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젊은 성인에서 흡연에 의한 상완동맥 내피기능의 부전에 관한 연구
이상철,권영주,방덕원,이선해,이보영,김지욱,김영훈,온영근,현민수,김성구 순천향의학연구소 2002 Journal of Soonchunhyang Medical Science Vol.8 No.1
Background and Objectives : Cigarette smoking is a major factor and the most modifiable risk factor for atherosclerosis. Endothelial dysfunction is an early event in atherosclerosis, before the structural change of the systemic arteries. We hypothesized that endothelial dysfunction might be present in the systemic arteries of young adult smokers and that this might be dose-dependent phenomenon. Therefore, we try to certify that smoking is associated with endothelial dysfunction in healthy young adults without other risk factor of atherosclerosis. Subjects and Methods : we studied noninvasively 29 subjects aged 3 to 4 decades without other risk factor of atherosclerosis, they were composed of the two groups, current smokers(n=15) and nonsmokers(n=14). Smoking history varied from 3 to 20 pack years. Using high-resolution ultrasound, vessel diameter and mean flow rate were measured at rest, during reactive hyperemia(with flow-mediated endothelium-dependent dilation), and after sublingual nitroglycerin(NG-induced endothelium-independent vasodilation). Result : Flow mediated endothelium dependent dilation was observed in the control subjects (9.4±3.44%) but was impaired in the smokers(5.8±2.51%)(p=0.004). NG-induced endothelium independent dilation is no difference in all subjects. Conclusion : Cigarette smoking is associated with endothelial dysfunction in healthy young adults.
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방지선(Bang, Ji Sun) 한국영유아교육지원학회 2017 영유아교육지원연구 Vol.2 No.1
본 연구는 만 0-5세 영유아를 양육하고 있는 조부모의 양육실태와 양육의 어려움, 사회적 지원에 대한 요구를 조사함으로써 조부모 양육참여를 도모할 수 있는 접근방법 및 조부모양육 지원의 방향을 모색하는 것을 목적으로 한다. 연구대상은 서울·경기 지역에 거주하고 있는 영유아기 손자녀를 양육하는 조부모 181명이다. 수집된 자료는 통계 프로그램(SPSS 23.0)을 사용하여 기술통계, t-test, ANOVA, Scheffe 검증을 실시하였다. 본 연구의 결과 첫째, 60대의 고졸 이상 조부모의 양육 참여비중이 높았으며, 성인자녀와 경제적으로 서로 독립되고, 손자녀와 따로 살면서 양육 돌봄을 하며, 성인자녀로부터 양육에 대한 보상을 받는 조부모의 형태가 많았으며, 대부분의 조부모가 양육만족감을 느끼고 있었다. 둘째, 조부모 양육참여에 있어서 생활지도참여가 높았고, 학습지도참여가 가장 낮게 나타났다. 셋째, 조부모의 양육 어려움 중 두드러진 요인은 체력적인 어려움이었으며 환경적, 교육적, 경제적 어려움 순으로 나타났다. 넷째, 조부모 양육지원요구 중 교육지원요구가 가장 높았으며, 환경지원요구, 경제지원요구, 체력지원요구 순으로 나타났다. 본 연구결과 조부모 양육참여의 제고를 위해서는 보다 체계적이며 정책적인 조부모 지원이 필요함을 시사한다. This study examined the current situation of the grandparents who are providing childcare to 0~5 year-old children, their childcare difficulties, and demand for social support. A survey was conducted on 200 grandparents who were providing childcare for young children of 0 to 5 years of age who were attending 12 kindergartens and day care centers located in Seoul and Gyeonggi Province area. As for survey method, visits to educational institutions were made to explain the purpose of research; then questionnaires were sent to the institutions and collected. 181 questionnaires were finally used and the data was analyzed by SPSS 23.0 program. The results are the followings. First, as for the current status of grandparents’ childcare, many grandparents in their 60s with high school or higher education were involved in grandparental childcare. Second, among the items of grandparents’ involvement in childcare, involvement in life guidance marked the highest score, followed by household guidance, leisure guidance, involvement in learning guidance. Third, the most outstanding difficulty in grandparental childcare was physical difficulty, followed in the order by environmental, educational, and economic difficulties. Fourth, among the items of demand for grandparental childcare support, demand for education support was the highest, followed by demands for environment support, economic support, and physical support. In order to boost grandparents’ involvement, more systematic and diverse forms of supports of grandparents are needed.
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채선미(Chae, Sun-Mi),방경숙(Bang, Kyung-Sook),유주연(Yu, Juyoun),이지혜(Lee, Ji-Hye),강현주(Kang, Hyun-Ju),황인주(Hwang, In Ju),송민경(Song, Min Kyung),박지선(Park, Ji-Sun) 한국간호교육학회 2015 한국간호교육학회지 Vol.21 No.3
Purpose: The purpose of this study was to examine the effects of simulation-based learning on the knowledge about and performance confidence in the nursing care of children with asthma. Methods: A one-group pre- and post- study design was used. A total of 70 nursing students participated in the study. In groups of five, the participants experienced simulation-based learning during their child health nursing practicum. The given scenario was about nursing care for children with asthma. The simulation learning was provided for 3 hours, and included a group discussion before the simulation and a debriefing. Results: After the simulation, knowledge about and performance confidence in the nursing care of children with asthma significantly increased. The nursing students reported a high level of satisfaction with the simulation-based learning. There was a significant positive correlation between knowledge and performance confidence. Conclusion: Simulation-based learning was effective for nursing students in the nursing care of children with asthma. Our results suggest utilizing this new way of learning to strengthen the clinical experience of child health nursing in nursing students.
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Sun-Duk Cho,Eun-Ji Lee,Hye-Yeol Bang,Byeong-Sam Kim,Gun-Hee Kim 한국원예학회 2017 원예과학기술지 Vol.35 No.6
Kimchi is a widely consumed food in Korea, and the quality of the final fermented product is affected by properties of the cabbage used to produce it. The objective of this study was to determine optimal means of storing spring kimchi cabbage by analyzing kimchi produced from cabbage subjected to one of six combinations of pre-treatment and storage conditions. Kimchi quality evaluation was through sensory tests, measurement of antioxidant effects, and analysis of associated microorganisms. The kimchi produced from cabbage stored under T6 conditions (upside down orientation, pre-cooling, high density polyethylene (HDPE) film wrap, and photocatalytic storage) possessed a static pH, which implied a slow progression of ripening that was also verified in sensory tests by a low sour taste score of 3.60 and a high green taste score of 3.00. The kimchi produced from T3 cabbage (upright orientation and low-temperature storage) showed the highest consumer preference according to the sensory test results, with scores of 6.40 and 5.40 from the time of making kimchi through to the fourth week of ripening, respectively. Analysis of antioxidant effects showed that the highest phenol content of 243.75 GAE mg·g<SUP>-1</SUP> was in kimchi produced from T2 cabbage (upside down orientation, pre-cooling, HDPE film wrap, and plasma storage). Furthermore, both the highest flavonoid content of 70.54 QE mg·g<SUP>-1</SUP> and the highest DPPH radical-scavenging activity level of 70.54% was in kimchi produced from T4 cabbage (upside down orientation, pre-cooling, HDPE film wrap, and low-temperature storage). Over eight weeks of maturation, the volume of lactic acid bacteria constantly rose by 7.98 log CFU·mL<SUP>-1</SUP> in kimchi produced from T3 cabbage and by 7.81 log CFU·mL<SUP>-1</SUP> in kimchi produced from T1 cabbage (upright orientation and plasma storage). The results of this study indicate that the T3 cabbage storage conditions are optimal for producing high-quality kimchi.
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( Ji Ho Kim ),( Sung Hoon Kim ),( Won Hyeong Park ),( Ji Sun Jang ),( Jei So Bang ),( Soo Hyun Yang ),( Jong Hoon Byun ),( Yoon Jung Kim ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1
Purpose: Recently, variable gastrointestinal tract tumors including early stage malignancies are treated by endoscopic procedure. But, sometimes the discrepancies of histologic diagnosis happened between the pretreatment results and post-treatment results, especially in the aspect of malignancy. So, we retrospectively reviewed the patients who were not diagnosed as malignancy by forcep biopsy and were treated by EMR or ESD. Then, we investigated the predictable factors of histologic discrepancy between forcep biopsied and endoscopically resected specimen in terms of malignancy by comparing the clinical and endoscopic features through the lesions which were diagnosed as adenoma in forceps biopsy but diagnosed as adenocarcinoma in endoscopically resected specimen. Methods: From March 2008 to April 2011, 129 gastric tumor lesions (119 patients) which were not diagnosed as malignancy and were treated with endoscopic procedure were enrolled retrospectively. We compared the pretreatment endoscopic forceps biopsy results and post-treatment specimen biopsy results, then, analyzed the tumor characteristics. Results: When we compared the biopsy results, histologic discrepancies happened in 21 cases (16.3%) in terms of malignancy. Especially, these situations occurred more frequently in depressed lesions than in the flat or elevated lesions (41.7% vs 13.7%, p=0.012), and in the lesions diagnosed as high grade adenomas than in those diagnosed as low or moderate grade adenomas (33.3% vs. 11.1%, p=0.004). Conclusions: Overall, 16.3% of meaningful histologic discrepancies happened in terms of malignancy between the forceps biopsy and post endoscopic procedure specimen, and those occurred frequently in depressed type lesion and those diagnosed as high grade adenoma significantly.
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Bang, Sun-Hwi,Yoon, Jeung-Won,Cho, Chong-Kwan,Shin, Ji-Eun,Lee, Yeon-Weol,Yoo, Hwa-Seung KOREAN PHARMACOPUNCTURE INSTITUTE 2012 Journal of pharmacopuncture Vol.15 No.2
Background and Objectives: Non-small-cell lung cancer (NSCLC) represents approximately 80% of all lung cancers. Unfortunately, at their time of diagnosis, most patients have advanced to unresectable disease with a very poor prognosis. The oriental herbal medicine HangAm-Plus (HAP) has been developed for antitumor purposes, and several previous studies have reported its therapeutic effects. In this study, the efficacy of HAP was evaluated as a third-line treatment for advanced-stage IIIb/IV NSCLC. Methods: The study involved six patients treated at the East- West Cancer Center (EWCC) from April 2010 to October 2011. Inoperable advanced-stage IIIb/IV NSCLC patients received 3,000 or 6,000 mg of HAP on a daily basis over a 12-week period. Computed tomography (CT) scans were obtained from the patients at the time of the initial administration and after 12 weeks of treatment. We observed and analyzed the patients overall survival (OS) and progression-free survival (PFS). Results: Of the six patients, three expired during the study, and the three remaining patients were alive as of October 31, 2011. The OS ranged from 234 to 512 days, with a median survival of 397 days and a one-year survival rate of 66.7%. In the 12-week-interval chest CT assessment, three patients showed stable disease (SD), and the other three showed progressive disease (PD). The PFS of patients ranged from 88 to 512 days, the median PFS being 96 days. Longer OS and PFS were correlated with SD. Although not directly comparable, the OS and the PFS of this study were greater than those of the docetaxel or the best supportive care group in other studies. Conclusion: HAP may prolong the OS and the PFS of inoperable stage IIIb/IV NSCLC patients without significant adverse effects. In the future, more controlled clinical trials with larger samples from multi-centers should be conducted to evaluate the efficacy and the safety of HAP.
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