질소산화물의 급성 노출로 인한 폐 손상 1례

김정호,김대환,손병철,이창희,김정원,문덕환,이채언,김주인 대한산업의학회 2000 대한직업환경의학회지 Vol.12 No.2

Objectives : Lung injuries due to exposure to nitrogen oxides can occur in various process in industry. We experienced a case of chemical pneumonitis induced by accidental inhalation of nitrogen oxides emitted from the bath in an acid dipping operation. Case : Dyspnea, cough and blood-tinged sputum production, cyanosis, and tachypnea occurred after exposure to oxides of nitrogen. There were bilateral diffuse ground glass opacities in simple chest radiography and high resolutional computed tomography, hypoxemia in arterial blood gas analysis, mixed ventilation defect and reduced diffusion capacity in spirometry. As an oxygen and supportive therapy, after hospitalization, was given, the patient recovered completely from the lung injury on the 8th day after admission. There was no evidence of delayed onset of bronchiolitis obliterance or pulmonary edema in a follow-up for about 6 months. Conclusions : Acid dip operation require more efficient hooding and exhausting system for the prevention of lung injuries caused by inhalation of nitrogen oxides. Also health education for worker need.

cDNA array 방법을 이용한 망간에 노출된 흰쥐 뇌기저핵의 유전자발현 분석

이채관,노성민,문덕환,,김정호,손병철,김대환,이창희,김휘동,김정원,김종은,안진홍,이채언 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Objectives: This study investigated the gene expression profile in basal ganglia of manganese-exposed rats based on cDNA array analysis. Methods: For cDNA array, 25 male Sprague-Dawley rats (250±25 g) were intraperitoneally injected with 25 ㎎/㎏ B. W./day of MnCl2 (0.3 ㎖) for 10 days. For dose-related gene expression analysis, rats were intraperitoneally injected with 0.2, 1.0, and 5.0 ㎎/㎏ B. W/day of MnCl2 for 10 days. Control rats were injected with an equal volume of saline. RNA samples were extracted from brain tissue and reverse-transcribed in the presence of [α^(32)P]-dATP. Membrane sets of the Atlas Rat 1.2 array Ⅱ and Toxicology array 1.2 kit (Clontech, Palo Alto, CA) were hybridized with cDNA probe sets. Northern blot hybridization method was employed to assess the dose-related gene expression. Results: Fifty-two genes showed significant changes in expression of more than two-fold. Twenty-eight were up-regulated and 24 were down-regulated in the manganese-exposed group compared to the control. Among the 52 genes, 28 genes including nuclear factor I-X1 (NF1-X1), neuroligin 2 and 3, mitochondrial stress-70 protein (MTHSP70), neurodegeneration-associated protein 1 (Neurodap 1), multidrug resistance protein (MDR), and endoplasmic reticulum stress protein 72 (ERP72), were reported for the first time related to the manganese-induced neurotoxic-metabolism in the rat basal ganglia. According to the dose-related gene expression analyses, MTHSP70, Neurodap 1 and ERP72 genes were up-regulated compared to the control even in the group exposed to low manganese dose ( 0.2 ㎎/㎏ B.W./day). Conclusions: Twenty-eight genes detected for the first time in this study were closely related to the manganese-induced neurotoxic-metabolism in the rat basal ganglia and further study of these genes can give some more useful information about the manganese metabolism.

들깨(Perilla) 品種改良 및 育成에 관한 硏究(Ⅰ) : 들깨 在來種의 特性調査 Characteristics of Korea local perilla

孫賢秀,金正基,安始榮,鄭大守 東亞大學校 1978 東亞論叢 Vol.15 No.2

1977年度 本 大學校 農科大學에서 들깨(Perilla) 品種改良 및 育成을 위하여 全國108個 募集在來種의 裁培에 의한 特性을 調査하여 選? 育種의 基礎的 資料를 얻고자 實施된 本 試驗의 結果를 要約하면 다음과 같다. 1. 草長, 葉面積 1ℓ重 및 1000粒重은 高度의 有意性이 있었고 莖値徑, 花房長, 花房數 子房數 및 株當收量에 있어서는 5% 水準에서 有意性이 認定되었다. 2. 株當收量을 Y로하는 收量構成要素의 相關係數에서 稈長, 莖値徑, 分技數, 子房數 및 1000粒重에서 高度의 正의 相關關係가 認定되었고 花房長은 5%水準에서 正의 相關關係가 있었다. 3. 1000粒重이 5g以上인것은 白色種皮가 많았고 油胎含有率은 40%以下였으며 褐色種皮는 50%以上의 油胎含有率을 나타내었다. 4. 本試驗에서 選?育種으로 推정할수 있는 在來系綜은 다음과 같다. ① 多收性인것 412 연기 51.18g/1株 614 성주 52.88g 〃 701 남제주51.30g 〃 809 문경 60.94g 〃 915 진양 50.71g 〃 ② 早生性인것 201 강능生育日數 131 日 307 제천生育日數 131 日 403 논산 〃 921 통영 〃 932 남해-2 〃 ③ 油胎含有率이 높은것 309 진천 50.2% 416 천원 52.9% 611 무안 52.9% 619 영암 50.1% 805 금능 50.5% ④ 葉面積이 넓은것 206 양구-1 154.40cm² per leaf 608 나주 150.90 〃 612 보성 150.70 〃 626 화순 171.10 〃 809 문경 160.20 〃 Fundamental experiments on Perilla breeding were carried out with 108 local perilla species, and the resuts obtioned were as follows. 1) Statistically high significance was revealsed in terms of plant length, leaf area and weight per 1 litre and weight of 1,000 grains, and significance was also recognized in the yield per plant at 5% level. 2) linear regression was positively appeard between the yield of plant and plant length, culm height, valid brances No, number of ovary, weight of 1,000 grains and positive correlation wasalso recognized between yield of plant and length of flower ovary at 5% level. 3) More than 50% of oil was contained in brown colored perilla seed, and less than 40% of oil was in white colored seed and its 1,000 grain weight was more than 5g. 4) Following local species were recommended for selecting the breeding; 1. For increasing the yields. 412 Yeon-Kie : 51.18g per plant 614 Seong-Ju : 52.88g 〃 701 Nam-Je Ju : 51.30g 〃 809 Moon-Keong : 60.94g 〃 915 Jin-Yang : 50.71g 〃 2. For early growing local species. 201 Kang-Neung growing periods : 131 days 307 Je-Cheon 〃 : 131 〃 403 Non-San 〃 : 131 〃 921 Tong-Yeong 〃 : 131 〃 932 Nam-Hae-2 〃 : 131 〃 3. For high conten tration of oil. 309 Jin-Cheon : 50.2% 416 Cheon-Weon : 52.9% 611 Moo-Ann : 52.9% 619 Yeong-Am : 50.1% 805 Geon-Neon : 50.5% 4. For wide leaf area. 206 Yang-Ku-1 : 154.40cm² per leaf 608 Nae-Jue : 150.90 〃 612 Bo-Seong : 150.70 〃 626 Hw-Soon : 171.10 〃 809 Moo-Kyeong : 160.20 〃

Nearest Neighbor Classifier를 이용한 한글 문자 인식에서의 피쳐 추출에 관한 연구

김대영,박인규,진성일,손현 경북대학교 산업기술연구소 1990 産業技術硏究誌 Vol.18 No.-

In this paper we studid feature extraction meathod concerning the recognition of printed Korean characters. Our meathod extract feature sets of the characters directly from the input device(scanner) and can enhance processing time for character recognition without using preprocesses such as size normalization, and thinning. And during the recognition process we also enhance the recognition rate of features by considering the noise component and using composite feature. Simulations concerning the recognition rate comparision for some features was carried out by using Nearest Neighbor Classifier. We used total of 2088 character image set (for training-1044, testing-1044) in the simulation.

쌍태아에서 제 1태아의 분만 후 제 2태아의 지연분만 : 중례보고

김주환,서민정,유희정,노권일,조대현,박정규,이정헌,조성남,손영수 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.3

With the widespread use of fertility medications and techniques of in vitro fertilization, multiple gestation has become epidemic in modern obstetric practice. Delivery of the initial fetus in a multiple gestation usually is followed by delivery of the subsequent fetus or fetuses shortly thereafter. However in rare circumstances, the delivery is delayed for days due to disappearance of uterine contraction after delivery of the first fetus. When uterine activity ceases after the delivery of the first neonate, a policy of nonintervention may be considered in case of an immature or very premature delivery, in order to achieve a gestational age for the remaining fetus(es) more compatible with neonatal survival. We report a case of twin gestation with prolongation of the delivery interval between the twins for 46 days.

곡관덕트에서 난류정상유동의 벽면전단응력분포와 입구길이에 관한 실험적 연구

손현철,이홍구,김대욱,김명호,박길문 朝鮮大學校 機械技術硏究所 2000 機械技術硏究 Vol.3 No.1

In this paper, an experimental investigation of characteristics of developing turbulent steady flows in a square-sectional 180°curved duct is presented. The experimental study using air in the square-sectional 180°curved duct is carried out to measure entrance length and wall shear stress distributions by using Laser Dopper Velocimeter(LDV) system with data acquisition and processing the system of FIND6260 software at 7 sections from the inlet(ø=0°) to the outlet(ø=180°)in 30°intervals of the curved duct. The results obtained from experimental studies are summarized as follows : (1) The critical Dean number of turbulent steady flow is about 560. (2) The value of the wall shear stress becomes minimum in the inner wall and gradually increases toward the outer wall where it becomes maximum. (3) The entrance length of the turbulent steady flow is shorter than that of the traditional steady flow, reaching the vicinity of bend angle 90°

연골막판으로 싼 정제된 산호의 조직학적 연구

김지수,손대구,한기환,최동원,박관규 大韓成形外科學會 1999 Archives of Plastic Surgery Vol.26 No.3

Autogenous costal cartilage graft has been commonly used for reconstruction of auricular deformity. However, the risk of complication and discomfort at the donor site, as well as distortion of the graft due to morphological change in the cartilage have been serious drawbacks to this procedure. Previous studies examining the chondrogenic potential of perichondrium have suggested that perichondrium may be used as graft for cartilage reconstruction. When a perichondrial flap or a free perichondrium was used as graft, new cartilage formed appositional to the grafted perichondrium. However, the neocartilage was often irregular in shape and varied considerably in quantity. In this study, the feasibility of controlling the shape and the mass of neocartilage was investigated using coral, a porous biomaterial, as a template. A coral a template was wrapped with perichondrial flap from the ears of New Zealand white rabbits and placed into a subcutaneous pocket in the rabbits and placed into a subcutaneous pocket in the rabbit's back by incision. A total of 12 animals were used. Formation of new cartilage was later evaluated by gross and histological examination of the perichondrial flap and the coral template. New cartilage was formed in 11 animals. Immature chondrocytes were visible by 3 weeks after the surgery, and by 8 weeks the immature chondrocytes had formed a cartilage. New cartilage was formed only on the surface of the coral template. These results indicated that the shape and the mass of new cartilage may be controlled by using coral template. Therefore, the desired shape of cartilage may be achieved using a coral template of corresponding shape, and this may help in correcting subtle auricular contour defect and in correcting other structural defects that also require new cartilage formation.

기체 방사성 물질 제거를 위한 첨착 활성탄 필터 시스템 성능에 관한 연구

김대욱,손현철,이명석,이석범,박길문 朝鮮大學校 機械技術硏究所 1999 機械技術硏究 Vol.2 No.1

This paper presents an application of impregnated activated carbon and impregnated activated carbon filters. They are used for the removal of gaseous radioactive materials at radioactive material handling facilities such as nuclear power plants and research facilities. High adsorption efficiencies as well as stability are required for them to remove hazardous radioactive gases such as activated free iodine released during normal operation or accident condition. This research was initiated to enhance the independence of nuclear industry and raise the level of nuclear technology to that of the leading nuclear nations. By attaining the capability of design and development of HVAC system, national technological competitiveness can be achieved. Also, the ground for technology export will be hardened. Therefore, it is well timed to initiate the project to develope those filter systems domestically utilizing all the relevant technologies available.

쇄골하정맥을 통하여 중심정맥도관 삽입 실패 후 나타난 혈흉 1예

김대영,김대우,손희원,박상진,이덕희 영남대학교 의과대학 2008 Yeungnam University Journal of Medicine Vol.25 No.2

Central venous catheterization via an internal jugular vein or subclavian vein has become a common procedure in monitonng CVP and managing severely ill patients. However, there have beennumerous reports of complications associated with central venous catheterization. These include vessel injury, pneumothorax, hemothorax, nerve injury, arrhythmias, artriovenous thrombosis, pulmonary embolism, and infection at the insertion site. We report a case of hemothorax after subclavian vein catheterization failure, along with successful treatment.

들깨(Perilla) 品種改良 및 育成에 관한 硏究(Ⅰ) : 施肥水準 및 栽植密度 試驗 Effect of Fertilizer application and Planting density on Perilla

金正基,孫賢秀,安始榮,鄭大守 東亞大學校 1978 東亞論叢 Vol.15 No.2

1977年 本大學校 農科大學에서 들깨栽培에 대한 施肥適量 및 栽培密植密度에 관한 試驗을 實施한 결과는 다음과 같았다. 1. ?酸質 肥料는 10a當 7kg을 施用하는 것이 效果的이었다. 2. 可里 肥料는 10a當 3kg을 施用하는 것이 들깨의 收量을 높여 주었다. 3. 本試驗에서 石?의 施用效果는 별로 없었다. 4. 들깨의 栽植密度는 60cm X 20cm가 가장 收量이 높았다. Factorial experiment was carried out in to determine the adequated amount of fertilizer and planting density for perilla breeding, and the results obtained were as follows; 1) 7kg per 10a of P²O fertilization was found reasonable. 2) 3kg per 10a of potash fertilization was effective for increasing the yields of perilla seed. 3) No effect was recognized in clcim application. 4) Adequate planting density was 60cmX20cm in order to increase the yields.