A Whole Genome Association Study on Meat Quality Traits Using High Density SNP Chips in a Cross between Korean Native Pig and Landrace

Lee, K.T.,Lee, Y.M.,Alam, M.,Choi, B.H.,Park, M.R.,Kim, K.S.,Kim, T.H.,Kim, Jong-Joo Asian Australasian Association of Animal Productio 2012 Animal Bioscience Vol.25 No.11

A whole genome association (WGA) study was performed to detect significant polymorphisms for meat quality traits in an $F_2$ cross population (N = 478) that were generated with Korean native pig sires and Landrace dams in National Livestock Research Institute, Songwhan, Korea. The animals were genotyped using Illumina porcine 60k SNP beadchips, in which a set of 46,865 SNPs were available for the WGA analyses on ten carcass quality traits; live weight, crude protein, crude lipids, crude ash, water holding capacity, drip loss, shear force, CIE L, CIE a and CIE b. Phenotypes were regressed on additive and dominance effects for each SNP using a simple linear regression model, after adjusting for sex, sire and slaughter stage as fixed effects. With the significant SNPs for each trait (p<0.001), a stepwise regression procedure was applied to determine the best set of SNPs with the additive and/or dominance effects. A total of 106 SNPs, or quantitative trait loci (QTL) were detected, and about 32 to 66% of the total phenotypic variation was explained by the significant SNPs for each trait. The QTL were identified in most porcine chromosomes (SSCs), in which majority of the QTL were detected in SSCs 1, 2, 12, 13, 14 and 16. Several QTL clusters were identified on SSCs 12, 16 and 17, and a cluster of QTL influencing crude protein, crude lipid, drip loss, shear force, CIE a and CIE b were located between 20 and 29 Mb of SSC12. A pleiotropic QTL for drip loss, CIE L and CIE b was also detected on SSC16. These QTL need to be validated in commercial pig populations for genetic improvement in meat quality via marker-assisted selection.

만성 B형 간염 환자에서 중증 간 섬유화 및 간경변의 예측 지표로써 AST/혈소판 비의 유용성

심성준 ( Sung Jun Sim ),정재연 ( Jae Youn Cheong ),조성원 ( Sung Won Cho ),김종수 ( Jong Su Kim ),임태영 ( Tae Young Lim ),신도현 ( Do Hyun Shin ),임선교 ( Sun Gyo Lim ),김영배 ( Young Bae Kim ),이기명 ( Kee Myung Lee ),유병무 ( B 대한소화기학회 2005 대한소화기학회지 Vol.45 No.5

Background/Aims: An ideal noninvasive diagnostic test for hepatic fibrosis should be simple, inexpensive, and accurate. We aimed to find the simple marker for predicting hepatic fibrosis and to compare the accuracy of AST, platelet, AST/ALT ratio and AST

Phylogeny of the Subfamily Mesochorinae (Hymenoptera: Ichneumonidae) based on Partial Mitochondrial DNA Sequences

Suh, Kyong-In,Lee, Jong-Wook,Whitfield, James B. 한국곤충학회 1999 Entomological Research Vol.29 No.1

The molecular phylogeny of the Subfamily Mesochorinae (Hymenoptera: Ichneumonidae) was inferred from nucleotide sequence variation across a 424-bp region in the Cytochrome b and a 430-bp region in the Cytochrome oxidase I of mitochondrial genome. Both genes indicate strong base bias at the third codon position and AT trans versions occurred more frequently than other type of substitutions. Maximum parsimony and Maximum likelihood analyses based on the CB gene separately give strong support for similar relationships based on morphological data. However, the phylogeny based on COI gene and combined data sets shows relationships discordant with both morphology and Cyt b.

Cycloexpansamines A and B: spiroindolinone alkaloids from a marine isolate of Penicillium sp. (SF-5292)

Lee, Chiwook,Sohn, Jae Hak,Jang, Jae-Hyuk,Ahn, Jong Seog,Oh, Hyuncheol,Baltrusaitis, Jonas,Hwang, In Hyun,Gloer, James B Nature Publishing Group 2015 The Journal of Antibiotics Vol. No.

공정 관리를 위한 자료 집중화 시스템

배동석,이장명,윤종보 釜山工業大學校 1995 論文集 Vol.37 No.-

The process data are integrated and utilized for the production management, with the rapid development of analog measurement technology and with the wide spread of computer users. This trend draws more attention to the process data integration system which makes it possible to improve the quality of products, to classify and count the products automatically and to provide the basis for the production plan through the analysis and modification of process factors based upon the integrated process data. The system may be classified (either analog data of digital data) and the operating methodology of the system. Generally for the process control, it is necessary to set and monitor the reference and tolerance values of control-related process data, for example, temperature, rpm and pressure. In using the conventional analog controllers, it is not feasible to get the process data required for the quality control. Recently the digital controllers are developed. which have more accurate control capability and feasivility in getting the process data then the old controllers; the old are going to be replaced by the new. By utilizing the process data integration system, the analog controllers still can be used for the process control with the continuous quality improvement.

골판지 고지의 물리화학적 처리에 의한 강도향상

서영범,이종훈 충남대학교 농업과학연구소 1999 농업과학연구 Vol.26 No.1

본 연구는 골판지고지의 가장 중요한 물성인 강도적 성질을 증대시키기 위하여 섬유의 전처리 방법으로서 Hobart mixer를 사용하여 섬유 내부의 결합제거 및 섬유표면에 Microcompression을 형성하여 개질처리 하였으며, 4가지 방법의 고해방법(Valley beater, Kady mill, Impact refining)을 채택하여 골판지고지의 최적고해 방법을 찾는데 그 목적을 두고 이 연구를 수행하였다. 그 결과는 다음과 같다. 1. 섬유장감소를 적게 유발하는 고해방법으로는 Kady mill과 PFI mill의 고해방법 이었으며 고해시 Curl을 펴주는 고해방법을 Kady mell과 Valley beater의 고해방법이 적절하였다. 2. 열단장은 Valley beating의 고해방법에 의하여 강도가 가장 많이 증가되었으며 인열강도는 가장 많이 감소하였다. 섬유전처리를 한 Comp-1과 Comp-2는 고해방식과 상관없이 열단장을 전체적으로 약 10% 증대시켰다. 3. 인열강도는 Comp-1, Comp-2의 전처리방법과 PFI mill 고해로 증대할수 있었다. 4. 파열강도는 Comp-1, Comp-2의 전처리방법과 Valley beater 고해로 증대할수 있었다. 5. 인열강도를 우지한채로 열단장을 가장 높이는 방법은 섬유전처리 방식인 Comp-1이나 Comp-2를 사용하여 Valley beating을 이용하는 방법으로 판단되었다. To increase the strength properties of recycled fiber, especially OCC (Old Corrugated Container) in this study, we used the mechanical pretreatment on the fibers before refining. The mechanical action in the Hobart mixer induced high shear and compression on the fibers, which resulted in the breakdowns of fiber internal structure, and microcompressions on the surface of the fibers. We evaluated the degree of mechanical treatment by fiber curl index. Four different refining techniques were applied to the pretreated fibers (Valley beater, Kady mill, PFI mill, and Impact refining) to find the best combination of the pretreatment and the refining methods. Conclusions were summarized as followed. 1. In keeping the fiber length from shortening, Kady mill and PFI mill refining were effective. Kady mill and Valley beater application tended to straighten out the fiber shapes. 2. Valley beating increased the breaking length of the handsheets better than other methods, while lowering the tear strength most. The mechanical pretreatment increased breaking length about 10% in average irrespective of four different refining methods. 3. Tear strength was increased by the mechanical pretreatment and by the PFI mill refining. 4. Burst strength was increased by the mechanical pretreatment and by valley beating method. 5. In increasing the breaking length and burst strength while keeping tear strength, combination of mechanical pretreatment and Valley beating were most effective.

마이크로 웨이브에 의한 Albite-Anorthite 이성분계의 결정화 특성

박성수,이종현,이윤복,손영국,김창욱 부산대학교 1995 生産技術硏究所論文集 Vol.48 No.-

The three different compositions of albite (Ab) and anorthite (An) were melted and then held at 1200℃ for 64 h and 128 h in microwave and thermal radiation environments. The amount of crystalline phase for samples processed in a 2.45 GHz microwave field was near zero or much less than that for samples processed in a conventional furnace. These results showed that a microwave field affected the nucleation of plagioclase crystal in its two phase region. Therefore, a 2.45 GHz electromagnetic field could prohibit to form crystalline phase. Albite (Ab)와 anorthite (An)의 세가지 다른 조성들을 마이크로 웨이브와 재래식 열파의 분위기에서 녹인 후 1200℃에서 64시간과 128시간 동안유지시켰다. 2.45GHz 마이크로 웨이브 에너지에 의해서 만들어진 시료 결정상의 양은 재래식 열파에 의해서 만들어진 시료 결정상의 양보다 훨씬 적거나 거의 존재하지 않았다. 그 결과 마이크로 웨이브가 二相영역에서 plagioclase 결정의 핵생성에 영향을 미치므로 2.45 GHz 전자기파가 용융상태에서 결정상의 형성을 저해한다고 추정된다.

Cerebral Leiomyoma in a Child

Wang, K.-C Korean Academy of Medical Science 1997 Journal of Korean medical science Vol.12 No.4

Development of selective inhibitors for the treatment of rheumatoid arthritis: (<i>R</i>)-3-(3-(Methyl(7<i>H</i>-pyrrolo[2,3-<i>d</i>]pyrimidin-4-yl)amino)pyrrolidin-1-yl)-3-oxopropanenitrile as a JAK1-selective inhibitor

Chough, Chieyeon,Joung, Misuk,Lee, Sunmin,Lee, Jaemin,Kim, Jong Hoon,Kim, B. Moon Elsevier 2018 Bioorganic & medicinal chemistry Vol.26 No.8

<P><B>Abstract</B></P> <P>A series of 3(<I>R</I>)-aminopyrrolidine derivatives were designed and synthesized for JAK1-selective inhibitors through the modification of tofacitinib’s core structure, (3<I>R</I>,4<I>R</I>)-3-amino-4-methylpiperidine. From the new core structures, we selected (<I>R</I>)-<I>N</I>-methyl-<I>N</I>-(pyrrolidin-3-yl)-7<I>H</I>-pyrrolo[2,3-<I>d</I>]pyrimidin-4-amine as a scaffold for further SAR studies. From biochemical enzyme assays and liver microsomal stability tests, (<I>R</I>)-3-(3-(methyl(7<I>H</I>-pyrrolo[2,3-<I>d</I>]pyrimidin-4-yl)amino)pyrrolidin-1-yl)-3-oxopropanenitrile (<B>6</B>) was chosen for further <I>in vivo</I> test through oral administration. Compound <B>6</B> showed improved selectivity for JAK1 compared to that of tofacitinib (IC<SUB>50</SUB> 11, 2.4 × 10<SUP>2</SUP>, 2.8 × 10<SUP>3</SUP>, and 1.1 × 10<SUP>2</SUP> nM for JAK1, JAK2, JAK3, and TYK2, respectively). In CIA and AIA model tests, compound <B>6</B> exhibited similar efficacy to tofacitinib citrate.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Radiation-Induced Autophagy Contributes to Cell Death and Induces Apoptosis Partly in Malignant Glioma Cells

Jo, Guk Heui,Bö,gler, Oliver,Chwae, Yong-Joon,Yoo, Heon,Lee, Seung Hoon,Park, Jong Bae,Kim, Youn-Jae,Kim, Jong Heon,Gwak, Ho-Shin Korean Cancer Association 2015 Cancer Research and Treatment Vol.47 No.2

<P><B>Purpose</B></P><P>Radiation-induced autophagy has been shown to play two different roles, in malignant glioma (MG) cells, cytocidal or cytoprotective. However, neither the role of radiation-induced autophagy for cell death nor the existence of autophagy-induced apoptosis, a well-known cell-death pathway after irradiation, has been verified yet.</P><P><B>Materials and Methods</B></P><P>We observed both temporal and dose-dependent response patterns of autophagy and apoptosis to radiation in MG cell lines. Additionally, we investigated the role of autophagy in apoptosis through knockdown of autophagy-related proteins.</P><P><B>Results</B></P><P>Autophagic activity measured by staining of acidic vesicle organelles and Western blotting of LC-3 protein increased in proportion to radiation dose from day 1 to 5 after irradiation. Apoptosis measured by annexin-V staining and Western blotting of cleaved poly(ADP-ribose) polymerase demonstrated relatively late appearance 3 days after irradiation that increased for up to 7 days. Blocking of pan-caspase (Z-VAD-FMK) did not affect apoptosis after irradiation, but silencing of Atg5 effectively reduced radiation-induced autophagy, which decreased apoptosis significantly. Inhibition of autophagy in Atg5 knockdown cells was shown to be beneficial for cell survival. Stable transfection of GFP-LC3 cells was observed after irradiation. Annexin-V was localized in cells bearing GFP-LC3 punctuated spots, indicating autophagy in immunofluorescence. Some of these punctuated GFP-LC3 bearing cells formed conglomerated spots and died in final phase.</P><P><B>Conclusion</B></P><P>These findings suggest that autophagy appears earlier than apoptosis after irradiation and that a portion of the apoptotic population that appears later is autophagy-dependent. Thus, autophagy is a pathway to cell death after irradiation of MG cells.</P>