통풍성 관절염의 임상적 고찰

윤채중,정승문,김영학,김동규,허광식,김태원,배학연,정종훈,이승일,김평남 朝鮮大學校 附設 醫學硏究所 1997 The Medical Journal of Chosun University Vol.22 No.2

통풍은 Purine 대사의 이상으로 발생하는 질환으로, 고뇨산혈증인 사람의 전부가 통풍으로 발현되지 않고 증상의 출현 양상이 다양하여 진단과 치료에 주의가 필요하며, 조기에 적절한 조치를 한다면 충분히 조절이 가능한 질환이다. 본대학 내과학교실에서는 통풍으로 치료한 32명의 환자에서 임상양상, 병력과 검사소견을 분석하여 다음과 같음 결과를 얻었다. 1. 32명 모두 남자이며, 최초 발병 시기는 24세에서 72세로 평균 43.8±11.9세이었으며, 30대에서 40대까지가 19명(59.4%)으로 대부분을 차지하였다. 내원 당시 나이는 27세에서 75세까지로 평균 52.3±10.4세였으며, 내원시 까지 평균 유병기간은 8.5±6.8년으로 나타났다. 2. 동반 질환으로는 고지혈증 12례, 신장질환 10례, 고혈압 12례, 비만 8례, 당뇨 2례 등이었다. 3. 이환된 관절은 단관절 침범이 19례(59.4%), 다관절 침범이 13례 이었으며, 최초 이한된 관절은 족무지 중족골지골 관절로 19례(59.4%)로 가장 많았고, 통풍 결절은 20례(62.5%)에서 관찰되었으며, 유병기간이 10년 이상된 12례중 11례 (91.7%)에서 결절이 관찰되었다. 4. 평균 혈중 요산치는 9.17±1.75 ㎎/dl이었으며, 8.0 ㎎/dl에서 9.9 ㎎/dl 사이가 19명으로 전체의 59.4%를 차지하였다. Objective: The gout is a heterogeneous group of diseases resulting from tissue deposition of monosodium urate or uric acid crystals from extracellular fluids supersaturated with respect to this end product of human purine metabolism. The clinical manifestations are such as hyperuricemia, gouty arthritis, gouty nephropathy, uric acid nephrolithiasis. We analyze of clinical manifestations and associated factors in gout. Method: We have reviewed the medical records, radiologic findings and clinical results of thirty-two patients admitted at our department from April 1996 to July 1997. Result: 1) All patients were male. The mean age at initial attack was 43.8 years old, ranging from 24 to 72 years old. 2) The mean level of serum uric acid was 9.17mg/dl on admission. 3) The first metatarsopharyngeal joint was involved in 19 cases (59.4%). Tophus was observed in 20 cases (62.5%). 4) Hyperuricemia was associated with hypertension, obesity, nephrolithiasis and hyperlipidemia.

당뇨병성 합병증을 가진 환자에서 혈증 Erythropoietin 농도

김동규,유기동,허광식,김상용,윤성호,조영신,권용은,김태원,김건영,정종훈,배학연 조선의대 1998 The Medical Journal of Chosun University Vol.23 No.1

당뇨병성 합병증을 가진 환자에서 혈중 Erythropoietin 농도

김동규,유기동,허광식,김상용,윤성호,조영신,권용은,김태원,김건영,정종훈,배학연 朝鮮大學校 附設 醫學硏究所 1998 The Medical Journal of Chosun University Vol.23 No.1

연구 배경 : 고혈당성에 의한 산화환원반응 이상(가저산소증)이 조절 되지않는 당뇨병의 특징으로 혈관과 신경 기능에 대한 진성 저산소증의 효과와 유사하며, 당뇨 합병증의 병태생리에 중요한 역할을 한다. 고혈당이 있는 인슐린 비의존형 당뇨병 환자에서 인슐린 수준이 정상이듯이, 빈혈이 있는 당뇨병 환자에서 EPO의 농도는 실제 혈색소 농도의 감소비율과 차이가 있을 것이라 추측된다. Friedman 등은 당뇨병성 합병증 원인 인자로 가저산소증(pseudohypoxia) 또는 저산소증(hypoxia)을 제기하였고 이런 인자들이 EPO의 상대적 또는 절대적 결핍에 의한 것임을 보고하였다. 방법 : EPO-Trac^(TM 125)I RIA kit을 이용하여 방사면역측정법으로 EPO 수준을 검사하였다. 전혈 3㎖을 5-10㎖ 시험관에 정맥 채혈하였으며, 용혈과 장기간의 보존을 위하여 원심분리를 즉시 시행하여 혈청을 영하 200C에서 냉동 보관 후 일괄적으로 검사 결과를 얻었다. 결과 : 1996년 9월부터 1997년 2월까지 조선대학교 부속병원 내과에 입원한 2형 당뇨병 환자 63례를 대상으로 하여 다음과 같은 결과를 얻었다. 1) 당뇨병성 합병증이 없는 군과 있는 군간의 혈색소, 혈중 EPO농도의 차이는 유의한 차이가 있었으며 혈색소의 감소율보다 혈중 EPO의 감소율이 더 높았다. 2) 당뇨병성 망막증의 유무에 따른 혈색소 농도의 차이는 유의한 차이가 없었으나 혈중 EPO농도는 유의한 차이가 있었다. 증식성군에서만 혈중 EPO의 감소비율이 혈색소에 비해 높았다. 3) 당뇨병성 신증의 유무에 따른 혈색소, 혈중 EPO농도는 유의한 차이가 있었고 혈색소 감소율에 비해 EPO농도의 감소율이 높았다. 신증의 중증도에 따른 혈색소, EPO의 차이는 미세알부민뇨군을 제외하고는 유의한 차이를 보였고 혈색소 감소율에 비해 EPO의 감소율이 더높았다. 4) 당뇨병성 신경병증의 유무에 따른 혈색소 농도의 차이는 유의한 차이가 없었으며 EPO농도는 유의한 차이를 보였다. 혈색소와 EPO의 감소비율은 비슷하였다. 신경병증의 중등도에 따른 혈색소와 EPO농도의 변화는 유의한 차이가 없었으나 stage 3에서는 혈색소감소율보다 EPO감소율이 더높았다. 결론 : 당뇨병성 합병증을 가진 환자에서 빈혈의 정도는 대부분 혈청 EPO치의 절대적 감소에 의함을 간접적으로 밝혀낼 수 있었으며 차후 더 많은 대상으로 비교 분석이 필요하리라 사료된다. Background: Hyperglycemic-induced redox(pseudohypoxia) imbalance is a characteristic feature of poorly controlled diabetes that mimics the effects of true hypoxia on vascular and neural functions and plays an important role on the pathogenesis of diabetic complications. As is true for apparently "normal" insulin levels typically found in NIDDM even in the presence of hyperglycemia, a "normal" erythropoietin level in an anemic diabetic subject may be disproportionally low for the actual red cell mass. Therefore, Friedman et al suggested that pseudohypoxia or hypoxia as an etiological factor of diabetic complications are due to absolute or relative erythropoietin deficiency Method: EPO-TracTM 125I RIA kit was used for the quantitative determination of erythropoietin(EPO) in serum by radioimmunoassay. An adequate sample of blood (3ml whole blood) was collected aseptically by venipuncture in a 5~10ml glass tube to yield a minimum of 400 L of serum per assay. The serum was promptly removed from the clot by centrifugation in order to avoid hemolysis. Then to increase its storage time it was frozen at -200C in a nonself defrosting freezer. Finally, tests were undertaken simultaneously Results We studied 63 cases with diabetes mellitus, who were admitted to Chosun University Hospital from September, 1996 to February, 1997 at the Department of Internal Medicine. We defined the control group, as diabetic patients who did not have anemia(<13mg/dl), diabetic complications(retinopathy, nephropathy, neuropathy) and the remainders were defined as the experimental group(we excluded anemic patients, who had secondary causes of anemia and diabetic patients with end stage renal disease)Data were as follow 1) The relationship of Hb and the 24hr urine protein between diabetic patients with and without complications significantly differed(p=0.02, < 0.001 respectively), but the Hb level was poorly related between diabetic patients with and without retinopathy(except in preproliferative, proliferative subgroups) and neuropathy. 2) Subgroups of patients with diabetic complications had higher 24hr urine protein than patients without diabetic complications, except stage I diabetic neuropathy 3) The EPO level was significantly different between diabetic patients with and without complications. 4) The correlation between EPO and Hb was significantly different, especially in diabetic patients with retinopathy and nephropathy according to severity of diabetic complications, compared with patients who did not have diabetic complications such as retinopathy and nephropathy. Conclusion: We know that anemia induced by diabetic complications is due to relative EPO deficiency than absolute EPO deficiency, and further evaluation and studies are needed on many cases in the future

특발성 과호산구 증후군 환자의 치료 도중 발생한 간혈종 1례

이영태,김동기,박지훈,김윤정,김기향,박보민,권민정,김애란,이원식,주영돈,손창학 白中央醫療院 2005 仁濟醫學 Vol.26 No.1

Idiopathic hypereosinophilic syndrome is characterized by marked elevation of eosinophil count ( >1,500/㎣) in peripheral blood without explaining etiology. It shows tissue involvement in many organs such as liver, G-I tract, myocar dium, lung, skin, kidney and nerve. Some case of hypereosinophilic syndrome with hepatic involvement have been reported, but not much. We have recently experienced a case with idiopathic hypereosinophilic syndrome of a 40 year old man who presented with RUQ pain. By abdominal CT, ill- defined subcapsular hematoma was detected. Liver biopsy showed eosinophilic infiltration within the portal tract and sinusoid. Drain procedure and corticosteroid adminiiatbrought marked improvement of clinical manifestation, hematologic abnormality and radiologic abnormality.

CTAX 미셀 용액속에서 유기인 에스테르 화합물의 탈인산화 반응에 대한 OH^(θ) 및 ο-Iodosobenzoate 이온의 영향

김정배,김학윤 한국환경과학회 2005 한국환경과학회지 Vol.14 No.2

This study deals with micellar effects on dephosphorylation of diphenyl-4- nitrophenylphosphate (DPNPPH), diphenyl-4-nitrophenylphosphinate (DPNPIN) and isopropylphenyl-4-nitrophenyl phosphinate (IPNPIN) mediated by OH^(Θ) or o-iodosobenzoate ion (IB^(Θ)) in aqueous and CTAX solutions. Dephosphorylation of DPNPPH, DPNPIN and IPNPIN mediated by OH^(Θ) or o-iodosobenzoate ion (IB^(Θ)) is relatively slow in aqueous solution. The reactions in CTAX micellar solutions are, however, much accelerated because CTAX micelles can accommodate both reactants in their Stern layer in which they can easily react, while hydrophilic OH^(Θ) (or IB^(Θ)) and hydrophobic substrates are not mixed in water. Even though the concentrations (>10^(-3) M) of OH^(Θ) (or IB^(Θ)) in CTAX solutions are much larger amounts than those (6×10^(-6) M) of substrates, the rate constants of the dephosphorylations are largely influenced by the change of concentration of the ions, which means that the reactions are not followed by the pseudo first order kinetics. In comparison to effect of the counter ions of CTAX in the reactions, CTAC1 is more effective on the dephosphorylation of substrates than CTABr due to easier expelling of Cl^(Θ) ion by OH^(Θ) (or IB^(Θ)) ion from the micelle, because of easier solvation of Cl^(Θ) ion by water molecules. The reactivity of IPNPIN with OH^(Θ) (or IB^(Θ)) is lower than that of DPNPIN. The reason seems that the 'bulky' isopropyl group of IPNPIN hinders the attack of the nucleophiles.

慶南地域 中小企業 體質改善에 關한 硏究

金學壽,金容萬,尹泰烈,許南秀,元裕東 慶南大學校 産業經營硏究所 1988 産業經營 Vol.11 No.-

고관성 Pre&Autortating 로터를 이용한 Super STOL 수송기 개념 설계의 타당성 연구

김학윤,이봉준 한국 항공대학교 항공산업기술연구소 1999 航空宇宙産業技術硏究所 硏究誌 Vol.9 No.-

산악이 많은 한국과 같은 지형적 조건에서 운용 가능한 지역 운송용 항공기를 설계하기 위한 임무 요구조건을 설정하고 유사기종에 대한 성능 분석을 하였다. 성능 분석에 따라 설계의 초기 파라미터를 결정하였고 초 단거리 이, 착륙 성능 구현을 위하여 새로운 개념의 고양력 장치인 고관성 Pre&Autorotating 로터를 도입하였다. 고관성 로터의 풍동실험 결과를 토대로 Prerotation에 의해 고관성 로터에 저장된 운동에너지를 발산시키는 방법에 의한 이륙 방식과 자동회전하는 로터를 이용하여 착륙하는 방식에 대하여 검토하였고 설계 파라미터간의 관계에 대해 고찰하였다. 가능성 검토의 결과 고관성 Pre&Autorotating 로터는 순항 성능을 훼손하지 않고 초단거리 이, 착륙 수송기를 설계하기 위한 보조 양력 증가장치로서 매우 유용할 수 있음을 알 수 있었다. Mission specifications were established for the regional transport aircraft which is operatable in the mountainous country like korea, and the performance of similar regional aircraft were analyzed. After that, for the research the initial design parameters were set simultaneously introducing the high inertia Pre&Autorotating rotor concept as a new high lift device. Feasibility research was made based on the wind tunnel test results of high inertia rotor for the ways of dissipating kinetic energy stored in the high inertia rotor for the take-off and of using autorotating rotor for the landing, correlations between design parameters were studied too. feasibility study indicated that the high inertia Pre&Autorotating rotor could be very useful augmented lift device in order to design super STOL transport not deteriorating cruising performance.

Association of Schizophrenia and Dopamine-hydroxylase (DBH) Polymorphismin β Korean Population

김학재,김정우,박윤형 순천향의학연구소 2010 Journal of Soonchunhyang Medical Science Vol.16 No.1

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自我尊重感이 衣服行動에 미치는 影響 : 男·女 高校生을 中心으로

金順九,尹鶴子 한국의류학회 1986 한국의류학회지 Vol.10 No.1

This study was undertaken to explore the relationship between the personality characteristic (the self-esteem) and the clothing behaviors according to the sex and the five environmental variables. This study was designed with the hypothetic model regarding the age and the five environmental variables as Independent Variable, the self-esteem as Intervening Variable, the eight clothing behaviors as Dependent Variable. For the testing hypothesis, the questionnaries were adminstered to 335 high school boys and 308 high school girls in Pusan. The data was analyzed statistically at the B.N.U. Computer Center using to the Path Analysis (by Multiple Regression Analysis Method). The results were as follows: 1. There was significant difference in the self-esteem according to the sex. Boys had nigher scores than girls. 2. There was no significant relationship between the self-esteem and all the environmental variables of this study. 3. There were significant differences in the clothing benavior subscales according to the sex. Girls had higher scores than boys in every clothing behavior subscales. 4. There were partial relationship between the clothing behavior subscales and the environmental variables. 5. There was a highly significant relationship between the self-esteem and the clothing behavior subscales except Comfort and Modesty. A negative significant subscale were Interest, Psychological Dependence, Social Approval and Special Attention. 6. There were positively significant relationship among the clothing behavior subscales except Modesty-Aesthetics, Modesty-Interest, Modesty-Psychological Dependence and ModestySpecial Attention.

接合型 二成分 纖維紡系에 있어서 다이 出口에서의 힘 現象

윤원식,김상용,임무산,김학묵 嶺南大學校 工業技術硏究所 1986 연구보고 Vol.14 No.1

An experimental result of the bending phenomenon at the die exit was compared with the theoretical result. The two result were same in the tendency of increasing bending angle with the melt viscosity ratio and the die swell ratio.