췌장 선방세포암 1예

이화정,지준호,박승찬,박정철,최은정,서혜진,이원식,이정림,배병조,손경락,이경희 영남대학교 의과대학 2008 Yeungnam University Journal of Medicine Vol.25 No.2

Acinar cell carcinoma is a rare tumor that represents 1~2% of al1 pancreatic cancers. Clinical and radiologic findings are inconclusive in this disease Acinar cell carcinoma is characterized by rapid progression and early metastasis, which lead to its poor prognosis. A 41-year-o1d man was admitted to our hospital for abdominal pain. Abdominal computed tomography (CT) and positron emission tomography-computed tomography (PET-CT) showed a splenic mass, which was being invaded by a pancreatic tail mass and which had increased ^(18)F-fluorodeoxyglucose (FDG) uptake Primary radical distal pancreatectomy and splenectomy were performed. Pathologic findings revealed an acinar cell carcinoma of the Pancreas The patient underwent a total gastrectomy three months later because of gastric recurrence Four months later, multiple hepatic metastases were discovered, and the patient underwent a left hepatectomy During treatment with capecitabine, there was no evidence of tumor progression for 14 months. We report a case of metastatic pancreatic acinar cell carcinoma, which did not progress for an extended period while the patient was being treated with capecitabme.

원발성 후복막 점액낭샘암종 1예

지준호,이화정,박승찬,박정철,최은정,서혜진,이원식,이정림,배병조,손경락,이경희 영남대학교 의과대학 2008 Yeungnam University Journal of Medicine Vol.25 No.2

Primary retroperitoneal mucinous cystadenocarcinoma is a very rare malignancy, and little is known concerning its Pathogenesis, optimal treatment, and prognosis. A 29-year-o1d pregnant woman (21 weeks) Presented with abdominal discomfort CA 19-9, CA 125, and CEA were normal Abdominal CT scanning revealed a 19x15x13 cm retropentoneal tumor Exploratory laparotomy and tumor excision were performed. Mucinous retropentoneal implants were removed as completely as possible Histologically, the tumor showed focal areas of capsular invasion, but free resection margins The uterus and both ovaries were normal in appearance No adjuvant therapy was pursued. Six months later, Peritoneal and bilateral ovarian metastases were discovered. Hence, we report the details of this case of primary retroperitoneal mucinous Cystadeno-carcinoma and present a review of the literature.

CANDU 사용후핵연료 수송용기 방사선차폐 영향평가

이홍영,정성환,윤정현,강희영,최종락 대한방사선 방어학회 1993 방사선방어학회지 Vol.18 No.2

중수로형 원자로에서 방출되는 사용후핵연료 다발을 안전하게 운반할 목적으로 CANDU 수송용기에 대한 방사선차폐해석을 수행하였다. 핵연료의 연소도는 7,800MWD/MTU, 냉각기간은 5년으로 하여 ORIGEN2 코드로 방사선원을 구하고 이것으로 핵연료 378다발을 운반할 수 있는 수송용기의 차폐체 두께변화에 따른 선량율 영향을 비교하였다. 계산은 ANISN과 DOT4.2 코드를 사용하였으며, 해석결과 최적의 차폐구조를 선정하였으며, 또한 IAEA 및 국내원자력법의 수송법규에 명시된 정상수송 및 가상사고조건에 따른 차폐해석을 수행하여 CANDU 수송용기의 안전성을 입증하였다. A shielding analysis of the shipping cask for transporting the CANDU spent fuel bundles has been studied. Radiation source term has been calculated on spent fuel with burnup of 7,800 MWD/MTU and 5 years cooling time by ORIGEN2 code. The shielding calculation for the cask capable of transporting 378 bundles of CANDU spent fuel has been made by use of 1-D ANISN and 2-D DOT 4.2 codes. As result of analysis, the optimum shield thickness of cask was obtained. And it is proved that the safety in radiation shielding under normal transport and hypothetical accident conditions is confirmed to satisfy the allowable values specified in IAEA Safety Series No. 6 and the Korean Atomic Law.

플라즈마를 이용한 VOCs 중 트리클로로에틸렌의 처리에 관한 연구

이일락,박석출,서정민,조정구,최금찬 동아대학교 환경문제연구소 1998 硏究報告 Vol.21 No.2

This study has carried out for evaluation of Trichloroethylene treatment let out at the working place using a silent discharge, one out of methods to control Volatile Organic Compounds. 1. Comparative test for Ozone creation as a function of whether Trichloroethylene included or not, both of them were increased by 270ppm when the electric field intensity goes up(~30kV/cm) and dry air condition included Trichloroethylene were high more or less. It is expected that Trichloroethylene has an influence on Ozone creation as Ozone presecution substance. 2. Input Trichloroethylene concentration and flow rate related to electric field intensity had effect on decomposition efficiency. Trichloroethylene decomposition efficiency increased with rising of applied voltage. But, Treatment efficiency were lower than N₂ condition, in case of using dry air as diluted gas, due to dissipation of electron energy by triplet oxygen molecules. 3. The more increased concentration(100, 200 and 300ppm1, the lower decreased removal efficiency(96, 93.6, 90.3% at N₂ and 86, 84, 90% at dry air) and these tendencies were released at the flow rate(1, 2 and 3 ℓ / min) similarly. 4. Byproducts generated by oxidation of Trichloroethylene-Carbon monooxide, Ozone, Methyl Chloride, Chlorofom, l,l,l-Trichloroethane and Tetrachloroethylene were found out.

女高生의 營養知識과 食習慣 및 健康狀態에 관한 硏究

오금향,정낙원,이효지 漢陽大學校 韓國生活科學硏究所 1994 韓國 生活 科學 硏究 Vol.- No.12

The diet has held weight in the basic life of the mankind. Its contents, closely connected with the state of health, play an important role in the physical and mental happiness in life. Especially, the youth at the age of 13 to 19, who show the rapid growth physically, mentally, and psychologically, must acquire nutrition knowledge and form the right diet habits. This research shows how these knowlege and diet habit have an effect on student's health. The following results, gained by means of SPSS/pc+, were analyzed in terms of frequency, percentage, dispersion analysis, X2- test, and pearson's correlation. The results are as follows : 1.The group was made up of the humanity group of 37.2% and the natural group of 34.3% and the vocational group of 28.5%, 48.1% of the subjects for research was at the age of 16. The distribution of their scholastic marks were 26.9% in the upper level 30.2% in the middle level. and 191.% the lower level. 2.In the parents' school carrer of the object students, persons who graduated high school were numerous. The mothers' educational level was than that of the fathers. In the parents' job, fathers engaged in office were 24.0% most of the students' mothers were home makers (53.6%), and mothers engaged in official work were 13.7%. 3.The students took up 61% who answered that knew about nutrition to some degree. Most students responded that they got knowledge and information about nutrition(83.2%). The source which students acquired nutrition knowledge from were schools (48.7%) and mass communication(30%). 4.The frequency of meals in a day, was usually three times. The meal that students were likely to have was breakfast, lunch, and dinner in its order. In most cases, The students skip meals three or four times a week. The meal that students enjoyed was lunch, which was taken regularly where as they had breakfast and dinner irregularly. The reason was that they had no time to eat. After dinner, the students sometimes ate refreshments(64.3%) and it took them tenor twenty minutes to have it. They tended to talk with each other while eating. The students thought that the trouble they're having was manintaining the regular diet habit. 5.The students were in good health, and 74.3% of them had never suffered from any illness, In terms of the physical fidelity its distribution was composed of 「da」 of 48.0% and 「ra」 of. It means that the students are in a normal condition of growth. and 22.4% of the took a variety of medicines for improving their health sight and for treating anemia. 6.There was a meaningful difference between nutrition knowledge of the students and their physical health(P<0.05). The students who knew much about nutrition were physically healthy, and mental health was closely connected with physical health(P<0.01). The students who had a good knowledge of nutrition and a good physical health got good school records.

Inoue Balloon을 이용한 PMV의 장·단기 결과 분석

진은선,이연아,전숙,김현숙,정승묵,박상선,최락경,임달수,홍석근,황흥곤 대한순환기학회 2003 Korean Circulation Journal Vol.33 No.11

서울 居住主婦의 通過儀禮에 대한 意識과 儀禮飮食의 利用實態에 대한 硏究

손유미,정낙원,이효지 漢陽大學校 韓國生活科學硏究所 1992 韓國 生活 科學 硏究 Vol.- No.10

The purpose of this study is to investigate the actual situation of the transitional rites and to reestablish the meaning of that by grasping the relation among urban housewives' view, knowledge and behavior about transitional rites, by grasping the relation of those and background variables, by grasping the actual use -pattern of ritual food. The results are as follows 1.The view of the transitional rites shows significant difference according to educational level(p <0.001) and religion(p<0.001), and shows partial difference according to age, income, and residing shape. The older, the more traditional. With the less income, the more traditional. So do for the less educated, for Buddhist, and for those who live in a private residense. 2.The mean of knowledge about the transitional rites is 13.03. The knowledge shows significant difference according to religion, and shows partial difference according to educational level and income. the mean of knowledge is higher for the less educated, and for Buddhist. Those who earn more than 1500 thousand won have more knowledge than the other groups. 3.The behavior about traditional rites shows significant difference according to religion (p<0.001), residing shape(p<0.05), and shows partial difference according to age, educational level, family constitution, and whether employed or not. 4.There is close correlation(p<0.001) among the views, knowledge, and behavior. The behavior is traditional and the mean of knowledge is high as the view of the transitional rites is traditional.

흉곽 내시경을 사용한 척추 기형 수술시 학습 곡선

김학선,최윤락,이환모,문성환,김경희,박진오,하중원,신동은 대한척추외과학회 2003 대한척추외과학회지 Vol.10 No.3

Involvement of the TLR4 (Toll-like receptor4) signaling pathway in palmitate-induced INS-1 beta cell death.

Lee, Sung-Mi,Choi, Sung-E,Lee, Ji-Hyun,Lee, Jung-Jin,Jung, Ik-Rak,Lee, Soo-Jin,Lee, Kwan-Woo,Kang, Yup Dr. W. Junk B. V. Publishers ; Kluwer Academic Pub 2011 MOLECULAR AND CELLULAR BIOCHEMISTRY - Vol.354 No.1

<P>Fatty acid-induced cytotoxicity is believed to recapitulate lipotoxicity seen in obese type-2 diabetes, and, thus, contribute to beta cell loss in the disease. These studies were initiated to determine whether the Toll-like receptor (TLR) signaling pathway was involved in palmitate-induced beta cell death. Treatment of INS-1 beta cells with palmitate enhanced interaction between TLR and myeloid differentiation factor88 (MyD88). Concomitant with TLR/MyD88 interaction, the level of phospho-C-Jun N-terminal kinase (phospho-JNK) showed an increase; however, the level of inhibitory factor kappa B alpha (IκBα) showed a decrease. Gene knockdown of TLR4 prevented palmitate-induced INS-1 cell death, while knockdown of TLR2 did not. In addition, gene knockdown of TLR4 prevented palmitate-induced increase of phospho-JNK and decrease of IκBα. JNK inhibitor SP60125 significantly protected against palmitate-induced INS-1 cell death, while IκB kinase (IKK) inhibitor acetylsalicylate did not. These data suggest involvement of JNK activation through the TLR4 signaling pathway in palmitate-induced INS-1 beta cell death.</P>

Anti-oxidant and anti-inflammatory activities of the various kinds of herbal tea

Lee, Jin Wook,Eo, Hyun Ji,Park, Gwang Hun,Song, Hun Min,Woo, So Hee,Kim, Mi Kyoung,Eom, Jung Hye,Lee, Man Hyo,Lee, Jeong Rak,Koo, Jin Suk,Jeong, Jin Boo The Korea Association of Herbology 2014 大韓本草學會誌 Vol.29 No.2

Objectives : Reactive oxygen species (ROS) are involved in a wide spectrum of diseases including chronic inflammation and cancer. In this study, we investigated the antioxidant activities and anti-inflammatory effects of the extracts from the herbal teas such as Lonicera japonica Thunberg (L. japonica), Chrysanthemum morifolium Ramat (C. morifolium), Mentha arvensis L. (M. arvensis), and P.rhizoma. Methods : Anti-oxidant activity was evaluated using DPPH radical scavenging assay and $Fe^{2+}$ chelating assay. And DNA cleavage assay was performed to evaluate an anti-oxidative effect. Anti-inflammatory effect was performed using NO generation assay and western blot in LPS-stimulated RAW264.7 cell line. Results : L. japonica scavenged DPPH radical by 9.8% at 12.5 ${\mu}g/ml$, 24.8% at 25 ${\mu}g/ml$, 34.3% at 50 ${\mu}g/ml$, 61.1% at 100 ${\mu}g/ml$ and 75.8% at 200 ${\mu}g/ml$, respectively. In addition, C. morifolium and M. arvensis removed DPPH radical by 15.6% and 10.4% at 12.5 ${\mu}g/ml$, 34.8% and 22.8% at 25 ${\mu}g/ml$, 66.9% and 43.3% at 50 ${\mu}g/ml$, 87.4% and 69.1% at 100 ${\mu}g/ml$, and 92.1% and 73.2% at 200 ${\mu}g/ml$, respectively. However, P. rhizoma did not affect on DPPH radical scavenging. The $Fe^{2+}$ chelating activity was highest in L. japonica, but lowest in P. rhizoma among the herbal teas. In addition, the extracts from L. japonica, C. morifolium and M. arvensis inhibited oxidative DNA damage via its anti-oxidant activity. In anti-inflammatory effect, the extracts from C. morifolium inhibited NO production. In addition, it suppressed the $NF-{\kappa}B$ signaling pathway in LPS-stimulated RAW 264.7 cells. Conclusions : Together, this study indicates that L. japonica, M. arvensis and C. morifolium possess the protective effect against the oxidative DNA damage. Furthermore, C. morifolium exerts an anti-inflammatory effect.