost answers(about 97%) do not know the way how to use the Olypic facilities. So anouncement using mass-media, guidebooks, and newsletters and many various and active information is required. We have very good sports facilities, but if we cannot run the facilities effectively, the rate of use is lowered. So we, who have few sports facilities, have to make a concrete plan to make the best use of the Olympic facilities. And now, we have to consider who, when, and how can use the Olympic facilities, according to the potentiality of each facilities, and make it can be used more easily than now to make the national spirit more sound and give more various chance of enjoying recreation. Also, we must consider the economical aspect in order to keep a ballance in management.

IRM 임시수복이 상아질 접착제의 변연 미세누출에 미치는 영향

조영곤,김현경,이영곤 大韓齒科保存學會 2003 Restorative Dentistry & Endodontics Vol.28 No.1

This study investigated the influence of IRM on marginal microleakage of 5th generation adhesives. Class V cavities with gingival margins in dentin were prepared on both buccal and lingual surfaces of 60 extracted human molar teeth. Prepared teeth were randomly divided into six groups. Group 1 and 4 received no temporary restoration with IRM. Group 2 and 5 were covered with IRM mixed at P/L ratio(10g/1g). The temporary restorations were removed mechanically with an ultrasonic scaler after one-week storage in distilled water. The cavities were restored using one of two adhesives and composites; Single Bond/Filtek Z 250(Group 1, 2 and 3), UniFil Bond/UniFil F(Group 4, 5 and 6). Following one day storage in distilled water, the restored teeth were thermocycled for 500 cycles(between 5℃ and 55℃)( and immersed in 2% methylene blue for dye penetration testing. The results were analysed using Kruskal-Wallis Test. Mann-Whitney and Wilcoxon singed ranked test at a significance level of 0.05. The results of this study were as follows: 1. Ranking of mean microleakage scores at the enamel margins was Group 1<Group 3<Group 2<Group 4<Group 5<Group 6. The microleakage of Group 6 was significantly higher than that of Groups 1, 2 and 3(p<0.05). 2. At the enamel margins, without regard to pretreatment with IRM, the microleakage of Single Bond was lower than that of UniFil Bond. 3. Ranking of mean microleakage scores at the dentin margins was Group 4<Group 1<Group 5<Group 6<Group 3<Group 2. But there were no significant difference among microleakage of each group(p>0.05). 4. At the dentin margins, the microleakage of the group not pretreated with IRM was lower than that of the group pretreated with IRM. And the microleakage of UniFil Bond was lower than that of Single Bond. 5. Compared with microleakages between the enamel and dentin margins of each groups, Group 1, 2, 3, 4, 5 and 6 at dentin margin were higher microleakage than those at enamel margin. There were significant difference between enamel and dentin microleakage of Group 2 and 3(p<0.05).

자기적 비선형성을 고려한 축방향 릴럭턴스 전동기의 정ㆍ동특성 해석

조윤현,김경호,윤선기 東亞大學校 大學院 2000 大學院論文集 Vol.25 No.-

The paper is described about the statatic and dynamic characteristics analysis of Axial Flux Reluctance Motor(AFRM) with the axial flux path against the rotating direction. To estiamte the performance considered the nonlinearity of magnetic circuit, the modeling parameters of AFRM are computed by the finite element method as functions of input current and angular displacement. The current, torque, back EMF and output power wave of AFRM are simulated from the motion equation by MATLAB/Simulink, and compared linearity simulation results with the nonlinearity ones.

심실중격결손증-치험 1예-

조광현,우종수,황윤호,이양행,박철호,김종성,김철호,이경순,조영일,박태인 인제대학교 1985 仁濟醫學 Vol.6 No.4

A successful treatment of infants and children with congenital heart defects depends upon several factors: diagnosis must be accurate, the operative technique, including techniques of perfusion and myocardial preservation, must be suited to the needs of patients and intensive cares, including accurate anesthesia, must be applied through all stages of investigation and treatment, i.e. before, during and after the operation. Recently we performed a open heart surgery successfully for a six-years old girl who had suffered from frequent upper respiratory tract infection and mild to moderate exertional dyspnea with congenital heart defects (ventricular septal defect, Kirklin type II, with patent foramen ovale). The operation and postoperative course were very smooth. And now we report this with review of literatures.