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경막 내 colistimethate 투여로 치료한 다제 내성 cinetobacter baumannii 뇌실염
홍유아,유진홍,김진진,모은영,안건희,정희경,김진석,이현정,정미향,윤승배 대한감염학회 2009 감염과 화학요법 Vol.41 No.4
Acinetobacter species is a non-fermentative aerobic gram-negative coccobacillus that is an important pathogen found in nosocomial infections. Recently, multi-drug resistant Acinetobacter baumannii (MDR-AB) infections have been increasing and pose a serious problem. Most such infections present as bacteremia, pneumonia, or a wound infection; however, CNS infections are very rare. We herein present a case of ventriculitis caused by MDR-AB in a 37-year old man after a neurosurgical intervention. The patient was successfully treated with intrathecal colistimethate.
활성탄 표면분석 및 CO_(2)와 N_(2)의 흡착속도에 관한 연구
유흥진,김성은 순천향대학교 부설 산업기술연구소 2001 순천향 산업기술연구소논문집 Vol.7 No.2
Adsorption rates of CO_(2) and N_(2) gases on domestic(SG-series) and foreign(BPL) activated carbons were studied because these can play a key role in designing a PSA bed for recovering CO_(2) from the power plant flue gas. Adsorption experiments for CO_(2) and N_(2) gases on various adsorbents were performed by a thermogravimetric analyzer. And surface analysis for activated carbon was performed by SEM and BET. Absorption rates for pure CO_(2) and N_(2) were measured at 298K ~ 343K. From the experimental results, adsorption rates of SGT activated carbon were faster than those of SGA-100, SGP-100 and BPL activated carbon. For all adsorbents, the adsorption rates of CO_(2) were much faster than those of N_(2). Also, adsorption rates increase as temperatures decrease. The SEM and BET results showed that surface area of SGT activated carbon were bigger than those of SGA-100, SGP-100 and BPL activated carbons.
유홍진 순천향대학교 부설 산업기술연구소 1995 순천향 산업기술연구소논문집 Vol.1 No.2
Adsorption equilibrium isotherms for pure CO² were studied at 293-323 K and 0.1-15 atm because these can play a key role in developing a PSA process. Volumetric method was used for the collection of adsorption isotherm data and domestic and foreign activated carbons were used as adsorbents. Adsorbed amount decreases as temperature increases and increases as pressure increases.
Characterization of a Constitutive β-Lactamase from a Pseudomonas aeruginosa
유진홍,허동호,최정현,김양리,신원식,강문원 대한화학요법학회 1996 대한화학요법학회지 Vol.14 No.2
Objective : We analyzed some physicochermical chracteristics of a constitutive β-lactamase from a clinical isolate of a Pseudomonas aeruginosa which resistant to various β-lactams except imipenem and susceptible to aminoglycosides the proportion of its contribution to such resistance profile. Method : 1. Antimicrobial susceptibility test was done by the broth dilution method. 2. In hibition profile was done using EDTA, HgCl₂ and p-chloromercuribenzoate (pCMB). We also measured 50% inhibitory concentration(IC??) using β-lactamase inhibitors, such as clavulanic acid, sulbactam. 3. Kinetics study for substrate profile was performed by spectrophotometric assay using crude extracts and various antimicrobial agents. Relative hydropysis rates were determined. 4. The isoelectric point(pI) was determined by isoelectric focusing. The molecular weight was estimated by SDS-polycrylamide gel electrophoresis. Results : 1. The strain was resistant to ceftriaxone, sulperazon, piperacillin, ceftazidime, and aztreonam, while it was susceptible to gontamicin, tobramycin, amikacin and imipenem. 2. The β-lactamase was not inhibited by EDTA, and pCMB, whereas it was inhibited by HgCI₂. The IC?? of clavulanic acid was over 100μM and that of sulbactam was 22μM. 3. The relative maximal hydrolysis rate was calculated by setting V_(max) for cephaloridine at 100. The enzyme hydrolyzed cephalosporins more rapidly than penicillins. 4. The pI was 9.3 by isoelectric focusing. The molecular weight was estimated to be 40kDa. Conclusion : According to its substrate profile, pI and molecular weight, the β-lactamase from a clinical isolate of P. aeruginosa was a cephalosporinase belonging to group 1 in the Bush-Jacoby-Medeiros classification scheme.
유홍진,한성록 순천향대학교 부설 산업기술연구소 2002 순천향 산업기술연구소논문집 Vol.8 No.1
Phenol was separated from wastewater by membrane solvent extraction, using a microporous bydrophobic hollow fiber module. The system was operated counter-currently and cocurrently with the aqueous phase flowing through the fiber lumens and the solvent flowing through the shell side. MIBK was used as an extracting solvent. Separation efficiency of countercurrent flow method was better than that of cocurrent flow method.