피리딘 치환제와 2-Bromoacetophenone과의 반응에 대한 속도론적 연구

조영재,김용건,김장열,경진범 한양대학교 이학기술연구소 2000 이학기술연구지 Vol.2 No.

메탄을 용매내에서 2-bromoacetophenone과 피리딘 치환체(3-CH3, 3,5-(CH3)2, H, 3-Cl)와의 반응속도를 여러 온도와 농도 조건하에서 전도도법으로 측정하였다. 이 때 반응속도상수는 온도와 피리딘 농도가 증가함에 따라 증가하였으며, 피리딘 치환체에서 치환기의 전자주게 능력이 클수록 반응속도는 증가하였다. 이들 반응속도상수로부터 활성화 엔탈피, ?H≠, 활성화 엔트로피, ?S≠, Hammett 반응상수, p 및 Bsonsted 상관계수, B를 결정하였다. 이 때 ?H≠는 상대적으로 낮은 양의 값을 갖는 반면, ?S≠는 큰 음의 값을 얻었으며, 친핵체의 치환기 효과인 p와 Bronsted 상관계수인 B는 40℃에서 각각 -2.49 및 0.38의 값을 나타내었다. 이러한 결과로부터 본 반응은 dissociative 이분자성 반응으로 진행됨을 알 수 있었다. Kinetics of 2-bromoacetophenone with substituted pyridines (3-CH3, 3,5-(CH3)2, H, 3-Cl) in methanol have been also studied using conductometric method at various temperatures and concentrations. Rate constants are increased with the increment of both temperature and concentration. They are also increased with more electron-donating ability of substituent in nucleophile. The activation enthalpy, ?H≠, the activation entropy, ?S≠, Hammett reaction constant, p and Bronsted coefficient, B are evaluated from the rate constants. The ?H≠ values are positive relatively small while the ??S≠?values are relatively large, and the corresponding coefficients, p and B are -2.49 and 0.38 at 40℃, respectively. From these results, it could be concluded that this reaction proceeds with the dissociative bimolecular pathway.

역행적 골수정 삽입술을 이용한 대퇴골 과상부 골절의 치료

권진우,신승호,조원호,성기호,김기환,손경태,이상훈,박세원,배종문,권태우 대한골절학회 2003 대한골절학회지 Vol.16 No.4

삼성동 은행나무공원 조성계획

김도경,이진민,조용철 경희대학교 디자인연구원 2005 예술· 디자인학연구 Vol.7 No.2

The purpose of this study is to provide basic data for making, operating and managing good golf practice place. So, we surveyed selection variable by questionnaire and analyzed selection variable by SPSS Windows Version 11. This study will give us qualitative evelopment of golf practice environment. This paper concludes with following points. First, Main customers were prospective golfer and people(management, professionalist, housewife) who have time and money to spare in their fories, and they usually came there with their friend or colleague. Facilities and practice environment to improve golf ability were main factors when they select golf practice place. Main purpose of going to golf practice place was to develop their golf ability. Second, The survey on the overall selection factor reveals that there are a significant difference according to gender, educational level, golf career, using time of driving range, using frequency of driving range, practicing time, using frequency of golf course, using purpose of driving range. And female in leisure factor, finishing high school in leisure factor, under six month(golf career) in leisure factor, (using time) pm 4-7 in popularly factor, (using frequency) more than sixth a week in ability improvement factor and less than once a week in leisure factor, (practicing time) over 3 hour in ability improvement factor, (using frequency of golf course) more than sixth a month in ability improvement factor and one or second a month in leisure factor, (using purpose) control fatness in popularly factor appear high selection reason value. Third, we measured selection reason value and user satisfaction value, the results can be summarized as follows. In selection reason, it appeared that help to improve golf ability and to practice golf variable was the largest value and help to train approach shot variable was the second value, and moderate prices in charge was the lowest value. Through this point, we can guess that pitching course user think that pitching course has positive thing to improve golf ability and to practice golf. Through the whole value, we can guess that something to improve golf ability is the best one among the selection reasons of pitching practicing course rather than charge, distance, friendship, and overall user satisfaction value appeared positive value as 3.67.

Escherichia coli 패혈증 환자에 합병된 대칭적 하지 말단 괴사증 1예

남해성,유진홍,권순석,민준기,조현선,박민경,심병주,남유정,이지인,김진수,길욱현,조근종,신완식 대한감염학회 2005 감염과 화학요법 Vol.37 No.6

We have encountered a rare case of symmetrical peripheral gangrene complicating Escherichia coli sepsis in a 47-years-old male. He was successfully treated with antibiotics, anticoagulants, and vasodilator. To our knowledge, this is the first report on symmetrical peripheral gangrene complicating E. coli sepsis in Korea.

뇌수술 시 과호흡과 만니톨의 투여가 뇌혈류와 뇌산소대사에 미치는 영향

김지헌,김경식,문봉기,조경기,신용삼,이영주,김진수 대한마취과학회 2002 Korean Journal of Anesthesiology Vol.43 No.4

Background: There are therapies to lower intracranial pressure (ICP) including head elevation, hyperventilation, diuretics injection, intravenous mannitol, hypothermia, cerebrospinal fluid drainage, and cerebral resection in neurosurgical patients. However in recent reports, hyperventilation followed by mannitol administration may lead to cerebral ischemia. Therefore, we investigated the effect of 0.5-1.0 g/kg mannitol administration on jugular venous oxygen saturation (SjVO_2) and cerebral arterial-jugular venous oxygen content difference (AVDO_2) at PaCO_2 25-30 mmHg and 35-40 mmHg in patients undergoing neurosurgery. Methods: we studied 17 patients undergoing neurosurgery in the Ajou University Hospital. Anesthesia was induced with fentanyl, midazolam, thiopental, and vecuronium, and maintained with )_2-Air-Isoflorane, a continuous infusion of fentanyl, and vecuronium. Patients were divided into two groups. Group 1 (n = 10) which is PaCO_2 25-30 mmHg and Group 2 (n = 7) which is PaCO_2 35-40 mmHg by controlling ventilator. Measurements of SjVO_2 and AVDO_2 in following time intervals: Ⅰ = preinjection of mannitol, Ⅱ = postinjection 20 minutes of mannitol, Ⅲ = postinjection 40 minutes of mannitol were obtainde for each group. 0.5-1.0 g/kg mannitol was administered intravenously just at duramater opening. Results: Hemodynamics and hematologics were not significantly different among the two groups. SjVO_2 of each group are as follows; Group 1; Ⅰ (70.3 ± 8.1%), Ⅱ (66.3 ± 6.9%), Ⅲ (69.1 ± 7.9%) and Group 2; Ⅰ (78.6 ± 7.4%), Ⅱ (75.1 ± 8.1%), Ⅲ (76.0 ± 11.2%), Hyperventilation significantly decreased SjVO_2- AVDO_2 was not significantly different but SjVO_2 in Ⅱ was significantly decreased compared with Ⅰ and Ⅲ in Group 1 (20% patients). Conclusions: Mannitol produced a change of SjVO_2 during hyterventilation. Therefore, intravenous mannitol during hyperventilation should be given cautiously according to the patients status because it may cause cerebral ischemia in critical patients. (Korean J Anesthediol 2002; 43: 462~467)

Original Article : Surgical Outcomes of Transconjunctival Anterior Orbitotomy for Intraconal Orbital Cavernous Hemangioma

( Kyong Jin Cho ),( Ji Sun Paik ),( Suk Woo Yang ) 대한안과학회 2010 Korean Journal of Ophthalmology Vol.24 No.5

Purpose: To describe surgical outcomes for transconjunctival anterior orbitotomy for intraconal cavernous hemangiomas. Methods: The medical records of 9 consecutive patients with intraconal cavernous hemangiomas who underwent surgical removal by transconjunctival anterior orbitotomy were retrospectively reviewed. The conjunctiva was incised and retracted with a traction suture. For large tumors, a rectus muscle was temporarily disinserted. Tenon`s capsule was separated and the tumor was removed with a cryoprobe or clamp. Surgical outcomes, positions of the tumors, methods of approach, and intra- and post-operative complications were evaluated. Results: The mean follow-up period was 33±6.8 months. No bony orbitotomy was used in this technique and the cosmetic results were very satisfactory. All tumors were removed intact. In 4 patients, tumors were extirpated with the aid of a cryoprobe. No patients had residual proptosis or limitation of ocular movement. No signs of recurrence were noted in any cases at 33 months follow-up. No serious or permanent complications were observed during or after the operation. Conclusions: Transconjunctival anterior orbitotomy is an important surgical procedure in the treatment of intraconal cavernous hemangiomas. It can produce an excellent result, even if the posterior border of the tumor abuts the orbital apex.

Modulation of Nrf2/ARE and Inflammatory Signaling Pathways by Hericium erinaceus Mycelia Extract

Kyong-Suk Jin,Ji-Young Park,Mi-Kyung Cho,Ji-Hyun Jang,Jae-Han Jeong,Seon Ok,Min-Ji Bak,Young-Sun Song,Myo-Jeong Kim,Chung-Won Cho,Woo-Sik Jeong 한국식품과학회 2009 Food Science and Biotechnology Vol.18 No.5

Hericium erinaceus is an edible mushroom used as a medicinal food in Asian countries. In this study, the chemopreventive effects of H. erinaceus mycelia hot water extract (HEW) were evaluated. HEW remarkably induced the luciferase activity of the antioxidant response element (ARE), located in the promoter region of phase 2 and antioxidant genes and regulated by nuclear factor E2-related factor 2 (Nrf2). The up-regulation of ARE activity by HEW corresponded with the induction of Nrf2 and the antioxidant enzyme, hemeoxygenase-1. The inhibition of cyclooxygenase-2 (COX-2) activity is a promising effective approach in cancer chemoprevention, and HEW prominently suppressed COX-2 protein expression in HepG2 cells. Furthermore, HEW showed anti-inflammatory activity by modulating inflammatory mediators such as nitric oxide (NO), inducible NO synthase, tumor necrosis factor-α, interleukin-1β, and the transcription factor, nuclear factor-κB, in lipopolysaccharide-stimulated RAW 264.7 cells. These results suggest that H. erinaceus possessed anti-tumor and antiinflammatory effects via the modulation of Nrf2/ARE and inflammatory signaling pathways, and may therefore have potential use as a natural chemopreventive agent.

<i>TGFBI</i> gene mutations in a Korean population with corneal dystrophy

Cho, Kyong Jin,Mok, Jee Won,Na, Kyung Sun,Rho, Chang Rae,Byun, Yong Soo,Hwang, Ho Sik,Hwang, Kyu Yeon,Joo, Choun-Ki Molecular Vision 2012 Molecular vision Vol.18 No.-

<P><B>Purpose</B></P><P>To investigate the clinical and genetic features of Korean patients with corneal dystrophies associated with mutations in the human transforming growth factor-β-induced (<I>TGFBI</I>) gene.</P><P><B>Methods</B></P><P>In this study, 387 subjects (71 families and 89 individuals - 268 patients having <I>TGFBI</I> corneal dystrophies and 119 normal relatives) were assessed. All subjects underwent a complete ophthalmologic evaluation, including biomicroscopic inspection and dilated fundus examination. As a control, 100 individuals without corneal disease were selected from the general population. The polymerase chain reaction (PCR) and direct sequencing were used to screen for mutations in <I>TGFBI</I>.</P><P><B>Results</B></P><P>All subjects recruited exhibited a range of corneal dystrophies, including Thiel-Behnke corneal dystrophy (TBCD, R555Q; 6 families and 4 individuals), granular corneal dystrophy type 2 (GCD2, R124H; 61 families and 80 individuals), lattice corneal dystrophy (LCD; 4 families and 5 individuals; 7 with type 1 [R124C], and 2 with a variant [L527R, P542R]). The disease showed an autosomal dominant inheritance pattern in all families.</P><P><B>Conclusions</B></P><P>R124H in GCD2 was the most common mutation. GCD1 and Reis-Bucklers corneal dystrophy were not found. In the GCD2 patients there were a large number of laser refractive surgery-induced corneal opacities. A spontaneous R124H mutation was confirmed in an already mutated allele that resulted in a change from a heterozygous into a homozygous form. Also, a novel mutation, P527R, was identified in LCD.</P>

Changes in Corneal Sensation and Ocular Surface in Patients With Asymmetrical Keratoconus

Cho, Kyong Jin,Mok, Jee Won,Choi, Min Yeong,Kim, Ja-yeon,Joo, Choun-Ki Masson Pub. USA 2013 Cornea Vol.32 No.2

PURPOSE:: To describe tear function, ocular surface changes, and corneal sensitivity in patients with asymmetrical keratoconus (KC). METHODS:: Thirty-one patients with asymmetrical KC (31 KC and 31 subclinical KC eyes) and 30 control subjects (1 eye in each subject) were enrolled in this prospective, case-control study. The patients and control subjects underwent ocular surface examinations including corneal sensitivity measurements, the Schirmer test using topical anesthesia, tear osmolarity test, and conjunctival impression cytology. RESULTS:: Mean corneal sensitivity and Schirmer test values were significantly lower in the KC and subclinical KC eyes compared with the control eyes. The conjunctiva of KC and subclinical KC eyes showed significantly higher grades of squamous metaplasia and goblet cell loss compared with the control group. However, no significant difference in tear osmolarity was found among the groups. CONCLUSIONS:: The corneal sensitivity and ocular surface changes were significant in the subclinical KC and KC eyes compared with the control subjects. Ocular surface disease in KC was characterized by tear deficiency disorder and abnormal impression cytology results. However, no significant difference in tear osmolarity was found among the groups. The decrease in corneal sensitivity and ocular surface change may be associated with the pathogenesis of ocular surface changes in KC and the progression of the disease.

The development of the enterotoxigenic Escherichia coli ghost vaccine candidate by GI24 against post weaning piglet colibacillosis

Won Kyong Kim(Won Kyong Kim),Ja Yong Moon(Ja Yong Moon),Jeong Sang Cho(Jeong Sang Cho),Enkhsaikhan Ochirkhuyag(Enkhsaikhan Ochirkhuyag ),Jin Hur(Jin Hur) 한국예방수의학회 2018 한국예방수의학회 학술대회자료집 Vol.2018 No.-