함침액막에서 운반체의 구조에 따른 트립토판의 플럭스

우인성,신석재,안형환,강안수 明知大學校 産業技術硏究所 1991 産業技術硏究所論文集 Vol.10 No.-

The relations between membrane potential and the flux of solutions, which were developed from the molecular structure of quaternary ammonium salts as carrier, have been analyzed for the counter transport system of tryptophan and nitrate anion across the supported liquid membrane. The liquid membrane was prepared by dissolving quaternary ammonium nitrates in toluene. The experimental results showed that the flux of tryptophan increased with increasing the carbon chain length of the alkyl group of carrier in the range of ??∼??, but in case of TDDAN, it decreased because of large membrane potential. The flux of tryptophan with the membrane structure of carrier increased in the order : Aliquat 336N, TOAN, TDDAN, and TDAN.

여성 요도증후군에서 Terazocin의 효과에 대한 연구

우승효,신관희,한광희,정원일,이형래,이상철,김용태,김원재 충북대학교 의학연구소 2000 忠北醫大學術誌 Vol.10 No.2

연구목적: 여성 요도증후군을 보이는 환자에서 교감신경차단제인 terazocin을 복용한 후 치료 효과에 대한 각 증상의 변화와 부작용을 알아보고자 하였다. 대상 및 방법: 1997년부터 1999년까지 충북대학교병원 비뇨기과에 내원한 35명의 여성 중 요검사 및 요배양 검사, 그리고 다른 이학적 검사에서 이상이 없는 요도증후군 환자를 대상으로 간질성방광염 증상점수(ICSS)를 terazocin (3mg/day for 3 months) 투여 전후에 조사하였고, 치료 후 3개월과 1년에 Likert scale 점수를 조사하였다. 결과: ICSS는 비치료군은 18.3±5.9점, 치료군은 16.5±6.8점으로 두군간의 차이는 없는 것으로 나타났다(p=0.52). 치료군은 치료 후 3개월에 시행한 ICSS가 9.9±7.8점으로 치료 전에 비해 현격히 증상이 호전되는 것으로 나타났다(p=0.0001). 특히 3개월에 시행한 Likert scale에서는 주간 및 야간빈뇨, 절박뇨, 배뇨통의 횟수 및 강도, 그리고 전체적인 증상정도에서 40-70% 가량 호전된 것으로 밝혀졌으며 이는 1년 후에도 증상의 호전이 지속되는 것으로 나타났다. 비치료군에서의 1년 후 Likert scale은 6명 중 2명이 전체적인 증상의 호전이 있는 것으로 나타났다. 결론: Terazocin은 환자의 약 70%가량에서 증상의 호전을 가져왔고, 비치료군에서도 환자의 33%가 저절로 증상이 좋아진 것으로 보아 Terazocin은 여성 요도증후군에서 분명히 효과가 있으나 증상이 심할 경우 보조적인 치료로 이용되는 것이 바람직할 것으로 사료된다. Purpose: We performed to assess the effects and complications of terazocin in women with chronic female urethral syndrome. Materials and Methods : Thirty-five women with chronic female urethral syndrome were studied from March 1997 to August 1999. The subjects exhibited normal findings without the pyuria and bacteriuria in urinalysis and urine culture and were invested the interstitial symptom score(ICSS). 29 subjects of them took a terazocin 1-4 mg/day for 3 months. They were reevaluated for the ICSS and Likert scale after 3 months and for Likert scale after 1 year. Results: The ICSS before treatment were showed 18.3±5.9 in the untreated patient group and 16.5±6.8 in the treated patient group, and no statistically difference between both patient groups(p=0.52). In the treated patient group, the ICSS after treatment were showed 9.9±7.8, significant difference between before and after treatment(p=0.0001). The Likert scale was showed at 3 months after treatment that frequency, nocturia, urgency, pain frequency, pain intensity, daily activities, and overall symptoms were improved in 65.5%, 55.2%, 24.1%, 41.4%, 41.4%, 70%, 70%, and 70% of 29 subjects, each other. Overall symptom score assessed at 1 year were showed that 3 subjects was aggravated. In untreated patient group, 2 of 6 was improved in overall symptom score. Conclusion: Terazocin was effective above 70% in the treated group, and symptoms were improved spontaneously in a third of the untreated group. So, we thought that terazocin would be useful as supportive treatment in period of severe symptoms.

Taxol 합성에 관한 연구 Ⅰ : O-(tert-Butyldiphenylsily1)-cis-5-methyl-4-hepten-6-yn-1-ol의 합성 Synthesis of O-(tert-Butyldiphenylsily1)-cis-5-methyl-4-hepten-6-yn-1-ol

신동수,박두천,주우홍,김형국 國立 昌原大學校 基礎科學硏究所 1994 基礎科學硏究所論文集 Vol.6 No.-

O-(tert-Butyldiphenylsily1)-cis-5-methyl-4-hepten-6-yn-1-ol, an intermediate in the synthesis of taxol, was efficiently synthesized from 3-methyl-2-penten-4-yn-1-ol by sequential alcohol/bromide interchange [NBS, PPh_(3), CH_(2)Cl_(2), -30℃, 82%], displacement with the lithium salt of tert-butylacetate [LDA, THF, -78 to 23℃, 84%], LAH reduction, and silylation [tBuPhSiCl, imidazole, CH_(2)Cl_(2), 45℃, 88%].

하악 매복 지치의 외과적 발거시 Methylprednisolone의 안면 부종 감소 효과에 대한 임상적 연구

신지훈,박진배,한지용,윤혜경,김우형,이희철 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.4

Objective : The third molars, expecially mandibular wisdom teeth, are commonly obliquely impacted, and surgical procedure with odontomy and osteotomy is necessary for their extraction. The surgical extracion of impacted wisdom teeth occasionally in duces variable discomfort. Especially, postoperative swelling, pain and limitation of mouth opening determine the degree of discomfort. For the reduction of these complicaions, drug therapy(antihistamine, enzyme, steroid), cole pack and pressure technique have been studied. It is known that the steroids are the most effective. Methods and Meterial : We selected fifty patients in their twenties, who visited Department of Dentistry, Pusan Paik Hospital from March to August in 1998. All of 50 patients has no other medical problems. Total 50 patients were randomly divided to 30 of experimental group and 20 of control group. The experimental group had orally administration of methyprednisolone 5㎎ every 8 hours 2 times preoperatively and 7 times postoperatively. Five points were marked on the patients' face, and the distances between the points were measured just before operation and 48 hours after operation. Results : Methyprednisolone reduces swelling about 50% after surgical extraction of obliquely impacted mandibular third molars with osteotomy and odontomy. The difference in the amount of tissue edema between experimental and control group was significant(p<0.01). However, there was no significant difference according to the operation time. Conclusion : It seems that the use of methylprednisolone is effective to reduce postoperative swelling following surgical extraction of third molars.

양방향성 형상기억합금을 이용한 초소형 공작물 클램핑 장치 개념설계

신우철,박형욱,노승국,박종권 한국공작기계학회 2008 한국공작기계학회 추계학술대회논문집 Vol.2008 No.-

In this paper, a micro workpiece clamping device, which is possible to be applied in micro machine-tools, based on a shape memory alloy is introduced. Especially, the train procedure to transform a commercial one-way shape memory alloy into a two-way shape memory alloy is described. Also, it is experimentally verified that through the train procedure, the applied shape memory alloy ring exhibits two-way shape memory behavior of 220㎛ deformation. In addition, a conceptual design and a basic configuration of the work-piece clamping device using the two-way type shape memory alloy are suggested.

형상기억합금 기반 공구 클램핑 장치의 원심력 영향 해석

신우철,박형욱,노승국,박종권 한국공작기계학회 2008 한국공작기계학회 추계학술대회논문집 Vol.2008 No.-

This paper presents analysis and experimental results for effects of centrifugal force of the SMA-based tool clamping device. First, the corresponding theories of radial deformations resulting from the centrifugal force were described, and based on them, the radial deformations of the contact region between a tool and a tool holder were verified according to rotational speeds. Next, as for 3D-model of the tool holder, analysis of the radial deformations were carried out based on FEM. Finally, the feasibility of the SMA-based tool clamping device at high-rotational speed was experimentally verified by monitoring the clamped tool in mill-machining at 220,000rpm.

곰쓸개 복용 후 발생한 육안적 혈뇨와 신유두부 괴사증 1예

김우진,한민석,김수항,박인형,박진석,선제형,홍세인,박옥영,신정현,이숭,신병철 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.3

Renal papillary necrosis occurs most commonly in association with urinary tract infection, diabetes mellitus, sickle cell disease, vascular disease, and analgesic nephropathy. Clinical presentation may be related to symptoms of pyelonephritis such as flank pain, renal colic, hematuria, Proteinuria, recurrent fever. The necrotic tissue may be sloughed off, and the diagnosis can sometimes be made by finding piece of renal medullary tissue in the urine. Pyelography may demonstrate cavities and sinuses in the resion of papillae. Anuria & oliguria can lead to the acute renal failure, and especially prognosis and progress may be affect influenced by urinary infection. We report a case of renal papillary necrosis with ingestion of bear gallbladder. On pyelography, Persistent contrast is diagnostic clue of renal papillary necrosis. This case is not be related to urinary tract infection, but occurred acute renal failure. Expectant treatment was gone.

산화물 반도체 가스 센서 어레이와 패턴 인식기술을 이용한 가스 인식

홍형기,윤동현,권철한,박현수,신현우,이규정 경북대학교 센서기술연구소 1994 센서技術學術大會論文集 Vol.5 No.1

In order to identify C_(2)H_(5)OH, (CH_(3))_(3)N and CH_(3)SH gases, a gas recognition system using gas sensor array and pattern recognition technique has been fabricated. The sensor array consists of four thick film oxide semiconductor gas sensors whose sensing layers are Pt-doped SnO_(2), Pd-doped SnO_(2), Pd-doped ZnO and Pd-doped WO_(3). Three kinds of pattern recognition techniques such as principal component analysis (PCA), discrimination analysis (DA) and back propagation (BP) were used for the discrimination of gas species. The identification of C_(2)H_(5)OH, (CH_(3))_(3)N and CH_(3)SH gases has been successfully demonstrated.

교량케이슨기초의 최적신뢰성 설계규준

손용우,신형우,이증빈,정철원 圓光大學校 環境建設硏究所 1992 環境建設論文集 Vol.1 No.-

This study is directed to propose a stability and Design Criteria for Bridge Caisson For Bridge Caisson foundations, with Could possibly replace the traditionals W.S.D provsions of the Current Code, based on the LFBOR (Load Factors Base on Reliability). The optimum reliability indices(Verticial bearing Capacity: β_opt=3.19, Lateral bearing Capacity: β_opt=3.15(ordinary), β_opt=2.93(earthquake), Shearing resistance Capacity: β=2.87) are Selected as optimal Values Considering our practice base on the Calibration with the current Bridge Caisson foundation design Safety provisions, Load and Resistance Factors are measure by using the proposed uncertainties and selected optimum reliability indies. Furthermore, a set of nominal safety factors are proposed for the U.S.D design provisions

췌십이지장절제술 후 발생한 지속적인 구토증과 Wernicke 뇌병증

박우영,김성완,이삼연,신일선,김재민,박기형,양수진,윤진상 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.3

Wernicke encephalopathy is an acute neurologic disorder attributable to thiamine (vitamin B1) deficiency. We report the case of a 61-year-old female patient who presented Wernicke encephalopathy after surgery for pancreatic head cancer. From the ninth postoperative day, she had suffered from nausea and vomiting and had difficulties ingesting food, she was given total parenteral nutrition (TPN), but lacked adequate vitamin (thiamine) supplementation. After 28 days, she developed ataxia, ophthalmoplegia, and mental confusion. The magnetic resonance image showed pathologic changes in the medial thalamus,periaqueductal gray matter, medulla and mamillary bodies. The blood level of thiamine was very low. After intravenous and oral supplementation of thiamine (200 mg/day), consciousness was soon normalized and neurologic symptoms have gradually been improving. Nausea and vomiting disappeared after administration of a low dose of mirtazapine (7.5 mg/day). We emphasize the importance of thiamine supplementation to the patients who suffer from vomiting which hinders them from taking food and who require prolonged TPN.