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      • 비혈연간 조혈모세포이식 후 재발한 만성골수성백혈병에서 Gleevec에 의한 완전관해 및 공여자 조혈 재건 1예

        박사라,김우건,이제환,최성준,형철호,손희정,강혜진,지형석,이정신,이규형 대한조혈모세포이식학회 2002 대한조혈모세포이식학회지 Vol.7 No.2

        저자들은 만성골수성백혈병으로 동종 골수이식 후 림프구성급성전환으로 재발한 환자에서, Gleevec 투약 후 DLI (donor lymphocyte infusion) 없이 공여자 조혈(donor hematopoiesis)의 재건이 이루어지고, 세포유전학적, 분자생물학적 기준에서 모두 완전관해에 이르고, 12개월째 관해를 유지하고 있는 환자를 경험하였기에 이를 보고하는 바이다. 본례의 환자에서 Gleevec은 동종 골수이식 후 급성전환기로 재발한 환자에서도 매우 효과적인 것으로 나타났다. Gleevec은 동종 골수이식 후 재발한 만성골수성백혈병에서 Interferon-α, DLI, 2차골수이식 등 기존의 치료의 문제점을 보완할 수 있는 유용한 치료방법으로 사용될 수 있을 것으로 생각되며, 이의 장기적 치료효과의 평가와 기존치료와의 병합요법의 유용성 등에 대한 향후 연구가 필요할 것으로 생각된다. We report a 32-year old woman with chronic myelongenous leukemia (CML) in lymphoid blast crisis, who underwent allogenic bone marrow transplantation (BMT) from HLA phenotype full mached unrelated donor. Her disease relapsed into full-blown blast crisis. Upon treatment with gleevec, she achieved immediate remission of leukemia as well as the donor type hematopoiesis without donor lymphocyte infusion (DLI). Our case suggests the high effectiveness of gleevec in CML relapsed after allogeneic BMT. Further studies are needed to define the role of gleevec (with or without DLI) in the management of CML relapsed after allogeneic BMT.

      • KCI등재
      • KCI등재

        납착 방법이 치과용 금속의 성상에 미치는 영향에 관한 연구

        김철형,송영균,이종혁 대한치과보철학회 2012 대한치과보철학회지 Vol.50 No.1

        연구 목적: 본 연구는 치과영역에서 많이 사용되는 비귀금속 합금인 니켈-크롬 합금을 산소-아세틸렌 불꽃 납착법과 적외선 용접법을 이용해 용접하고 용접부 및 그 주변을 광학 현미경과 EPMA (Electron Probe Micro Analyzer, 전자미세현미분석기)를 통해 관찰하여 용접방법이 금속의 성상(性狀)에 미치는 영향을 조사하였다. 연구 재료 및 방법:니켈-크롬 합금을 이용하여 3.0 mm 직경, 30 mm 길이의 시편을 제작하였다. 시편은 산소-아세틸렌 불꽃 납착법, 적외선 용접법의 두 개의 그룹으로 분류하였다(n = 4). 시편을 low-speed disc로 자른 후 각각을 산소-아세틸렌 토치와 적외선 용접기를 이용해 용접하였다. 용접과 마무리 후에 시편을 광학현미경으로 용접부, 5 mm 떨어진 지점, 10 mm 떨어진 지점의 3개 부위에서 관찰하고EPMA를 이용하여 분석하였다. 결과: 광학 현미경 관찰 결과 용접부에서는 두 방법 모두 다수의 파절선이 관찰되었고, 10.0 mm 떨어진 거리에서는 두 방법 모두 시편의 표면에서 파절선이 발견되지 않았으나 5.0 mm 떨어진 거리에서는 적외선 용접법에서는 시편의 표면이 다소 거칠기는 했으나 파절선은 발견되지 않았고 산소-아세틸렌 불꽃 납착 표면에서는 다수의 파절선이 관찰되었다. EPMA분석에서 적외선 용접법에 의한 방법에서는 용접부위, 5.0 mm 떨어진 부위, 10.0 mm 떨어진 부위 모두에서 시편 금속의 구성성분 비율이 제조사의 구성성분 비율과 10.0%이내의 오차를 나타내었고, 산소-아세틸렌 불꽃 납착법에서는 5.0, 10.0 mm에서는 시편금속의 구성성분이 10.0%이내의 오차를 나타내었으나, 납착 부위에서는 Ni만이 검출되어 적외선 용접법과는 차이를 나타내었다. 이와 같은 분석결과를 살펴 볼 때 적외선 용접을 시행한 시편의 구성 성분이 모금속의 성분과 유사한 것을 알 수 있었다. 결론: 이상의 결과로 산소-아세틸렌 불꽃 납착법보다 적외선 용접법을 이용할 때, 금속의 결함 및 성분의 변화가 적어서 좀 더 우수한 금속 보철물의 제작이 가능할 것으로 사료된다. PURPOSE. The purpose of this study was to compare Ni-Cr alloy property of gas-oxygen torch soldering and infrared welding using optical microscope and Electron Probe Micro Analyzer (EPMA). MATERIALS AND METHODS. Ni-Cr alloys were casted for specimens. Specimens had 3.0 mm diameter, 30.0 mm length and were divided into two groups. Each group had 4 specimens. One group was for gas-oxygen torch soldering and the other was infrared welding. Specimens were cut with low-speed disc and soldered each other with gas-oxygen torch and infrared machine. After soldering and polishing, specimens were observed at 3 points (soldering point, 5 mm distance point, 10 mm distance point) with optical microscope and analyzed 3 points (soldering point, 5 mm distance point, 10 mm distance point with EPMA. RESULTS. The results of this study were as follows: 1. The observation of gas-oxygen torch soldering at 10 mm distance point under the optical microscope was not founded any specific surface properties, but some crack lines were observed at 5 mm distance and soldering point. 2. There were no crack lines were founded at the observation of infrared welding at 10 mm distance and 5 mm distance points under the optical microscope. However, at the 5 mm distance, the surface was not smooth enough compared with at 10 mm distance point. Some crack lines were observed at the welding point as well. 3. In the EPMA analysis of the gas-oxygen torch soldering, the component of Ni was increased by 4.5%, Cr was increased by 7.5% than that of the Ni-Cr alloy at the 10.0 mm distance. At the 5 mm distance, the component of Ni was decreased by 6.1%, Mo was increased by 9.0% than that of the Ni-Cr alloy but Cr was equally shown at the 5.0 mm distance. Only Ni was shown at the soldering point. 4. In the EPMA analysis of the infrared welding, the component of Ni was increased by 9.1%, Cr was increased by 0.4% than that of the Ni-Cr alloy but Al was equal at the 10.0 mm distance. At the 5 mm distance, the component of Ni was increased by 4.7%, Cr was increased by 4.7% and Al was increased by 0.1% than that of the Ni-Cr alloy. At the welding point, the component of Ni was increased by 8.8%, Cr was increased by 8.2% than that of the Ni-Cr alloy. CONCLUSION.From these results, at the 5 mm distance from the soldering point, the surface of the infrared welding was more smoother than that of the gas-oxygen torch soldering. On the EPMA analysis, the component of the specimens with infrared welding was more similar than that of the gas-oxygen torch soldering compared with the component of the Ni-Cr alloy.

      • 인체의 수동적 전기특성 계측법 개발

        이현철,윤재현,박형준 원광대학교 공업기술개발연구소 2003 工業技術開發硏究誌 Vol.23 No.-

        In this study, a system for the method measuring of passive electrical properties in the human body was developed. The system was composed of the stimulating part for input with voltage(about 2[㎷]) and of the measuring part for measurement of electrical properties in human body. As a result of this experiment, the frequency characteristic of each subject represent that the electrical properties goes up in spite of a constant stimulate-voltage according to frequency (l[㎐]-50[㎑]) increment. Namely, the amplitude of stimulate-signal was not reflected but frequency was reflected on the measured results. This result be estimated that the proposed system is able to measure the passive electrical properties of human body. Also, it would be estimated neural signal propagation directions by using the method developed in this study was measured passive electrical properties in each part of body.

      • 중성자 방사화분석에 의한 조선시대 청·백자 분류연구

        姜炯台,李澈,諸元穆 漢陽大學校 環境科學硏究所 1989 環境科學論文集 Vol.10 No.-

        조선시대 자기의 특성화를 위하여 중성자방사화분석법으로 15개의 미량성분원소 (Sm,Ga,K,La,Ce,Yb,Th,Hf,Na,Cs,Sc,Rb,Fe,Co,Eu) 함량을 결정하였다. 데이타의 수학적 처리법으로서 선형판별식분석법을 사용하였다. 이 선형판별식분석법으로서 자기의 분류에 유용한 변수를 선정한 다음 재차 선형결합방식으로 분류규칙을 구하였다. 판별점수로서 평면상에 도시한 결과 경기도 광주군 상번천리5호, 상번천리9호 및 도수리 청·백자의 분류효율은 각각 12/15,15/15,10/10이었다. Data on the concentration of Sm,Ga,K,La,Ce,Yb,Th,Hf,Na,Cs,Sc,Rb,Fe,Co and Eu obtained by neutron activation analysis have been used to characterize Korean porcelain by multivariate analysis. A combination of analytical data by means of statistical linear discriminant analysis(SLDA) has resulted in removal of redundant variables, optimal linear combination of meaningful variables and formulation of classification rules. The plot in the first-to-second discriminant scores has shown that the three distinct territorial regions exist among porcelains of Kyungkido Sangbunchulli No. 5, Sangbunchulli No. 9 and Dosuri, with respective efficiencies of 12/15,15/15 and 10/10.

      • 漸進的·急進的 運動負荷가 血液의 pH, Sugar 및 Lactate에 미치는 影響

        姜炯基,辛元太,白永守,殷熙寬,宋基成,河哲秀 漢陽大學校 體育科學硏究所 1986 體育科學 Vol.6 No.6

        The purpose of this study is to in-vestigate the effects of gradual and radical exercise load on the treadmill for PH, Sugar and Lactate in Blood by selecting 14 subjects in H university, All subjects began exercise by 6mPH for 4 minutes at start and increased exercise speed up to HR 140 by increasing every minute as gradual load. And subjects began exercise by 9mPH at first and increased load up to HR 140 as radical exercise load. The results are as follows: (1) In PH in Blood, gradual exercise load is lower than radical training in all subjects. (p<0.05) (2) In Sugar in Blood, radical exercise load is higher than gradual exercise load in all subjects. (p<0.05) (3) In Lactic Acid in Blood, gradual training is higher than radical exercise load in all subjects. (p<0.01) (4) In Lactic Acid, all subjects showed high value and its is also in Sugar, than the method of exercise load is according to anaerobic energy metabolism.

      • 상용 실시간 운영체제에서 EDF스케줄링 알고리즘 및 스택자원정책의 구현

        이형철,김용석 강원대학교 정보통신연구소 2001 정보통신논문지 Vol.5 No.-

        We implemented the EDF scheduling algorithm and the Stack Resource Policy to overcome the upper bound of processor utilization and to solve the priority inversion problem, respectively. The target for the implementation is a VME board based on MPC 860 which is family of PowerPC processor. RTEMS(Real-Time Executive for Multiprocessor Systems) which is a real-time OS developed OAR, is the basis of the implementation of EDF algorithm. The original RTEMS is based on fixed priority scheduling. Implementation shows better processor utilization than the rate monotonic scheduling algorithm. The implementation of stack resource policy is shown to solve the priority inversion problem by applying the well known PathFinder example.

      • 아세톤-물 혼합용매내에서 1_1 전해질의 전기전도도에 대한 연구

        오형식,김종현,전동철 木浦大學校基礎科學硏究所 1988 基礎科學硏究誌 Vol.6 No.-

        여러가지 조성의 아세톤-물 혼합용매중에서 LiC1, LiBr 및 Lil의 희박용액 전도도를 25℃에서 측정하였다. 그 결과 각 전해질들의 여러 농도에 따르는 당량전도도의 변화가 Fuoss-Onsager's semiem-pirical 식에 대해서 좋은 일치를 보여 주었다. 또한 아세톤-물 혼합용매의 몰 분율이 증가함에 따라 극한당량전도도??값이 LiC1, LiI는 0.3 몰 분율에서, LiBr는 0.2 몰 분율에서 가장 작은 값을 나타내었다. Walden Product??는 LiC1와 LiBr가 0.1 몰 분율에서, LiI는 0.0 몰 분율에서 최대치를 보여 주었고, 그 후로는 아세톤 몰 분율의 증가에 따라 계속 감소하였다. The equivalent conductance of LiC1, LiBr and LiI have been measured in Acetone-Water mixtures of various composition (0.0∼0.6 mole fraction) at 25℃. The value of equivalent conductance agreed well with the Fuoss-Onsager's semiempirical equation. The minimum limiting equivalent conductance was found in 0.3 mole fraction Acetone for LiC1, LiI and LiBr was found in 0.2 mole fraction Acetone. The maximum Limiting Walden Products?? of LiC1 and LiBr was found in 0.0 mole fraction Acetone, and LiI was found in 0.0 mole fraction Acetone. And also, after 0.1 mole fraction and 0.0 mole fraction, decreased with increasing of mole fraction Acetone.

      • 고분자 복합재료를 위한 액정중합체(I)

        조철형,조성휴,조병욱,김정규,김숭평,권중근 조선대학교 생산기술연구소 1983 生産技術硏究 Vol.1983 No.-

        Copolyesters containing oxybenzoate as a rigid rod molecule and methylene group and dimethyl tetramethyl disiloxane as flexible spacers were prepared by room temperature solution polymerization for the purpose of the developement of polymeric composite materials. The thermal properties and the characteristics of the polymers were investigated by DSC and a polarizing microscope. The polymers may be formed nematic liquid crystal phase, and the thermodynamic characteristics of their mesophase to isotropic phase transition could be explained on the basis of its structural features.

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