Water-soluble Genistin Glycoside Isoflavones Upregulate Antioxidant Metallothionein Expression and Scavenge Free Radicals

Chung, Mi-Ja,Kang, Ah-Young,Jun, Hee-Jin,Kim Sang-Yeon,Moon, Tae-Hwa,Park, Kwan-Hwa,Lee, Sung-Joon 생명자원연구 2005 생명자원연구 Vol.13 No.-

아태지역 무선통신 표준화 동향 및 향후 대응 방향

정용준(Yong-Jun Chung),김대중(Dae-Jung Kim),박주홍(Joo-Hong Park),하준홍(Joon Hong Ha),김남경(Nam-Kyoung Kim),진병문(Byoung-Moon Chin) 한국통신학회 2011 한국통신학회 학술대회논문집 Vol.2011 No.2

HBV : Dynamic Change of HBsAg Titer during Anti-Viral Therapy in Treatment-Na?ve Patients with Chronic Hepatitis B

( Han Wook Chung ),( Yu Jin Ko ),( Sang Wook Lee ),( Hyun Woong Lee ),( Hyung Joon Kim ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1

Background/Aims: Quantitative HBsAg (qHBsAg) titers are emerging as useful tools for measuring viral load and predicting predicting virologic response (VR). This study aimed to determine whether serial monitoring of HBsAg levels could predict virologic response to entecavir(ETV) & clevudine(CLV) therapy in treatment-naive patients with CHB Methods: A total of 157 treatment-naive patients with CHB, who visited Chung-Ang University Hospital between January 2007 and December 2008, were enrolled in this study (100 males). 97 patients(69 males, mean age 48) were treated with ETV for average 53 months, and 60 patients (31 males, mean age 43) were treated with CLV for 26months average. HBsAg levels were measured at baseline, week 12, 24, and 48. All patients were assessed for virological response (HBV DNA<140 copies/mL). Serum HBV DNA was quantified using the real time PCR assay (Artus HBV LC PCR Kit, Roche Diagnostics, lower limit of quantification, 140 copies/mL). Results: In 97 ETV-treated patients, the rates of virological response were 56.7% (55/97) at 48months and 60 CLV-treated patients, 30% (18/60) at 24 months, respectively. Mean reduction of baseline HBV DNA was -5.3, and -4.9 log10 copies/mL. In 55 VR patients treated with ETV, 43(78.1%) patients showed early decline of HBsAg titer and 31(56.3%) patients had lower baseline HBsAg levels (< 3.7 log IU/mL). In 18 VR patients treated with CLV, 9(50%) patients showed early decline of HBsAg titer and 11(61.1%) patients had also lower baseline HBsAg levels (< 3.7 log IU/mL) . Conclusions: Early decline of HBsAg was useful for predicting VR, and baseline HBsAg could be indicative as well in CHB patients treated with ETV than patients treated with CLV.

패러글라이딩 사고에 대한 분석

김승환,김인병,정순미,정성필,장석준 대한외상학회 1999 大韓外傷學會誌 Vol.12 No.1

$quot;Background: Paragliding injuries are increasing recently due to the growing popularity of this sport. This topic has been discussed in numerous journals in the European countries with large mountains, such as Austria, Germany and Switzerland, Those studies gave information regarding the flight phase during which an injury ocurred, the type and site of injury, and suspected reasons for the accidents. This study was done to compare our data to those of other nations and give preventive advices to reduce injuries occurring during paragliding. Method: Nineteen paragliders documented as having injuries during paragliding at Chung-Ju, Korea from 1990 to 1997 were included in the study. Their accident reports including medical records, were analyzed retrospectively. Result: Eighteen of the injured were male with one female and their mean age was 25.6 years old. Five injuries were suffered during take-off, of which technical error was the cause in most cases. Also, 5 injuries occurred during flight due to a sudden change of thermal and wind condi- tions. The majority of injuries were suffered during the landing period, affecting 9 paragliders. They were mostly due to forced landings, unexpected obstacles, and sudden change of wind conditions. Thirty-three percent suffered spine trauma and 29% were involved in injuries of the lower extremities. Upper limb injuries occurred in 19%, and 19% also suffered cerebral concussion or contusion. Conclusion: We have found that spine and ankle injuries were commonly occur during paragliding, especially the landing phase. Proper knowledge of the procedures, adequate training and appropriate foot wear could help in reducing injuries while paragliding.$quot;

Chatter 解析에 對한 非線形 理論

鄭準基 弘益大學校 1983 弘大論叢 Vol.15 No.2

The chatter analysis has been studied by many authors using non-linear theory. In this study, the stability chart was obtained experimentally in lathe turning, and was compared with the result of chatter analysis by non-linear theory qualitatively. From experimental results, it was verified that the stability of cutting process is affected by the depth of cut in the following manner. Keeping the rotational speed of workpiece constant, as the chip thickness is increased from zero, the stability can be distinguished by three ranges; (a) unconditionally stable range, (b) conditionally stable range, (c) unstable range. In the conditionally stable range the system is stable for small disturbances but unstable when these exceed a certain level. When the chatter occurs, the amplitude initially increases and stabilized itself at a finite level. This phenomenon agree well with the analysis of non-linear theory qualitatively.

위성체용 알루미늄 히트파이프의 성능에 관한 실험 연구

정원복,부준홍 한국항공대학교 1997 論文集 Vol.35 No.-

본 논문에서는 위성체에 사용될 수 있는 알루미늄 히트파이프들의 제작과 성능시험을 다루었다. 기본적인 써모사이펀, 복합 스르킨 웍을 갖는 히트파이트, 그리고 그루브 히트파이프의 대체할 수 있는 형상으로서 groove-artery 히트파이프가 비교되었다. 실험은 히트파이프의 열이송 능력 범위 내에서 경사각과 열부하를 변화시키면서 수행되었다. 결과적으로 groove-artery를 갖는 히트파이프의 작동한계는 복합 스크린 웍을 갖는 히트파이프의 약 2배까지 확장될 수 있었다. This study deals with fabrication and performance test of aluminum heat pipes for satellite use. A thermosyphon, a composite screen wick heat pipe and a groove-artery heat pipe, in place of grooved heat pipe, are compared. The experiment was conducted by varying the inclination angle and heat load within the heat transfer capability of the heat pipes. The result showed that the operation limit of a groove-artery heat pipe was extended to almost two times that of a composite screen wick heat pipe.

Real-Time RT-PCR 기법을 이용한 사이토카인 유전자 발현의 정량분석

정준용 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.2

The analysis of cytokine profiles plays a central part in the characterization of disease-related inflammatory pathways and the identification of functional properties of immune cells, both for research and for clinical diagnosis. Because tissue biopsy samples are too small to allow the detection of cytokine protein, the detection of mRNA expression level by reverse transcription-polymerase chain reaction (RT-PCR) analysis is often used to investigate the cytokine profiles in inflammatory lesions. RT-PCR itself is a qualitative method, indicating the presence or absence of specific mRNA. The most widely accepted method is qualitative competitive RT-PCR, based on internal shortened standards. Recently, real-time RT-PCR has been introduced for quantitative analysis of cytokine expression profiles. The real-time RT-PCR is becoming widely used to quantify cytokines from cells, tissues, tissue biopsies or body fluids. Being a very powerful and sensitive method it can be used to quantify mRNA expression levels of cytokines, which are often very low in the tissues under investigation. The method allows for the direct detection of PCR product during the exponential phases of the reaction, combining amplification and detection in one single step. In the review, I discussed the principle of real-time RT-PCR, the different methodologies and chemistries available, the assets, and some of pitfalls. Also, validation for a large panel of human cytokines and other factors playing a role in the immune system is discussed in detail. In summary, the real-time RT-PCR technique is very accurate and sensitive, allows a high throughput, and can be performed on very small samples.

합병증이 동반된 Meckel씨 게실 2례 보고

정병욱,박동일,이준희,서정욱,원유홍,김웅,신현종,권영무 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

합병증이 동반된 Meckel씨 게실을 가진 환자의 치료에 대한 필요성은 과정이 문제이다. 하지만 우연히 만나는 게실의 처치는 논란 중이다. 부수적인 게실 절제술(incidental diverticulectomy)의 제안자는 증상이 있는 게실의 외과적 처치는 중요한 이환 및 사망률은 지적한다. 이를 반대하는 사람들은 전 생애를 통해 합병증의 위험성이 낮게 나타나므로 필요가 없다고한다. 게실의 예방적 제거는 개복술시 우연히 발견 될 때 시행한다. 이는 남아있는 게실이 나중에 합병증을 일으키는 것보다 술후 합병증의 위험성이 매우 적음을 알 수 있다. 저자들은 합병증이 동반된 Meckel씨 게실 2예를 경험하였기에 문헌 고찰과 더불어 보고하는 바이다. The necessity for therapy with complicated Meckel's diverticular is a matter of course.However, management of the incidentally encountered diverticulum is controversial. Proponents of incidental diverticulectomy point to the significant morbidity and mortality rates of surgical treatment of symptomatic divenicular. Other authors base their opposition to incidental diveniculectomy on the low risk of complications developing during lifetime. Prophyillctic removal of the diveniculum is indicated when it is found incidentally at laparotomy, because there are few postoperative complications and the risk exists that the remaining diverticulum may be the cause of later complication. The 2 cases of complicated Meckel's diverticulum are reported with a brief review of literature.

로타리 공구의 절삭특성

鄭準基,沈昇天 弘益大學校 科學技術硏究所 2004 科學技術硏究論文集 Vol.15 No.-

The feasibility of application of the rotary carbide tools in the machining of aluminium alloys is studied in this paper. For the experiment, a new rotary tool holder has been designed and manufactured. Experiments were performed using Taguchi methods and regression analysis to analyse the influence of various factors and their interactions on the cutting characteristics of rotary carbide tools during machining. It turns out that the inclination angle has the greatest influence on the cutting force and the depth of cut has a clear effect on the surface roughness. The cutting force and surface roughness can be estimated using an equation proposed in this paper, which will be well matched to the data of physical experiments.

151종 생약제 추출물이 B형 간염 바이러스 표면 항원(HBsAg)과 항체(HBsAb)의 결합반응 그리고 HBV DNA polymerase 활성에 미치는 효과 : 한국산 각종 생약제를 이용한 B형 간염치료제의 개발

정태호,김정철,김문규,이인선,채성철,김승래,정준모,이인수,김승호,함경수 慶北大學校 醫科大學 1992 慶北醫大誌 Vol.33 No.3

세계인구 43억명 중 B형 간염 바이러스 보균자는 2억 1천 5백만명이며 이중 78%인 1억 6천만명 이상이 아시아 대륙에 집중되어 있다. 한국도 B형 바이러스 간염의 침윤지대이다. 본 연구는 B형 바이러스 보균자 혹은 만성간염을 치료할 수 있는 생약제를 탐색할 목적의 일환으로 한국에서 시판하는 생약제 151종을 구입하여 증류수로 추출하고 여과한 후 냉동건조하여 HBs 항원에 대한 결합능, HBV DNA polymerase억제능, tumor necrosis factor(TNF) 유리에 미치는 영향, 그리고 galactosamine 유발 간염에 대한간장보호 작용을 조사하였다. 151종의 생약제중 0.16㎍/㎖ 농도에서 간염 vaccine 내에 함유된 HBs 항원과 결합하는 생약제는 지유, 가자, 복분자, 대황, 정향, 빈량, 산수유, 소목, 마황, 쇄양, 후박, 목과, 양강, 오약, 산사, 목단피 등 16종이었다. 이들 생약제중 대황(Rheum palmatum L. 大黃), 가자(Terminalia chebula R. 訶子), 지유(Sanguisorba officinalis L. 地楡), 복분자(Rubus coreanus M. 覆盆子)는 HBV DNA polymerase 활성도를 비교적 강하게 억제하였으며 빈량(Areca catechu L. 빈랑), 정향(Eugenia caryophyllata T. 丁香), 목과(Chaenomeles japonica L. 木瓜), 산수유(Cornus officinalis S. 山茱萸)는 약하게나마 HBV DNA polymerase 활성을 억제하였다. 또한 HBV DNA polymerase를 억제한 대황, 가자, 지유, 복분자, 빈량, 정향, 마황, 소목, 산수유를 대상으로 TNF 유리에 미치는 영향을 조사한 결과 소목을 제외한 8종의 생약제 모두가 대식세포를 자극하여 TNF를 유리시켰다. 그리고 장차 임상에 사용함을 전제로 HBV DNA polymerase를 억제한 대황, 가자, 지유, 복분자, 빈량, 정향, 마황, 소목, 산수유를 galactosamine 유발 간염(백서)에 투여하여 간기능 검사에 미치는 효과를 조사하였으나 간기능 검사상으로는 특별한 보호작용을 나타내지 못하였으며 생약제 단독 투여로서는 간기능에 대하여 나쁜 영향을 주지 않았다. Hepatitis B virus infection is major cause of acute and chrome hepatitis, cirrhosis of liver, and hepatocellular carcinoma. There are over 200 million carriers of hepatitis B virus in the world, nearly 80 % of whom live in the South East Asia, Korea is also highly endemic area of hepatitis B virus infection. This study was performed to evaluate the effect of extracts of traditional Korean herbal medicines on hepatitis B virus. 151 traditional herbs were extracted, filtered and lyophilized. Using 151 herbal extracts we tested binding capability to the HBs Ag, inhibition of HBV DNA polymerase, release of tumor necrosis factor (TNF), and protection against galactosamine induced liver damage. Among 151 herbs, 16 herbs (Sanguisorba officinalis L., Terminalia chebula R., rubus coreanus M., Rheum palmatum L., Eugenia caryophyllata T., Areca catechu L., Cornus officinalis S., Caesalpinia sappan L, Ephedra sinica S., Cynomorium songaricum R., Machilus thunbergii S., Chaenomeles japonica L., Alpinia officinarum H., Lindera strychnifolia V., Crataegus pinnatifida B., Paeonia suffruticasa A. ) had binding capability to HBs Ag which contained in the commercial hepatitis vaccine, at 16 ug/㎖ of concentratioa Among the above 16 herbs, Rheum palmatum L., Terminalia chebula R., Sanguisorba officinalis L., Rubus coreanus M. significantly inhibited the HBV DNA polymerase activity, and Areca catechu L., Eugenia caryophyllata T., Ephedra sinica S., Caesalpinia sappan L., Chaenomeles Japonica L., Cornus officinalis S. also inibited the HBV DNA polymerase activity but less effective. All of the herbs, except Caesalpinia sappan L., which inhibited the HBV DNA polymerase activity, actively stimulated the mononuclear cells to release tumor necrosis factor(TNF) in whole blood culture system. The herbs which inhibited the HBV DNA polymerase activity, did not show any protective effect in galactosamine-induced hepatitis in rats, but there was no direct toxic effect when herbs were administered alone.